BRPI0809656B8 - atropisômero, composto, agente profilático ou terapêutico, e, composição farmacêutica - Google Patents

atropisômero, composto, agente profilático ou terapêutico, e, composição farmacêutica

Info

Publication number
BRPI0809656B8
BRPI0809656B8 BRPI0809656A BRPI0809656A BRPI0809656B8 BR PI0809656 B8 BRPI0809656 B8 BR PI0809656B8 BR PI0809656 A BRPI0809656 A BR PI0809656A BR PI0809656 A BRPI0809656 A BR PI0809656A BR PI0809656 B8 BRPI0809656 B8 BR PI0809656B8
Authority
BR
Brazil
Prior art keywords
atropisomer
compound
prophylactic
pharmaceutical composition
therapeutic agent
Prior art date
Application number
BRPI0809656A
Other languages
English (en)
Inventor
Tsuruoka Hiroyuki
Yoshida Juri
Aoki Kazumasa
Hayashi Noriyuki
Asoh Yusuke
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of BRPI0809656A2 publication Critical patent/BRPI0809656A2/pt
Publication of BRPI0809656B1 publication Critical patent/BRPI0809656B1/pt
Publication of BRPI0809656B8 publication Critical patent/BRPI0809656B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

atropisômero, composto, agente profilático ou terapêutico, e, composição farmacêutica. é divulgado um agente a prevenção ou tratamento de doenças cardiovasculares. especificamente é divulgado um atropisômero de um composto representando pela seguinte fórmula geral (i) na fórmula, r1 representada um grupo de alquila c1-c3 ou um grupo de hidróxi-alquila c1-c3; e r2 é um átomo de hidrogênio ou um grupo de alcóxi c1-c3.
BRPI0809656A 2007-04-09 2008-04-08 atropisômero, composto, agente profilático ou terapêutico, e, composição farmacêutica BRPI0809656B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007-101938 2007-04-09
JP2007101938 2007-04-09
PCT/JP2008/056907 WO2008126831A1 (ja) 2007-04-09 2008-04-08 ピロール誘導体のアトロプ異性体

Publications (3)

Publication Number Publication Date
BRPI0809656A2 BRPI0809656A2 (pt) 2014-10-07
BRPI0809656B1 BRPI0809656B1 (pt) 2019-07-09
BRPI0809656B8 true BRPI0809656B8 (pt) 2021-05-25

Family

ID=39863928

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0809656A BRPI0809656B8 (pt) 2007-04-09 2008-04-08 atropisômero, composto, agente profilático ou terapêutico, e, composição farmacêutica

Country Status (14)

Country Link
US (2) US8524918B2 (pt)
EP (1) EP2133330B1 (pt)
JP (1) JP5363312B2 (pt)
KR (2) KR101477579B1 (pt)
CN (1) CN101679243B (pt)
BR (1) BRPI0809656B8 (pt)
CA (1) CA2683059C (pt)
DK (1) DK2133330T3 (pt)
ES (1) ES2448498T3 (pt)
IL (1) IL201261A0 (pt)
PL (1) PL2133330T3 (pt)
PT (1) PT2133330E (pt)
TW (1) TWI444185B (pt)
WO (1) WO2008126831A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2349997B1 (en) 2008-10-08 2015-08-12 Exelixis, Inc. Atropisomers of (hydroxyalkyl) pyrrole derivatives
CA2736930C (en) * 2008-10-08 2016-11-22 Exelixis Inc. 1-phenylpyrrole compounds
WO2010098286A1 (ja) * 2009-02-25 2010-09-02 第一三共株式会社 ミネラルコルチコイド受容体拮抗薬を含有する医薬
JP5536869B2 (ja) * 2009-03-26 2014-07-02 ポクセル・エスアーエス 優先晶出法を利用したジヒドロ−１，３，５トリアジンラセミ体のエナンチオマー分離のための方法
HUE041725T2 (hu) * 2013-04-10 2019-05-28 Daiichi Sankyo Co Ltd (S)-1-(2-hidroxietil)-4-metil-N-[4-(metilszulfonil)fenil]-5-[2-(trifluormetil)fenil]-1H-pirrol-3-karboxamid kristálya
EP3025711B1 (en) * 2013-07-23 2020-11-18 Daiichi Sankyo Company, Limited Medicine for preventing or treating hypertension
KR102226982B1 (ko) 2013-08-27 2021-03-11 다이이찌 산쿄 가부시키가이샤 피롤 유도체의 제조 방법 및 그 중간체
RS58274B1 (sr) 2014-06-30 2019-03-29 Astrazeneca Ab Benzoksazinon amidi kao modulatori mineralokortikoidnog receptora
CA2973944C (en) * 2015-01-26 2019-07-30 Daiichi Sankyo Company, Limited Solid composition of pyrrole carboxamide
CN109053608A (zh) * 2015-02-17 2018-12-21 华润赛科药业有限责任公司 一种旋光纯的硫代乙酸类化合物、其药物组合物和用途
CN105622531A (zh) * 2015-04-03 2016-06-01 南京明德新药研发股份有限公司 轴手性异构体及其制备方法和制药用途
US20180280414A1 (en) 2015-10-13 2018-10-04 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation
CN108778334A (zh) * 2016-03-24 2018-11-09 第三共株式会社 用于治疗肾脏疾病的药物
WO2018019843A1 (en) 2016-07-26 2018-02-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis
US12527763B2 (en) 2019-10-25 2026-01-20 Sunshine Lake Pharma Co., Ltd. Pyrrole amide compound and use thereof
JP7697961B2 (ja) 2020-03-11 2025-06-24 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 対象が中心性漿液性脈絡網膜症を有するか、または有する危険性があるかどうかを決定する方法。
US20240376051A1 (en) * 2021-03-30 2024-11-14 Sunshine Lake Pharma Co., Ltd. Crystalline form of pyrrole amide compound, preparation method therefor and use thereof
CN115246785B (zh) * 2021-04-26 2024-03-26 年衍药业(珠海)有限公司 吡咯酰胺化合物的制备方法
WO2023031277A1 (en) 2021-08-31 2023-03-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of ocular rosacea
CN115784961A (zh) * 2021-09-10 2023-03-14 上海鼎雅药物化学科技有限公司 埃沙西林酮及其中间体的合成方法
CN119306644A (zh) * 2023-07-12 2025-01-14 广东东阳光药业股份有限公司 制备吡咯甲酸化合物的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323208B1 (en) 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JP2005532982A (ja) * 2001-09-24 2005-11-04 バイエル・フアーマシユーチカルズ・コーポレーシヨン 肥満の処置のためのピロール誘導体の製造及び使用
US6939968B2 (en) 2002-12-23 2005-09-06 Bristol-Myers Squibb Company Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives
DE10354060A1 (de) * 2003-11-19 2005-06-02 Merck Patent Gmbh Pyrrolderivate
EP1773768B8 (en) * 2004-07-30 2018-12-26 Exelixis, Inc. Pyrrole derivatives as pharmaceutical agents
EP1844020B1 (en) * 2005-01-10 2017-09-06 Exelixis, Inc. Heterocyclic carboxamide compounds as steroid nuclear receptor ligands

Also Published As

Publication number Publication date
TW200901968A (en) 2009-01-16
TWI444185B (zh) 2014-07-11
EP2133330B1 (en) 2014-01-01
IL201261A0 (en) 2010-05-31
WO2008126831A1 (ja) 2008-10-23
HK1139942A1 (en) 2010-09-30
KR20090127421A (ko) 2009-12-11
US20140024696A1 (en) 2014-01-23
EP2133330A1 (en) 2009-12-16
US8524918B2 (en) 2013-09-03
CA2683059C (en) 2012-09-25
KR101477579B1 (ko) 2014-12-30
PL2133330T3 (pl) 2014-06-30
JPWO2008126831A1 (ja) 2010-07-22
US8754118B2 (en) 2014-06-17
EP2133330A4 (en) 2010-08-11
JP5363312B2 (ja) 2013-12-11
DK2133330T3 (da) 2014-03-31
BRPI0809656A2 (pt) 2014-10-07
CN101679243A (zh) 2010-03-24
CA2683059A1 (en) 2008-10-23
US20100093826A1 (en) 2010-04-15
BRPI0809656B1 (pt) 2019-07-09
KR20140048337A (ko) 2014-04-23
ES2448498T3 (es) 2014-03-14
CN101679243B (zh) 2012-09-26
PT2133330E (pt) 2014-03-31

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/07/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/07/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/04/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF