EA200970793A1 - Модуляторы рецепторов, активируемых пролифераторами пероксисом - Google Patents

Модуляторы рецепторов, активируемых пролифераторами пероксисом

Info

Publication number
EA200970793A1
EA200970793A1 EA200970793A EA200970793A EA200970793A1 EA 200970793 A1 EA200970793 A1 EA 200970793A1 EA 200970793 A EA200970793 A EA 200970793A EA 200970793 A EA200970793 A EA 200970793A EA 200970793 A1 EA200970793 A1 EA 200970793A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
phenyl
peroxis
proliferators
modulators
Prior art date
Application number
EA200970793A
Other languages
English (en)
Inventor
Ланс Аллен Пфайфер
Тяньвэй Ма
Натан Брайан Мэнтло
Лаура Фри Майкл
Фезе Мамбо Мокубе
Чахрзад Монроз-Рафезадех
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200970793A1 publication Critical patent/EA200970793A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к соединениям, соответствующим структурной формулегде Rпредставляет собой -Н или -С-С-алкил; Rвыбирают из группы, состоящей из -Н, -С-С-алкила, -С-С-алкил-CF, фенила и пиридинила; и Rвыбирают из группы, состоящей из -Н, -С-С-алкила, -С-С-алкил-O-СН, -СН-циклопропила, -СН-С=СН, -СНСН-(2-F-фенила) и фенила, имеющего от 1 до 2 заместителей, представляющих собой атомы фтора; при условии, что если каждый из Rи Rпредставляет собой Н, то Rвыбирают из группы, состоящей из -С-С-алкила, -С-С-алкил-О-СН, -СН-циклопропила, -СН-С=СН, -СНСН-(2-F-фенила) и фенила, имеющего от 1 до 2 заместителей, представляющих собой атомы фтора; или к их стереоизомерам и фармацевтически приемлемым солям.
EA200970793A 2007-02-23 2008-02-12 Модуляторы рецепторов, активируемых пролифераторами пероксисом EA200970793A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89126107P 2007-02-23 2007-02-23
PCT/US2008/053653 WO2008103574A2 (en) 2007-02-23 2008-02-12 Peroxisome proliferator activated receptor modulators

Publications (1)

Publication Number Publication Date
EA200970793A1 true EA200970793A1 (ru) 2010-02-26

Family

ID=39691178

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970793A EA200970793A1 (ru) 2007-02-23 2008-02-12 Модуляторы рецепторов, активируемых пролифераторами пероксисом

Country Status (11)

Country Link
US (1) US20100099725A1 (ru)
EP (1) EP2129667A2 (ru)
JP (1) JP2010519308A (ru)
KR (1) KR20090129406A (ru)
CN (1) CN101616900A (ru)
AU (1) AU2008218841A1 (ru)
BR (1) BRPI0807949A2 (ru)
CA (1) CA2678846A1 (ru)
EA (1) EA200970793A1 (ru)
MX (1) MX2009008998A (ru)
WO (1) WO2008103574A2 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101643451B (zh) * 2008-08-07 2013-03-06 浙江海正药业股份有限公司 过氧化物酶增殖物激活受体亚型δ类激动剂化合物及其制备方法
CA2740366A1 (en) * 2008-10-21 2010-04-29 Metabolex, Inc. Aryl gpr120 receptor agonists and uses thereof
WO2010071813A1 (en) * 2008-12-19 2010-06-24 Aryx Therapeutics, Inc. AGONISTS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-α
JP5708652B2 (ja) * 2010-08-31 2015-04-30 コニカミノルタ株式会社 Ｘ線撮影システム
US9505728B2 (en) 2012-03-09 2016-11-29 Inception 2, Inc. Triazolone compounds and uses thereof
MX2015007433A (es) 2012-12-20 2015-12-07 Inception 2 Inc Compuestos de triazolona y usos de los mismos.
WO2014202510A1 (de) 2013-06-20 2014-12-24 Bayer Cropscience Ag Arylsulfid- und arylsulfoxid-derivate als akarizide und insektizide
US9981928B2 (en) 2013-06-20 2018-05-29 Bayer Cropscience Aktiengesellschaft Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides
CN105517995B (zh) 2013-07-08 2018-10-02 拜耳作物科学股份公司 作为农药的六元c-n键合的芳基硫化物和芳基硫氧化物衍生物
WO2015035059A1 (en) 2013-09-06 2015-03-12 Inception 2, Inc. Triazolone compounds and uses thereof
CN114853686B (zh) * 2021-08-23 2023-06-20 中国药科大学 三氮唑酮类化合物及其医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA82048C2 (ru) * 2000-11-10 2008-03-11 Эли Лилли Энд Компани Агонисты альфа-рецепторов, активированных пролифератором пероксисом
GB0111523D0 (en) * 2001-05-11 2001-07-04 Glaxo Group Ltd Chemical compounds
US6875780B2 (en) * 2002-04-05 2005-04-05 Warner-Lambert Company Compounds that modulate PPAR activity and methods for their preparation
WO2004063165A1 (en) * 2003-01-06 2004-07-29 Eli Lilly And Company A pyrazole derivative as ppar modulator

Also Published As

Publication number Publication date
JP2010519308A (ja) 2010-06-03
WO2008103574A2 (en) 2008-08-28
BRPI0807949A2 (pt) 2014-06-03
MX2009008998A (es) 2009-09-02
WO2008103574A3 (en) 2008-12-18
CN101616900A (zh) 2009-12-30
CA2678846A1 (en) 2008-08-28
EP2129667A2 (en) 2009-12-09
AU2008218841A1 (en) 2008-08-28
KR20090129406A (ko) 2009-12-16
US20100099725A1 (en) 2010-04-22

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