MX2009008998A - Moduladores del receptor activado por proliferador de peroxisoma. - Google Patents
Moduladores del receptor activado por proliferador de peroxisoma.Info
- Publication number
- MX2009008998A MX2009008998A MX2009008998A MX2009008998A MX2009008998A MX 2009008998 A MX2009008998 A MX 2009008998A MX 2009008998 A MX2009008998 A MX 2009008998A MX 2009008998 A MX2009008998 A MX 2009008998A MX 2009008998 A MX2009008998 A MX 2009008998A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- receptor modulators
- activated receptor
- peroxisome proliferator
- proliferator activated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos de la Fórmula estructural: en donde: R1 es -H o -alquilo C1-C3; R2 se selecciona a partir del grupo que consiste de -H, -alquilo C1-C4, -alquilo C1-C3-CF3, fenilo, y piridinilo; y R3 se selecciona a partir del grupo que consiste de -H, -alquilo C1-C4, -alquilo C1-C3-O-CH3, -CH2-ciclopropilo, -CH2-C=CH2, - CH2CH2-(2-F-fenilo), y fenilo sustituido con desde 1 a 2 fluoros; siempre que cuando R1 y R2 sean cada uno H, entonces R3 se selecciona a partir del grupo que consiste de -alquilo C1-C4, -alquilo C1-C3-O-CH3, -CH2-ciclopropilo, -CH2-C=CH2, -CH2CH2-(2-F-fenilo), y fenilo sustituido con desde 1 a 2 fluoros; o estereoisómeros y sales de los mismos farmacéuticamente aceptables. (ver fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89126107P | 2007-02-23 | 2007-02-23 | |
| PCT/US2008/053653 WO2008103574A2 (en) | 2007-02-23 | 2008-02-12 | Peroxisome proliferator activated receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009008998A true MX2009008998A (es) | 2009-09-02 |
Family
ID=39691178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009008998A MX2009008998A (es) | 2007-02-23 | 2008-02-12 | Moduladores del receptor activado por proliferador de peroxisoma. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100099725A1 (es) |
| EP (1) | EP2129667A2 (es) |
| JP (1) | JP2010519308A (es) |
| KR (1) | KR20090129406A (es) |
| CN (1) | CN101616900A (es) |
| AU (1) | AU2008218841A1 (es) |
| BR (1) | BRPI0807949A2 (es) |
| CA (1) | CA2678846A1 (es) |
| EA (1) | EA200970793A1 (es) |
| MX (1) | MX2009008998A (es) |
| WO (1) | WO2008103574A2 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101643451B (zh) * | 2008-08-07 | 2013-03-06 | 浙江海正药业股份有限公司 | 过氧化物酶增殖物激活受体亚型δ类激动剂化合物及其制备方法 |
| EP2350016A2 (en) * | 2008-10-21 | 2011-08-03 | Metabolex Inc. | Aryl gpr120 receptor agonists and uses thereof |
| US20100184815A1 (en) * | 2008-12-19 | 2010-07-22 | Luehr Gary W | Agonists of peroxisome proliferator activated receptor-alpha |
| WO2012029340A1 (ja) * | 2010-08-31 | 2012-03-08 | コニカミノルタエムジー株式会社 | Ｘ線撮影システム |
| EP2822931B1 (en) | 2012-03-09 | 2017-05-03 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| EP2935228B9 (en) | 2012-12-20 | 2017-12-06 | Inception 2, Inc. | Triazolone compounds and uses thereof |
| US9981940B2 (en) | 2013-06-20 | 2018-05-29 | Bayer Cropscience Aktiengesellschaft | Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides |
| CN105722830B (zh) | 2013-06-20 | 2019-06-04 | 拜耳作物科学股份公司 | 作为杀螨剂和杀昆虫剂的芳基硫醚衍生物和芳基亚砜衍生物 |
| TW201542532A (zh) | 2013-07-08 | 2015-11-16 | Bayer Cropscience Ag | 作為殺蟲劑的六員ｃ－ｎ－鍵結之芳基硫化物及芳基亞碸衍生物 |
| CN105579440A (zh) | 2013-09-06 | 2016-05-11 | 因森普深2公司 | 三唑酮化合物及其应用 |
| CN114853686B (zh) * | 2021-08-23 | 2023-06-20 | 中国药科大学 | 三氮唑酮类化合物及其医药用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA82048C2 (uk) * | 2000-11-10 | 2008-03-11 | Эли Лилли Энд Компани | Агоністи альфа-рецепторів, активованих проліфератором пероксисом |
| GB0111523D0 (en) * | 2001-05-11 | 2001-07-04 | Glaxo Group Ltd | Chemical compounds |
| US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| WO2004063166A1 (en) * | 2003-01-06 | 2004-07-29 | Eli Lilly And Company | Heterocyclic ppar modulators |
-
2008
- 2008-02-12 JP JP2009550963A patent/JP2010519308A/ja not_active Withdrawn
- 2008-02-12 BR BRPI0807949-8A patent/BRPI0807949A2/pt not_active IP Right Cessation
- 2008-02-12 CA CA002678846A patent/CA2678846A1/en not_active Abandoned
- 2008-02-12 US US12/522,723 patent/US20100099725A1/en not_active Abandoned
- 2008-02-12 EP EP08743458A patent/EP2129667A2/en not_active Withdrawn
- 2008-02-12 AU AU2008218841A patent/AU2008218841A1/en not_active Abandoned
- 2008-02-12 MX MX2009008998A patent/MX2009008998A/es not_active Application Discontinuation
- 2008-02-12 CN CN200880005443A patent/CN101616900A/zh active Pending
- 2008-02-12 KR KR1020097017356A patent/KR20090129406A/ko not_active Application Discontinuation
- 2008-02-12 WO PCT/US2008/053653 patent/WO2008103574A2/en active Application Filing
- 2008-02-12 EA EA200970793A patent/EA200970793A1/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2129667A2 (en) | 2009-12-09 |
| JP2010519308A (ja) | 2010-06-03 |
| AU2008218841A1 (en) | 2008-08-28 |
| US20100099725A1 (en) | 2010-04-22 |
| WO2008103574A3 (en) | 2008-12-18 |
| CA2678846A1 (en) | 2008-08-28 |
| KR20090129406A (ko) | 2009-12-16 |
| BRPI0807949A2 (pt) | 2014-06-03 |
| EA200970793A1 (ru) | 2010-02-26 |
| CN101616900A (zh) | 2009-12-30 |
| WO2008103574A2 (en) | 2008-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HH | Correction or change in general | ||
| FA | Abandonment or withdrawal |