ES2159839T3 - Derivados del propano, su preparacion y su uso. - Google Patents

Derivados del propano, su preparacion y su uso.

Info

Publication number
ES2159839T3
ES2159839T3 ES97903355T ES97903355T ES2159839T3 ES 2159839 T3 ES2159839 T3 ES 2159839T3 ES 97903355 T ES97903355 T ES 97903355T ES 97903355 T ES97903355 T ES 97903355T ES 2159839 T3 ES2159839 T3 ES 2159839T3
Authority
ES
Spain
Prior art keywords
rent
cicloalcoxi
alcoxi
replaced
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97903355T
Other languages
English (en)
Inventor
Joergen Scheel-Kruger
Peter Moldt
Frank Watjen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Application granted granted Critical
Publication of ES2159839T3 publication Critical patent/ES2159839T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof

Abstract

LA PRESENTE INVENCION DESCRIBE COMPUESTOS DE FORMULA (A), (B), (C) O (D), O CUALQUIER MEZCLA DE LOS MISMOS, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS; EN LA QUE R ES HIDROGENO, ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, CICLOALQUILALQUILO O 2 - HIDROXIETILO; R 3 ES -CH 2 -XR , EN LA Q UE X ES O, S O NR , EN LA QUE R ES HIDROGENO O ALQUILO Y R ES ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, CICLOALQUILALQUILO O -CO-ALQUILO; R 4 ES FENILO, EL CUAL PUEDE ESTAR SUSTITUIDO UNA O MAS VECES CON SUSTITUYENTES SELECCIONADOS ENTRE EL GRUPO QUE CONSISTE EN HALOGENO, CF 3 , CN, ALCOXI, CICLOALCOXI, ALQUILO, CICOALQUILO, ALQUENILO, ALQUINILO, AMINO, NITRO, HETEROARILO Y ARILO; 3,4 METILENDIOXIFENILO; BENCILO, EL CUAL PUEDE ESTAR SUSTITUIDO UNO O MAS VECES CON SUSTITUYENTES SELECCIONADOS ENTRE EL GRUPO QUE CONSISTE EN HALOGENO, CF 3 , C N, ALCOXI, CICLOALCOXI, ALQUILO, CICLOALQUILO, ALQUENILO, ALQUINILO, AMINO, NITRO, HETEROARILO Y ARILO; HETEROARILO EL CUAL PUEDE ESTAR SUSTITUIDO UNA O MAS VECES CON SUSTITUYENTES SELECCIONADOS ENTRE EL GRUPO QUE CONSISTE EN HALOGENO, CF 3 , C N, ALCOXI, CICLOALCOXI, ALQUILO, CICLOALQUILO, ALQUENILO, ALQUINILO, AMINO, NITRO, HETEROARILO Y ARILO; O NAFTILO, EL CUAL PUEDE ESTAR SUSTITUIDO UNA O MAS VECES CON SUSTITUYENTES SELECCIONADOS ENTRE EL GRUPO QUE CONSISTE EN HALOGENO, CF 3 , CN, ALCOXI, CICLOALCOXI, ALQUILO, CICLOALQUILO, ALQUENILO, ALQUINILO, AMINO, NITRO, HETEROARILO Y ARILO. LOS COMPUESTOS POSEEN PROPIEDADES FARMACEUTICAS VALIOSAS COMO NEUROTRANSMISORES MONOAMINA, ES DECIR, DOPAMINA, SEROTONINA Y NORADRENALINA E INHIBIDORES DE RECAPTACION.
ES97903355T 1996-02-22 1997-02-21 Derivados del propano, su preparacion y su uso. Expired - Lifetime ES2159839T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK19496 1996-02-22

Publications (1)

Publication Number Publication Date
ES2159839T3 true ES2159839T3 (es) 2001-10-16

Family

ID=8090830

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97903355T Expired - Lifetime ES2159839T3 (es) 1996-02-22 1997-02-21 Derivados del propano, su preparacion y su uso.

Country Status (32)

Country Link
US (3) US6288079B1 (es)
EP (2) EP0885220B1 (es)
JP (1) JP3238414B2 (es)
KR (1) KR100446571B1 (es)
CN (1) CN1077574C (es)
AT (1) ATE203023T1 (es)
AU (1) AU720358B2 (es)
BG (1) BG63945B1 (es)
BR (1) BR9707636A (es)
CA (1) CA2244773C (es)
CZ (1) CZ287007B6 (es)
DE (1) DE69705608T2 (es)
DK (1) DK0885220T3 (es)
EE (1) EE04751B1 (es)
ES (1) ES2159839T3 (es)
GR (1) GR3036829T3 (es)
HK (1) HK1018957A1 (es)
HU (1) HU228356B1 (es)
IL (1) IL125146A (es)
IS (1) IS1824B (es)
NO (1) NO318731B1 (es)
NZ (1) NZ330886A (es)
PL (1) PL185132B1 (es)
PT (1) PT885220E (es)
RU (1) RU2167876C2 (es)
SG (1) SG99853A1 (es)
SI (1) SI0885220T1 (es)
SK (1) SK281813B6 (es)
TR (1) TR199801641T2 (es)
UA (1) UA49872C2 (es)
WO (1) WO1997030997A1 (es)
ZA (1) ZA971525B (es)

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IS4825A (is) 1998-08-17
WO1997030997A1 (en) 1997-08-28
PL328503A1 (en) 1999-02-01
US6288079B1 (en) 2001-09-11
CA2244773C (en) 2006-01-03
ATE203023T1 (de) 2001-07-15
SI0885220T1 (en) 2001-12-31
SK281813B6 (sk) 2001-08-06
US20020128284A1 (en) 2002-09-12
CN1077574C (zh) 2002-01-09
SG99853A1 (en) 2003-11-27
KR19990087127A (ko) 1999-12-15
DE69705608T2 (de) 2002-05-16
IS1824B (is) 2002-10-01
JP3238414B2 (ja) 2001-12-17
NO983877L (no) 1998-08-21
DE69705608D1 (de) 2001-08-16
JP2000504739A (ja) 2000-04-18
HUP9901199A2 (hu) 1999-08-30
HK1018957A1 (en) 2000-01-14
EE04751B1 (et) 2006-12-15
SK92998A3 (en) 1998-11-04
PL185132B1 (pl) 2003-02-28
IL125146A0 (en) 1999-01-26
NZ330886A (en) 1999-02-25
ZA971525B (en) 1997-10-21
CZ287007B6 (en) 2000-08-16
US6395748B2 (en) 2002-05-28
BR9707636A (pt) 1999-07-27
EP1130020A1 (en) 2001-09-05
NO318731B1 (no) 2005-05-02
UA49872C2 (uk) 2002-10-15
EE9800254A (et) 1999-02-15
CA2244773A1 (en) 1997-08-28
CZ252098A3 (cs) 1998-11-11
AU1794097A (en) 1997-09-10
HU228356B1 (en) 2013-03-28
CN1211982A (zh) 1999-03-24
IL125146A (en) 2002-03-10
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HUP9901199A3 (en) 2001-02-28
BG63945B1 (bg) 2003-07-31
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US20010018444A1 (en) 2001-08-30
TR199801641T2 (xx) 1998-11-23
RU2167876C2 (ru) 2001-05-27
EP0885220B1 (en) 2001-07-11
NO983877D0 (no) 1998-08-21
KR100446571B1 (ko) 2004-11-03
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