HUP9901199A2 - Neurotranszmitter újrafelvételt gátló tropánszármazékok és eljárás előállításukra, e vegyületeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása - Google Patents

Neurotranszmitter újrafelvételt gátló tropánszármazékok és eljárás előállításukra, e vegyületeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása

Info

Publication number
HUP9901199A2
HUP9901199A2 HU9901199A HUP9901199A HUP9901199A2 HU P9901199 A2 HUP9901199 A2 HU P9901199A2 HU 9901199 A HU9901199 A HU 9901199A HU P9901199 A HUP9901199 A HU P9901199A HU P9901199 A2 HUP9901199 A2 HU P9901199A2
Authority
HU
Hungary
Prior art keywords
alkyl
pipe powder
compounds
alkynyl
alkenyl
Prior art date
Application number
HU9901199A
Other languages
English (en)
Inventor
Peter Moldt
Jorgen Scheel-Krüger
Frank Wätjen
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of HUP9901199A2 publication Critical patent/HUP9901199A2/hu
Publication of HUP9901199A3 publication Critical patent/HUP9901199A3/hu
Publication of HU228356B1 publication Critical patent/HU228356B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof

Abstract

A találmány szerinti vegyületek (Ia), (Ib), (Ic) vagy (Id) általánősképletében R jelentése hidrőgénatőm vagy alkil-, alkenil-, alkinil-, ciklőalkil-,ciklőalkil-alkil- vagy 2- hidrőxi-etil-csőpőrt, R3 jelentése -CH2-X-R' általánős képletű csőpőrt, ahől X jelentéseőxigén- vagy kénatőm vagy NR'' általánős képletű csőpőrt, amelyképletben R'' jelentése hidrőgénatőm vagy alkilcsőpőrt, és R'jelentése alkil-, alkenil-, alkinil-, ciklőalkil- vagy ciklőalkil-alkil-csőpőrt vagy -CO-alkil-csőpőrt, és R4 jelentése fenil-, benzil-, heterőaril- vagy naftilcsőpőrt, amelyekegy- vagy többszörösen helyettesítettek lehetnek, ahől ahelyettesítő(k) halőgénatőm, CF3 és CN képletű csőpőrt, alkőxi-,ciklőalkőxi-, alkil-, ciklőalkil-, alkenil-, alkinil-, aminő-, nitrő-,heterőaril- és arilcsőpőrt lehet(nek), vagy 3,4-metilén-diőxi-fenil-csőpőrt. A találmány tárgyköréhez tartőznak tővábbá a fenti vegyületekelőállítása, a hatóanyagként e vegyületeket tartalmazó gyógyászatikészítmények, valamint e vegyületek alkalmazása gyógyászatikészítmények előállítására. A találmány szerinti gyógyászatikészítmények Parkinsőn-kór, depresszió, pszeűdőelmebaj, elhízás,narkőlepszia, kábítószer szedése és/vagy azzal való visszaélés,túlzőtt aktivitással járó figyelemcsökkenés, időskőri elmebaj vagyemlékezetkiesés kezelésére alkalmasak. ŕ
HU9901199A 1996-02-22 1997-02-21 Tropane-derivatives, inhibiting neurotransmitter re-uptake, their preparation, pharmaceutical compositions containing them and use of the compounds HU228356B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK19496 1996-02-22
PCT/EP1997/000850 WO1997030997A1 (en) 1996-02-22 1997-02-21 Tropane-derivatives, their preparation and use

Publications (3)

Publication Number Publication Date
HUP9901199A2 true HUP9901199A2 (hu) 1999-08-30
HUP9901199A3 HUP9901199A3 (en) 2001-02-28
HU228356B1 HU228356B1 (en) 2013-03-28

Family

ID=8090830

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901199A HU228356B1 (en) 1996-02-22 1997-02-21 Tropane-derivatives, inhibiting neurotransmitter re-uptake, their preparation, pharmaceutical compositions containing them and use of the compounds

Country Status (32)

Country Link
US (3) US6288079B1 (hu)
EP (2) EP0885220B1 (hu)
JP (1) JP3238414B2 (hu)
KR (1) KR100446571B1 (hu)
CN (1) CN1077574C (hu)
AT (1) ATE203023T1 (hu)
AU (1) AU720358B2 (hu)
BG (1) BG63945B1 (hu)
BR (1) BR9707636A (hu)
CA (1) CA2244773C (hu)
CZ (1) CZ287007B6 (hu)
DE (1) DE69705608T2 (hu)
DK (1) DK0885220T3 (hu)
EE (1) EE04751B1 (hu)
ES (1) ES2159839T3 (hu)
GR (1) GR3036829T3 (hu)
HK (1) HK1018957A1 (hu)
HU (1) HU228356B1 (hu)
IL (1) IL125146A (hu)
IS (1) IS1824B (hu)
NO (1) NO318731B1 (hu)
NZ (1) NZ330886A (hu)
PL (1) PL185132B1 (hu)
PT (1) PT885220E (hu)
RU (1) RU2167876C2 (hu)
SG (1) SG99853A1 (hu)
SI (1) SI0885220T1 (hu)
SK (1) SK281813B6 (hu)
TR (1) TR199801641T2 (hu)
UA (1) UA49872C2 (hu)
WO (1) WO1997030997A1 (hu)
ZA (1) ZA971525B (hu)

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US6288079B1 (en) 2001-09-11
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CA2244773C (en) 2006-01-03
ATE203023T1 (de) 2001-07-15
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CN1077574C (zh) 2002-01-09
SG99853A1 (en) 2003-11-27
KR19990087127A (ko) 1999-12-15
DE69705608T2 (de) 2002-05-16
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NO983877L (no) 1998-08-21
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JP2000504739A (ja) 2000-04-18
HK1018957A1 (en) 2000-01-14
EE04751B1 (et) 2006-12-15
SK92998A3 (en) 1998-11-04
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NO318731B1 (no) 2005-05-02
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