UA49872C2 - Похідні тропану, спосіб їх одержання, фармацевтична композиція та спосіб лікування - Google Patents
Похідні тропану, спосіб їх одержання, фармацевтична композиція та спосіб лікуванняInfo
- Publication number
- UA49872C2 UA49872C2 UA98073814A UA98073814A UA49872C2 UA 49872 C2 UA49872 C2 UA 49872C2 UA 98073814 A UA98073814 A UA 98073814A UA 98073814 A UA98073814 A UA 98073814A UA 49872 C2 UA49872 C2 UA 49872C2
- Authority
- UA
- Ukraine
- Prior art keywords
- alkyl
- alkynyl
- cycloalkyl
- alkenyl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Згідно з винаходом запропоновано сполуки формул (а), (b), (с) та (d) або будь-яка їх суміш, або їх фармацевтично прийнятні солі; де R - гідроген, алкіл, алкеніл, алкініл, циклоалкіл, циклоалкілалкіл або 2-гідроксіетил; R3 - СН2-Х-R’, де Ч - О, S або NR", де R" - гідроген чи алкіл, а R' - алкіл, алкеніл, алкініл, циклоалкіл, циклоалкілалкіл або -СО-алкіл; R4 - феніл, що може бути заміщеним один чи більше разів замісниками, вибраними з групи, що включає галоген, СF3, CN, алкоксил, циклоалкоксил, алкіл, алкеніл, алкініл, циклоалкіл, аміно- та нітрогрупу, гетероарил та арил; 3,4-метилендіоксифеніл; бензил, що може бути заміщеним один чи більше разів замісниками, вибраними з групи, що включає галоген, СF3, CN, алкоксил, циклоалкоксил, алкіл, алкеніл, алкініл, циклоалкіл, аміно- та нітрогрупу, гетероарил та арил; гетероарил, що може бути заміщеним один чи більше разів замісниками, вибраними з групи, що включає галоген, СF3, CN, алкоксил, циклоалкоксил, алкіл, алкеніл, алкініл, циклоалкіл, аміно- та нітрогрупу, гетероарил та арил; або нафтил, що може бути заміщеним один чи більше разів замісниками, вибраними з групи, що включає галоген, СF3, CN, алкоксил, циклоалкоксил, алкіл, алкеніл, алкініл, циклоалкіл, аміно- та нітрогрупу, гетероарил та арил. Сполуки виявляють корисні фармацевтичні властивості як інгібітори реабсорбції моноамінних нейротрансмітерів, тобто допаміну, норадреналіну, серотоніну. (a) (b) (c) (d)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK19496 | 1996-02-22 | ||
PCT/EP1997/000850 WO1997030997A1 (en) | 1996-02-22 | 1997-02-21 | Tropane-derivatives, their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
UA49872C2 true UA49872C2 (uk) | 2002-10-15 |
Family
ID=8090830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA98073814A UA49872C2 (uk) | 1996-02-22 | 1997-02-21 | Похідні тропану, спосіб їх одержання, фармацевтична композиція та спосіб лікування |
Country Status (32)
Country | Link |
---|---|
US (3) | US6288079B1 (uk) |
EP (2) | EP1130020A1 (uk) |
JP (1) | JP3238414B2 (uk) |
KR (1) | KR100446571B1 (uk) |
CN (1) | CN1077574C (uk) |
AT (1) | ATE203023T1 (uk) |
AU (1) | AU720358B2 (uk) |
BG (1) | BG63945B1 (uk) |
BR (1) | BR9707636A (uk) |
CA (1) | CA2244773C (uk) |
CZ (1) | CZ287007B6 (uk) |
DE (1) | DE69705608T2 (uk) |
DK (1) | DK0885220T3 (uk) |
EE (1) | EE04751B1 (uk) |
ES (1) | ES2159839T3 (uk) |
GR (1) | GR3036829T3 (uk) |
HK (1) | HK1018957A1 (uk) |
HU (1) | HU228356B1 (uk) |
IL (1) | IL125146A (uk) |
IS (1) | IS1824B (uk) |
NO (1) | NO318731B1 (uk) |
NZ (1) | NZ330886A (uk) |
PL (1) | PL185132B1 (uk) |
PT (1) | PT885220E (uk) |
RU (1) | RU2167876C2 (uk) |
SG (1) | SG99853A1 (uk) |
SI (1) | SI0885220T1 (uk) |
SK (1) | SK281813B6 (uk) |
TR (1) | TR199801641T2 (uk) |
UA (1) | UA49872C2 (uk) |
WO (1) | WO1997030997A1 (uk) |
ZA (1) | ZA971525B (uk) |
Families Citing this family (77)
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AU2003302609B9 (en) | 2002-12-02 | 2008-05-15 | Xenome Ltd | Novel chi-conotoxin peptides (-I) |
EP2412719A1 (en) | 2002-12-02 | 2012-02-01 | Xenome Ltd | Chi-conotoxin peptides |
CN100551924C (zh) * | 2003-02-12 | 2009-10-21 | 神经研究公司 | 8-氮杂-双环[3.2.1]辛烷衍生物和它们作为单胺神经递质再摄取抑制剂的用途 |
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WO2013120935A1 (en) | 2012-02-16 | 2013-08-22 | Neurosearch A/S | Pharmaceutical compositions for combination therapy |
PT3265126T (pt) | 2015-03-03 | 2021-08-30 | Saniona As | Formulação combinada de tesofensina e metoprolol |
EA026727B1 (ru) * | 2015-09-10 | 2017-05-31 | Замертон Холдингс Лимитед | Соль (1r,2r,3s)-3-(3,4-дихлорфенил)-2-(этоксиметил)-8-метил-8-азабицикло[3.2.1]октана и фталевой кислоты, способ её получения, продукт способа, фармацевтические композиции для лечения и/или профилактики нарушений, связанных с ожирением, их применение и способы лечения и/или профилактики нарушений, связанных с ожирением |
WO2017121432A1 (en) | 2016-01-15 | 2017-07-20 | Saniona A/S | Tesofensine and metoprolol for treatment of hypertension |
EA028995B1 (ru) * | 2016-02-25 | 2018-01-31 | Замертон Холдингс Лимитед | Соль тезофензина и оптически активных ацетиламинокислот, их применение для лечения и/или профилактики нарушений, связанных с ожирением |
MX2019002647A (es) | 2016-09-07 | 2019-07-01 | Saniona As | Composiciones de tesofensina. |
DE102017210141A1 (de) | 2017-06-16 | 2018-12-20 | Henkel Ag & Co. Kgaa | Portion zur Bereitstellung tensidhaltiger Flotten |
BR112021013463A2 (pt) | 2019-01-07 | 2021-09-14 | Saniona A/S | Tesofensina para redução do peso corporal em pacientes com prader-willi |
JP2023523738A (ja) | 2020-04-22 | 2023-06-07 | サニオナ エー/エス | 視床下部性肥満症の処置 |
TWI772928B (zh) * | 2020-10-21 | 2022-08-01 | 行政院原子能委員會核能研究所 | 非放射性標準品β-CFT之製備方法 |
WO2024008808A1 (en) | 2022-07-08 | 2024-01-11 | Initiator Pharma A/S | Compound for treatment of female sexual dysfunction |
CN115572289A (zh) * | 2022-10-24 | 2023-01-06 | 龙曦宁(上海)医药科技有限公司 | 一种特索芬辛的合成方法 |
WO2024089247A1 (en) | 2022-10-28 | 2024-05-02 | Initiator Pharma A/S | Compound for treatment of pain |
WO2024146892A1 (en) | 2023-01-03 | 2024-07-11 | Initiator Pharma A/S | Compound for treatment of erectile dysfunction |
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US4281130A (en) * | 1979-05-24 | 1981-07-28 | Sterling Drug Inc. | Lower-alkyl 4,6,7,8,8a-9-hexahydro-6,9-ethanothieno[3,2-f]indolizine-10-carboxylate |
US5496953A (en) | 1990-08-09 | 1996-03-05 | Research Triangle Institute | Cocaine receptor binding ligands |
US5128118A (en) * | 1990-08-09 | 1992-07-07 | Research Triangle Institute | Cocaine receptor binding ligands |
US5380848A (en) * | 1990-08-09 | 1995-01-10 | Research Triangle Institute | Cocaine receptor binding ligands |
DK0644775T3 (da) * | 1991-11-15 | 2000-03-06 | Nat Inst Health | Kokainreceptorbindende ligander |
AU671163B2 (en) * | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
AU672644B2 (en) * | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
WO1995028401A1 (en) * | 1994-04-19 | 1995-10-26 | Neurosearch A/S | Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors |
GB9626611D0 (en) * | 1996-12-20 | 1997-02-05 | Unilever Plc | Agglomerated silicas |
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