JP2010524965A5 - - Google Patents
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- Publication number
- JP2010524965A5 JP2010524965A5 JP2010504257A JP2010504257A JP2010524965A5 JP 2010524965 A5 JP2010524965 A5 JP 2010524965A5 JP 2010504257 A JP2010504257 A JP 2010504257A JP 2010504257 A JP2010504257 A JP 2010504257A JP 2010524965 A5 JP2010524965 A5 JP 2010524965A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- hydroxy
- hydrogen
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 38
- 229910052739 hydrogen Inorganic materials 0.000 claims 26
- 239000001257 hydrogen Substances 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 24
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 24
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical class 0.000 claims 17
- 150000002431 hydrogen Chemical class 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 6
- 208000037259 Amyloid Plaque Diseases 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- -1 R 31 Chemical compound 0.000 claims 5
- 230000002285 radioactive effect Effects 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004104 aryloxy group Chemical class 0.000 claims 3
- 125000001231 benzoyloxy group Chemical class C(C1=CC=CC=C1)(=O)O* 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 150000004696 coordination complex Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90784107P | 2007-04-19 | 2007-04-19 | |
| US92980607P | 2007-07-13 | 2007-07-13 | |
| PCT/US2008/060710 WO2008131148A1 (en) | 2007-04-19 | 2008-04-18 | Diphenyl-heteroaryl derivatives and their use for binding and imaging amyloid plaques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010524965A JP2010524965A (ja) | 2010-07-22 |
| JP2010524965A5 true JP2010524965A5 (enExample) | 2011-06-02 |
Family
ID=39875907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010504257A Pending JP2010524965A (ja) | 2007-04-19 | 2008-04-18 | ジフェニル−ヘテロアリール誘導体並びにアミロイド斑への結合及び画像化のためのその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20110158907A1 (enExample) |
| EP (1) | EP2144507A4 (enExample) |
| JP (1) | JP2010524965A (enExample) |
| WO (1) | WO2008131148A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007334436A1 (en) | 2006-12-15 | 2008-06-26 | Abbott Laboratories | Novel oxadiazole compounds |
| PL2247558T5 (pl) * | 2008-02-14 | 2024-10-14 | Eli Lilly And Company | Nowe środki obrazujące do wykrywania czynnościowych zaburzeń neurologicznych |
| US8932557B2 (en) | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
| JP2011523997A (ja) * | 2008-05-30 | 2011-08-25 | フォスター ホイーラー エナージア オサケ ユキチュア | 酸素燃焼によって動力を発生させるための方法及び装置 |
| JP5896739B2 (ja) | 2008-06-09 | 2016-03-30 | ルートヴィヒ‐マクシミリアンズ‐ウニヴェルジテート・ミュンヘン | タンパク質凝集関連の疾患および／または神経変性性疾患に関係するタンパク質の凝集を阻害するための新規薬物 |
| US8420052B2 (en) | 2008-07-24 | 2013-04-16 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying AD pathology |
| US8575150B2 (en) * | 2008-12-16 | 2013-11-05 | Merck Sharp & Dohme Corp. | Triazole derivatives for treatment of Alzheimer's disease |
| EP2411057B1 (en) | 2009-03-23 | 2020-05-06 | Eli Lilly and Company | Imaging agents for detecting neurological disorders |
| US8691187B2 (en) | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
| GB0921573D0 (en) | 2009-12-10 | 2010-01-27 | Ge Healthcare Ltd | Iodine radiolabelling method |
| US20120251448A1 (en) * | 2011-03-03 | 2012-10-04 | Hefti Franz F | Compounds for Use in the Detection of Neurodegenerative Diseases |
| WO2012118935A1 (en) | 2011-03-03 | 2012-09-07 | Proteotech Inc | Compounds for the treatment of neurodegenerative diseases |
| BR112017009937B8 (pt) * | 2014-12-15 | 2022-08-23 | Dow Agrosciences Llc | Moléculas, composições pesticidas, e processos para controlar uma peste |
| WO2018206778A1 (en) | 2017-05-12 | 2018-11-15 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN111217752A (zh) * | 2020-02-12 | 2020-06-02 | 温州市人民医院 | 芳基吡唑类化合物及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2856311A (en) * | 1952-05-21 | 1958-10-14 | Ciba Ltd | Process for optically brightening fibrous materials |
| US4713383A (en) * | 1984-10-01 | 1987-12-15 | Ciba-Geigy Corporation | Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses |
| US5235044A (en) * | 1992-09-09 | 1993-08-10 | Raychem Corporation | Compounds having oxadiazole and triazene moieties, crosslinkable polymers therefrom, and methods therefor |
| DE19816880A1 (de) * | 1998-04-17 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| ES2211420T3 (es) * | 1999-07-21 | 2004-07-16 | F. Hoffmann-La Roche Ag | Derivados de triazol. |
| TW200413009A (en) * | 2002-10-04 | 2004-08-01 | Univ Pennsylvania | Biphenyls and fluorenes as imaging agents in alzheimer's disease |
| WO2007002540A2 (en) * | 2005-06-24 | 2007-01-04 | Kung Hank F | Radiolabeled-pegylation of ligands for use as imaging agents |
| EP2023919A4 (en) * | 2006-05-08 | 2010-12-22 | Molecular Neuroimaging Llc | COMPOUNDS AND AMYLOID PROBES FOR THERAPY AND IMAGING USES |
-
2008
- 2008-04-18 EP EP08746182A patent/EP2144507A4/en not_active Withdrawn
- 2008-04-18 US US12/595,131 patent/US20110158907A1/en not_active Abandoned
- 2008-04-18 JP JP2010504257A patent/JP2010524965A/ja active Pending
- 2008-04-18 WO PCT/US2008/060710 patent/WO2008131148A1/en not_active Ceased
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