JP2018518201A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018518201A5 JP2018518201A5 JP2018518771A JP2018518771A JP2018518201A5 JP 2018518201 A5 JP2018518201 A5 JP 2018518201A5 JP 2018518771 A JP2018518771 A JP 2018518771A JP 2018518771 A JP2018518771 A JP 2018518771A JP 2018518201 A5 JP2018518201 A5 JP 2018518201A5
- Authority
- JP
- Japan
- Prior art keywords
- sirna
- amine
- containing compound
- pharmaceutically acceptable
- cholesterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510364229.8 | 2015-06-26 | ||
| CN201510364229 | 2015-06-26 | ||
| PCT/CN2016/087034 WO2016206626A1 (zh) | 2015-06-26 | 2016-06-24 | 一种siRNA、含有该siRNA的药物组合物和缀合物及它们的应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518201A JP2018518201A (ja) | 2018-07-12 |
| JP2018518201A5 true JP2018518201A5 (enExample) | 2019-06-13 |
| JP6715325B2 JP6715325B2 (ja) | 2020-07-01 |
Family
ID=57584730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518771A Active JP6715325B2 (ja) | 2015-06-26 | 2016-06-24 | ｓｉＲＮＡ、ｓｉＲＮＡを含む医薬組成物及び結合体、並びにそれらの応用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190062749A1 (enExample) |
| EP (1) | EP3315608B1 (enExample) |
| JP (1) | JP6715325B2 (enExample) |
| CN (1) | CN107849567B (enExample) |
| WO (1) | WO2016206626A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3675826T (lt) | 2017-08-31 | 2023-09-11 | Life Technologies Corporation | Katijoninės lipidų kompozicijos audiniams-specifiniam įterpimui |
| EP3719126B1 (en) * | 2017-12-01 | 2025-01-01 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| DK3719128T3 (da) * | 2017-12-01 | 2025-03-03 | Suzhou Ribo Life Science Co Ltd | Dobbelt-strenget oligonukleotid, sammensætning og konjugat bestaende dobbelt-strenget oligonukleotid, fremgangsmåde herfor og anvendelse heraf |
| EP3719127A4 (en) | 2017-12-01 | 2021-10-20 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH IT, MANUFACTURING METHOD AND USE |
| CA3083970A1 (en) * | 2017-12-01 | 2019-06-06 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| WO2019105404A1 (zh) * | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CN110944675B9 (zh) * | 2017-12-01 | 2024-08-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CN110945131B (zh) * | 2017-12-01 | 2024-05-28 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| AU2018394875B2 (en) | 2017-12-29 | 2023-08-03 | Suzhou Ribo Life Science Co., Ltd. | Conjugates and preparation and use thereof |
| WO2020038377A1 (zh) * | 2018-08-21 | 2020-02-27 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的药物组合物和缀合物及其用途 |
| US11896674B2 (en) | 2018-09-30 | 2024-02-13 | Suzhou Ribo Life Science Co., Ltd. | SiRNA conjugate, preparation method therefor and use thereof |
| WO2020135581A1 (zh) * | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| WO2020135673A1 (zh) | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CN111377985B (zh) * | 2018-12-29 | 2023-11-10 | 苏州瑞博生物技术股份有限公司 | 化合物和缀合物及其制备方法和用途 |
| CN113330117B (zh) * | 2019-01-18 | 2024-05-28 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| AU2020280439B2 (en) | 2019-05-22 | 2025-08-14 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| US12590304B2 (en) | 2019-05-22 | 2026-03-31 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| CN111979237A (zh) * | 2019-05-22 | 2020-11-24 | 苏州瑞博生物技术股份有限公司 | 核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途 |
| KR20220011689A (ko) * | 2019-05-22 | 2022-01-28 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 약제학적 조성물, 접합체, 제조 방법, 및 용도 |
| CN111973617A (zh) * | 2019-05-23 | 2020-11-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| CN111973618B (zh) * | 2019-05-23 | 2024-02-02 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与siRNA缀合物及制备方法和用途 |
| CN113795582B (zh) | 2019-05-24 | 2024-05-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| US20230076803A1 (en) * | 2019-08-29 | 2023-03-09 | Suzhou Ribo Life Science Co., Ltd. | Compound and drug conjugate, and preparation method and use thereof |
| WO2021110148A1 (zh) * | 2019-12-06 | 2021-06-10 | 南京明德新药研发有限公司 | siRNA缀合物、双链siRNA缀合物及其盐和应用 |
| CN111110866B (zh) * | 2019-12-30 | 2023-04-11 | 福州大学 | 还原性聚谷氨酸/聚乙烯亚胺/siRNA复合纳米粒及制备与应用 |
| US20240033278A9 (en) * | 2020-06-10 | 2024-02-01 | Medshine Discovery Inc. | Conjugate group and conjugate |
| CN113663089B (zh) * | 2021-06-25 | 2022-10-28 | 北京理工大学 | 可电离脂质纳米颗粒组合物、制备方法及应用 |
| WO2023116764A1 (zh) * | 2021-12-23 | 2023-06-29 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及其用途 |
| CN114634984A (zh) * | 2022-02-02 | 2022-06-17 | 复旦大学 | 一种脑胶质瘤生物标记物mlkl基因及其应用 |
| CN115487308B (zh) * | 2022-09-29 | 2024-09-27 | 北京大学 | 反义核酸糖基缀合物及其制备方法和在肝癌治疗中的应用 |
| JP2025542581A (ja) * | 2022-12-08 | 2025-12-26 | １グローブ ヘルス インスティテュート エルエルシー | アンチセンスＲＮＡ（ａｓＲＮＡ）技術およびその使用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2423060T3 (es) * | 2004-03-12 | 2013-09-17 | Alnylam Pharmaceuticals, Inc. | Agentes iRNA que tienen como diana al VEGF |
| KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| WO2006096018A1 (en) * | 2005-03-09 | 2006-09-14 | Mogam Biotechnology Research Institute | Small interfering rna and pharmaceutical composition for treatment of hepatitis b comprising the same |
| CN101426912A (zh) * | 2005-08-17 | 2009-05-06 | 瑟纳治疗公司 | 介导rna干扰的化学修饰短干扰核酸分子 |
| CN102140461B (zh) * | 2010-01-29 | 2012-12-05 | 苏州瑞博生物技术有限公司 | 小干扰核酸和药物组合物及其制药应用 |
| CN102140458B (zh) * | 2010-01-29 | 2013-05-22 | 苏州瑞博生物技术有限公司 | 小干扰核酸和药物组合物及其制药应用 |
| CN103380113B (zh) * | 2010-11-15 | 2018-03-30 | 生命科技公司 | 含胺的转染试剂及其制备和使用方法 |
| WO2013061295A1 (en) * | 2011-10-28 | 2013-05-02 | University Of The Witwatersrand, Johannesburg | Inhibition of viral gene expression |
| EP3730618A1 (en) * | 2011-11-18 | 2020-10-28 | Alnylam Pharmaceuticals, Inc. | Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases |
| AU2013299717B2 (en) * | 2012-08-06 | 2018-06-28 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugated RNA agents and process for their preparation |
| CA2893824A1 (en) * | 2012-12-14 | 2014-06-19 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of ckap5 by double-stranded rna |
| IL288931B2 (en) * | 2013-03-14 | 2025-05-01 | Alnylam Pharmaceuticals Inc | Compositions comprising a complementary portion of C5 IRNA and methods of using them |
-
2016
- 2016-06-24 CN CN201680036513.5A patent/CN107849567B/zh active Active
- 2016-06-24 WO PCT/CN2016/087034 patent/WO2016206626A1/zh not_active Ceased
- 2016-06-24 US US15/738,006 patent/US20190062749A1/en not_active Abandoned
- 2016-06-24 EP EP16813742.0A patent/EP3315608B1/en active Active
- 2016-06-24 JP JP2018518771A patent/JP6715325B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018518201A5 (enExample) | ||
| JP6715325B2 (ja) | ｓｉＲＮＡ、ｓｉＲＮＡを含む医薬組成物及び結合体、並びにそれらの応用 | |
| JP2021533800A5 (enExample) | ||
| JP2021502120A5 (enExample) | ||
| JP2022505234A5 (enExample) | ||
| JP2014515406A5 (enExample) | ||
| IL274503B1 (en) | Nucleic acids for inhibiting expression of lpa in a cell | |
| JP2010530014A5 (enExample) | ||
| JP2019512478A5 (enExample) | ||
| JP2016520312A5 (enExample) | ||
| AU2017326372B2 (en) | Modified oligonucleotides and methods of use | |
| JP2021503940A5 (enExample) | ||
| JP2015528002A5 (enExample) | ||
| JP2014528466A5 (enExample) | ||
| JP2014528467A5 (enExample) | ||
| JP2018520685A5 (enExample) | ||
| JP2008538381A5 (enExample) | ||
| JP2016529230A5 (enExample) | ||
| JP2010505741A5 (enExample) | ||
| JP2011528654A5 (enExample) | ||
| JP2004537517A5 (enExample) | ||
| JP2010527913A5 (enExample) | ||
| JP2010526917A5 (enExample) | ||
| FI3550023T3 (fi) | Oligomeerejä ja oligomeerikonjugaatteja | |
| JP2022534069A5 (enExample) |