CN107849567B - 一种siRNA、含有该siRNA的药物组合物和缀合物及它们的应用 - Google Patents

一种siRNA、含有该siRNA的药物组合物和缀合物及它们的应用 Download PDF

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CN107849567B
CN107849567B CN201680036513.5A CN201680036513A CN107849567B CN 107849567 B CN107849567 B CN 107849567B CN 201680036513 A CN201680036513 A CN 201680036513A CN 107849567 B CN107849567 B CN 107849567B
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CN107849567A (zh
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张鸿雁
高山
黄渊余
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Suzhou Ruibo Biotechnology Co ltd
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CN201680036513.5A 2015-06-26 2016-06-24 一种siRNA、含有该siRNA的药物组合物和缀合物及它们的应用 Active CN107849567B (zh)

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WO2019105404A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
JP7273417B2 (ja) 2017-12-01 2023-05-15 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用
WO2019105419A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
US11414661B2 (en) 2017-12-01 2022-08-16 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof
WO2019105403A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
KR20250107294A (ko) * 2017-12-01 2025-07-11 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 핵산, 이를 포함하는 조성물과 컨쥬게이트, 및 그의 제조 방법과 용도
WO2019105418A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途
DK3732185T3 (da) 2017-12-29 2025-03-31 Suzhou Ribo Life Science Co Ltd Konjugater og fremstilling og anvendelse heraf
EP3842534A4 (en) * 2018-08-21 2022-07-06 Suzhou Ribo Life Science Co., Ltd. NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND CONJUGATE WITH NUCLEIC ACID AND THEIR USE
WO2020063198A1 (zh) * 2018-09-30 2020-04-02 苏州瑞博生物技术有限公司 一种siRNA缀合物及其制备方法和用途
CN112423795A (zh) * 2018-12-28 2021-02-26 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
JP7507495B2 (ja) 2018-12-28 2024-06-28 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
CN111377985B (zh) * 2018-12-29 2023-11-10 苏州瑞博生物技术股份有限公司 化合物和缀合物及其制备方法和用途
CN113330117B (zh) * 2019-01-18 2024-05-28 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
EP3974530A4 (en) 2019-05-22 2023-07-12 Suzhou Ribo Life Science Co., Ltd. NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, METHOD OF MANUFACTURE AND USE
CA3139195A1 (en) * 2019-05-22 2020-11-26 Suzhou Ribo Life Science Co., Ltd. Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use
CN111979237A (zh) * 2019-05-22 2020-11-24 苏州瑞博生物技术股份有限公司 核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途
CN111973617A (zh) * 2019-05-23 2020-11-24 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
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CN111110866B (zh) * 2019-12-30 2023-04-11 福州大学 还原性聚谷氨酸/聚乙烯亚胺/siRNA复合纳米粒及制备与应用
WO2021249484A1 (zh) * 2020-06-10 2021-12-16 南京明德新药研发有限公司 缀合基团及其缀合物
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US20190062749A1 (en) 2019-02-28
JP6715325B2 (ja) 2020-07-01
CN107849567A (zh) 2018-03-27
EP3315608A4 (en) 2018-12-12
WO2016206626A1 (zh) 2016-12-29
EP3315608B1 (en) 2020-09-16
JP2018518201A (ja) 2018-07-12
EP3315608A1 (en) 2018-05-02

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