JP2011528654A5 - - Google Patents
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- Publication number
- JP2011528654A5 JP2011528654A5 JP2011516733A JP2011516733A JP2011528654A5 JP 2011528654 A5 JP2011528654 A5 JP 2011528654A5 JP 2011516733 A JP2011516733 A JP 2011516733A JP 2011516733 A JP2011516733 A JP 2011516733A JP 2011528654 A5 JP2011528654 A5 JP 2011528654A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- optionally substituted
- compound according
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 23
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229920001059 synthetic polymer Polymers 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
- 0 CC*C(*)(*)NC(C)(*)** Chemical compound CC*C(*)(*)NC(C)(*)** 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13314808P | 2008-06-26 | 2008-06-26 | |
| US61/133,148 | 2008-06-26 | ||
| US19205008P | 2008-09-15 | 2008-09-15 | |
| US61/192,050 | 2008-09-15 | ||
| PCT/US2009/048943 WO2009158668A1 (en) | 2008-06-26 | 2009-06-26 | Prodrugs and drug-macromolecule conjugates having controlled drug release rates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015126754A Division JP2015172078A (ja) | 2008-06-26 | 2015-06-24 | 制御された薬剤放出速度を有するプロドラッグ及び薬剤−高分子のコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528654A JP2011528654A (ja) | 2011-11-24 |
| JP2011528654A5 true JP2011528654A5 (enExample) | 2012-08-16 |
| JP6084770B2 JP6084770B2 (ja) | 2017-02-22 |
Family
ID=41444985
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516733A Active JP6084770B2 (ja) | 2008-06-26 | 2009-06-26 | 制御された薬剤放出速度を有するプロドラッグ及び薬剤−高分子のコンジュゲート |
| JP2015126754A Pending JP2015172078A (ja) | 2008-06-26 | 2015-06-24 | 制御された薬剤放出速度を有するプロドラッグ及び薬剤−高分子のコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015126754A Pending JP2015172078A (ja) | 2008-06-26 | 2015-06-24 | 制御された薬剤放出速度を有するプロドラッグ及び薬剤−高分子のコンジュゲート |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8680315B2 (enExample) |
| EP (1) | EP2306986B1 (enExample) |
| JP (2) | JP6084770B2 (enExample) |
| CN (1) | CN102076331B (enExample) |
| DK (1) | DK2306986T3 (enExample) |
| ES (1) | ES2672526T3 (enExample) |
| WO (1) | WO2009158668A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140376A1 (en) * | 2010-05-05 | 2011-11-10 | Prolynx Llc | Controlled drug release from dendrimers |
| WO2011140393A1 (en) | 2010-05-05 | 2011-11-10 | Prolynx Llc | Controlled release from macromolecular conjugates |
| EP2566334B1 (en) * | 2010-05-05 | 2018-04-18 | Prolynx, LLC | Controlled drug release from solid supports |
| HUE052285T2 (hu) | 2011-06-06 | 2021-04-28 | Starpharma Pty Ltd | Makromolekulák |
| WO2013036857A1 (en) * | 2011-09-07 | 2013-03-14 | Prolynx Llc | Sulfone linkers |
| SG11201400444VA (en) | 2011-09-07 | 2014-04-28 | Prolynx Llc | Hydrogels with biodegradable crosslinking |
| EP2768856A4 (en) * | 2011-10-18 | 2015-05-27 | Prolynx Llc | PEG CONJUGATES OF EXENATIDE |
| US9545449B2 (en) * | 2012-05-11 | 2017-01-17 | Advanced Proteone Therapeutics Inc. | Site-specific labeling and targeted delivery of proteins for the treatment of cancer |
| JP2016534064A (ja) | 2013-10-22 | 2016-11-04 | プロリンクス エルエルシー | ソマトスタチン及びその類似体のコンジュゲート |
| CN105813653B (zh) | 2013-12-19 | 2020-06-26 | 西雅图基因公司 | 与目标-药物偶联物并用的亚甲基氨基甲酸酯连接物 |
| WO2016025752A1 (en) * | 2014-08-14 | 2016-02-18 | Prolynx Llc | Reagents for thiol conjugation and conjugates formed therefrom |
| CN107001440A (zh) | 2014-09-26 | 2017-08-01 | 拜耳制药股份公司 | 稳定化的肾上腺髓质素衍生物及其用途 |
| GB201508024D0 (en) * | 2015-05-11 | 2015-06-24 | Haemostatix Ltd | Haemostatic compositions |
| CA3016814A1 (en) | 2016-03-16 | 2017-09-21 | Prolynx Llc | Extended release conjugates of exenatide analogs |
| CN106177977B (zh) * | 2016-07-11 | 2020-09-04 | 天津科技大学 | 一种抗肿瘤药物三元偶联物及合成和应用 |
| TWI773730B (zh) | 2017-02-22 | 2022-08-11 | 瑞典商阿斯特捷利康公司 | 治療性樹枝狀聚合物 |
| JP2021510702A (ja) | 2018-01-12 | 2021-04-30 | プロリンクス エルエルシー | 相乗的がん治療 |
| EP3823961A4 (en) | 2018-07-19 | 2022-06-08 | Starpharma Pty Limited | THERAPEUTIC DENDRIMER |
| US12071517B2 (en) | 2018-07-19 | 2024-08-27 | Starpharma Pty Ltd. | Therapeutic dendrimer |
| JPWO2020050378A1 (ja) * | 2018-09-06 | 2021-08-30 | 生化学工業株式会社 | 第３級アミン化合物又はイミン化合物を結合させた、ポリマーコンジュゲートとその製造方法 |
| WO2020067507A1 (ja) * | 2018-09-28 | 2020-04-02 | 生化学工業株式会社 | 第１級アミン化合物又は第２級アミン化合物－酸性多糖コンジュゲートとその製造方法 |
| MX2021011997A (es) * | 2019-04-05 | 2021-11-04 | Prolynx Llc | Enlazadores de conjugacion mejorados. |
| WO2020219943A1 (en) | 2019-04-26 | 2020-10-29 | Prolynx Llc | Slow-release cytokine conjugates |
| CA3143584A1 (en) | 2019-06-18 | 2020-12-24 | Bayer Aktiengesellschaft | Adrenomedullin-analogues for long-term stabilization and their use |
| BR112022002308A2 (pt) | 2019-08-07 | 2022-04-26 | Prolynx Llc | Esterilização a vapor de hidrogéis reticulados por ligantes beta-eliminativos |
| CN110423355B (zh) * | 2019-08-29 | 2021-09-14 | 武汉轻工大学 | 羧甲基化莲藕多糖-曲古霉素a轭合物的制备方法 |
| WO2021067458A1 (en) | 2019-09-30 | 2021-04-08 | Beijing Xuanyi Pharmasciences Co., Ltd. | Protein-macromolecule conjugates and methods of use thereof |
| KR102986821B1 (ko) | 2020-04-22 | 2026-07-06 | 머크 샤프 앤드 돔 엘엘씨 | 인터류킨-2 수용체 베타 감마c 이량체에 대해 편향되고 비펩티드성 수용성 중합체에 접합된 인간 인터류킨-2 접합체 |
| EP4319821A4 (en) * | 2021-04-09 | 2026-05-06 | Nanjing University | CONJUGATE AND ITS PREPARATION PROCESS AND ITS USE |
| EP4713024A1 (en) * | 2023-05-16 | 2026-03-25 | Nanjing University | Conjugate and the preparation thereof |
| WO2026138790A1 (zh) * | 2024-12-24 | 2026-07-02 | 长春金赛药业有限责任公司 | 一种具有可控的药物释放速率的前药和药物 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0270595B1 (en) | 1986-05-16 | 1990-08-16 | Eka Nobel Ab | An optically active reagent and a method for the determination of enantiomeric amine compounds |
| US5101059A (en) * | 1989-12-05 | 1992-03-31 | Research Corporation Technologies, Inc. | Amino acid protecting groups |
| DE4321946A1 (de) | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| CA2262502C (en) * | 1996-07-31 | 2002-11-26 | Nikken Chemicals Co., Ltd. | 6-phenyltetrahydro-1,3-oxazin-2-one derivatives and pharmaceutical composition containing the same |
| IL119029A0 (en) | 1996-08-07 | 1996-11-14 | Yeda Res & Dev | Long-acting drugs and pharamaceutical compositions comprising them |
| JPH11130711A (ja) * | 1997-10-24 | 1999-05-18 | Teijin Ltd | １α，２４，２５−トリヒドロキシビタミンＤ３類の合成中間体およびその製造法 |
| AU1345600A (en) * | 1998-11-12 | 2000-06-05 | Merck & Co., Inc. | Pyrimidinedione derivatives useful as alpha 1a adrenoceptor antagonists |
| US6114566A (en) * | 1999-05-24 | 2000-09-05 | Board Of Trustees Operating Michigan State University | 4-cyano-3-hydroxybutanoyl hydrazines, derivatives and process for the preparation thereof |
| JP2003528939A (ja) * | 1999-09-03 | 2003-09-30 | スクール オブ ファーマシー， ユニヴァーシティ オブ ロンドン | 分解性ポリマー |
| US6861162B2 (en) | 2002-08-28 | 2005-03-01 | Cityu Research Ltd. | Organic electroluminescence devices using pyrazolo[3,4b]quinoxaline derivatives |
| WO2004089280A2 (en) * | 2003-04-08 | 2004-10-21 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
| WO2004089279A2 (en) | 2003-04-08 | 2004-10-21 | Yeda Research And Development Co. Ltd. | Long-acting derivatives of pyy agonists |
| US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| GB0319759D0 (en) | 2003-08-22 | 2003-09-24 | Astrazeneca Ab | Chemical compounds |
| CA2786794C (en) | 2004-03-23 | 2017-09-12 | Complex Biosystems Gmbh | Aromatic polymeric cascade prodrug linker reagent |
| JP2006067889A (ja) | 2004-09-01 | 2006-03-16 | Japan Science & Technology Agency | Ｐｅｏと二本鎖核酸のコンジュゲート |
| JP5167473B2 (ja) | 2005-03-03 | 2013-03-21 | コヴェックス・テクノロジーズ・アイルランド・リミテッド | 抗血管新生化合物 |
| CN101287835A (zh) | 2005-08-17 | 2008-10-15 | 株式会社百奥尼 | 用于siRNA细胞内输送的siRNA-亲水性聚合物结合物及其方法 |
| JP5224016B2 (ja) * | 2006-03-10 | 2013-07-03 | 晃二 有光 | 感活性エネルギー線塩基発生剤、感活性エネルギー線塩基発生剤組成物、塩基反応性組成物及びパターン形成方法 |
| US20100168443A1 (en) | 2006-11-02 | 2010-07-01 | University Of Virginia Patent Foundation | Ethoid-Containing Compounds, Methods for Preparing Ethoid-Containing Compounds, and Methods of Use |
| CA3004716C (en) * | 2008-04-29 | 2022-04-12 | Ascendis Pharma Endocrinology Division A/S | Pegylated recombinant human growth hormone compounds |
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2009
- 2009-06-26 CN CN2009801238298A patent/CN102076331B/zh active Active
- 2009-06-26 JP JP2011516733A patent/JP6084770B2/ja active Active
- 2009-06-26 ES ES09771199.8T patent/ES2672526T3/es active Active
- 2009-06-26 US US12/999,287 patent/US8680315B2/en active Active
- 2009-06-26 DK DK09771199.8T patent/DK2306986T3/en active
- 2009-06-26 EP EP09771199.8A patent/EP2306986B1/en active Active
- 2009-06-26 WO PCT/US2009/048943 patent/WO2009158668A1/en not_active Ceased
-
2014
- 2014-03-21 US US14/221,842 patent/US9387254B2/en active Active
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2015
- 2015-06-24 JP JP2015126754A patent/JP2015172078A/ja active Pending