JP2013525080A5 - - Google Patents

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Publication number
JP2013525080A5
JP2013525080A5 JP2013509279A JP2013509279A JP2013525080A5 JP 2013525080 A5 JP2013525080 A5 JP 2013525080A5 JP 2013509279 A JP2013509279 A JP 2013509279A JP 2013509279 A JP2013509279 A JP 2013509279A JP 2013525080 A5 JP2013525080 A5 JP 2013525080A5
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JP
Japan
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optionally substituted
solid support
alkyl
heteroarylalkyl
arylalkyl
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JP2013509279A
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English (en)
Japanese (ja)
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JP2013525080A (ja
JP5964815B2 (ja
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Priority claimed from PCT/US2011/035422 external-priority patent/WO2011140392A1/en
Publication of JP2013525080A publication Critical patent/JP2013525080A/ja
Publication of JP2013525080A5 publication Critical patent/JP2013525080A5/ja
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Publication of JP5964815B2 publication Critical patent/JP5964815B2/ja
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JP2013509279A 2010-05-05 2011-05-05 固体担体からの放出制御薬物 Active JP5964815B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33174210P 2010-05-05 2010-05-05
US61/331,742 2010-05-05
PCT/US2011/035422 WO2011140392A1 (en) 2010-05-05 2011-05-05 Controlled drug release from solid supports

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016050380A Division JP6250723B2 (ja) 2010-05-05 2016-03-15 固体担体からの放出制御薬物

Publications (3)

Publication Number Publication Date
JP2013525080A JP2013525080A (ja) 2013-06-20
JP2013525080A5 true JP2013525080A5 (enExample) 2014-06-19
JP5964815B2 JP5964815B2 (ja) 2016-08-03

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ID=44904089

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013509279A Active JP5964815B2 (ja) 2010-05-05 2011-05-05 固体担体からの放出制御薬物
JP2016050380A Active JP6250723B2 (ja) 2010-05-05 2016-03-15 固体担体からの放出制御薬物

Family Applications After (1)

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JP2016050380A Active JP6250723B2 (ja) 2010-05-05 2016-03-15 固体担体からの放出制御薬物

Country Status (6)

Country Link
US (1) US8946405B2 (enExample)
EP (1) EP2566334B1 (enExample)
JP (2) JP5964815B2 (enExample)
CN (1) CN103025164B (enExample)
DK (1) DK2566334T3 (enExample)
WO (1) WO2011140392A1 (enExample)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009091531A2 (en) * 2008-01-16 2009-07-23 The General Hospital Corporation Uniform-sized, multi-drug carrying and photosensitive liposomes for advance drug delivery
ES2584381T3 (es) 2010-05-05 2016-09-27 Prolynx Llc Liberación controlada de compuestos activos desde conjugados macromoleculares
BR112013031556B1 (pt) 2011-06-06 2022-03-29 Starpharma Pty Ltd Macromoléculas, uso das mesmas para tratar ou suprimir o crescimento de um câncer e composições farmacêuticas
JP6158185B2 (ja) 2011-09-07 2017-07-05 プロリンクス エルエルシー 生分解性架橋を有するヒドロゲル
WO2013036857A1 (en) * 2011-09-07 2013-03-14 Prolynx Llc Sulfone linkers
JP6290187B2 (ja) * 2012-05-11 2018-03-07 クランツ,アレクサンダー 癌の処置のためのタンパク質の部位特異的標識及び標的送達
EP2925256A4 (en) * 2013-01-22 2016-08-17 Prolynx Llc SEALANTS HAVING CONTROLLED DEGRADATION
WO2014205126A1 (en) 2013-06-19 2014-12-24 The Regents Of The University Of California Chemical structures for localized delivery of therapeutic agents
SG11201603115YA (en) * 2013-10-22 2016-05-30 Prolynx Llc Conjugates of somatostatin and its analogs
WO2015095755A1 (en) * 2013-12-19 2015-06-25 Seattle Genetics, Inc. Methylene carbamate linkers for use with targeted-drug conjugates
CN106659796B (zh) 2014-03-14 2021-04-30 加利福尼亚大学董事会 Tco缀合物和治疗剂递送方法
CA3008017C (en) 2016-01-08 2024-01-02 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with reduced side-effects
US10835578B2 (en) 2016-01-08 2020-11-17 Ascendis Pharma Growth Disorders A/S CNP prodrugs with large carrier moieties
AU2017205688C1 (en) 2016-01-08 2022-03-10 Ascendis Pharma Growth Disorders A/S Cnp prodrugs with carrier attachment at the ring moiety
AU2017205690B2 (en) 2016-01-08 2022-04-28 Ascendis Pharma Growth Disorders A/S Controlled-release CNP agonists with increased NEP stability
NZ743488A (en) 2016-01-08 2023-02-24 Ascendis Pharma Growth Disorders As Controlled-release cnp agonists with low initial npr-b activity
AU2017205694B2 (en) 2016-01-08 2022-05-26 Ascendis Pharma Growth Disorders A/S Controlled-release CNP agonists with low NPR-C binding
IL317744A (en) * 2016-03-01 2025-02-01 Ascendis Pharma Bone Diseases As PTH drug agonists
JP7017248B2 (ja) * 2016-03-16 2022-02-08 プロリンクス エルエルシー エキセナチド類似体の持続放出コンジュゲート
EP3484523A1 (en) 2016-07-13 2019-05-22 Ascendis Pharma A/S Conjugation method for carrier-linked prodrugs
PL3518961T3 (pl) 2016-09-29 2023-08-14 Ascendis Pharma Bone Diseases A/S Związki pth o niskim stosunku wartości maksymalnej do minimalnej
RS64440B1 (sr) 2016-09-29 2023-09-29 Ascendis Pharma Bone Diseases As Režim doziranja za pth jedinjenje sa kontrolisanim oslobađanjem
FI3518982T3 (fi) 2016-09-29 2025-02-11 Ascendis Pharma Bone Diseases As Säädellysti vapautuvia PTH-yhdisteitä
HRP20230385T1 (hr) 2016-09-29 2023-06-23 Ascendis Pharma Growth Disorders A/S Kombinirana terapija sa cnp agonistima s kontroliranim oslobađanjem
TWI773730B (zh) 2017-02-22 2022-08-11 瑞典商阿斯特捷利康公司 治療性樹枝狀聚合物
IL269506B2 (en) 2017-03-22 2024-04-01 Genentech Inc Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
EP3684785B1 (en) 2017-09-19 2024-10-02 Technische Universität München N-methylated cyclic peptides and their prodrugs
EP3684417A1 (en) * 2017-09-19 2020-07-29 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Lipophilic peptide prodrugs
EP3737383A4 (en) 2018-01-12 2021-12-15 Prolynx LLC SYNERGISTIC CANCER TREATMENT
WO2019177740A1 (en) * 2018-03-12 2019-09-19 Boston Scientific Scimed, Inc. Scavenging methods, and scavenging system for radiocontrast agents
CA3093083A1 (en) 2018-03-28 2019-10-03 Ascendis Pharma A/S Conjugates
CN119504973A (zh) 2018-03-28 2025-02-25 阿森迪斯药物肿瘤股份有限公司 Il-2缀合物
CA3099620A1 (en) 2018-05-18 2019-11-21 Ascendis Pharma Bone Diseases A/S Starting dose of pth conjugates
US12071517B2 (en) 2018-07-19 2024-08-27 Starpharma Pty Ltd. Therapeutic dendrimer
CA3106568A1 (en) 2018-07-19 2020-01-23 Starpharma Pty Ltd Therapeutic dendrimer
EP3856255A1 (en) 2018-09-26 2021-08-04 Ascendis Pharma A/S Treatment of infections
MX2021003186A (es) 2018-09-26 2021-07-16 Ascendis Pharma As Nuevos conjugados de hidrogel.
US12594345B2 (en) 2018-09-26 2026-04-07 Ascendis Pharma A/S Degradable hyaluronic acid hydrogels
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
WO2020141223A1 (en) 2019-01-04 2020-07-09 Ascendis Pharma A/S Induction of sustained local inflammation
SG11202105833WA (en) 2019-01-04 2021-07-29 Ascendis Pharma Oncology Div A/S Minimization of systemic inflammation
US20220054476A1 (en) 2019-01-04 2022-02-24 Ascendis Pharma Oncology Division A/S Sustained local drug levels for innate immune agonists
TWI856997B (zh) 2019-01-04 2024-10-01 丹麥商阿仙帝斯製藥公司 模式辨別受體(pattern recognition receptor)促效劑的共軛物
EP3923906A1 (en) 2019-02-11 2021-12-22 Ascendis Pharma Growth Disorders A/S Dry pharmaceutical formulations of cnp conjugates
US12403182B2 (en) 2019-02-11 2025-09-02 Ascendis Pharma Bone Diseases A/S Liquid pharmaceutical formulations of PTH conjugates
CN114286693A (zh) * 2019-04-05 2022-04-05 普罗林科斯有限责任公司 改良偶联接头
SG11202111175YA (en) * 2019-04-26 2021-11-29 Prolynx Llc Slow-release cytokine conjugates
WO2020247151A1 (en) 2019-06-05 2020-12-10 Boston Scientific Scimed, Inc. Click chemistry capturable platinum-based antineoplastic agents
WO2020254617A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pk properties
WO2020254613A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pk properties
CA3143278A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Tyrosine kinase inhibitor conjugates
AU2020295721B2 (en) * 2019-06-21 2025-04-03 Ascendis Pharma A/S Conjugates of π-electron-pair-donating heteroaromatic nitrogen-comprising compounds
TW202114738A (zh) 2019-06-21 2021-04-16 丹麥商阿仙帝斯製藥公司 抗ctla4結合物
WO2020254607A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pd properties
WO2020254612A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pd properties
CN114630818A (zh) * 2019-09-30 2022-06-14 北京轩义医药科技有限公司 蛋白-大分子偶联物及其使用方法
CN115003320A (zh) 2020-01-13 2022-09-02 阿森迪斯药物骨疾病股份有限公司 甲状旁腺功能减退的治疗
AU2021269007A1 (en) 2020-05-04 2022-11-24 Ascendis Pharma A/S Hydrogel irradiation
IL298642A (en) 2020-06-03 2023-01-01 Ascendis Pharma Oncology Div A/S il-2 sequences and uses thereof
CA3189715A1 (en) 2020-08-28 2022-03-03 Ascendis Pharma Oncology Division A/S Glycosylated il-2 proteins and uses thereof
EP4217004A1 (en) 2020-09-28 2023-08-02 Ascendis Pharma Bone Diseases A/S Improvement of physical and mental well-being of patients with hypoparathyroidism
KR20230164709A (ko) 2021-04-01 2023-12-04 아센디스 파마 에이에스 염증 유발 질환을 치료하기 위한 지속형 성장 호르몬의 용도
EP4404951A1 (en) 2021-09-22 2024-07-31 Ascendis Pharma Bone Diseases A/S Long-acting pth compound treatments
WO2023069510A1 (en) * 2021-10-19 2023-04-27 The United States Government As Represented By The Department Of Veterans Affairs Cannabinoid compositions for gastroesophageal disorders
CA3236278A1 (en) 2021-12-13 2023-06-22 Kennett Sprogoe Effective doses of cnp conjugates
MX2024006698A (es) 2021-12-13 2024-06-19 Ascendis Pharma Oncology Div A/S Tratamientos de cancer con agonistas de los receptores tipo toll 7 y 8 (tlr7/8).
WO2023227505A1 (en) 2022-05-23 2023-11-30 Ascendis Pharma Growth Disorders A/S Liquid pharmaceutical formulations of cnp compounds
CN114874624B (zh) * 2022-05-27 2023-04-07 深圳市博致远科技有限公司 一种导热吸波室温固化硅橡胶产品及其制备方法
CN120752051A (zh) 2022-11-02 2025-10-03 阿森迪斯药物骨疾病股份有限公司 包含两种pth化合物的pth治疗方案
WO2024104922A1 (en) 2022-11-14 2024-05-23 Ascendis Pharma Growth Disorders A/S Method of improving skeletal muscle function
TW202430223A (zh) 2023-01-05 2024-08-01 丹麥商阿仙帝斯眼科製藥有限公司 用於治療眼部病症之藥物結合物
TW202434299A (zh) 2023-01-05 2024-09-01 丹麥商阿仙帝斯製藥公司 製造水凝膠微球之方法
AU2024232125A1 (en) 2023-03-06 2025-08-28 Ascendis Pharma A/S Compounds of drugs with an albumin binding moiety
AU2024233842A1 (en) 2023-03-06 2025-09-04 Ascendis Pharma A/S Multi-albumin binding compounds
IL323039A (en) 2023-03-06 2025-10-01 Ascendis Pharma As Drug compounds containing albumin-binding moieties
JP2026510974A (ja) 2023-03-20 2026-04-10 アセンディス ファーマ グロース ディスオーダーズ エー/エス 軟骨形成不全症のヒト対象における胸腰椎奇形の治療の方法
WO2024231442A1 (en) 2023-05-09 2024-11-14 Ascendis Pharma Oncology Division A/S Novel cancer treatments with il-2 conjugates
IL326658A (en) 2023-09-04 2026-04-01 Ascendis Pharma Bone Diseases As PTH treatment in chronic kidney disease
WO2025208117A1 (en) * 2024-03-29 2025-10-02 Maha Therapeutics, Inc. Cleavable ester compounds and uses thereof
WO2026013135A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Albumin-binding reagents
WO2026013136A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Albumin-binding compounds
WO2026013138A1 (en) 2024-07-10 2026-01-15 Ascendis Pharma A/S Compounds with improved albumin-binding

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563968A (en) 1967-10-03 1971-02-16 Gaf Corp Process for the preparation of functional polymers from n-vinyl pyrrolidone
US4265233A (en) 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
US4769445A (en) 1985-03-04 1988-09-06 Pennwalt Corporation Process for the solid phase synthesis of peptides which contain sulfated tyrosine
US6033719A (en) 1996-04-25 2000-03-07 Medtronic, Inc. Method for covalent attachment of biomolecules to surfaces of medical devices
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
AU7522601A (en) * 2000-06-02 2001-12-11 Eidgenoess Tech Hochschule Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US7264822B2 (en) * 2002-04-03 2007-09-04 Poly-Med, Inc. Conjugated drug-polymer coated stent
AU2003221770A1 (en) 2002-04-29 2003-11-17 Stephen T. Flock Controlled release transdermal drug delivery
US7732535B2 (en) 2002-09-05 2010-06-08 Advanced Cardiovascular Systems, Inc. Coating for controlled release of drugs from implantable medical devices
CA2521784C (en) 2003-04-08 2012-03-27 Yeda Research And Development Co. Ltd. Reversible pegylated drugs
JP2010512355A (ja) 2006-12-11 2010-04-22 トポターゲット・アクティーゼルスカブ 癌の処置のためのジフェニルオキシ−インドール−2−オン化合物のプロドラッグ
US7863387B2 (en) * 2007-10-25 2011-01-04 Boston Scientific Scimed, Inc. Dehydrofluorination and surface modification of fluoropolymers for drug delivery applications
WO2009158668A1 (en) 2008-06-26 2009-12-30 Prolynx Llc Prodrugs and drug-macromolecule conjugates having controlled drug release rates
US8703907B2 (en) * 2010-05-05 2014-04-22 Prolynx Llc Controlled drug release from dendrimers
ES2584381T3 (es) 2010-05-05 2016-09-27 Prolynx Llc Liberación controlada de compuestos activos desde conjugados macromoleculares

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