JP2012526548A5 - - Google Patents
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- JP2012526548A5 JP2012526548A5 JP2012510752A JP2012510752A JP2012526548A5 JP 2012526548 A5 JP2012526548 A5 JP 2012526548A5 JP 2012510752 A JP2012510752 A JP 2012510752A JP 2012510752 A JP2012510752 A JP 2012510752A JP 2012526548 A5 JP2012526548 A5 JP 2012526548A5
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- Prior art keywords
- polymer compound
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- compound
- Prior art date
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- 229920001223 polyethylene glycol Polymers 0.000 claims description 20
- 239000002202 Polyethylene glycol Substances 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 10
- -1 4-monomethoxytrityl group Chemical group 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 150000002431 hydrogen Chemical group 0.000 claims description 2
- 239000011800 void material Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 25
- 229920001600 hydrophobic polymer Polymers 0.000 claims 11
- 108020004459 Small interfering RNA Proteins 0.000 claims 7
- 239000005289 controlled pore glass Substances 0.000 claims 6
- 229920001477 hydrophilic polymer Polymers 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 238000000137 annealing Methods 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 claims 1
- NXLNNXIXOYSCMB-UHFFFAOYSA-N (4-nitrophenyl) carbonochloridate Chemical compound [O-][N+](=O)C1=CC=C(OC(Cl)=O)C=C1 NXLNNXIXOYSCMB-UHFFFAOYSA-N 0.000 claims 1
- JBWYRBLDOOOJEU-UHFFFAOYSA-N 1-[chloro-(4-methoxyphenyl)-phenylmethyl]-4-methoxybenzene Chemical compound C1=CC(OC)=CC=C1C(Cl)(C=1C=CC(OC)=CC=1)C1=CC=CC=C1 JBWYRBLDOOOJEU-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 238000003763 carbonization Methods 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 0 CCC=CC(C(C1C=*=ICC1)(*=C)c(cc1)ccc1OC)=CCCOI Chemical compound CCC=CC(C(C1C=*=ICC1)(*=C)c(cc1)ccc1OC)=CCCOI 0.000 description 2
- DBWPJNWEBPQPOW-UHFFFAOYSA-N CC(c(cc1)ccc1OC)(C(C=C1)=CCC1OC)O Chemical compound CC(c(cc1)ccc1OC)(C(C=C1)=CCC1OC)O DBWPJNWEBPQPOW-UHFFFAOYSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020090042297A KR101224828B1 (ko) | 2009-05-14 | 2009-05-14 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
| KR10-2009-0042297 | 2009-05-14 | ||
| PCT/KR2010/003039 WO2010131916A2 (ko) | 2009-05-14 | 2010-05-13 | siRNA 접합체 및 그 제조방법 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013098798A Division JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Division JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526548A JP2012526548A (ja) | 2012-11-01 |
| JP2012526548A5 true JP2012526548A5 (enExample) | 2013-05-30 |
| JP5758381B2 JP5758381B2 (ja) | 2015-08-05 |
Family
ID=43085466
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510752A Active JP5758381B2 (ja) | 2009-05-14 | 2010-05-13 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2013098798A Active JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Pending JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013098798A Active JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Pending JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8779114B2 (enExample) |
| EP (3) | EP2463371B1 (enExample) |
| JP (3) | JP5758381B2 (enExample) |
| KR (1) | KR101224828B1 (enExample) |
| CN (3) | CN102439148B (enExample) |
| AU (1) | AU2010248239B2 (enExample) |
| BR (1) | BRPI1012141B1 (enExample) |
| CA (2) | CA2871888A1 (enExample) |
| RU (2) | RU2558258C2 (enExample) |
| WO (1) | WO2010131916A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101224828B1 (ko) | 2009-05-14 | 2013-01-22 | (주)바이오니아 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
| KR101722948B1 (ko) * | 2012-01-05 | 2017-04-04 | (주)바이오니아 | 리간드가 결합된 이중나선 올리고 ｒｎａ 구조체 및 그 제조방법 |
| BR112014014730B1 (pt) * | 2011-12-15 | 2021-05-18 | Bioneer Corporation | estrutura de droga polímero terapêutica, métodos para preparar uma estrutura de oligo rna de dupla hélice, nanoparticula e composição farmacêutica |
| AU2013206989B2 (en) * | 2012-01-05 | 2015-05-28 | Bioneer Corporation | High-efficiency nanoparticle-type double-helical oligo-RNA structure and method for preparing same |
| US9649388B2 (en) * | 2012-01-18 | 2017-05-16 | Bioneer Corporation | Magnetic nanoparticle-samirna complex and method for preparing same |
| IN2015DN02055A (enExample) | 2012-09-17 | 2015-08-14 | Grace W R & Co | |
| CN104781403A (zh) * | 2012-10-05 | 2015-07-15 | 株式会社百奥尼 | 双调蛋白特异性-双螺旋寡核糖核苷酸,包含双螺旋寡核糖核苷酸的双螺旋寡核糖核苷酸结构,和包含以上成分的用于预防或治疗呼吸道疾病的组合物 |
| US9816095B2 (en) * | 2012-12-06 | 2017-11-14 | Kyowa Hakko Bio Co., Ltd. | Double-stranded ribonucleic acid for adjuvants |
| CN105705638B (zh) * | 2013-07-05 | 2019-11-26 | 柏业公司 | 改善的具有高效能的纳米颗粒型寡核苷酸结构及其制备方法 |
| MX2016000021A (es) | 2013-07-05 | 2017-04-06 | Bioneer Corp | Sirna virus especifico del dengue, estructura arn oligo helicoidal, y composicion para la supresion de proliferacion del virus del dengue que comprende la estructura arn. |
| US20160122764A1 (en) * | 2013-07-05 | 2016-05-05 | Bioneer Corporation | Respiratory disease-related gene specific sirna, double-helical oligo rna structure containing sirna, compositon containing same for preventing or treating respiratory disease |
| KR20150006742A (ko) * | 2013-07-09 | 2015-01-19 | (주)바이오니아 | 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| KR20150006743A (ko) * | 2013-07-09 | 2015-01-19 | (주)바이오니아 | 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| JP6426268B2 (ja) * | 2014-04-04 | 2018-11-21 | バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ | 新規の二重らせんオリゴｒｎａおよびこれを含む線維症または呼吸器疾患の予防または治療用薬学組成物 |
| ES2929099T3 (es) | 2014-05-02 | 2022-11-24 | Grace W R & Co | Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado |
| CA2974195A1 (en) | 2014-10-15 | 2016-04-21 | University Of Connecticut | Bio-reducible self-assembled liquid crystalline block copolymer for drug delivery |
| ES2896897T3 (es) | 2015-06-05 | 2022-02-28 | Grace W R & Co | Agentes de clarificación para el bioprocesamiento de adsorbentes y métodos para producir y usar los mismos |
| WO2016204515A1 (ko) * | 2015-06-15 | 2016-12-22 | (주)바이오니아 | STAT3 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체, 이를 포함하는 조성물 및 이의 용도 |
| KR101861738B1 (ko) | 2016-08-24 | 2018-05-29 | (주)바이오니아 | 마이크로 rna를 포함하는 이중나선 올리고 rna 구조체 |
| AU2018237139A1 (en) * | 2017-03-22 | 2019-10-17 | The Regents Of The University Of California | Modified oligonucleotides and therapeutic uses thereof |
| KR20250107294A (ko) * | 2017-12-01 | 2025-07-11 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 이를 포함하는 조성물과 컨쥬게이트, 및 그의 제조 방법과 용도 |
| WO2019105418A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 |
| WO2019105419A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| JP7273417B2 (ja) | 2017-12-01 | 2023-05-15 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 |
| US11414661B2 (en) | 2017-12-01 | 2022-08-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| DK3732185T3 (da) | 2017-12-29 | 2025-03-31 | Suzhou Ribo Life Science Co Ltd | Konjugater og fremstilling og anvendelse heraf |
| KR102141124B1 (ko) | 2018-01-30 | 2020-08-04 | (주)바이오니아 | 이중 가닥 miRNA를 포함하는 이중나선 올리고뉴클레오타이드 구조체 및 이의 용도 |
| AU2019272190B2 (en) | 2018-05-25 | 2022-12-01 | Bioneer Corporation | Amphiregulin gene-specific double-stranded oligonucleotide and composition for preventing and treating fibrosis-related diseases and respiratory diseases, comprising same |
| EP3842534A4 (en) | 2018-08-21 | 2022-07-06 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND CONJUGATE WITH NUCLEIC ACID AND THEIR USE |
| WO2020063198A1 (zh) * | 2018-09-30 | 2020-04-02 | 苏州瑞博生物技术有限公司 | 一种siRNA缀合物及其制备方法和用途 |
| KR102473989B1 (ko) * | 2018-11-28 | 2022-12-07 | (주)바이오니아 | 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물 |
| JP7507495B2 (ja) | 2018-12-28 | 2024-06-28 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| US20220088051A1 (en) | 2019-01-15 | 2022-03-24 | Bioneer Corporation | Double-stranded oligonucleotide targeting dkk1 gene, construct including same, and hair loss prevention or hair growth composition containing same |
| CA3139195A1 (en) | 2019-05-22 | 2020-11-26 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
| EP3974530A4 (en) | 2019-05-22 | 2023-07-12 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, METHOD OF MANUFACTURE AND USE |
| JP7610849B2 (ja) | 2019-05-24 | 2025-01-09 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、薬物組成物及び複合体ならびに調製方法と使用 |
| KR102757180B1 (ko) | 2019-11-22 | 2025-01-21 | (주)바이오니아 | Ctgf 유전자 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 섬유증 관련 질환 및 호흡기 관련 질환 예방 및 치료용 조성물 |
| CA3178609A1 (en) | 2020-05-14 | 2021-11-18 | Jun Hong Park | Composition for preventing or treating obesity-related disease containing amphiregulin-specific double-stranded oligonucleotide structure |
| KR102701681B1 (ko) | 2020-05-22 | 2024-09-09 | (주)바이오니아 | 이중가닥 올리고뉴클레오티드 및 이를 포함하는 코로나바이러스감염증-19〔covid-19〕치료용 조성물 |
| KR102272800B1 (ko) | 2020-06-30 | 2021-07-05 | 국방과학연구소 | 코로나바이러스 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 코로나바이러스 감염증-19 예방 및 치료용 조성물 |
| US20240299437A1 (en) * | 2021-02-25 | 2024-09-12 | Bioneer Corporation | Composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising double-stranded mirna as active ingredient |
| JP2024509906A (ja) | 2021-03-08 | 2024-03-05 | バイオニア コーポレーション | Ｃｏｖｉｄ‐１９を含む呼吸器系ウイルス感染症、ウイルス感染を原因とする肺線維症、又は呼吸器疾患の予防又は治療のために超音波ネブライザを使用して二本鎖オリゴヌクレオチド構造物を投与するための組成物 |
| AU2023404700A1 (en) | 2022-12-02 | 2025-07-10 | Shanghai Argo Biopharmaceutical Co., Ltd. | Bicyclic abasic nucleic acid analogs and oligomeric compounds prepared therefrom |
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| KR101224828B1 (ko) | 2009-05-14 | 2013-01-22 | (주)바이오니아 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
-
2009
- 2009-05-14 KR KR1020090042297A patent/KR101224828B1/ko active Active
-
2010
- 2010-05-13 EP EP10775118.2A patent/EP2463371B1/en active Active
- 2010-05-13 CA CA2871888A patent/CA2871888A1/en not_active Abandoned
- 2010-05-13 AU AU2010248239A patent/AU2010248239B2/en active Active
- 2010-05-13 BR BRPI1012141A patent/BRPI1012141B1/pt active IP Right Grant
- 2010-05-13 US US13/319,885 patent/US8779114B2/en active Active
- 2010-05-13 RU RU2011150787/10A patent/RU2558258C2/ru active
- 2010-05-13 CN CN201080021324.3A patent/CN102439148B/zh active Active
- 2010-05-13 JP JP2012510752A patent/JP5758381B2/ja active Active
- 2010-05-13 CN CN201210301551.2A patent/CN102888404B/zh active Active
- 2010-05-13 CA CA2761749A patent/CA2761749C/en active Active
- 2010-05-13 EP EP13159602.5A patent/EP2626427A3/en not_active Withdrawn
- 2010-05-13 WO PCT/KR2010/003039 patent/WO2010131916A2/ko not_active Ceased
- 2010-05-13 CN CN201310147988.XA patent/CN103233003B/zh active Active
- 2010-05-13 EP EP13185358.2A patent/EP2682466B1/en active Active
-
2012
- 2012-09-13 US US13/613,071 patent/US8772472B2/en active Active
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2013
- 2013-05-08 JP JP2013098798A patent/JP5797688B2/ja active Active
- 2013-11-21 RU RU2013151977/10A patent/RU2571218C2/ru active
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2014
- 2014-05-30 US US14/291,656 patent/US20140350233A1/en not_active Abandoned
- 2014-05-30 US US14/291,540 patent/US9211343B2/en active Active
- 2014-12-02 JP JP2014244541A patent/JP2015107115A/ja active Pending
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