JP2012526548A5 - - Google Patents
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- JP2012526548A5 JP2012526548A5 JP2012510752A JP2012510752A JP2012526548A5 JP 2012526548 A5 JP2012526548 A5 JP 2012526548A5 JP 2012510752 A JP2012510752 A JP 2012510752A JP 2012510752 A JP2012510752 A JP 2012510752A JP 2012526548 A5 JP2012526548 A5 JP 2012526548A5
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- polymer compound
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- compound
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- 229920001223 polyethylene glycol Polymers 0.000 claims description 20
- 239000002202 Polyethylene glycol Substances 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 10
- -1 4-monomethoxytrityl group Chemical group 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims description 3
- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 150000002431 hydrogen Chemical group 0.000 claims description 2
- 239000011800 void material Substances 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 25
- 229920001600 hydrophobic polymer Polymers 0.000 claims 11
- 108020004459 Small interfering RNA Proteins 0.000 claims 7
- 239000005289 controlled pore glass Substances 0.000 claims 6
- 229920001477 hydrophilic polymer Polymers 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 238000000137 annealing Methods 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 claims 1
- NXLNNXIXOYSCMB-UHFFFAOYSA-N (4-nitrophenyl) carbonochloridate Chemical compound [O-][N+](=O)C1=CC=C(OC(Cl)=O)C=C1 NXLNNXIXOYSCMB-UHFFFAOYSA-N 0.000 claims 1
- JBWYRBLDOOOJEU-UHFFFAOYSA-N 1-[chloro-(4-methoxyphenyl)-phenylmethyl]-4-methoxybenzene Chemical compound C1=CC(OC)=CC=C1C(Cl)(C=1C=CC(OC)=CC=1)C1=CC=CC=C1 JBWYRBLDOOOJEU-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 238000003763 carbonization Methods 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920000765 poly(2-oxazolines) Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 0 CCC=CC(C(C1C=*=ICC1)(*=C)c(cc1)ccc1OC)=CCCOI Chemical compound CCC=CC(C(C1C=*=ICC1)(*=C)c(cc1)ccc1OC)=CCCOI 0.000 description 2
- DBWPJNWEBPQPOW-UHFFFAOYSA-N CC(c(cc1)ccc1OC)(C(C=C1)=CCC1OC)O Chemical compound CC(c(cc1)ccc1OC)(C(C=C1)=CCC1OC)O DBWPJNWEBPQPOW-UHFFFAOYSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2009-0042297 | 2009-05-14 | ||
| KR1020090042297A KR101224828B1 (ko) | 2009-05-14 | 2009-05-14 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
| PCT/KR2010/003039 WO2010131916A2 (ko) | 2009-05-14 | 2010-05-13 | siRNA 접합체 및 그 제조방법 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013098798A Division JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Division JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526548A JP2012526548A (ja) | 2012-11-01 |
| JP2012526548A5 true JP2012526548A5 (enExample) | 2013-05-30 |
| JP5758381B2 JP5758381B2 (ja) | 2015-08-05 |
Family
ID=43085466
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510752A Active JP5758381B2 (ja) | 2009-05-14 | 2010-05-13 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2013098798A Active JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Pending JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013098798A Active JP5797688B2 (ja) | 2009-05-14 | 2013-05-08 | ｓｉＲＮＡ接合体及びその製造方法 |
| JP2014244541A Pending JP2015107115A (ja) | 2009-05-14 | 2014-12-02 | ｓｉＲＮＡ接合体及びその製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8779114B2 (enExample) |
| EP (3) | EP2682466B1 (enExample) |
| JP (3) | JP5758381B2 (enExample) |
| KR (1) | KR101224828B1 (enExample) |
| CN (3) | CN102439148B (enExample) |
| AU (1) | AU2010248239B2 (enExample) |
| BR (1) | BRPI1012141B1 (enExample) |
| CA (2) | CA2871888A1 (enExample) |
| RU (2) | RU2558258C2 (enExample) |
| WO (1) | WO2010131916A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101224828B1 (ko) | 2009-05-14 | 2013-01-22 | (주)바이오니아 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
| KR101722948B1 (ko) * | 2012-01-05 | 2017-04-04 | (주)바이오니아 | 리간드가 결합된 이중나선 올리고 ｒｎａ 구조체 및 그 제조방법 |
| BR112014014730B1 (pt) * | 2011-12-15 | 2021-05-18 | Bioneer Corporation | estrutura de droga polímero terapêutica, métodos para preparar uma estrutura de oligo rna de dupla hélice, nanoparticula e composição farmacêutica |
| RU2577227C1 (ru) * | 2012-01-05 | 2016-03-10 | Байонир Корпорейшн | Высокоэффективная двухспиральная олиго-рнк конструкция типа наночастицы и способ ее изготовления |
| KR101629233B1 (ko) * | 2012-01-18 | 2016-06-10 | (주)바이오니아 | 자성나노입자-SAMiRNA 복합체 및 그 제조방법 |
| CN104968403A (zh) | 2012-09-17 | 2015-10-07 | 格雷斯公司 | 色谱介质和装置 |
| KR20150064065A (ko) * | 2012-10-05 | 2015-06-10 | (주)바이오니아 | 엠피레귤린 특이적 이중 나선 올리고 rna, 그러한 이중나선 올리고 rna 를 포함하는 이중나선 올리고 rna 구조체 및 이를 포함하는 호흡기 질환의 예방 또는 치료용 조성물 |
| WO2014088087A1 (ja) * | 2012-12-06 | 2014-06-12 | 協和発酵バイオ株式会社 | アジュバント用二重鎖リボ核酸 |
| WO2015002512A1 (ko) | 2013-07-05 | 2015-01-08 | (주)바이오니아 | 뎅기 바이러스 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 뎅기 바이러스 증식 억제용 조성물 |
| EP3591053A1 (en) * | 2013-07-05 | 2020-01-08 | Bioneer Corporation | Respiratory disease-related gene specific sirna, double-helical oligo rna structure containing sirna, compositon containing same for preventing or treating respiratory disease |
| WO2015002511A1 (ko) | 2013-07-05 | 2015-01-08 | (주)바이오니아 | 개선된 고효율 나노입자형 올리고뉴클레오타이드 구조체 및 그의 제조방법 |
| KR20150006743A (ko) * | 2013-07-09 | 2015-01-19 | (주)바이오니아 | 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| KR20150006742A (ko) * | 2013-07-09 | 2015-01-19 | (주)바이오니아 | 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| ES2984979T3 (es) * | 2014-04-04 | 2024-10-31 | Bioneer Corp | Oligo ARN de doble cadena y composición farmacéutica que comprende el mismo para la prevención o tratamiento de fibrosis o enfermedades respiratorias |
| ES2929099T3 (es) | 2014-05-02 | 2022-11-24 | Grace W R & Co | Material de soporte funcionalizado y métodos de fabricación y uso de material de soporte funcionalizado |
| CA2974195A1 (en) * | 2014-10-15 | 2016-04-21 | University Of Connecticut | Bio-reducible self-assembled liquid crystalline block copolymer for drug delivery |
| PL3302784T3 (pl) | 2015-06-05 | 2022-01-17 | W.R. Grace & Co.-Conn. | Adsorbentowe środki klarujące do bioprzetwarzania oraz sposoby ich wytwarzania i stosowania |
| WO2016204515A1 (ko) * | 2015-06-15 | 2016-12-22 | (주)바이오니아 | STAT3 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체, 이를 포함하는 조성물 및 이의 용도 |
| KR101861738B1 (ko) | 2016-08-24 | 2018-05-29 | (주)바이오니아 | 마이크로 rna를 포함하는 이중나선 올리고 rna 구조체 |
| KR20190123351A (ko) * | 2017-03-22 | 2019-10-31 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 개질된 올리고뉴클레오티드 및 이의 치료 용도 |
| WO2019105419A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| US12083142B2 (en) * | 2017-12-01 | 2024-09-10 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| WO2019105435A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| KR102756073B1 (ko) | 2017-12-01 | 2025-01-20 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 이중-가닥 올리고뉴클레오티드, 조성물 및 이중-가닥 올리고뉴클레오티드를 포함하는 접합체, 그의 제조 방법 및 그의 용도 |
| JP7261494B2 (ja) | 2017-12-01 | 2023-04-20 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| HRP20250408T1 (hr) | 2017-12-29 | 2025-06-06 | Suzhou Ribo Life Science Co., Ltd. | Kojugati i njihova priprema i uporaba |
| KR102141124B1 (ko) * | 2018-01-30 | 2020-08-04 | (주)바이오니아 | 이중 가닥 miRNA를 포함하는 이중나선 올리고뉴클레오타이드 구조체 및 이의 용도 |
| EP3816285A4 (en) | 2018-05-25 | 2022-03-16 | Bioneer Corporation | DOUBLE-STRANDED OLIGONUCLEOTIDE SPECIFIC TO THE AMPHIREGULIN GENE AND COMPOSITION, FOR THE PREVENTION AND TREATMENT OF FIBROSIS-RELATED DISEASES AND RESPIRATORY DISEASES, INCLUDING THE SAME |
| US11918600B2 (en) | 2018-08-21 | 2024-03-05 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition and conjugate containing nucleic acid, and use thereof |
| CN111655297A (zh) * | 2018-09-30 | 2020-09-11 | 苏州瑞博生物技术有限公司 | 一种siRNA缀合物及其制备方法和用途 |
| KR102473989B1 (ko) * | 2018-11-28 | 2022-12-07 | (주)바이오니아 | 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물 |
| JP7356505B2 (ja) | 2019-01-15 | 2023-10-04 | バイオニア コーポレーション | Ｄｋｋ１遺伝子を標的にする二本鎖オリゴヌクレオチド、これを含む構造体及びこれを含む脱毛予防又は発毛用組成物 |
| KR102757180B1 (ko) | 2019-11-22 | 2025-01-21 | (주)바이오니아 | Ctgf 유전자 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 섬유증 관련 질환 및 호흡기 관련 질환 예방 및 치료용 조성물 |
| CA3178609A1 (en) | 2020-05-14 | 2021-11-18 | Jun Hong Park | Composition for preventing or treating obesity-related disease containing amphiregulin-specific double-stranded oligonucleotide structure |
| MX2022014496A (es) | 2020-05-22 | 2023-03-10 | Bioneer Corp | Oligonucleótido de doble hebra y composición para el tratamiento de la covid-19 que contiene el mismo. |
| KR102272800B1 (ko) | 2020-06-30 | 2021-07-05 | 국방과학연구소 | 코로나바이러스 특이적 이중가닥 올리고뉴클레오티드 및 이를 포함하는 코로나바이러스 감염증-19 예방 및 치료용 조성물 |
| CN116847888A (zh) | 2021-02-25 | 2023-10-03 | 柏业公司 | 用于减轻毛发变白、促进毛发生长和/或预防或减轻脱发的包含双链miRNA作为活性成分的组合物 |
| JP2024509906A (ja) | 2021-03-08 | 2024-03-05 | バイオニア コーポレーション | Ｃｏｖｉｄ‐１９を含む呼吸器系ウイルス感染症、ウイルス感染を原因とする肺線維症、又は呼吸器疾患の予防又は治療のために超音波ネブライザを使用して二本鎖オリゴヌクレオチド構造物を投与するための組成物 |
| AU2023404700A1 (en) | 2022-12-02 | 2025-07-10 | Shanghai Argo Biopharmaceutical Co., Ltd. | Bicyclic abasic nucleic acid analogs and oligomeric compounds prepared therefrom |
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| US5141813A (en) * | 1989-08-28 | 1992-08-25 | Clontech Laboratories, Inc. | Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis |
| US5451463A (en) * | 1989-08-28 | 1995-09-19 | Clontech Laboratories, Inc. | Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides |
| US6221959B1 (en) * | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
| US6348583B1 (en) * | 1999-08-30 | 2002-02-19 | Bio-Rad Laboratories, Inc. | Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids |
| US7491805B2 (en) * | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| EP2213738B1 (en) | 2002-11-14 | 2012-10-10 | Dharmacon, Inc. | siRNA molecules targeting Bcl-2 |
| WO2004087931A1 (en) | 2003-04-03 | 2004-10-14 | Korea Advanced Institute Of Science And Technology | Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof |
| US7851615B2 (en) * | 2003-04-17 | 2010-12-14 | Alnylam Pharmaceuticals, Inc. | Lipophilic conjugated iRNA agents |
| CA2524495A1 (en) * | 2003-06-03 | 2005-01-13 | Eli Lilly And Company | Modulation of survivin expression |
| KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| AU2006280600B2 (en) | 2005-08-17 | 2012-01-19 | Bioneer Corporation | Sirna-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof |
| EP2395012B8 (en) | 2005-11-02 | 2018-06-06 | Arbutus Biopharma Corporation | Modified siRNA molecules and uses thereof |
| JP2010507361A (ja) * | 2006-07-31 | 2010-03-11 | キュアバック ゲーエムベーハー | 具体的には免疫刺激剤／アジュバントとしての、一般式（Ｉ）：ＧｌＸｍＧｎ、または一般式（ＩＩ）：ＣｌＸｍＣｎで表される核酸 |
| EP2025348A1 (en) * | 2007-08-13 | 2009-02-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Targeted block copolymer micelles |
| DK2195428T3 (en) * | 2007-09-19 | 2014-03-03 | Applied Biosystems Llc | SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMS TO REDUCE TARGET-FAILING PHENOTYPIC EFFECTS OF RNAI, AND STABILIZED FORMS THEREOF |
| TW200927177A (en) * | 2007-10-24 | 2009-07-01 | Nat Inst Of Advanced Ind Scien | Lipid-modified double-stranded RNA having potent RNA interference effect |
| KR101224828B1 (ko) | 2009-05-14 | 2013-01-22 | (주)바이오니아 | ｓｉＲＮＡ 접합체 및 그 제조방법 |
-
2009
- 2009-05-14 KR KR1020090042297A patent/KR101224828B1/ko active Active
-
2010
- 2010-05-13 BR BRPI1012141A patent/BRPI1012141B1/pt active IP Right Grant
- 2010-05-13 CA CA2871888A patent/CA2871888A1/en not_active Abandoned
- 2010-05-13 CA CA2761749A patent/CA2761749C/en active Active
- 2010-05-13 EP EP13185358.2A patent/EP2682466B1/en active Active
- 2010-05-13 US US13/319,885 patent/US8779114B2/en active Active
- 2010-05-13 CN CN201080021324.3A patent/CN102439148B/zh active Active
- 2010-05-13 EP EP13159602.5A patent/EP2626427A3/en not_active Withdrawn
- 2010-05-13 EP EP10775118.2A patent/EP2463371B1/en active Active
- 2010-05-13 JP JP2012510752A patent/JP5758381B2/ja active Active
- 2010-05-13 CN CN201310147988.XA patent/CN103233003B/zh active Active
- 2010-05-13 WO PCT/KR2010/003039 patent/WO2010131916A2/ko not_active Ceased
- 2010-05-13 CN CN201210301551.2A patent/CN102888404B/zh active Active
- 2010-05-13 RU RU2011150787/10A patent/RU2558258C2/ru active
- 2010-05-13 AU AU2010248239A patent/AU2010248239B2/en active Active
-
2012
- 2012-09-13 US US13/613,071 patent/US8772472B2/en active Active
-
2013
- 2013-05-08 JP JP2013098798A patent/JP5797688B2/ja active Active
- 2013-11-21 RU RU2013151977/10A patent/RU2571218C2/ru active
-
2014
- 2014-05-30 US US14/291,656 patent/US20140350233A1/en not_active Abandoned
- 2014-05-30 US US14/291,540 patent/US9211343B2/en active Active
- 2014-12-02 JP JP2014244541A patent/JP2015107115A/ja active Pending
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