MX2016000021A - Sirna virus especifico del dengue, estructura arn oligo helicoidal, y composicion para la supresion de proliferacion del virus del dengue que comprende la estructura arn. - Google Patents

Sirna virus especifico del dengue, estructura arn oligo helicoidal, y composicion para la supresion de proliferacion del virus del dengue que comprende la estructura arn.

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Publication number
MX2016000021A
MX2016000021A MX2016000021A MX2016000021A MX2016000021A MX 2016000021 A MX2016000021 A MX 2016000021A MX 2016000021 A MX2016000021 A MX 2016000021A MX 2016000021 A MX2016000021 A MX 2016000021A MX 2016000021 A MX2016000021 A MX 2016000021A
Authority
MX
Mexico
Prior art keywords
double helix
rna structure
sirna
dengue virus
rna
Prior art date
Application number
MX2016000021A
Other languages
English (en)
Inventor
Oh Park Han
Sung Yang Joo
Ja Choi Soon
Seok KIM Woo
Original Assignee
Bioneer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioneer Corp filed Critical Bioneer Corp
Publication of MX2016000021A publication Critical patent/MX2016000021A/es

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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

Abstract

La presente invención se refiere a un siRNA especifico del virus del dengue, una estructura oligo ARN bicatenario que comprende el siRNA, y una composición para inhibir la replica del virus del dengue, el cual comprende el mismo, en el que la estructura oligo ARN bicatenario comprende un compuesto hidrofilico y un compuesto hidrofóbico conjugado en ambos extremos del ARN bicatenario (siRNA) por medio de un enlace covalente simple o un enlace covalente mediado por un conector para que se entreguen de manera eficiente en las células, y se puedan convertir en nanoparticulas mediante interacciones hidrofóbicas entre las estructuras oligo ARN bicatenariasen una solución acuosa. El siRNA incluido eñ ña estructura oligo ARN bicatenario actúa de manera específica en todos los serotipos del virus del dengue. La presente invención también se refiere a un método para preparar una estructura oligo ARN bicatenario, y una composición farmacéutica para prevenir o tratar la infección del virus del dengue, la cual comprende la estructura oligo ARN bicatenario.
MX2016000021A 2013-07-05 2014-07-04 Sirna virus especifico del dengue, estructura arn oligo helicoidal, y composicion para la supresion de proliferacion del virus del dengue que comprende la estructura arn. MX2016000021A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20130079310 2013-07-05
PCT/KR2014/006032 WO2015002512A1 (ko) 2013-07-05 2014-07-04 뎅기 바이러스 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 뎅기 바이러스 증식 억제용 조성물

Publications (1)

Publication Number Publication Date
MX2016000021A true MX2016000021A (es) 2017-04-06

Family

ID=52144017

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000021A MX2016000021A (es) 2013-07-05 2014-07-04 Sirna virus especifico del dengue, estructura arn oligo helicoidal, y composicion para la supresion de proliferacion del virus del dengue que comprende la estructura arn.

Country Status (10)

Country Link
US (1) US9695421B2 (es)
EP (1) EP3018210A4 (es)
JP (1) JP6368363B2 (es)
KR (1) KR101715228B1 (es)
CN (1) CN105705639A (es)
AU (1) AU2014284835B2 (es)
CA (1) CA2917318A1 (es)
MX (1) MX2016000021A (es)
SG (1) SG11201507571TA (es)
WO (1) WO2015002512A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2018144745A (ru) * 2016-06-01 2020-07-09 Эксижн Биотерапьютикс, Инк. Композиции и способы лечения, направленные на литические и лизогенные вирусы
KR101888104B1 (ko) * 2016-10-12 2018-08-14 사회복지법인 삼성생명공익재단 MET 엑손 14 스키핑 특이적 siRNA 및 이를 포함하는 암 예방 또는 치료용 약학적 조성물
KR101986188B1 (ko) 2017-07-12 2019-06-07 서울대학교산학협력단 Rna 의존성 rna 중합효소 활성 확인 방법 및 키트
KR102473989B1 (ko) * 2018-11-28 2022-12-07 (주)바이오니아 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물

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Also Published As

Publication number Publication date
EP3018210A1 (en) 2016-05-11
AU2014284835A1 (en) 2016-02-18
KR20150143425A (ko) 2015-12-23
CA2917318A1 (en) 2015-01-08
SG11201507571TA (en) 2015-10-29
AU2014284835B2 (en) 2017-08-10
JP6368363B2 (ja) 2018-08-01
CN105705639A (zh) 2016-06-22
KR101715228B1 (ko) 2017-03-13
JP2016524901A (ja) 2016-08-22
WO2015002512A1 (ko) 2015-01-08
US9695421B2 (en) 2017-07-04
US20160145622A1 (en) 2016-05-26
EP3018210A4 (en) 2017-06-07

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