JP2008516011A5 - - Google Patents
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- JP2008516011A5 JP2008516011A5 JP2007534633A JP2007534633A JP2008516011A5 JP 2008516011 A5 JP2008516011 A5 JP 2008516011A5 JP 2007534633 A JP2007534633 A JP 2007534633A JP 2007534633 A JP2007534633 A JP 2007534633A JP 2008516011 A5 JP2008516011 A5 JP 2008516011A5
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- JP
- Japan
- Prior art keywords
- polymer
- polymer according
- group
- pharmaceutical composition
- daltons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920000642 polymer Polymers 0.000 claims 43
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 229920002873 Polyethylenimine Polymers 0.000 claims 6
- 210000003527 eukaryotic cell Anatomy 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 238000002059 diagnostic imaging Methods 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 238000010361 transduction Methods 0.000 claims 2
- 230000026683 transduction Effects 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 108020004491 Antisense DNA Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 claims 1
- 239000003816 antisense DNA Substances 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000005019 carboxyalkenyl group Chemical group 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001841 cholesterols Chemical class 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 210000001163 endosome Anatomy 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000030648 nucleus localization Effects 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 238000000527 sonication Methods 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61576404P | 2004-10-04 | 2004-10-04 | |
| US60/615,764 | 2004-10-04 | ||
| US69835705P | 2005-07-11 | 2005-07-11 | |
| US60/698,357 | 2005-07-11 | ||
| PCT/US2005/033274 WO2006041617A1 (en) | 2004-10-04 | 2005-09-16 | Biodegradable cationic polymers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008516011A JP2008516011A (ja) | 2008-05-15 |
| JP2008516011A5 true JP2008516011A5 (enExample) | 2008-10-16 |
| JP5191233B2 JP5191233B2 (ja) | 2013-05-08 |
Family
ID=35759127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534633A Expired - Fee Related JP5191233B2 (ja) | 2004-10-04 | 2005-09-16 | 生分解性カチオン性ポリマー |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7358223B2 (enExample) |
| EP (1) | EP1799748B1 (enExample) |
| JP (1) | JP5191233B2 (enExample) |
| KR (1) | KR20070059171A (enExample) |
| CN (2) | CN101035835B (enExample) |
| AT (1) | ATE458021T1 (enExample) |
| AU (1) | AU2005294699B2 (enExample) |
| CA (1) | CA2581632C (enExample) |
| DE (1) | DE602005019439D1 (enExample) |
| DK (1) | DK1799748T3 (enExample) |
| MX (1) | MX2007003822A (enExample) |
| RU (1) | RU2440380C2 (enExample) |
| WO (1) | WO2006041617A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1667732B1 (en) * | 2003-09-29 | 2010-04-21 | Nitto Denko Corporation | Biodegradable polyacetals for in vivo polynucleotide delivery |
| US7358223B2 (en) * | 2004-10-04 | 2008-04-15 | Nitto Denko Corporation | Biodegradable cationic polymers |
| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| SI2727583T1 (sl) | 2004-12-22 | 2022-01-31 | Nitto Denko Corporation | Nosilec učinkovine in komplet nosilca učinkovine za zaviranje fibroze |
| US7674452B2 (en) * | 2005-03-16 | 2010-03-09 | Nitto Denko Corporation | Polymer coating of cells |
| JP4870941B2 (ja) * | 2005-05-09 | 2012-02-08 | 公立大学法人大阪府立大学 | 高分子化合物 |
| US20060263328A1 (en) * | 2005-05-19 | 2006-11-23 | Sang Van | Hydrophilic polymers with pendant functional groups and method thereof |
| JP5059312B2 (ja) * | 2005-09-16 | 2012-10-24 | Ｈｏｙａ株式会社 | 高分散性リン酸カルシウム系化合物ナノ粒子及びその製造方法 |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| US7700541B2 (en) * | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
| CN100549044C (zh) * | 2006-11-16 | 2009-10-14 | 南京慧基生物技术有限公司 | 可生物降解的交联聚乙烯亚胺及其应用 |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
| US20080312174A1 (en) * | 2007-06-05 | 2008-12-18 | Nitto Denko Corporation | Water soluble crosslinked polymers |
| CN107049965A (zh) * | 2007-08-06 | 2017-08-18 | Clsn实验室股份有限公司 | 核酸‑脂聚合物组合物 |
| WO2009036368A2 (en) * | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
| JP2011509944A (ja) * | 2008-01-14 | 2011-03-31 | サーモディクス，インコーポレイティド | 核酸送達複合体の溶出のための装置及び方法 |
| US20100004315A1 (en) * | 2008-03-14 | 2010-01-07 | Gregory Slobodkin | Biodegradable Cross-Linked Branched Poly(Alkylene Imines) |
| KR101100770B1 (ko) | 2009-04-14 | 2011-12-29 | 전북대학교산학협력단 | 유가금속의 회수방법 |
| WO2009148292A2 (ko) * | 2008-05-30 | 2009-12-10 | 전북대학교 산학협력단 | 표면개질된 바이오매스, 그의 제조방법 및 그를 이용하는 유가금속의 회수 방법 |
| KR100894585B1 (ko) * | 2008-05-30 | 2009-04-24 | 전북대학교산학협력단 | 표면개질된 바이오매스, 그의 제조방법 및 그를 이용하는 생체흡착제 |
| DE102008002254A1 (de) * | 2008-06-06 | 2010-01-21 | Evonik Röhm Gmbh | Monomermischungen, Polymere sowie Beschichtungszusammensetzungen |
| KR101050383B1 (ko) * | 2009-03-11 | 2011-07-19 | 전북대학교산학협력단 | 표면개질된 대장균 바이오매스의 제조방법 및 이에 의한 생체흡착제 |
| BR112012002341A8 (pt) | 2009-08-06 | 2017-10-10 | Koninklijke Philips Electronics Nv | Semente radioativa para uso na terapia oncológica e método de terapia oncológica |
| CA2780741C (en) | 2009-10-12 | 2023-04-04 | Smith Holdings, Llc | Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro |
| DK2509991T3 (en) | 2009-12-09 | 2015-12-21 | Nitto Denko Corp | MODULATION OF HSP47 EXPRESSION |
| JP2013528665A (ja) | 2010-03-26 | 2013-07-11 | メルサナ セラピューティックス， インコーポレイテッド | ポリヌクレオチドの送達のための修飾ポリマー、その製造方法、およびその使用方法 |
| KR101937498B1 (ko) | 2011-03-03 | 2019-04-10 | 쿠아크 파마수티칼스 인코퍼레이티드 | 폐 질환 및 손상을 치료하기 위한 조성물 및 방법 |
| ES2708932T3 (es) | 2011-06-21 | 2019-04-12 | Nitto Denko Corp | Agente inductor de apoptosis |
| CN103509183A (zh) * | 2012-06-21 | 2014-01-15 | 中国科学院苏州纳米技术与纳米仿生研究所 | 基于聚乙烯亚胺可降解的基因载体及其制备方法 |
| CN103509182A (zh) * | 2012-06-21 | 2014-01-15 | 中国科学院苏州纳米技术与纳米仿生研究所 | 具有高缓冲能力基于聚乙烯亚胺的基因载体及其制备方法 |
| US9109087B2 (en) * | 2012-09-13 | 2015-08-18 | International Business Machines Corporation | Low molecular weight branched polyamines for delivery of biologically active materials |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| JP6076076B2 (ja) | 2012-12-21 | 2017-02-08 | 日東電工株式会社 | 組織再生促進剤 |
| CN104109241B (zh) * | 2013-04-17 | 2019-01-11 | 复旦大学附属肿瘤医院 | 共价疏水修饰的聚乙烯亚胺及其制备方法和应用 |
| WO2015194522A1 (ja) | 2014-06-17 | 2015-12-23 | 日東電工株式会社 | アポトーシス誘導剤 |
| KR101809795B1 (ko) | 2014-10-30 | 2017-12-18 | 서울대학교산학협력단 | 폴리올계 삼투압적 폴리디자일리톨 폴리머 유전자 전달체 및 이의 용도 |
| CN105732981A (zh) * | 2014-12-10 | 2016-07-06 | 深圳先进技术研究院 | 改性聚乙烯亚胺、基因载体复合物及其制备方法和应用 |
| EP3225246A1 (en) * | 2016-03-31 | 2017-10-04 | Klinikum der Universität München | Synthetic compound for improving efficiency of transfection |
| EP3443091A4 (en) | 2016-04-14 | 2019-11-27 | Benitec Biopharma Limited | REAGENTS FOR THE TREATMENT OF OCULOPHARYNGEAL MUSCLE DYSTROPHY (OPMD) AND USE THEREOF |
| US20220025403A1 (en) * | 2018-12-05 | 2022-01-27 | Fred Hutchinson Cancer Research Center | Reduced and minimal manipulation manufacturing of genetically-modified cells |
| CN109776347B (zh) * | 2019-02-18 | 2021-03-26 | 华南农业大学 | 一种热固性植物油基丙烯酸酯衍生物及其制备方法和应用 |
| WO2021023796A1 (en) | 2019-08-05 | 2021-02-11 | Polyplus Transfection | Compositions for transfecting a nucleic acid molecule into a cell comprising heterocyclic compounds grafted to a cationic polymer, and their applications |
| GB2603454A (en) | 2020-12-09 | 2022-08-10 | Ucl Business Ltd | Novel therapeutics for the treatment of neurodegenerative disorders |
| GB202117758D0 (en) | 2021-12-09 | 2022-01-26 | Ucl Business Ltd | Therapeutics for the treatment of neurodegenerative disorders |
| CN114874422B (zh) * | 2022-06-16 | 2023-05-12 | 上海云沂生物医药科技有限公司 | 一种聚烷基胺、其合成方法、颗粒及用途 |
| WO2025072615A1 (en) | 2023-09-29 | 2025-04-03 | Orbital Therapeutics, Inc. | Improved methods of making rna by splinted ligation and compositions thereof |
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| US7358223B2 (en) | 2004-10-04 | 2008-04-15 | Nitto Denko Corporation | Biodegradable cationic polymers |
| CA2590820A1 (en) | 2004-12-17 | 2006-06-22 | Nitto Denko Corporation | Immobilized degradable cationic polymer for transfecting eukaryotic cells |
| SI2727583T1 (sl) | 2004-12-22 | 2022-01-31 | Nitto Denko Corporation | Nosilec učinkovine in komplet nosilca učinkovine za zaviranje fibroze |
| JP2009221164A (ja) | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | 肺線維症処置剤 |
| US7588754B2 (en) * | 2005-05-10 | 2009-09-15 | Nitto Denko Corporation | Biodegradable polyacetals and methods |
| US20060263328A1 (en) * | 2005-05-19 | 2006-11-23 | Sang Van | Hydrophilic polymers with pendant functional groups and method thereof |
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| US7700541B2 (en) * | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
| US20080312174A1 (en) | 2007-06-05 | 2008-12-18 | Nitto Denko Corporation | Water soluble crosslinked polymers |
| WO2009036368A2 (en) | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
| KR20110051214A (ko) | 2008-07-30 | 2011-05-17 | 닛토덴코 가부시키가이샤 | 약물 담체 |
| TWI556831B (zh) | 2008-09-12 | 2016-11-11 | 日東電工股份有限公司 | 纖維化疾病之造影劑 |
-
2005
- 2005-08-31 US US11/216,986 patent/US7358223B2/en not_active Expired - Fee Related
- 2005-09-16 MX MX2007003822A patent/MX2007003822A/es active IP Right Grant
- 2005-09-16 KR KR1020077009203A patent/KR20070059171A/ko not_active Abandoned
- 2005-09-16 DE DE602005019439T patent/DE602005019439D1/de not_active Expired - Lifetime
- 2005-09-16 EP EP05812055A patent/EP1799748B1/en not_active Expired - Lifetime
- 2005-09-16 JP JP2007534633A patent/JP5191233B2/ja not_active Expired - Fee Related
- 2005-09-16 AU AU2005294699A patent/AU2005294699B2/en not_active Ceased
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