JP2006067889A5 - - Google Patents
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- Publication number
- JP2006067889A5 JP2006067889A5 JP2004254824A JP2004254824A JP2006067889A5 JP 2006067889 A5 JP2006067889 A5 JP 2006067889A5 JP 2004254824 A JP2004254824 A JP 2004254824A JP 2004254824 A JP2004254824 A JP 2004254824A JP 2006067889 A5 JP2006067889 A5 JP 2006067889A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- nucleic acid
- polyion complex
- peo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims description 19
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 14
- 229920000831 ionic polymer Polymers 0.000 claims description 12
- 108091034117 Oligonucleotide Proteins 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000003446 ligand Chemical group 0.000 claims description 8
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 125000005647 linker group Chemical group 0.000 claims description 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 5
- 125000000524 functional group Chemical group 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 239000000693 micelle Substances 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims description 3
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 3
- -1 carbonyliminophenyl Chemical group 0.000 claims description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- 150000001450 anions Chemical class 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 4
- 229920000768 polyamine Polymers 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 3
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims 2
- 108010039918 Polylysine Proteins 0.000 claims 2
- 108091028664 Ribonucleotide Proteins 0.000 claims 2
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 150000001241 acetals Chemical class 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 230000004962 physiological condition Effects 0.000 claims 2
- 229920000656 polylysine Polymers 0.000 claims 2
- 239000002336 ribonucleotide Substances 0.000 claims 2
- 125000002652 ribonucleotide group Chemical group 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 241000737052 Naso hexacanthus Species 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 1
- 230000000739 chaotic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004254824A JP2006067889A (ja) | 2004-09-01 | 2004-09-01 | Ｐｅｏと二本鎖核酸のコンジュゲート |
| US11/661,810 US20080064863A1 (en) | 2004-09-01 | 2005-08-24 | Conjugate of Peo and Double Stranded Nucleic Acid |
| CA002578616A CA2578616A1 (en) | 2004-09-01 | 2005-08-24 | Conjugate of peo with double-stranded nucleic acid |
| EP05781466A EP1801210A4 (en) | 2004-09-01 | 2005-08-24 | CONJUGATED PEO AND NUCLEIC ACID DOUBLE STRAND |
| KR1020077004747A KR100865062B1 (ko) | 2004-09-01 | 2005-08-24 | Ｐｅｏ 와 2 개 사슬 핵산의 콘쥬게이트 |
| PCT/JP2005/015831 WO2006025419A1 (ja) | 2004-09-01 | 2005-08-24 | Ｐｅｏと二本鎖核酸のコンジュゲート |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004254824A JP2006067889A (ja) | 2004-09-01 | 2004-09-01 | Ｐｅｏと二本鎖核酸のコンジュゲート |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006067889A JP2006067889A (ja) | 2006-03-16 |
| JP2006067889A5 true JP2006067889A5 (enExample) | 2007-07-12 |
Family
ID=36000069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004254824A Pending JP2006067889A (ja) | 2004-09-01 | 2004-09-01 | Ｐｅｏと二本鎖核酸のコンジュゲート |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080064863A1 (enExample) |
| EP (1) | EP1801210A4 (enExample) |
| JP (1) | JP2006067889A (enExample) |
| KR (1) | KR100865062B1 (enExample) |
| CA (1) | CA2578616A1 (enExample) |
| WO (1) | WO2006025419A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8969543B2 (en) | 2003-04-03 | 2015-03-03 | Bioneer Corporation | SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof |
| WO2004087931A1 (en) | 2003-04-03 | 2004-10-14 | Korea Advanced Institute Of Science And Technology | Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| AU2005251676B2 (en) * | 2004-03-03 | 2011-09-29 | Revance Therapeutics, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
| US7642343B2 (en) * | 2004-04-16 | 2010-01-05 | Japan Science And Technology Agency | PEG-functional nucleic acid conjugate |
| BRPI0608249A2 (pt) * | 2005-03-03 | 2009-12-08 | Revance Therapeutics Inc | formulação, método para aplicação tópica e kit para distribuição transdérmica de toxina botulìnica |
| EP1915449B1 (en) * | 2005-08-17 | 2016-03-23 | Bioneer Corporation | Sirna-hydrophilic polymer conjugates for intracellular delivery of sirna and method thereof |
| WO2008109105A2 (en) * | 2007-03-06 | 2008-09-12 | Flagship Ventures | Methods and compositions for improved therapeutic effects with sirna |
| EP2306986B1 (en) | 2008-06-26 | 2018-03-21 | Prolynx Llc | Prodrugs and drug-macromolecule conjugates having controlled drug release rates |
| WO2010021720A1 (en) * | 2008-08-19 | 2010-02-25 | Nektar Therapeutics | Conjugates of small-interfering nucleic acids |
| CN102369242B (zh) | 2009-03-27 | 2014-09-24 | 国立大学法人鹿儿岛大学 | 包含疏水化聚氨基酸的聚离子复合物及其用途 |
| CN102250348B (zh) * | 2011-05-31 | 2013-02-20 | 安徽丰原淮海制药有限公司 | 一种聚乙烯亚胺衍生物及其作为基因传递的载体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4659937B2 (ja) * | 1999-11-19 | 2011-03-30 | ナノキャリア株式会社 | コア−シェル構造のポリイオンコンプレックスミセル |
| US7094605B2 (en) * | 2001-01-02 | 2006-08-22 | Mirus Bio Corporation | Formation of polyampholytes in the presence of a polyion |
| US20040162235A1 (en) * | 2003-02-18 | 2004-08-19 | Trubetskoy Vladimir S. | Delivery of siRNA to cells using polyampholytes |
| JP4109559B2 (ja) * | 2003-02-19 | 2008-07-02 | 独立行政法人科学技術振興機構 | オリゴヌクレオチドとポリエチレンオキシドのコンジュゲート |
-
2004
- 2004-09-01 JP JP2004254824A patent/JP2006067889A/ja active Pending
-
2005
- 2005-08-24 KR KR1020077004747A patent/KR100865062B1/ko not_active Expired - Fee Related
- 2005-08-24 EP EP05781466A patent/EP1801210A4/en not_active Ceased
- 2005-08-24 CA CA002578616A patent/CA2578616A1/en not_active Abandoned
- 2005-08-24 US US11/661,810 patent/US20080064863A1/en not_active Abandoned
- 2005-08-24 WO PCT/JP2005/015831 patent/WO2006025419A1/ja not_active Ceased
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