CN102439148B - siRNA缀合物及其制备方法 - Google Patents

siRNA缀合物及其制备方法 Download PDF

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CN102439148B
CN102439148B CN201080021324.3A CN201080021324A CN102439148B CN 102439148 B CN102439148 B CN 102439148B CN 201080021324 A CN201080021324 A CN 201080021324A CN 102439148 B CN102439148 B CN 102439148B
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sirna
conjugate
polymer
group
peg
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CN102439148A (zh
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韩宝蓝
朴翰浯
申美湜
李三用
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Bioneer Corp
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Bioneer Corp
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    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
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    • B82—NANOTECHNOLOGY
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CN201080021324.3A 2009-05-14 2010-05-13 siRNA缀合物及其制备方法 Active CN102439148B (zh)

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CN201310147988.XA CN103233003B (zh) 2009-05-14 2010-05-13 siRNA缀合物及其制备方法

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KR10-2009-0042297 2009-05-14
KR1020090042297A KR101224828B1 (ko) 2009-05-14 2009-05-14 ｓｉＲＮＡ 접합체 및 그 제조방법
PCT/KR2010/003039 WO2010131916A2 (ko) 2009-05-14 2010-05-13 siRNA 접합체 및 그 제조방법

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CN201210301551.2A Division CN102888404B (zh) 2009-05-14 2010-05-13 siRNA缀合物及其制备方法

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US (4) US8779114B2 (enExample)
EP (3) EP2682466B1 (enExample)
JP (3) JP5758381B2 (enExample)
KR (1) KR101224828B1 (enExample)
CN (3) CN102439148B (enExample)
AU (1) AU2010248239B2 (enExample)
BR (1) BRPI1012141B1 (enExample)
CA (2) CA2871888A1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11896674B2 (en) 2018-09-30 2024-02-13 Suzhou Ribo Life Science Co., Ltd. SiRNA conjugate, preparation method therefor and use thereof

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KR101722948B1 (ko) * 2012-01-05 2017-04-04 (주)바이오니아 리간드가 결합된 이중나선 올리고 ｒｎａ 구조체 및 그 제조방법
BR112014014730B1 (pt) * 2011-12-15 2021-05-18 Bioneer Corporation estrutura de droga polímero terapêutica, métodos para preparar uma estrutura de oligo rna de dupla hélice, nanoparticula e composição farmacêutica
RU2577227C1 (ru) * 2012-01-05 2016-03-10 Байонир Корпорейшн Высокоэффективная двухспиральная олиго-рнк конструкция типа наночастицы и способ ее изготовления
KR101629233B1 (ko) * 2012-01-18 2016-06-10 (주)바이오니아 자성나노입자-SAMiRNA 복합체 및 그 제조방법
CN104968403A (zh) 2012-09-17 2015-10-07 格雷斯公司 色谱介质和装置
KR20150064065A (ko) * 2012-10-05 2015-06-10 (주)바이오니아 엠피레귤린 특이적 이중 나선 올리고 rna, 그러한 이중나선 올리고 rna 를 포함하는 이중나선 올리고 rna 구조체 및 이를 포함하는 호흡기 질환의 예방 또는 치료용 조성물
WO2014088087A1 (ja) * 2012-12-06 2014-06-12 協和発酵バイオ株式会社 アジュバント用二重鎖リボ核酸
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EP3591053A1 (en) * 2013-07-05 2020-01-08 Bioneer Corporation Respiratory disease-related gene specific sirna, double-helical oligo rna structure containing sirna, compositon containing same for preventing or treating respiratory disease
WO2015002511A1 (ko) 2013-07-05 2015-01-08 (주)바이오니아 개선된 고효율 나노입자형 올리고뉴클레오타이드 구조체 및 그의 제조방법
KR20150006743A (ko) * 2013-07-09 2015-01-19 (주)바이오니아 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물
KR20150006742A (ko) * 2013-07-09 2015-01-19 (주)바이오니아 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물
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