JP2002540137A5 - - Google Patents
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- JP2002540137A5 JP2002540137A5 JP2000607603A JP2000607603A JP2002540137A5 JP 2002540137 A5 JP2002540137 A5 JP 2002540137A5 JP 2000607603 A JP2000607603 A JP 2000607603A JP 2000607603 A JP2000607603 A JP 2000607603A JP 2002540137 A5 JP2002540137 A5 JP 2002540137A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- tumor
- group
- carbon atoms
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 32
- 239000002246 antineoplastic agent Substances 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 125000004432 carbon atom Chemical group C* 0.000 claims 14
- 229920000642 polymer Polymers 0.000 claims 10
- 125000001931 aliphatic group Chemical group 0.000 claims 9
- 229920002988 biodegradable polymer Polymers 0.000 claims 9
- 239000004621 biodegradable polymer Substances 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 206010006187 Breast cancer Diseases 0.000 claims 6
- 208000026310 Breast neoplasm Diseases 0.000 claims 6
- 229930012538 Paclitaxel Natural products 0.000 claims 6
- 239000000178 monomer Substances 0.000 claims 6
- 229960001592 paclitaxel Drugs 0.000 claims 6
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 6
- 230000002601 intratumoral effect Effects 0.000 claims 5
- 229940123237 Taxane Drugs 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000004470 heterocyclooxy group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000002723 alicyclic group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 230000009036 growth inhibition Effects 0.000 claims 2
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 125000004825 2,2-dimethylpropylene group Chemical group [H]C([H])([H])C(C([H])([H])[H])(C([H])([H])[*:1])C([H])([H])[*:2] 0.000 claims 1
- 125000004810 2-methylpropylene group Chemical group [H]C([H])([H])C([H])(C([H])([H])[*:2])C([H])([H])[*:1] 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- -1 and R 3 is H Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 210000000038 chest Anatomy 0.000 claims 1
- 125000004956 cyclohexylene group Chemical group 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 150000002391 heterocyclic compounds Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/276,866 US6537585B1 (en) | 1999-03-26 | 1999-03-26 | Methods and compositions for treating solid tumors |
| US09/276,866 | 1999-03-26 | ||
| PCT/US2000/007304 WO2000057852A2 (en) | 1999-03-26 | 2000-03-20 | Methods and compositions for treating solid tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011132938A Division JP2011219483A (ja) | 1999-03-26 | 2011-06-15 | 固型腫瘍の治療方法及び組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002540137A JP2002540137A (ja) | 2002-11-26 |
| JP2002540137A5 true JP2002540137A5 (enExample) | 2007-05-17 |
Family
ID=23058398
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000607603A Pending JP2002540137A (ja) | 1999-03-26 | 2000-03-20 | 固型腫瘍の治療方法及び組成物 |
| JP2011132938A Pending JP2011219483A (ja) | 1999-03-26 | 2011-06-15 | 固型腫瘍の治療方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011132938A Pending JP2011219483A (ja) | 1999-03-26 | 2011-06-15 | 固型腫瘍の治療方法及び組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6537585B1 (enExample) |
| EP (1) | EP1185249B1 (enExample) |
| JP (2) | JP2002540137A (enExample) |
| KR (1) | KR20010111578A (enExample) |
| CN (1) | CN1367684A (enExample) |
| AT (1) | ATE306251T1 (enExample) |
| AU (1) | AU778279B2 (enExample) |
| BR (1) | BR0009213A (enExample) |
| CA (1) | CA2368621C (enExample) |
| CZ (1) | CZ20013260A3 (enExample) |
| DE (1) | DE60023138T2 (enExample) |
| HU (1) | HUP0201436A3 (enExample) |
| IL (1) | IL145492A0 (enExample) |
| NO (1) | NO20014662L (enExample) |
| PL (1) | PL351280A1 (enExample) |
| TR (1) | TR200102801T2 (enExample) |
| WO (1) | WO2000057852A2 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6350464B1 (en) * | 1999-01-11 | 2002-02-26 | Guilford Pharmaceuticals, Inc. | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same |
| US6537585B1 (en) | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
| AU2001270310A1 (en) * | 2000-07-07 | 2002-01-21 | Guilford Pharmaceuticals Inc. | Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same |
| US20020045668A1 (en) * | 2000-07-17 | 2002-04-18 | Wenbin Dang | Compositions for sustained release of analgesic agents, and methods of making and using the same |
| WO2002030472A2 (en) * | 2000-10-12 | 2002-04-18 | Guilford Pharmaceuticals, Inc. | Compositions for release of radiosensitizers, and methods of making and using the same |
| US20020141966A1 (en) * | 2000-11-16 | 2002-10-03 | Wenbin Dang | Compositions for treatment of malignant effusions, and methods of making and using the same |
| US20020081339A1 (en) * | 2000-12-22 | 2002-06-27 | Philippe Menei | Treatment of inoperable tumors by stereotactic injection of microspheres |
| US7345138B2 (en) * | 2001-05-14 | 2008-03-18 | Johns Hopkins Singapore Pte Ltd. | Biodegradable polyphosphates for controlled release of bioactive substances |
| WO2003000776A1 (en) * | 2001-05-14 | 2003-01-03 | Johns Hopkins Singapore Pte Ltd | Biodegradable polyphosphoramidates for controlled release of bioactive substances |
| US20030134892A1 (en) * | 2001-07-19 | 2003-07-17 | Wenbin Dang | Compositions for treatment of head and neck cancers, and methods of making and using the same |
| AU2002354957A1 (en) * | 2001-07-19 | 2003-03-03 | Guilford Pharmaceuticals, Inc. | Biocompatible polymer containing composition for treatment of prostate cancers |
| WO2003060799A2 (en) * | 2002-01-09 | 2003-07-24 | Guilford Pharmaceuticals, Inc. | Compositions for treatment of central nervous system neoplasms, and methods of making and using the same |
| US7479535B2 (en) * | 2002-02-25 | 2009-01-20 | Guilford Pharmaceuticals, Inc. | Phosphorous-containing compounds with polymeric chains, and methods of making and using the same |
| GB0223379D0 (en) * | 2002-10-09 | 2002-11-13 | Angiogene Pharm Ltd | Combination therapy |
| EP1694307A2 (en) * | 2003-10-21 | 2006-08-30 | PSIMEDICA Limited | Methods for the treatment of cancer |
| US7795205B2 (en) * | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
| US20080124400A1 (en) * | 2004-06-24 | 2008-05-29 | Angiotech International Ag | Microparticles With High Loadings Of A Bioactive Agent |
| WO2006002366A2 (en) * | 2004-06-24 | 2006-01-05 | Surmodics, Inc. | Biodegradable ocular devices, methods and systems |
| WO2006002399A2 (en) * | 2004-06-24 | 2006-01-05 | Surmodics, Inc. | Biodegradable implantable medical devices, methods and systems |
| WO2006062917A2 (en) * | 2004-12-06 | 2006-06-15 | Sciclone Pharmaceuticals, Inc. | Alpha thymosin peptides as cancer vaccine adjuvants |
| CN103169729A (zh) | 2005-02-18 | 2013-06-26 | 阿布拉科斯生物科学有限公司 | 治疗剂的组合和给予方式以及联合治疗 |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| US20100278725A1 (en) * | 2005-08-12 | 2010-11-04 | Jiang Liu | Methods and devices for lymphatic targeting |
| GB0525864D0 (en) * | 2005-12-20 | 2006-02-01 | Novartis Ag | Organic compounds |
| EP3009477B1 (en) | 2006-07-20 | 2024-01-24 | Orbusneich Medical Pte. Ltd | Bioabsorbable polymeric composition for a medical device |
| US7959942B2 (en) | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
| CN101631513B (zh) | 2006-10-20 | 2013-06-05 | 奥巴斯尼茨医学公司 | 可生物吸收的聚合物组合物和医疗设备 |
| CN101390828B (zh) * | 2007-02-12 | 2010-06-09 | 济南康泉医药科技有限公司 | 同载抗代谢类药物和增效剂的抗癌组合物 |
| US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
| KR101522918B1 (ko) | 2009-05-29 | 2015-05-27 | 사이덱스 파마슈티칼스, 인크. | 사이클로덱스트린 유도체를 포함하는 주사용 멜팔란 조성물 및 이의 제조 및 사용 방법 |
| ES2362525B8 (es) | 2009-10-08 | 2013-01-03 | Azurebio, S.L. | Formulación de medicamentos en forma de agujas percutaneas penetrantes. |
| TWI438009B (zh) * | 2010-02-19 | 2014-05-21 | Teikoku Pharma Usa Inc | 紫杉烷前－乳劑調配物及其製造與使用之方法 |
| KR20130028727A (ko) | 2010-03-29 | 2013-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
| US9393318B2 (en) | 2010-03-29 | 2016-07-19 | Abraxis Bioscience, Llc | Methods of treating cancer |
| JP5824511B2 (ja) | 2010-05-03 | 2015-11-25 | テイコク ファーマ ユーエスエー インコーポレーテッド | 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法 |
| KR20130088116A (ko) | 2010-06-04 | 2013-08-07 | 아브락시스 바이오사이언스, 엘엘씨 | 췌장암의 치료 방법 |
| MX375442B (es) | 2012-09-21 | 2025-03-06 | Intensity Therapeutics Inc | Un agente terapéutico y un agente mejorador de la permeación intracelular para usarse en el tratamiento de cáncer. |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| US9545447B2 (en) * | 2013-01-04 | 2017-01-17 | The Texas A&M University System | Polymer-drug systems |
| JP6758325B2 (ja) | 2015-06-04 | 2020-09-23 | クリティテック・インコーポレイテッド | タキサン粒子およびその使用 |
| CN114767860A (zh) | 2016-04-04 | 2022-07-22 | 克里蒂泰克公司 | 实体肿瘤治疗方法 |
| CA3063420A1 (en) | 2017-06-09 | 2018-12-13 | Crititech, Inc. | Treatment of epithelial cysts by intracystic injection of antineoplastic particles |
| AU2018284247B2 (en) | 2017-06-14 | 2020-04-30 | Crititech Inc. | Methods for treating lung disorders |
| CA3076919A1 (en) | 2017-10-03 | 2019-04-11 | Crititech, Inc. | Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer |
| WO2020072090A1 (en) * | 2018-10-03 | 2020-04-09 | Crititech, Inc. | Use of antineoplastic agents to stimulate the immune system for production of tertiary lymphoid structures (tls) |
| BR112021005104A2 (pt) | 2018-10-16 | 2021-06-08 | US Nano Food & Drug INC | formulação de injeção intratumoral |
| JP2023520975A (ja) | 2020-04-13 | 2023-05-23 | ユーエス・ナノ・フード・アンド・ドラッグ・インコーポレーテッド | 塩基性化学療法腫瘍内注射製剤 |
| GB2623319A (en) | 2022-10-11 | 2024-04-17 | Af Chempharm Ltd | Method of synthesis of chloro-oxo-dioxaphospholane oxides and derivates |
Family Cites Families (46)
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|---|---|---|---|---|
| US3271329A (en) | 1958-09-19 | 1966-09-06 | Eastman Kodak Co | Method for producing polymers derived from phosphites and glycols |
| US3442982A (en) | 1965-10-15 | 1969-05-06 | Weston Chemical Corp | Polyphosphites of 2,2-dimethyl-3-hydroxypropyl - 2 - dimethyl - 3-hydroxypropionate |
| FR2219193B1 (enExample) | 1973-02-28 | 1976-05-21 | Rhone Poulenc Sa | |
| US3932566A (en) | 1974-09-16 | 1976-01-13 | Celanese Corporation | Phosphonate polymers |
| US4100354A (en) | 1976-08-05 | 1978-07-11 | Owens-Corning Fiberglass Corporation | Terephthalate ester polyols |
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| DE2925206A1 (de) | 1979-06-22 | 1981-01-29 | Bayer Ag | Aromatische polyesterphosphonate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung thermoplastischer formkoerper |
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| US6350464B1 (en) | 1999-01-11 | 2002-02-26 | Guilford Pharmaceuticals, Inc. | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same |
| US6537585B1 (en) | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
| AU777528B2 (en) | 1999-04-22 | 2004-10-21 | Abraxis Bioscience, Llc | Long term administration of pharmacologically active agents |
| AU2001270310A1 (en) | 2000-07-07 | 2002-01-21 | Guilford Pharmaceuticals Inc. | Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same |
| US20020045668A1 (en) | 2000-07-17 | 2002-04-18 | Wenbin Dang | Compositions for sustained release of analgesic agents, and methods of making and using the same |
| WO2002030472A2 (en) | 2000-10-12 | 2002-04-18 | Guilford Pharmaceuticals, Inc. | Compositions for release of radiosensitizers, and methods of making and using the same |
| US20030134892A1 (en) | 2001-07-19 | 2003-07-17 | Wenbin Dang | Compositions for treatment of head and neck cancers, and methods of making and using the same |
| AU2002354957A1 (en) | 2001-07-19 | 2003-03-03 | Guilford Pharmaceuticals, Inc. | Biocompatible polymer containing composition for treatment of prostate cancers |
-
1999
- 1999-03-26 US US09/276,866 patent/US6537585B1/en not_active Expired - Fee Related
-
2000
- 2000-03-20 EP EP00916536A patent/EP1185249B1/en not_active Expired - Lifetime
- 2000-03-20 CZ CZ20013260A patent/CZ20013260A3/cs unknown
- 2000-03-20 PL PL00351280A patent/PL351280A1/xx not_active Application Discontinuation
- 2000-03-20 DE DE60023138T patent/DE60023138T2/de not_active Expired - Lifetime
- 2000-03-20 HU HU0201436A patent/HUP0201436A3/hu unknown
- 2000-03-20 AU AU37625/00A patent/AU778279B2/en not_active Ceased
- 2000-03-20 JP JP2000607603A patent/JP2002540137A/ja active Pending
- 2000-03-20 CN CN00806972A patent/CN1367684A/zh active Pending
- 2000-03-20 WO PCT/US2000/007304 patent/WO2000057852A2/en not_active Ceased
- 2000-03-20 KR KR1020017012256A patent/KR20010111578A/ko not_active Withdrawn
- 2000-03-20 AT AT00916536T patent/ATE306251T1/de not_active IP Right Cessation
- 2000-03-20 CA CA2368621A patent/CA2368621C/en not_active Expired - Fee Related
- 2000-03-20 BR BR0009213-4A patent/BR0009213A/pt not_active Application Discontinuation
- 2000-03-20 IL IL14549200A patent/IL145492A0/xx unknown
- 2000-03-20 TR TR2001/02801T patent/TR200102801T2/xx unknown
-
2001
- 2001-09-25 NO NO20014662A patent/NO20014662L/no not_active Application Discontinuation
-
2003
- 2003-02-03 US US10/357,292 patent/US7101568B2/en not_active Expired - Fee Related
-
2011
- 2011-06-15 JP JP2011132938A patent/JP2011219483A/ja active Pending
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