ES2362525B8 - Formulación de medicamentos en forma de agujas percutaneas penetrantes. - Google Patents

Formulación de medicamentos en forma de agujas percutaneas penetrantes. Download PDF

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Publication number
ES2362525B8
ES2362525B8 ES200930820A ES200930820A ES2362525B8 ES 2362525 B8 ES2362525 B8 ES 2362525B8 ES 200930820 A ES200930820 A ES 200930820A ES 200930820 A ES200930820 A ES 200930820A ES 2362525 B8 ES2362525 B8 ES 2362525B8
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ES
Spain
Prior art keywords
needles
hardness
drug
stiffness
medication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200930820A
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English (en)
Other versions
ES2362525A1 (es
ES2362525B1 (es
Inventor
Arcadio Garcia De Castro Andrews
Raúl García Carrodeaguas
Niuris Acosta Contreras
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Azurebio SL
Original Assignee
Azurebio SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200930820A priority Critical patent/ES2362525B8/es
Application filed by Azurebio SL filed Critical Azurebio SL
Priority to AP2012006260A priority patent/AP2012006260A0/xx
Priority to CA2785315A priority patent/CA2785315A1/en
Priority to BR112012010443A priority patent/BR112012010443A2/pt
Priority to AU2010305368A priority patent/AU2010305368A1/en
Priority to CN2010800559557A priority patent/CN102647977A/zh
Priority to US13/500,279 priority patent/US9271927B2/en
Priority to PCT/EP2010/065106 priority patent/WO2011042542A1/en
Priority to EP10771379A priority patent/EP2485711A1/en
Publication of ES2362525A1 publication Critical patent/ES2362525A1/es
Application granted granted Critical
Publication of ES2362525B1 publication Critical patent/ES2362525B1/es
Publication of ES2362525B8 publication Critical patent/ES2362525B8/es
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/04—Acids; Metal salts or ammonium salts thereof
    • C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/102—Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/30—Nitriles
    • C08F222/32—Alpha-cyano-acrylic acid; Esters thereof
    • C08F222/321—Alpha-cyano-acrylic acid methyl ester
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/30—Nitriles
    • C08F222/32—Alpha-cyano-acrylic acid; Esters thereof
    • C08F222/322—Alpha-cyano-acrylic acid ethyl ester, e.g. ethyl-2-cyanoacrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/30—Nitriles
    • C08F222/32—Alpha-cyano-acrylic acid; Esters thereof
    • C08F222/324—Alpha-cyano-acrylic acid butyl ester
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/30—Nitriles
    • C08F222/32—Alpha-cyano-acrylic acid; Esters thereof
    • C08F222/326—Alpha-cyano-acrylic acid longer chain ester
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La invención se refiere a formulaciones de medicamentos para su administración en forma de agujas percutáneas penetrantes sólidas, “agujas inyectables”, fabricadas mediante procesos de polimerización por adición. El proceso de polimerización implica la transformación de una fase líquida que contiene monómeros en un cuerpo sólido monolítico, que contiene el medicamento, con la forma, dureza y rigidez requeridas para ser inyectadas en el tejido subcutáneo mediante sencillos dispositivos empujadores o inyectores. Estos procedimientos permiten la incorporación directa del medicamento a las agujas inyectables, o su incorporación en nano- o micro-partículas preformuladas para preservar la integridad y acción terapéutica del medicamento que contienen, así como de agentes modificadores de la velocidad de degradación, perfil de liberación del medicamento, dureza y rigidez, o inmunogenicidad.
ES200930820A 2009-10-08 2009-10-08 Formulación de medicamentos en forma de agujas percutaneas penetrantes. Expired - Fee Related ES2362525B8 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES200930820A ES2362525B8 (es) 2009-10-08 2009-10-08 Formulación de medicamentos en forma de agujas percutaneas penetrantes.
EP10771379A EP2485711A1 (en) 2009-10-08 2010-10-08 Formulation of drugs and vaccines in the form of percutaneous injectable needles
BR112012010443A BR112012010443A2 (pt) 2009-10-08 2010-10-08 formulação de fármacos e vacinas na forma de agulhas injetáveis por via percutãnea
AU2010305368A AU2010305368A1 (en) 2009-10-08 2010-10-08 Formulation of drugs and vaccines in the form of percutaneous injectable needles
CN2010800559557A CN102647977A (zh) 2009-10-08 2010-10-08 经皮注射针形式的药物和疫苗的配制剂
US13/500,279 US9271927B2 (en) 2009-10-08 2010-10-08 Formulation of drugs and vaccines in the form of percutaneous injectable needles
AP2012006260A AP2012006260A0 (en) 2009-10-08 2010-10-08 Formulation of drugs and vaccines in the form of percutaneous injectable needles.
CA2785315A CA2785315A1 (en) 2009-10-08 2010-10-08 Formulation of drugs and vaccines in the form of percutaneous injectable needles
PCT/EP2010/065106 WO2011042542A1 (en) 2009-10-08 2010-10-08 Formulation of drugs and vaccines in the form of percutaneous injectable needles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200930820A ES2362525B8 (es) 2009-10-08 2009-10-08 Formulación de medicamentos en forma de agujas percutaneas penetrantes.

Publications (3)

Publication Number Publication Date
ES2362525A1 ES2362525A1 (es) 2011-07-07
ES2362525B1 ES2362525B1 (es) 2012-06-07
ES2362525B8 true ES2362525B8 (es) 2013-01-03

Family

ID=43662245

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200930820A Expired - Fee Related ES2362525B8 (es) 2009-10-08 2009-10-08 Formulación de medicamentos en forma de agujas percutaneas penetrantes.

Country Status (9)

Country Link
US (1) US9271927B2 (es)
EP (1) EP2485711A1 (es)
CN (1) CN102647977A (es)
AP (1) AP2012006260A0 (es)
AU (1) AU2010305368A1 (es)
BR (1) BR112012010443A2 (es)
CA (1) CA2785315A1 (es)
ES (1) ES2362525B8 (es)
WO (1) WO2011042542A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012103257A2 (en) * 2011-01-25 2012-08-02 The Regents Of The University Of California Transcutaneous multimodal delivery systems
US10251841B2 (en) * 2011-10-17 2019-04-09 Trustees Of Boston University Polymeric depots for localization of agent to biological sites
GB2498774A (en) * 2012-01-27 2013-07-31 Bruce Roser Glass-stabilised biological materials and syringe
WO2013136176A1 (en) 2012-03-13 2013-09-19 Becton Dickinson France Injection device having a miniaturized drug delivery portion
CN103083659B (zh) * 2013-01-18 2015-05-13 北京华夏兴洋生物科技有限公司 新型无油佐剂制备方法及用途
CN104248760B (zh) * 2013-12-16 2021-07-23 普莱柯生物工程股份有限公司 一种疫苗组合物及其制备方法和应用
CN107405306A (zh) * 2014-09-19 2017-11-28 奥叙拉尔有限公司 眼部药物组合物
KR102517757B1 (ko) * 2015-05-13 2023-04-04 주식회사 엘지생활건강 사포닌 또는 사포닌 유도체를 함유한 용해성 마이크로니들 패치
CN106177939B (zh) * 2015-06-01 2021-01-19 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
US10400105B2 (en) 2015-06-19 2019-09-03 The Research Foundation For The State University Of New York Extruded starch-lignin foams
CN106344920B (zh) * 2015-07-16 2020-11-27 普莱柯生物工程股份有限公司 一种疫苗用佐剂及其应用
ES2814287T3 (es) * 2016-03-15 2021-03-26 Amgen Inc Reducir la probabilidad de rotura de cristal en dispositivos de administración de fármaco
CN106177944A (zh) * 2016-08-18 2016-12-07 山东滨州博莱威生物技术有限公司 一种用于鸡新城疫活疫苗的佐剂
CN106177942A (zh) * 2016-08-18 2016-12-07 山东滨州博莱威生物技术有限公司 一种用于仔猪副伤寒活疫苗佐剂
CN106466295A (zh) * 2016-10-17 2017-03-01 四川华神兽用生物制品有限公司 一种疫苗稀释液及其制备方法与应用
WO2018141810A1 (en) 2017-01-31 2018-08-09 Alf Lamprecht Use of nanoparticles for immunotherapy
CN107375921B (zh) * 2017-06-12 2019-10-29 商丘美兰生物工程有限公司 一种甘草皂苷脂质体免疫佐剂及其制备方法
JP6482604B2 (ja) * 2017-06-22 2019-03-13 教裕 南郷 外皮内溶解型ニードル及びニードル装置
EP3681469A1 (en) 2017-09-15 2020-07-22 Oxular Limited Ophthalmic drug compositions
GB201909280D0 (en) 2019-06-27 2019-08-14 Enesi Pharma Ltd Solid dose formulation
CN112426524A (zh) * 2020-12-21 2021-03-02 中国医学科学院生物医学工程研究所 植物性多糖作为佐剂在制备自身性免疫疾病药物中的应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901158A (en) 1969-05-13 1975-08-26 Thomas E Ferb Hypodermic projectile
US3857932A (en) * 1970-09-09 1974-12-31 F Gould Dry hydrophilic acrylate or methacrylate polymer prolonged release drug implants
CA1019638A (en) 1973-05-16 1977-10-25 John C. Muirhead Liquid injection projectile
US3948263A (en) 1974-08-14 1976-04-06 Minnesota Mining And Manufacturing Company Ballistic animal implant
US4326524A (en) * 1980-09-30 1982-04-27 Minnesota Mining And Manufacturing Company Solid dose ballistic projectile
GB2091554B (en) * 1981-01-13 1984-09-12 Mitsui Toatsu Chemicals Rod like moulded drug
EP0139286B1 (en) * 1983-10-14 1991-08-21 Sumitomo Pharmaceuticals Company, Limited Prolonged sustained-release preparations
US4855134A (en) * 1983-10-14 1989-08-08 Sumitomo Pharmaceuticals Company, Limited Sustained-release preparation
US4891319A (en) 1985-07-09 1990-01-02 Quadrant Bioresources Limited Protection of proteins and the like
JPH01500034A (ja) 1986-04-10 1989-01-12 ダラテック　プロプライエタリー　リミテッド ワクチンおよび植込剤
DK42093D0 (da) 1993-04-07 1993-04-07 Bukh Meditec Administrationsmetode
US5542920A (en) 1994-09-12 1996-08-06 Delab Needle-less parenteral introduction device
NL9401534A (nl) 1994-09-21 1996-05-01 Gijsbertus Gerardus Petrus Van Gebruik van zetmeel voor parenterale toepassingen.
WO1996040351A1 (en) 1995-06-07 1996-12-19 American Cyanamid Company Injection dart system
GB9612629D0 (en) 1996-06-17 1996-08-21 Oxford Biosciences Ltd Method for providing dense particle compositions for use in transdermal particle delivery
US6537585B1 (en) * 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
US6102896A (en) 1999-09-08 2000-08-15 Cambridge Biostability Limited Disposable injector device
DE10029694A1 (de) * 2000-06-16 2001-12-20 Basf Ag Verwendung eines polymeren Umsetzungsprodukts
ES2337252T3 (es) 2000-10-13 2010-04-22 Nova Bio-Pharma Technologies Limited Suspensiones liquidas farmaceuticas.
GB2379390B (en) 2001-09-11 2005-01-26 Caretek Medical Ltd A novel drug delivery technology
CA2638788A1 (en) * 2003-04-25 2004-11-11 Kos Life Sciences, Inc. Formation of strong superporous hydrogels
CA2629393C (en) * 2005-09-06 2014-06-10 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles
GB2446780A (en) * 2007-02-22 2008-08-27 Glide Pharmaceutical Technolog An elongate parenteral injection body having an injection point of angle 10 to 40 degrees.
EP2200682B1 (en) * 2007-10-09 2012-02-08 Azurebio, S. L. Hypodermic needle with water-soluble obstruction for the administration of drugs and vaccines
EP2254625B1 (en) * 2008-02-18 2015-08-26 Azurebio, S.L. Devices for the administration of drugs and vaccines in the form of injectable needles

Also Published As

Publication number Publication date
US20120219589A1 (en) 2012-08-30
EP2485711A1 (en) 2012-08-15
ES2362525A1 (es) 2011-07-07
ES2362525B1 (es) 2012-06-07
BR112012010443A2 (pt) 2019-01-08
WO2011042542A1 (en) 2011-04-14
AP2012006260A0 (en) 2012-06-30
CN102647977A (zh) 2012-08-22
CA2785315A1 (en) 2011-04-14
US9271927B2 (en) 2016-03-01
AU2010305368A1 (en) 2012-05-24

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