JP2012514007A5 - - Google Patents

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Publication number
JP2012514007A5
JP2012514007A5 JP2011543721A JP2011543721A JP2012514007A5 JP 2012514007 A5 JP2012514007 A5 JP 2012514007A5 JP 2011543721 A JP2011543721 A JP 2011543721A JP 2011543721 A JP2011543721 A JP 2011543721A JP 2012514007 A5 JP2012514007 A5 JP 2012514007A5
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JP
Japan
Prior art keywords
ethoxy
pyridin
radiopharmaceutical composition
procedure
vinyl
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JP2011543721A
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English (en)
Japanese (ja)
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JP5717650B2 (ja
JP2012514007A (ja
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Priority claimed from PCT/US2009/069741 external-priority patent/WO2010078370A1/en
Publication of JP2012514007A publication Critical patent/JP2012514007A/ja
Publication of JP2012514007A5 publication Critical patent/JP2012514007A5/ja
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JP2011543721A 2008-12-31 2009-12-29 トシラート前駆体からの１８ｆ−放射性標識スチリルピリジンおよびその安定性医薬組成物の合成 Active JP5717650B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14188508P 2008-12-31 2008-12-31
US61/141,885 2008-12-31
PCT/US2009/069741 WO2010078370A1 (en) 2008-12-31 2009-12-29 Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof

Publications (3)

Publication Number Publication Date
JP2012514007A JP2012514007A (ja) 2012-06-21
JP2012514007A5 true JP2012514007A5 (enExample) 2013-06-06
JP5717650B2 JP5717650B2 (ja) 2015-05-13

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ID=42310197

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JP2011543721A Active JP5717650B2 (ja) 2008-12-31 2009-12-29 トシラート前駆体からの１８ｆ−放射性標識スチリルピリジンおよびその安定性医薬組成物の合成

Country Status (35)

Country Link
US (1) US20100172836A1 (enExample)
EP (1) EP2381967B1 (enExample)
JP (1) JP5717650B2 (enExample)
KR (1) KR20110119670A (enExample)
CN (1) CN102271716B (enExample)
AU (1) AU2009335049B2 (enExample)
BR (1) BRPI0923890A2 (enExample)
CA (1) CA2748705C (enExample)
CO (1) CO6341578A2 (enExample)
CR (1) CR20110410A (enExample)
CY (1) CY1118658T1 (enExample)
DK (1) DK2381967T3 (enExample)
DO (1) DOP2011000210A (enExample)
EA (1) EA023014B1 (enExample)
EC (1) ECSP11011242A (enExample)
ES (1) ES2620402T3 (enExample)
HN (1) HN2011001810A (enExample)
HR (1) HRP20170453T1 (enExample)
HU (1) HUE033649T2 (enExample)
IL (1) IL213674A (enExample)
LT (1) LT2381967T (enExample)
MA (1) MA33004B1 (enExample)
MX (1) MX2011007063A (enExample)
MY (1) MY162312A (enExample)
NZ (1) NZ593848A (enExample)
PE (1) PE20120007A1 (enExample)
PL (1) PL2381967T3 (enExample)
PT (1) PT2381967T (enExample)
RS (1) RS55674B1 (enExample)
SG (1) SG172439A1 (enExample)
SI (1) SI2381967T1 (enExample)
TN (1) TN2011000318A1 (enExample)
UA (1) UA105914C2 (enExample)
WO (1) WO2010078370A1 (enExample)
ZA (1) ZA201104824B (enExample)

Families Citing this family (30)

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EP2910945B1 (en) * 2008-09-30 2018-07-18 Case Western Reserve University Molecular probes for imaging of myelin
JP2013532136A (ja) 2010-06-04 2013-08-15 ピラマル イメージング ソシエテ アノニム Ｆ−１８標識アミロイド・ベータ・リガンドの製造方法
TWI504414B (zh) * 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
US20130209363A1 (en) 2010-06-04 2013-08-15 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
CN106729771A (zh) 2011-04-21 2017-05-31 加利福尼亚大学董事会 官能化磁性纳米颗粒及在淀粉样沉积物和神经原纤维缠结成像中用途
PT2723394T (pt) * 2011-06-21 2018-07-30 Life Molecular Imaging Sa Formulações de estilbeno fluorado, apropriadas para a imagiologia por pet
AU2012324940A1 (en) 2011-10-19 2014-04-17 Piramal Imaging Sa Improved method for production of F-18 labeled Abeta ligands
CN102432529B (zh) * 2011-11-14 2014-03-26 江苏省原子医学研究所 一种苯乙烯基吡啶二硫二氮衍生物的制备方法
US20150004100A1 (en) * 2011-12-15 2015-01-01 Ge Healthcare Limited Heterocyclic compounds as imaging probes of tau pathology
CN102526765B (zh) * 2011-12-31 2014-07-30 郑州泰基鸿诺药物科技有限公司 一种Aβ斑块显像剂及其制备方法
CN103965105A (zh) * 2013-01-29 2014-08-06 中山大学 苯乙烯基喹啉衍生物及其在治疗阿尔茨海默病症中的应用
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
WO2017014599A1 (ko) * 2015-07-22 2017-01-26 주식회사 씨코헬스케어 [18f]플루오로-도파의 방사화학적 순도를 안정화시키는 조성물 및 이의 제조방법
PT3374358T (pt) * 2015-11-13 2021-03-31 Lilly Co Eli Derivados de azetidina para a formação de imagens de tau
WO2017156303A1 (en) * 2016-03-09 2017-09-14 Case Western Reserve University Radioligands for myelin
CN107198780A (zh) * 2016-03-18 2017-09-26 南京江原安迪科正电子研究发展有限公司 放射性药物组合物及其制备方法、应用
CN106018575B (zh) * 2016-05-05 2018-10-19 江苏省原子医学研究所 一种PET显像剂前体TsOP-(+)-DTBZ及其光学异构体的分离测定方法
US10695450B2 (en) * 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
BR112019009036A2 (pt) * 2016-11-08 2019-07-16 Univ California métodos para a síntese de múltiplas doses de [f-18]fddnp para ajustes clínicos
TW201906818A (zh) * 2017-05-31 2019-02-16 美商５１１製藥公司 新穎氘取代之正子發射斷層掃描（ｐｅｔ）顯影劑及其藥理應用
IL275990B2 (en) * 2018-01-24 2024-08-01 Ac Immune Sa Diagnostic preparations for PET imaging, a method for producing a diagnostic preparation and its use in diagnostics
CN111499544B (zh) * 2019-01-31 2022-12-02 中国医学科学院放射医学研究所 一种一锅法制备N-Boc-N-甲基-4-氨基苯乙烯的合成方法
CN111499570B (zh) * 2019-01-31 2023-05-16 中国医学科学院放射医学研究所 一种av-45中间体的合成方法
JP7576334B2 (ja) * 2019-03-29 2024-10-31 国立研究開発法人量子科学技術研究開発機構 放射性医薬の製造方法及び放射性医薬
CN115400232A (zh) * 2021-05-26 2022-11-29 汉中汉核医疗科技有限公司 一种放射性药物合成方法
CN115403434A (zh) * 2021-05-26 2022-11-29 汉中汉核医疗科技有限公司 一种放射性药物的合成方法
CN113582885B (zh) * 2021-08-30 2023-04-21 南京克米斯璀新能源科技有限公司 一种烷基磺酸钠的生产方法
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
AU2023381809A1 (en) * 2022-11-14 2025-05-22 Eli Lilly And Company Polymorphic forms of florbetapir precursor av-105
CN119080714A (zh) * 2024-09-12 2024-12-06 四川大学 一种偶氮苯磺酸酯化合物及其制备方法和应用、放射性探针的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007525211A (ja) * 2004-01-19 2007-09-06 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド パーキンソン病の診断検査
EP1838298A4 (en) * 2004-12-17 2009-03-04 Univ Pennsylvania STYLENE DERIVATIVES AND THEIR USE OF THE BINDING AND IMAGE DISPLAY OF AMYLOID PLAQUE
NZ570887A (en) * 2006-03-30 2011-05-27 Univ Pennsylvania Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

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