CR20110410A - Síntesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmacéuticas estables de estas - Google Patents

Síntesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmacéuticas estables de estas

Info

Publication number
CR20110410A
CR20110410A CR20110410A CR20110410A CR20110410A CR 20110410 A CR20110410 A CR 20110410A CR 20110410 A CR20110410 A CR 20110410A CR 20110410 A CR20110410 A CR 20110410A CR 20110410 A CR20110410 A CR 20110410A
Authority
CR
Costa Rica
Prior art keywords
synthesis
pharmaceutical compositions
thosilate
stirilpiridinas
radiomarcated
Prior art date
Application number
CR20110410A
Other languages
English (en)
Inventor
Tyler Benedum
Geoff Golding
Nathaniel Lim
Wei Zhang
Original Assignee
Avid Radiopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avid Radiopharmaceuticals Inc filed Critical Avid Radiopharmaceuticals Inc
Publication of CR20110410A publication Critical patent/CR20110410A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a los métodos de síntesis de la 18F-estirilpiridina radiomarcada y su precursor de tosilato. La presente invención se refiere, además, a las composiciones farmacéuticas estables que comprenden estirilpiridina radiomarcada con 18F.
CR20110410A 2008-12-31 2011-07-29 Síntesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmacéuticas estables de estas CR20110410A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14188508P 2008-12-31 2008-12-31

Publications (1)

Publication Number Publication Date
CR20110410A true CR20110410A (es) 2011-12-08

Family

ID=42310197

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20110410A CR20110410A (es) 2008-12-31 2011-07-29 Síntesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmacéuticas estables de estas

Country Status (36)

Country Link
US (1) US20100172836A1 (es)
EP (1) EP2381967B1 (es)
JP (1) JP5717650B2 (es)
KR (1) KR20110119670A (es)
CN (1) CN102271716B (es)
AU (1) AU2009335049B2 (es)
BR (1) BRPI0923890A2 (es)
CA (1) CA2748705C (es)
CO (1) CO6341578A2 (es)
CR (1) CR20110410A (es)
CY (1) CY1118658T1 (es)
DK (1) DK2381967T3 (es)
DO (1) DOP2011000210A (es)
EA (1) EA023014B1 (es)
EC (1) ECSP11011242A (es)
ES (1) ES2620402T3 (es)
HK (1) HK1162951A1 (es)
HN (1) HN2011001810A (es)
HR (1) HRP20170453T1 (es)
HU (1) HUE033649T2 (es)
IL (1) IL213674A (es)
LT (1) LT2381967T (es)
MA (1) MA33004B1 (es)
MX (1) MX2011007063A (es)
MY (1) MY162312A (es)
NZ (1) NZ593848A (es)
PE (1) PE20120007A1 (es)
PL (1) PL2381967T3 (es)
PT (1) PT2381967T (es)
RS (1) RS55674B1 (es)
SG (1) SG172439A1 (es)
SI (1) SI2381967T1 (es)
TN (1) TN2011000318A1 (es)
UA (1) UA105914C2 (es)
WO (1) WO2010078370A1 (es)
ZA (1) ZA201104824B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010039815A1 (en) * 2008-09-30 2010-04-08 Case Western Reserve University Molecular probes for imaging of myelin
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
ES2642086T5 (es) 2010-06-04 2020-04-13 Life Molecular Imaging Sa Procedimiento para la producción de ligandos de beta amiloide marcados con F-18
SG185785A1 (en) * 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligand
CA3058702C (en) * 2011-04-21 2023-11-07 Massoud Akhtari Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
CA2839961C (en) * 2011-06-21 2019-08-13 Piramal Imaging Sa Formulations of fluorinated stilbene suitable for pet imaging
MX2014004274A (es) 2011-10-19 2014-07-09 Piramal Imaging Sa METODO MEJORADO PARA LA PRODUCCION DE LIGANDOS Aß MARCADOS CON F-18.
CN102432529B (zh) * 2011-11-14 2014-03-26 江苏省原子医学研究所 一种苯乙烯基吡啶二硫二氮衍生物的制备方法
CN104136420A (zh) * 2011-12-15 2014-11-05 通用电气健康护理有限公司 作为tau病理学的成像探针的杂环化合物
CN102526765B (zh) * 2011-12-31 2014-07-30 郑州泰基鸿诺药物科技有限公司 一种Aβ斑块显像剂及其制备方法
CN103965105A (zh) * 2013-01-29 2014-08-06 中山大学 苯乙烯基喹啉衍生物及其在治疗阿尔茨海默病症中的应用
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
WO2017014599A1 (ko) * 2015-07-22 2017-01-26 주식회사 씨코헬스케어 [18f]플루오로-도파의 방사화학적 순도를 안정화시키는 조성물 및 이의 제조방법
PL3374358T3 (pl) * 2015-11-13 2021-07-12 Eli Lilly And Company Pochodne azetydyny do obrazowania białka tau
WO2017156303A1 (en) * 2016-03-09 2017-09-14 Case Western Reserve University Radioligands for myelin
CN107198780A (zh) * 2016-03-18 2017-09-26 南京江原安迪科正电子研究发展有限公司 放射性药物组合物及其制备方法、应用
CN106018575B (zh) * 2016-05-05 2018-10-19 江苏省原子医学研究所 一种PET显像剂前体TsOP-(+)-DTBZ及其光学异构体的分离测定方法
US10695450B2 (en) * 2016-07-26 2020-06-30 Laboratoires Cyclopharma Synthesis of a radioactive agent composition
EP3538161B1 (en) * 2016-11-08 2022-07-27 The Regents of The University of California Methods for multi-dose synthesis of [f-18]fddnp for clinical settings
TW201906818A (zh) * 2017-05-31 2019-02-16 美商５１１製藥公司 新穎氘取代之正子發射斷層掃描（ｐｅｔ）顯影劑及其藥理應用
CA3088232A1 (en) * 2018-01-24 2019-08-01 Ac Immune Sa Diagnostic compositions for pet imaging, a method for manufacturing the diagnostic composition and its use in diagnostics
CN111499544B (zh) * 2019-01-31 2022-12-02 中国医学科学院放射医学研究所 一种一锅法制备N-Boc-N-甲基-4-氨基苯乙烯的合成方法
CN111499570B (zh) * 2019-01-31 2023-05-16 中国医学科学院放射医学研究所 一种av-45中间体的合成方法
US20220175973A1 (en) * 2019-03-29 2022-06-09 National Institutes for Quantum Science and Technology Method for producing radiopharmaceutical and radiopharmaceutical
CN115400232A (zh) * 2021-05-26 2022-11-29 汉中汉核医疗科技有限公司 一种放射性药物合成方法
CN115403434A (zh) * 2021-05-26 2022-11-29 汉中汉核医疗科技有限公司 一种放射性药物的合成方法
CN113582885B (zh) * 2021-08-30 2023-04-21 南京克米斯璀新能源科技有限公司 一种烷基磺酸钠的生产方法
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007525211A (ja) * 2004-01-19 2007-09-06 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド パーキンソン病の診断検査
DK2213652T3 (en) * 2004-12-17 2015-01-26 Univ Pennsylvania Stilbene AND USE THEREOF FOR BINDING AND IMAGING OF amyloid plaques
AU2007243712B2 (en) * 2006-03-30 2013-01-10 The Trustees Of The University Of Pennsylvania Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

Also Published As

Publication number Publication date
EA023014B1 (ru) 2016-04-29
KR20110119670A (ko) 2011-11-02
AU2009335049B2 (en) 2015-07-16
LT2381967T (lt) 2017-04-25
MY162312A (en) 2017-05-31
SI2381967T1 (sl) 2017-03-31
HRP20170453T1 (hr) 2017-06-02
PL2381967T3 (pl) 2017-06-30
CN102271716A (zh) 2011-12-07
SG172439A1 (en) 2011-07-28
DOP2011000210A (es) 2011-09-15
EP2381967B1 (en) 2017-01-18
HUE033649T2 (en) 2017-12-28
US20100172836A1 (en) 2010-07-08
BRPI0923890A2 (pt) 2015-07-28
IL213674A0 (en) 2011-07-31
CA2748705C (en) 2017-05-02
CY1118658T1 (el) 2017-07-12
ES2620402T3 (es) 2017-06-28
AU2009335049A1 (en) 2011-07-21
EP2381967A4 (en) 2013-01-02
UA105914C2 (uk) 2014-07-10
HN2011001810A (es) 2013-08-12
HK1162951A1 (en) 2012-09-07
MX2011007063A (es) 2011-12-16
JP2012514007A (ja) 2012-06-21
CO6341578A2 (es) 2011-11-21
CN102271716B (zh) 2014-11-19
MA33004B1 (fr) 2012-01-02
RS55674B1 (sr) 2017-06-30
ZA201104824B (en) 2013-01-30
CA2748705A1 (en) 2010-07-08
TN2011000318A1 (en) 2012-12-17
IL213674A (en) 2016-04-21
EP2381967A1 (en) 2011-11-02
PE20120007A1 (es) 2012-01-16
JP5717650B2 (ja) 2015-05-13
ECSP11011242A (es) 2011-10-31
DK2381967T3 (en) 2017-03-27
NZ593848A (en) 2013-09-27
WO2010078370A1 (en) 2010-07-08
EA201170911A1 (ru) 2011-12-30
PT2381967T (pt) 2017-02-24

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