PL3374358T3 - Pochodne azetydyny do obrazowania białka tau - Google Patents

Pochodne azetydyny do obrazowania białka tau

Info

Publication number
PL3374358T3
PL3374358T3 PL16798874T PL16798874T PL3374358T3 PL 3374358 T3 PL3374358 T3 PL 3374358T3 PL 16798874 T PL16798874 T PL 16798874T PL 16798874 T PL16798874 T PL 16798874T PL 3374358 T3 PL3374358 T3 PL 3374358T3
Authority
PL
Poland
Prior art keywords
azetidine derivatives
tau imaging
tau
imaging
azetidine
Prior art date
Application number
PL16798874T
Other languages
English (en)
Inventor
Giorgio Attardo
Shyamali Ghosh
Carey Horchler
Hui Xiong
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of PL3374358T3 publication Critical patent/PL3374358T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0444Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002Heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
PL16798874T 2015-11-13 2016-11-04 Pochodne azetydyny do obrazowania białka tau PL3374358T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254906P 2015-11-13 2015-11-13
PCT/US2016/060621 WO2017083198A1 (en) 2015-11-13 2016-11-04 Azetidine derivatives for tau imaging
EP16798874.0A EP3374358B1 (en) 2015-11-13 2016-11-04 Azetidine derivatives for tau imaging

Publications (1)

Publication Number Publication Date
PL3374358T3 true PL3374358T3 (pl) 2021-07-12

Family

ID=57389526

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16798874T PL3374358T3 (pl) 2015-11-13 2016-11-04 Pochodne azetydyny do obrazowania białka tau

Country Status (19)

Country Link
US (1) US10301308B2 (pl)
EP (1) EP3374358B1 (pl)
JP (1) JP2018531978A (pl)
KR (1) KR20180061364A (pl)
CN (1) CN108290883B (pl)
AU (1) AU2016351609B2 (pl)
BR (1) BR112018006969B1 (pl)
CA (1) CA3003884C (pl)
DK (1) DK3374358T3 (pl)
EA (1) EA034018B1 (pl)
ES (1) ES2864825T3 (pl)
HK (1) HK1257042A1 (pl)
IL (1) IL258313B (pl)
MX (1) MX2018005376A (pl)
PL (1) PL3374358T3 (pl)
PT (1) PT3374358T (pl)
SA (1) SA518391527B1 (pl)
WO (1) WO2017083198A1 (pl)
ZA (1) ZA201802526B (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023150483A1 (en) * 2022-02-03 2023-08-10 Eli Lilly And Company Regional tau imaging for diagnosing and treating alzheimer's disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004054978A1 (ja) * 2002-12-16 2006-04-20 株式会社 ビーエフ研究所 タウ蛋白蓄積性疾患の診断プローブとしてのキノリン誘導体
US20110046378A1 (en) 2008-02-14 2011-02-24 Siemens Medical Solutions Usa, Inc. Novel Imaging Agents for Detecting Neurological Dysfunction
PT2381967T (pt) * 2008-12-31 2017-02-24 Avid Radiopharmaceuticals Inc Síntese de estirilpiridinas radiomarcadas com 18f a partir de precursores tosilato e as suas composições farmacêuticas estáveis
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
WO2013176698A1 (en) 2012-05-22 2013-11-28 Eli Lilly And Company Carboline and carbazole based imaging agents for detecting neurological dysfunction

Also Published As

Publication number Publication date
BR112018006969B1 (pt) 2022-04-26
EP3374358B1 (en) 2021-02-17
EA201890799A1 (ru) 2018-10-31
WO2017083198A1 (en) 2017-05-18
PT3374358T (pt) 2021-03-31
AU2016351609A1 (en) 2018-04-19
JP2018531978A (ja) 2018-11-01
SA518391527B1 (ar) 2021-02-07
IL258313A (en) 2018-05-31
EA034018B1 (ru) 2019-12-19
CA3003884C (en) 2020-04-21
KR20180061364A (ko) 2018-06-07
CN108290883A (zh) 2018-07-17
IL258313B (en) 2021-04-29
CA3003884A1 (en) 2017-05-18
BR112018006969A2 (pt) 2018-10-16
HK1257042A1 (zh) 2019-10-11
AU2016351609B2 (en) 2019-08-08
US10301308B2 (en) 2019-05-28
US20180282322A1 (en) 2018-10-04
ES2864825T3 (es) 2021-10-14
MX2018005376A (es) 2018-08-01
CN108290883B (zh) 2021-02-09
ZA201802526B (en) 2019-10-30
EP3374358A1 (en) 2018-09-19
DK3374358T3 (da) 2021-03-08

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