CY1111045T1 - Μεθοδος παραγωγης ενος παραγωγου βενζιμιδαζολιου - Google Patents

Μεθοδος παραγωγης ενος παραγωγου βενζιμιδαζολιου

Info

Publication number
CY1111045T1
CY1111045T1 CY20101100957T CY101100957T CY1111045T1 CY 1111045 T1 CY1111045 T1 CY 1111045T1 CY 20101100957 T CY20101100957 T CY 20101100957T CY 101100957 T CY101100957 T CY 101100957T CY 1111045 T1 CY1111045 T1 CY 1111045T1
Authority
CY
Cyprus
Prior art keywords
fuelzimidazol
producer
production
davigatran
ethoxylate
Prior art date
Application number
CY20101100957T
Other languages
English (en)
Inventor
Wolfgang Broeder
Rainer Sobotta
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of CY1111045T1 publication Critical patent/CY1111045T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Η εφεύρεση σχετίζεται με μια μέθοδο παρασκευής της ένωσης του τύπου 1, ενός πολυτίμου ενδιάμεσου προϊόντος στη σύνθεση της φαρμακευτικής δραστικής ουσίας ετεξιλική δαβιγατράνη.
CY20101100957T 2007-02-06 2010-10-25 Μεθοδος παραγωγης ενος παραγωγου βενζιμιδαζολιου CY1111045T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07101822A EP1956018A1 (de) 2007-02-06 2007-02-06 Verfahren zur Herstellung eines Benzimidazolderivats
EP08708696A EP2118090B1 (en) 2007-02-06 2008-02-05 Process for the preparation of a benzimidazole derivative

Publications (1)

Publication Number Publication Date
CY1111045T1 true CY1111045T1 (el) 2015-06-11

Family

ID=38166801

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100957T CY1111045T1 (el) 2007-02-06 2010-10-25 Μεθοδος παραγωγης ενος παραγωγου βενζιμιδαζολιου

Country Status (34)

Country Link
US (2) US8119810B2 (el)
EP (2) EP1956018A1 (el)
JP (1) JP5247728B2 (el)
KR (1) KR20090116781A (el)
CN (1) CN101600709B (el)
AR (1) AR065196A1 (el)
AT (1) ATE476430T1 (el)
AU (1) AU2008212908B2 (el)
BR (1) BRPI0807197A2 (el)
CA (1) CA2675624C (el)
CL (1) CL2008000355A1 (el)
CY (1) CY1111045T1 (el)
DE (1) DE602008002057D1 (el)
DK (1) DK2118090T3 (el)
EA (1) EA015967B1 (el)
EC (1) ECSP099509A (el)
ES (1) ES2349905T3 (el)
HK (1) HK1136559A1 (el)
HR (1) HRP20100458T1 (el)
IL (1) IL199330A (el)
MA (1) MA31118B1 (el)
MX (1) MX2009006834A (el)
MY (1) MY148629A (el)
NZ (1) NZ579133A (el)
PE (1) PE20081737A1 (el)
PL (1) PL2118090T3 (el)
PT (1) PT2118090E (el)
SI (1) SI2118090T1 (el)
TN (1) TN2009000327A1 (el)
TW (1) TWI417291B (el)
UA (1) UA94988C2 (el)
UY (1) UY30888A1 (el)
WO (1) WO2008095928A1 (el)
ZA (1) ZA200906050B (el)

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US8471033B2 (en) * 2008-06-16 2013-06-25 Boehringer Ingelheim International Gmbh Method for producing an intermediate product of dabigatran etexilate
AU2009272796A1 (en) 2008-07-14 2010-01-21 Boehringer Ingelheim International Gmbh Method for manufacturing medicinal compounds containing dabigatran
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CN102050815B (zh) * 2009-11-06 2014-04-02 北京美倍他药物研究有限公司 作为前药的达比加群的酯衍生物
CN102050814B (zh) * 2009-11-06 2014-05-28 北京美倍他药物研究有限公司 达比加群的酯衍生物
US8399678B2 (en) 2009-11-18 2013-03-19 Boehringer Ingelheim International Gmbh Process for the manufacture of dabigatran etexilate
MX2013000295A (es) 2010-07-09 2013-05-28 Esteve Quimica Sa Procedimiento de preparacion de un inhibidor especifico de la trombina.
WO2012077136A2 (en) * 2010-12-06 2012-06-14 Msn Laboratories Limited Process for the preparation of benzimidazole derivatives and its salts
CN102838588B (zh) * 2011-06-24 2014-03-19 中国药科大学 一类可用于口服的凝血酶抑制剂、其制法以及医药用途
CN102633713B (zh) * 2012-03-22 2013-12-11 南京工业大学 达比加群酯中间体及其制备方法、以及制备达比加群酯的方法
EP2834224B1 (en) 2012-04-02 2018-06-06 MSN Laboratories Limited Process for the preparation of benzimidazole derivatives and salts thereof
CN102911160B (zh) * 2012-06-29 2014-10-22 上海奥博生物医药技术有限公司 一种制备和纯化达比加群酯中间体的方法
US9365544B2 (en) * 2012-07-16 2016-06-14 Interquim, S.A. Process for the preparation of intermediates for the synthesis of Dabigatran Etexilate, and crystalline forms of said intermediates
US9533971B2 (en) 2012-10-29 2017-01-03 Biophore India Pharmaceuticals Pvt. Ltd Process for the synthesis of dabigatran and its intermediates
US10077251B2 (en) 2012-10-29 2018-09-18 Biophore India Pharmaceuticals Pvt. Ltd. Process for the synthesis of Dabigatran Etexilate and its intermediates
CN102977077A (zh) * 2012-11-28 2013-03-20 浙江燎原药业有限公司 一种达比加群酯中间体的制备方法
CN103224469A (zh) * 2013-05-16 2013-07-31 上海应用技术学院 一种以含氟基团修饰的苯环为中心的达比加群酯类似物及其合成方法
CN103288744A (zh) * 2013-06-04 2013-09-11 上海应用技术学院 一种含氟基团修饰的达比加群酯类似物及其合成方法
CN104418839B (zh) * 2013-08-26 2019-02-01 深圳翰宇药业股份有限公司 达比加群酯的合成方法
CN103710406B (zh) * 2013-12-05 2017-08-11 蚌埠丰原医药科技发展有限公司 一种酶促反应制备达比加群酯主要中间体的方法
CN103772358A (zh) * 2014-01-07 2014-05-07 万特制药(海南)有限公司 一种制备达比加群酯的合成方法
CN104003977B (zh) * 2014-06-05 2016-04-13 雅本化学股份有限公司 N-(2-氯甲基-1-甲基-1h-苯并咪唑-5-酰基)-n-(吡啶-2-基) -3-氨基丙酸乙酯的制备方法
CN104045628B (zh) * 2014-06-13 2019-04-09 深圳翰宇药业股份有限公司 苯并咪唑衍生物的纯化方法
CN105315257A (zh) * 2014-06-24 2016-02-10 华仁药业股份有限公司 一种达比加群酯的合成及纯化方法
JP6403865B2 (ja) 2014-07-03 2018-10-10 シャンハイ インスティテュート オブ ファーマシューティカル インダストリー ダビガトランエテキシラート中間体の製造方法及び中間体化合物
WO2016027077A1 (en) * 2014-08-18 2016-02-25 Cipla Limited Processes for the preparation of dabigatran etexilate and intermediates thereof
CN104744438A (zh) * 2014-12-17 2015-07-01 烟台东诚药业集团股份有限公司 一种用于合成制备达比加群酯苯并咪唑中间体的方法
WO2016132296A1 (en) * 2015-02-18 2016-08-25 Piramal Enterprises Limited A process for the preparation of an intermediate of dabigatran etexilate
CN105601615A (zh) * 2015-11-17 2016-05-25 烟台东诚药业集团股份有限公司 一种用于纯化公斤级达比加群酯游离碱的方法
CN105330645B (zh) * 2015-11-30 2020-06-02 常州市阳光药业有限公司 达比加群酯中间体的制备方法
CN106866626A (zh) * 2015-12-14 2017-06-20 天津药物研究院有限公司 一种达比加群酯中间体的制备方法

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Also Published As

Publication number Publication date
PL2118090T3 (pl) 2011-01-31
BRPI0807197A2 (pt) 2014-06-03
EP1956018A1 (de) 2008-08-13
ECSP099509A (es) 2009-08-28
NZ579133A (en) 2010-12-24
DK2118090T3 (da) 2010-11-01
US20100099882A1 (en) 2010-04-22
AU2008212908A1 (en) 2008-08-14
MY148629A (en) 2013-05-15
KR20090116781A (ko) 2009-11-11
UA94988C2 (ru) 2011-06-25
AR065196A1 (es) 2009-05-20
JP5247728B2 (ja) 2013-07-24
TW200838860A (en) 2008-10-01
MX2009006834A (es) 2009-08-13
EP2118090A1 (en) 2009-11-18
ATE476430T1 (de) 2010-08-15
PT2118090E (pt) 2010-08-31
HK1136559A1 (en) 2010-07-02
WO2008095928A1 (en) 2008-08-14
ES2349905T3 (es) 2011-01-12
IL199330A (en) 2013-03-24
UY30888A1 (es) 2008-09-30
PE20081737A1 (es) 2009-06-20
CA2675624A1 (en) 2008-08-14
EP2118090B1 (en) 2010-08-04
US20120116089A1 (en) 2012-05-10
CA2675624C (en) 2014-07-08
EA015967B1 (ru) 2012-01-30
EA200901039A1 (ru) 2010-02-26
MA31118B1 (fr) 2010-01-04
CN101600709A (zh) 2009-12-09
AU2008212908B2 (en) 2013-06-20
JP2010517979A (ja) 2010-05-27
DE602008002057D1 (de) 2010-09-16
TWI417291B (zh) 2013-12-01
CN101600709B (zh) 2012-12-12
US8119810B2 (en) 2012-02-21
CL2008000355A1 (es) 2008-06-20
SI2118090T1 (sl) 2010-11-30
ZA200906050B (en) 2010-05-26
US8455650B2 (en) 2013-06-04
TN2009000327A1 (fr) 2010-12-31
HRP20100458T1 (hr) 2010-09-30

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