RU2018121946A - Модуляторы ror-гамма - Google Patents

Модуляторы ror-гамма Download PDF

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RU2018121946A
RU2018121946A RU2018121946A RU2018121946A RU2018121946A RU 2018121946 A RU2018121946 A RU 2018121946A RU 2018121946 A RU2018121946 A RU 2018121946A RU 2018121946 A RU2018121946 A RU 2018121946A RU 2018121946 A RU2018121946 A RU 2018121946A
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Russia
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compound according
paragraphs
alkyl
compound
pharmaceutically acceptable
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RU2018121946A
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RU2018121946A3 (enExample
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Дэвид А. Клэрмон
Лоуренс Уэйн Диллард
И Фань
Ланьци Цзя
Суреш Б. СИНГХ
Колин М. ТАЙС
Чжэньжун Сюй
Цзин Юань
Линхан Чжуан
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Вайтаи Фармасьютиклз, Ллк
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Publication of RU2018121946A publication Critical patent/RU2018121946A/ru
Publication of RU2018121946A3 publication Critical patent/RU2018121946A3/ru

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    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Cardiology (AREA)
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  • Anesthesiology (AREA)
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  • Child & Adolescent Psychology (AREA)
RU2018121946A 2015-11-20 2016-11-17 Модуляторы ror-гамма RU2018121946A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562257964P 2015-11-20 2015-11-20
US62/257,964 2015-11-20
US201662320805P 2016-04-11 2016-04-11
US62/320,805 2016-04-11
PCT/US2016/062422 WO2017087608A1 (en) 2015-11-20 2016-11-17 Modulators of ror-gamma

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RU2018121946A true RU2018121946A (ru) 2019-12-23
RU2018121946A3 RU2018121946A3 (enExample) 2020-04-16

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RU2018121946A RU2018121946A (ru) 2015-11-20 2016-11-17 Модуляторы ror-гамма

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US (1) US11008340B2 (enExample)
EP (2) EP3868750A1 (enExample)
JP (1) JP6914257B2 (enExample)
KR (1) KR20180086221A (enExample)
CN (1) CN108463458B (enExample)
AU (1) AU2016355710B2 (enExample)
BR (1) BR112018010018A2 (enExample)
CA (1) CA3005658A1 (enExample)
IL (2) IL259421B (enExample)
MA (1) MA53943A (enExample)
MX (2) MX385332B (enExample)
RU (1) RU2018121946A (enExample)
SA (1) SA518391624B1 (enExample)
WO (1) WO2017087608A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS59007B1 (sr) 2014-02-03 2019-08-30 Vitae Pharmaceuticals Llc Dihidropirolopiridinski inhibitori ror-gama
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
MX394388B (es) 2015-05-15 2025-03-21 Aurigene Discovery Tech Ltd Compuestos de tetrahidroquinolinona sustituidos como moduladores de ror gamma
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