JP2021522262A5 - - Google Patents
Info
- Publication number
- JP2021522262A5 JP2021522262A5 JP2020560186A JP2020560186A JP2021522262A5 JP 2021522262 A5 JP2021522262 A5 JP 2021522262A5 JP 2020560186 A JP2020560186 A JP 2020560186A JP 2020560186 A JP2020560186 A JP 2020560186A JP 2021522262 A5 JP2021522262 A5 JP 2021522262A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- group
- heteroaryl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862666312P | 2018-05-03 | 2018-05-03 | |
| US62/666,312 | 2018-05-03 | ||
| PCT/US2019/030526 WO2019213470A1 (en) | 2018-05-03 | 2019-05-03 | Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (rorϒ) and pharmaceutical uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021522262A JP2021522262A (ja) | 2021-08-30 |
| JP2021522262A5 true JP2021522262A5 (enExample) | 2022-05-12 |
| JP7351851B2 JP7351851B2 (ja) | 2023-09-27 |
Family
ID=68386171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560186A Active JP7351851B2 (ja) | 2018-05-03 | 2019-05-03 | レチノイド関連オルファン受容体ガンマ（ＲＯＲγ）のモジュレーターとしてのベンジイミダゾール誘導体およびそれらの医薬品用途 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11512055B2 (enExample) |
| EP (1) | EP3781161B1 (enExample) |
| JP (1) | JP7351851B2 (enExample) |
| KR (1) | KR102709804B1 (enExample) |
| CN (2) | CN112135611B (enExample) |
| AU (1) | AU2019262169B2 (enExample) |
| BR (1) | BR112020021967A2 (enExample) |
| CA (1) | CA3097519A1 (enExample) |
| ES (1) | ES2949366T3 (enExample) |
| HR (1) | HRP20230643T1 (enExample) |
| HU (1) | HUE062273T2 (enExample) |
| MX (1) | MX2020011405A (enExample) |
| MY (1) | MY208400A (enExample) |
| PL (1) | PL3781161T3 (enExample) |
| RS (1) | RS64348B1 (enExample) |
| SM (1) | SMT202300212T1 (enExample) |
| TW (1) | TWI818985B (enExample) |
| UA (1) | UA128161C2 (enExample) |
| WO (1) | WO2019213470A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE062273T2 (hu) * | 2018-05-03 | 2023-10-28 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Benzimidazolszármazékok mint a retinsavreceptor rokon árvareceptor-gamma (RORy) modulátorai és gyógyszerészeti felhasználásaik |
| AU2020377114A1 (en) * | 2019-10-31 | 2022-06-16 | Jiangsu Hengrui Medicine Co., Ltd. | Acid addition salt of RORγ regulator |
| CN112745268B (zh) * | 2019-10-31 | 2022-09-16 | 江苏恒瑞医药股份有限公司 | 苯并咪唑衍生物的晶型及制备方法 |
| TW202136237A (zh) * | 2020-01-06 | 2021-10-01 | 大陸商廣東東陽光藥業有限公司 | RORγt抑制劑及其製備方法和用途 |
| TW202136238A (zh) * | 2020-01-06 | 2021-10-01 | 大陸商廣東東陽光藥業有限公司 | RORγt抑制劑及其製備方法和用途 |
| CN111269126B (zh) * | 2020-03-12 | 2023-04-07 | 北京理工大学重庆创新中心 | 一种熔铸载体1,2-二氟-4,5-二硝基苯的制备方法 |
| JP7682920B2 (ja) * | 2020-04-07 | 2025-05-26 | ユーシービー バイオファルマ エスアールエル | Ｉｌ－１７モジュレータとしてのジフルオロシクロヘキシル誘導体 |
| CN113666853B (zh) * | 2020-05-15 | 2023-04-18 | 上海辉启生物医药科技有限公司 | 可用作RORγ调节剂的联芳基类化合物 |
| US20250082592A1 (en) * | 2021-05-17 | 2025-03-13 | Seoul National University R & Db Foundation | PHARMACEUTICAL COMPOSITION FOR PREVENTION, ALLEVIATION OR TREATMENT OF SARCOPENIA, CONTAINING ROR-alpha ACTIVATOR JC1-40 |
| CN121045325A (zh) * | 2024-05-31 | 2025-12-02 | 中国科学院广州生物医药与健康研究院 | 磺酰胺基乙酰胺类化合物及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3075991A (en) * | 1960-01-20 | 1963-01-29 | Dow Chemical Co | Benzimidazolylalkylbenzene-sulfonamide compounds |
| CA2382789A1 (en) * | 1999-08-27 | 2001-03-08 | Sugen, Inc. | Phosphate mimics and methods of treatment using phosphatase inhibitors |
| US7951829B2 (en) * | 2006-05-03 | 2011-05-31 | Janssen Pharmaceutica Nv | Benzimidazole modulators of VR1 |
| WO2011148956A1 (ja) | 2010-05-24 | 2011-12-01 | トーアエイヨー株式会社 | 縮合イミダゾール誘導体 |
| WO2012027965A1 (en) | 2010-09-01 | 2012-03-08 | Glaxo Group Limited | Novel compounds |
| CN102060780B (zh) | 2010-12-27 | 2014-11-05 | 雅本化学股份有限公司 | 2-(n-取代)-氨基苯并咪唑衍生物的制备方法 |
| WO2013029338A1 (en) | 2011-09-01 | 2013-03-07 | Glaxo Group Limited | Novel compounds |
| CA2874303C (en) | 2012-06-11 | 2020-10-13 | Ucb Biopharma Sprl | Tnf -alpha modulating benz imidazoles |
| CN105849090A (zh) | 2013-10-30 | 2016-08-10 | 诺华股份有限公司 | 2-苄基-苯并咪唑补体因子b抑制剂及其用途 |
| PE20211002A1 (es) | 2014-04-14 | 2021-06-01 | Boehringer Ingelheim Int | Compuestos como moduladores de ror gamma |
| AP2016009542A0 (en) * | 2014-04-16 | 2016-11-30 | Glenmark Pharmaceuticals Sa | Aryl and heteroaryl ether compounds as ror gamma modulators |
| WO2015196335A1 (en) * | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Pyrazole compounds as modulators of fshr and uses thereof |
| US20160024052A1 (en) * | 2014-07-25 | 2016-01-28 | Innov17 Llc | Benzimidazole retinoic acid receptor-related orphan receptor modulators and uses thereof |
| FR3030516B1 (fr) * | 2014-12-19 | 2019-12-27 | Galderma Research & Development | Derives sulfonamides bicycles en tant qu'agonistes inverses du recepteur gamma orphelin associe aux retinoides ror gamma (t) |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| HUE062273T2 (hu) * | 2018-05-03 | 2023-10-28 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Benzimidazolszármazékok mint a retinsavreceptor rokon árvareceptor-gamma (RORy) modulátorai és gyógyszerészeti felhasználásaik |
-
2019
- 2019-05-03 HU HUE19796430A patent/HUE062273T2/hu unknown
- 2019-05-03 PL PL19796430.7T patent/PL3781161T3/pl unknown
- 2019-05-03 ES ES19796430T patent/ES2949366T3/es active Active
- 2019-05-03 HR HRP20230643TT patent/HRP20230643T1/hr unknown
- 2019-05-03 EP EP19796430.7A patent/EP3781161B1/en active Active
- 2019-05-03 JP JP2020560186A patent/JP7351851B2/ja active Active
- 2019-05-03 WO PCT/US2019/030526 patent/WO2019213470A1/en not_active Ceased
- 2019-05-03 BR BR112020021967-3A patent/BR112020021967A2/pt unknown
- 2019-05-03 KR KR1020207032236A patent/KR102709804B1/ko active Active
- 2019-05-03 MY MYPI2020005364A patent/MY208400A/en unknown
- 2019-05-03 SM SM20230212T patent/SMT202300212T1/it unknown
- 2019-05-03 CA CA3097519A patent/CA3097519A1/en active Pending
- 2019-05-03 MX MX2020011405A patent/MX2020011405A/es unknown
- 2019-05-03 RS RS20230505A patent/RS64348B1/sr unknown
- 2019-05-03 UA UAA202007544A patent/UA128161C2/uk unknown
- 2019-05-03 CN CN201980027956.1A patent/CN112135611B/zh active Active
- 2019-05-03 AU AU2019262169A patent/AU2019262169B2/en active Active
- 2019-05-03 TW TW108115438A patent/TWI818985B/zh active
- 2019-05-03 CN CN202310017171.4A patent/CN116514722A/zh active Pending
- 2019-05-03 US US17/052,451 patent/US11512055B2/en active Active
-
2022
- 2022-11-21 US US18/057,537 patent/US12187684B2/en active Active
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