HRP20230643T1 - Derivati benzimidazola kao modulatori receptora siroče gama (rory) povezanih s retinoidima i njihova farmaceutska upotreba - Google Patents

Derivati benzimidazola kao modulatori receptora siroče gama (rory) povezanih s retinoidima i njihova farmaceutska upotreba Download PDF

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HRP20230643T1
HRP20230643T1 HRP20230643TT HRP20230643T HRP20230643T1 HR P20230643 T1 HRP20230643 T1 HR P20230643T1 HR P20230643T T HRP20230643T T HR P20230643TT HR P20230643 T HRP20230643 T HR P20230643T HR P20230643 T1 HRP20230643 T1 HR P20230643T1
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Croatia
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alkyl
cycloalkyl
heterocyclyl
heteroaryl
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HRP20230643TT
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English (en)
Croatian (hr)
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Yinfa Yan
Minsheng Zhang
Dong Liu
Fengqi Zhang
Suxing Liu
Rumin Zhang
Feng He
Weikang Tao
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Jiangsu Hengrui Pharmaceuticals Co., Ltd.
Shanghai Hengrui Pharmaceutical Co., Ltd.
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Application filed by Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd. filed Critical Jiangsu Hengrui Pharmaceuticals Co., Ltd.
Publication of HRP20230643T1 publication Critical patent/HRP20230643T1/hr

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Chemical & Material Sciences (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
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  • Urology & Nephrology (AREA)
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  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HRP20230643TT 2018-05-03 2019-05-03 Derivati benzimidazola kao modulatori receptora siroče gama (rory) povezanih s retinoidima i njihova farmaceutska upotreba HRP20230643T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862666312P 2018-05-03 2018-05-03
EP19796430.7A EP3781161B1 (en) 2018-05-03 2019-05-03 Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (rory) and pharmaceutical uses thereof
PCT/US2019/030526 WO2019213470A1 (en) 2018-05-03 2019-05-03 Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (rorϒ) and pharmaceutical uses thereof

Publications (1)

Publication Number Publication Date
HRP20230643T1 true HRP20230643T1 (hr) 2023-09-29

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HRP20230643TT HRP20230643T1 (hr) 2018-05-03 2019-05-03 Derivati benzimidazola kao modulatori receptora siroče gama (rory) povezanih s retinoidima i njihova farmaceutska upotreba

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US (2) US11512055B2 (enExample)
EP (1) EP3781161B1 (enExample)
JP (1) JP7351851B2 (enExample)
KR (1) KR102709804B1 (enExample)
CN (2) CN116514722A (enExample)
AU (1) AU2019262169B2 (enExample)
BR (1) BR112020021967A2 (enExample)
CA (1) CA3097519A1 (enExample)
ES (1) ES2949366T3 (enExample)
HR (1) HRP20230643T1 (enExample)
HU (1) HUE062273T2 (enExample)
MX (1) MX2020011405A (enExample)
MY (1) MY208400A (enExample)
PL (1) PL3781161T3 (enExample)
RS (1) RS64348B1 (enExample)
SM (1) SMT202300212T1 (enExample)
TW (1) TWI818985B (enExample)
UA (1) UA128161C2 (enExample)
WO (1) WO2019213470A1 (enExample)

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Publication number Priority date Publication date Assignee Title
KR102709804B1 (ko) * 2018-05-03 2024-09-25 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 레티노이드-관련 희귀 수용체 감마(ＲＯＲγ)의 조절제로서 벤즈이미다졸 유도체 및 이의 약학적 용도
KR20220093340A (ko) * 2019-10-31 2022-07-05 지앙수 헨그루이 메디슨 컴퍼니 리미티드 RORγ 조절제의 산부가염
CN112745268B (zh) * 2019-10-31 2022-09-16 江苏恒瑞医药股份有限公司 苯并咪唑衍生物的晶型及制备方法
TW202136238A (zh) * 2020-01-06 2021-10-01 大陸商廣東東陽光藥業有限公司 RORγt抑制劑及其製備方法和用途
TW202136237A (zh) * 2020-01-06 2021-10-01 大陸商廣東東陽光藥業有限公司 RORγt抑制劑及其製備方法和用途
CN111269126B (zh) * 2020-03-12 2023-04-07 北京理工大学重庆创新中心 一种熔铸载体1,2-二氟-4,5-二硝基苯的制备方法
WO2021204801A1 (en) * 2020-04-07 2021-10-14 UCB Biopharma SRL Difluorocyclohexyl derivatives as il-17 modulators
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