HRP20200263T1 - Upotreba derivata pirazolopirimidina za liječenje poremećaja povezanih sa pi3k - Google Patents
Upotreba derivata pirazolopirimidina za liječenje poremećaja povezanih sa pi3k Download PDFInfo
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- HRP20200263T1 HRP20200263T1 HRP20200263TT HRP20200263T HRP20200263T1 HR P20200263 T1 HRP20200263 T1 HR P20200263T1 HR P20200263T T HRP20200263T T HR P20200263TT HR P20200263 T HRP20200263 T HR P20200263T HR P20200263 T1 HRP20200263 T1 HR P20200263T1
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- OGEBRHQLRGFBNV-RZDIXWSQSA-N chembl2036808 Chemical class C12=NC(NCCCC)=NC=C2C(C=2C=CC(F)=CC=2)=NN1C[C@H]1CC[C@H](N)CC1 OGEBRHQLRGFBNV-RZDIXWSQSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 32
- 238000000034 method Methods 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 6
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 6
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 3
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 2
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 241000721454 Pemphigus Species 0.000 claims 2
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 2
- 206010043540 Thromboangiitis obliterans Diseases 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 210000001102 germinal center b cell Anatomy 0.000 claims 2
- 208000015446 immunoglobulin a vasculitis Diseases 0.000 claims 2
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 2
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 2
- ZQPDJCIXJHUERQ-MNOVXSKESA-N (4r)-4-[3-[(1r)-1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one Chemical compound CCOC1=C([C@@H](C)N2C3=NC=NC(N)=C3C(C)=N2)C=C(Cl)C(F)=C1[C@@H]1CNC(=O)C1 ZQPDJCIXJHUERQ-MNOVXSKESA-N 0.000 claims 1
- ZQPDJCIXJHUERQ-QWRGUYRKSA-N (4r)-4-[3-[(1s)-1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one Chemical compound CCOC1=C([C@H](C)N2C3=NC=NC(N)=C3C(C)=N2)C=C(Cl)C(F)=C1[C@@H]1CNC(=O)C1 ZQPDJCIXJHUERQ-QWRGUYRKSA-N 0.000 claims 1
- ZQPDJCIXJHUERQ-GHMZBOCLSA-N (4s)-4-[3-[(1r)-1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one Chemical compound CCOC1=C([C@@H](C)N2C3=NC=NC(N)=C3C(C)=N2)C=C(Cl)C(F)=C1[C@H]1CNC(=O)C1 ZQPDJCIXJHUERQ-GHMZBOCLSA-N 0.000 claims 1
- ZQPDJCIXJHUERQ-WDEREUQCSA-N (4s)-4-[3-[(1s)-1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one Chemical compound CCOC1=C([C@H](C)N2C3=NC=NC(N)=C3C(C)=N2)C=C(Cl)C(F)=C1[C@H]1CNC(=O)C1 ZQPDJCIXJHUERQ-WDEREUQCSA-N 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- UCYDWQYLQRHHCX-UHFFFAOYSA-N 4-[3-[1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]-1,3-oxazolidin-2-one Chemical compound CCOC1=C(C(C)N2C3=NC=NC(N)=C3C(C)=N2)C=C(Cl)C(F)=C1C1COC(=O)N1 UCYDWQYLQRHHCX-UHFFFAOYSA-N 0.000 claims 1
- ZQPDJCIXJHUERQ-UHFFFAOYSA-N 4-[3-[1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one Chemical compound CCOC1=C(C(C)N2C3=NC=NC(N)=C3C(C)=N2)C=C(Cl)C(F)=C1C1CNC(=O)C1 ZQPDJCIXJHUERQ-UHFFFAOYSA-N 0.000 claims 1
- XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 claims 1
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 208000027496 Behcet disease Diseases 0.000 claims 1
- 208000033386 Buerger disease Diseases 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 208000010007 Cogan syndrome Diseases 0.000 claims 1
- 208000019707 Cryoglobulinemic vasculitis Diseases 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000007465 Giant cell arteritis Diseases 0.000 claims 1
- 206010018372 Glomerulonephritis membranous Diseases 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000011200 Kawasaki disease Diseases 0.000 claims 1
- 208000034624 Leukocytoclastic Cutaneous Vasculitis Diseases 0.000 claims 1
- 208000032514 Leukocytoclastic vasculitis Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000004732 Systemic Vasculitis Diseases 0.000 claims 1
- 208000001106 Takayasu Arteritis Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 208000010353 central nervous system vasculitis Diseases 0.000 claims 1
- 230000001086 cytosolic effect Effects 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 201000006362 hypersensitivity vasculitis Diseases 0.000 claims 1
- 201000007919 lymphoplasmacytic lymphoma Diseases 0.000 claims 1
- 201000008350 membranous glomerulonephritis Diseases 0.000 claims 1
- 231100000855 membranous nephropathy Toxicity 0.000 claims 1
- 206010063344 microscopic polyangiitis Diseases 0.000 claims 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims 1
- 201000006292 polyarteritis nodosa Diseases 0.000 claims 1
- 206010043207 temporal arteritis Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Claims (19)
1. Spoj za upotrebu u postupku liječenja idiopatske trombocitopenične purpure (ITP), autoimune hemolitične anemije, Behçetove bolesti, Coganovog sindroma, arteritisa divovskih stanica, reumatske polimialgije (PMR), Takayasuvog arteritisa, Buergerove bolesti (lat. thromboangiitis obliterans), vaskulitisa središnjeg živčanog sustava Kawasaki bolesti, poliarteritis nodoze, Churg-Straussovog sindroma, miješanog krioglobulinemičnog vaskulitisa (esencijalnog ili induciranog virusom hepatitisa C (HCV)), Henoch-Schönleinove purpure (HSP), hipersenzitivnog vaskulitisa, mikroskopskog poliangiitisa, Wegenerove granulomatoze, antineutrofilnih citoplazmatskih anititijela povezanih sa (ANCA) sistemskim vaskulitisom (AASV), pemfigusa, membranske nefropatije, kronične limfocitne leukemije (CLL), leukemije dlakavih stanica, limfoma stanice plašta, malog limfocitnog limfoma, folikularnog limfoma, limfoplazmacitnog limfoma, ekstranodalnog limfoma marginalne zone, difuznog B-velikostaničnog limfoma sličnog aktiviranoj B-stanici (ABC), ili difuznog B-velikostaničnog limfoma B-stanice germinalnog centra (GCB) kod pacijenta, gdje je Spoj Formule IV:
[image]
ili njegova farmaceutski prihvatljiva sol, gdje:
G je NH, n je 1, i V je O; ili
G je NH, n je 0, i V je CH2; ili
G je O, n je 0 i V je NH;
R2 je C1-6 alkil ili C1-6 haloalkil;
R4 je halo, OH, CN, C1-4 alkil, C1-4 haloalkil, C1-4 alkoksi, ili C1-4 haloalkoksi;
R5 je halo, OH, CN, C1-4 alkil, C1-4 haloalkil, C1-4 alkoksi, ili C1-4 haloalkoksi.
2. Spoj za upotrebu prema zahtjevu 1, gdje:
a) R2 je C1-3 alkil ili C1-3 fluoroalkil; ili
b) R2 je metil, etil, ili 2,2-difluorometil; ili
c) R2 je metil; ili
d) R2 je etil.
3. Spoj za upotrebu prema zahtjevu 1 ili 2, gdje:
a) R4 je halo, CN, ili C1-3 alkil; ili
b) R4 je F, Cl, CN, ili metil; ili
c) R4 je F; ili
d) R4 je Cl; ili
e) R4 je CN; ili
f) R4 je metil.
4. Spoj za upotrebu prema bilo kojem od zahtjeva 1 do 3, gdje:
a) R5 je halo, CN, ili C1-3 alkil; ili
b) R5 je Cl, CN, ili metil; ili
c) R5 je Cl; ili
d) R5 je CN; ili
e) R5 je metil.
5. Spoj za upotrebu prema zahtjevu 1, gdje:
R2 je C1-3 alkil ili C1-3 fluoroalkil;
R4 je halo, CN, ili C1-3 alkil; i
R5 je halo, CN, ili C1-3 alkil.
6. Spoj za upotrebu prema zahtjevu 1, gdje:
R2 je metil, etil, ili 2,2-difluorometil;
R4 je F, Cl, CN, ili metil; i
R5 je Cl, CN, ili metil;
7. Spoj za upotrebu prema bilo kojem od zahtjeva 1 do 6, gdje:
a) Spoj je Spoj Formule IVa:
[image]
ili njegova farmaceutski prihvatljiva sol; ili
b) Spoj je Spoj Formule IVb:
[image]
ili njegova farmaceutski prihvatljiva sol; ili
c) Spoj je Spoj Formule IVc:
[image]
ili njegova farmaceutski prihvatljiva sol.
8. Spoj za upotrebu prema zahtjevu 1, gdje je Spoj izabran od:
4-{3-[1-(4-amino-3-metil-1H-pirazolo[3,4-d]pirimidin-1-il)etil]-5-kloro-2-etoksi-6-fluorofenil} pirolidin-2-ona;
4-[1-(4-amino-3-metil-1H-pirazolo[3,4-d]pirimidin-1-il)etil]-6-kloro-3-etoksi-2-(5-oksopirolidin-3-il)benzonitrila; i
4-{3-[1-(4-amino-3-metil-1H-pirazolo[3,4-d]pirimidin-1-il)etil]-5-kloro-2-etoksi-6-fluorofenil}-1,3-oksazolidin-2-ona;
ili farmaceutski prihvatljive soli bilo kojeg od gore spomenutog.
9. Spoj za upotrebu prema zahtjevu 1, gdje je postupak postupak za liječenje idiopatske trombocitopenične purpure (ITP) izabrane od relapsirane ITP i refraktorne ITP.
10. Spoj za upotrebu prema zahtjevu 1, gdje je postupak postupak za liječenje pemfigusa.
11. Spoj za upotrebu prema zahtjevu 1, gdje je postupak postupak za liječenje autoimune hemolitičke anemije.
12. Spoj za upotrebu prema zahtjevu 1, gdje je postupak postupak za liječenje limfoma stanica plašta.
13. Spoj za upotrebu prema zahtjevu 1, gdje je postupak postupak za liječenje folikularnog limfoma.
14. Spoj za upotrebu prema zahtjevu 1, gdje je postupak postupak za liječenje ekstranodalnog limfoma marginalne zone.
15. Spoj za upotrebu prema bilo kojem od zahtjeva 1 do 14, gdje je Spoj 4-{3-[1-(4-amino-3-metil-1H-pirazolo[3,4-d]pirimidin-1-il)etil]-5-kloro-2-etoksi-6-fluorofenil}pirolidin-2-on, ili njegova farmaceutski prihvatljiva sol.
16. Spoj za upotrebu prema zahtjevu 15, gdje je Spoj (R)-4-{3-[(R)-1-(4-amino-3-metil-1H-pirazolo[3,4-d]pirimidin-1-il)etil]-5-kloro-2-etoksi-6-fluorofenil}pirolidin-2-on, ili njegova farmaceutski prihvatljiva sol.
17. Spoj za upotrebu prema zahtjevu 15, gdje je Spoj (R)-4-{3-[(S)-1-(4-amino-3-metil-1H-pirazolo[3,4-d]pirimidin-1-il)etil]-5-kloro-2-etoksi-6-fluorofenil}pirolidin-2-on, ili njegova farmaceutski prihvatljiva sol.
18. Spoj za upotrebu prema zahtjevu 15, gdje je Spoj (S)-4-{3-[(R)-1-(4-amino-3-metil-1H-pirazolo[3,4-d]pirimidin-1-il)etil]-5-kloro-2-etoksi-6-fluorofenil}pirolidin-2-on, ili njegova farmaceutski prihvatljiva sol.
19. Spoj za upotrebu prema zahtjevu 15, gdje je Spoj (S)-4-{3-[(S)-1-(4-amino-3-metil-1H-pirazolo[3,4-d]pirimidin-1-il)etil]-5-kloro-2-etoksi-6-fluorofenil}pirolidin-2-on, ili njegova farmaceutski prihvatljiva sol.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361771480P | 2013-03-01 | 2013-03-01 | |
| EP14710739.5A EP2961410B1 (en) | 2013-03-01 | 2014-02-28 | Use of pyrazolopyrimidine derivatives for the treatment of pi3k related disorders |
| PCT/US2014/019372 WO2014134426A1 (en) | 2013-03-01 | 2014-02-28 | USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3Kδ RELATED DISORDERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200263T1 true HRP20200263T1 (hr) | 2020-05-29 |
Family
ID=50288319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200263TT HRP20200263T1 (hr) | 2013-03-01 | 2020-02-17 | Upotreba derivata pirazolopirimidina za liječenje poremećaja povezanih sa pi3k |
Country Status (32)
| Country | Link |
|---|---|
| US (5) | US9932341B2 (hr) |
| EP (3) | EP4233869A3 (hr) |
| JP (4) | JP6545106B2 (hr) |
| KR (4) | KR20230145517A (hr) |
| CN (2) | CN105120871B (hr) |
| AR (1) | AR094964A1 (hr) |
| AU (4) | AU2014223257B2 (hr) |
| BR (1) | BR112015020941A2 (hr) |
| CA (1) | CA2901993C (hr) |
| CL (1) | CL2015002442A1 (hr) |
| CR (1) | CR20150472A (hr) |
| CY (1) | CY1122712T1 (hr) |
| DK (1) | DK2961410T3 (hr) |
| EA (2) | EA202192151A1 (hr) |
| ES (2) | ES2774436T3 (hr) |
| HK (1) | HK1221398A1 (hr) |
| HR (1) | HRP20200263T1 (hr) |
| HU (1) | HUE047719T2 (hr) |
| IL (5) | IL301180A (hr) |
| LT (1) | LT2961410T (hr) |
| MX (2) | MX367713B (hr) |
| MY (1) | MY177875A (hr) |
| PE (1) | PE20151996A1 (hr) |
| PH (2) | PH12015501920A1 (hr) |
| PL (1) | PL2961410T3 (hr) |
| PT (1) | PT2961410T (hr) |
| RS (1) | RS59958B1 (hr) |
| SG (3) | SG10201912275YA (hr) |
| SI (1) | SI2961410T1 (hr) |
| TW (4) | TWI657090B (hr) |
| UA (1) | UA119641C2 (hr) |
| WO (1) | WO2014134426A1 (hr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077280A1 (es) | 2009-06-29 | 2011-08-17 | Incyte Corp | Pirimidinonas como inhibidores de pi3k, y composiciones farmaceuticas que los comprenden |
| SI2751109T1 (sl) | 2011-09-02 | 2017-03-31 | Incyte Holdings Corporation | Heterociklilamini kot inhibitorji pi3k |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
| ME03780B (me) | 2013-01-15 | 2021-04-20 | Incyte Holdings Corp | Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze |
| TWI657090B (zh) * | 2013-03-01 | 2019-04-21 | 英塞特控股公司 | 吡唑并嘧啶衍生物治療PI3Kδ 相關病症之用途 |
| WO2015027124A1 (en) | 2013-08-23 | 2015-02-26 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
| KR20220066179A (ko) | 2014-04-08 | 2022-05-23 | 인사이트 코포레이션 | Ｊａｋ 및 ｐｉ3ｋ 억제제 조합에 의한 ｂ-세포 악성종양의 치료 |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016130501A1 (en) | 2015-02-09 | 2016-08-18 | Incyte Corporation | Aza-heteroaryl compounds as pi3k-gamma inhibitors |
| CN117800973A (zh) | 2015-02-27 | 2024-04-02 | 因赛特控股公司 | Pi3k抑制剂的盐及其制备方法 |
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