JP2013527162A5 - - Google Patents
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- JP2013527162A5 JP2013527162A5 JP2013506723A JP2013506723A JP2013527162A5 JP 2013527162 A5 JP2013527162 A5 JP 2013527162A5 JP 2013506723 A JP2013506723 A JP 2013506723A JP 2013506723 A JP2013506723 A JP 2013506723A JP 2013527162 A5 JP2013527162 A5 JP 2013527162A5
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- 150000001875 compounds Chemical class 0.000 claims 31
- 125000001931 aliphatic group Chemical group 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 12
- 208000035475 disorder Diseases 0.000 claims 10
- 206010012289 Dementia Diseases 0.000 claims 8
- 208000002705 Glucose Intolerance Diseases 0.000 claims 8
- 208000010877 cognitive disease Diseases 0.000 claims 8
- 208000010125 myocardial infarction Diseases 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 208000027534 Emotional disease Diseases 0.000 claims 6
- 206010022489 Insulin Resistance Diseases 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 208000019901 Anxiety disease Diseases 0.000 claims 4
- 208000028698 Cognitive impairment Diseases 0.000 claims 4
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 4
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 4
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 4
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 4
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 4
- 206010020772 Hypertension Diseases 0.000 claims 4
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 4
- 208000008589 Obesity Diseases 0.000 claims 4
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 4
- 230000036506 anxiety Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 230000000302 ischemic effect Effects 0.000 claims 4
- 150000002632 lipids Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 208000027061 mild cognitive impairment Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 235000020824 obesity Nutrition 0.000 claims 4
- 201000009104 prediabetes syndrome Diseases 0.000 claims 4
- 102000008645 11-beta-Hydroxysteroid Dehydrogenase Type 1 Human genes 0.000 claims 3
- 108010088011 11-beta-Hydroxysteroid Dehydrogenase Type 1 Proteins 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 150000004677 hydrates Chemical class 0.000 claims 3
- -1 pyrrolidino, piperidino, piperazino, morpholino Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 206010065040 AIDS dementia complex Diseases 0.000 claims 2
- 208000004611 Abdominal Obesity Diseases 0.000 claims 2
- 208000036487 Arthropathies Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 206010065941 Central obesity Diseases 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 208000014311 Cushing syndrome Diseases 0.000 claims 2
- 206010012218 Delirium Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 208000004930 Fatty Liver Diseases 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000031773 Insulin resistance syndrome Diseases 0.000 claims 2
- 208000012659 Joint disease Diseases 0.000 claims 2
- 208000006264 Korsakoff syndrome Diseases 0.000 claims 2
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims 2
- 208000009829 Lewy Body Disease Diseases 0.000 claims 2
- 201000002832 Lewy body dementia Diseases 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 2
- 208000026072 Motor neurone disease Diseases 0.000 claims 2
- 206010068871 Myotonic dystrophy Diseases 0.000 claims 2
- 208000010577 Niemann-Pick disease type C Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 206010033307 Overweight Diseases 0.000 claims 2
- 208000016222 Pancreatic disease Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 2
- 206010034912 Phobia Diseases 0.000 claims 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 2
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 2
- 201000009916 Postpartum depression Diseases 0.000 claims 2
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 206010038923 Retinopathy Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 206010044688 Trisomy 21 Diseases 0.000 claims 2
- 208000007930 Type C Niemann-Pick Disease Diseases 0.000 claims 2
- 201000004810 Vascular dementia Diseases 0.000 claims 2
- 206010063661 Vascular encephalopathy Diseases 0.000 claims 2
- 201000008485 Wernicke-Korsakoff syndrome Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- 206010003246 arthritis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 208000025748 atypical depressive disease Diseases 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 206010008118 cerebral infarction Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000024732 dysthymic disease Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000010706 fatty liver disease Diseases 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 239000003862 glucocorticoid Substances 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 201000001421 hyperglycemia Diseases 0.000 claims 2
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 208000006132 lipodystrophy Diseases 0.000 claims 2
- 208000005264 motor neuron disease Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 2
- 201000003077 normal pressure hydrocephalus Diseases 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 208000019899 phobic disease Diseases 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 2
- 201000009395 primary hyperaldosteronism Diseases 0.000 claims 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 2
- 208000020016 psychiatric disease Diseases 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 2
- 230000035882 stress Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 230000003820 β-cell dysfunction Effects 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32945310P | 2010-04-29 | 2010-04-29 | |
| US61/329,453 | 2010-04-29 | ||
| PCT/GB2011/000345 WO2011135276A1 (en) | 2010-04-29 | 2011-03-10 | 3, 3 -disubstituted- ( 8 - aza - bicyclo [3.2.1] oct- 8 - yl) -[5- (1h - pyrazol - 4 -yl) -thiophen-3 -yl] methanones as inhibitors of 11 (beta) -hsd1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013527162A JP2013527162A (ja) | 2013-06-27 |
| JP2013527162A5 true JP2013527162A5 (enExample) | 2014-03-27 |
| JP5899202B2 JP5899202B2 (ja) | 2016-04-06 |
Family
ID=43880967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013506723A Active JP5899202B2 (ja) | 2010-04-29 | 2011-03-10 | １１β−ＨＳＤ１の阻害剤としての３，３−二置換−（８−アザ−ビシクロ［３．２．１］オクタ−８−イル）−［５−（１Ｈ−ピラゾール−４−イル）−チオフェン−３−イル］−メタノン類 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9365564B2 (enExample) |
| EP (1) | EP2563780B1 (enExample) |
| JP (1) | JP5899202B2 (enExample) |
| KR (1) | KR101714820B1 (enExample) |
| CN (1) | CN102947295B (enExample) |
| AU (1) | AU2011247116B2 (enExample) |
| BR (1) | BR112012027640B1 (enExample) |
| CA (1) | CA2796297C (enExample) |
| DK (1) | DK2563780T3 (enExample) |
| ES (1) | ES2543692T3 (enExample) |
| IL (1) | IL222417A (enExample) |
| MX (1) | MX344142B (enExample) |
| RU (1) | RU2593753C2 (enExample) |
| WO (1) | WO2011135276A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0724251D0 (en) | 2007-12-12 | 2008-02-06 | Univ Edinburgh | Therapeutic compounds and their use |
| GB0804685D0 (en) | 2008-03-13 | 2008-04-16 | Univ Edinburgh | Therapeutic compounds and their use |
| US8642621B2 (en) | 2009-09-16 | 2014-02-04 | The University Of Edinburgh | (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use |
| CN102947295B (zh) | 2010-04-29 | 2016-01-20 | 爱丁堡大学 | 作为11β-HSD1抑制剂的3,3-二取代的-(8-氮杂双环[3.2.1]辛烷-8-基)-[5-(1H-吡唑-4基)-噻吩-3-基]-甲酮 |
| FR2993563B1 (fr) * | 2012-07-20 | 2015-12-18 | Metabrain Res | Derives de thiophenes utiles dans le traitement du diabete |
| US10100047B2 (en) * | 2014-03-06 | 2018-10-16 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Piperidine derivatives as orexin receptor antagonist |
| FR3035326B1 (fr) * | 2015-04-21 | 2017-05-12 | Pf Medicament | Utilisation de la (4-hydroxy-2-methyl-1,1-dioxido-2h-benzo[e][1,2]thiazin-3-yl)(naphtalen-2-yl)methanone dans la prevention et/ou le traitement de la steatohepatite non-alcoolique |
| CN104961698A (zh) * | 2015-07-13 | 2015-10-07 | 佛山市赛维斯医药科技有限公司 | 末端硝基取代的三氮唑亚砜类化合物、其制备方法及其用途 |
| CN104961677A (zh) * | 2015-07-19 | 2015-10-07 | 佛山市赛维斯医药科技有限公司 | 一类腈基二吡啶叔醇结构的11β-HSD1抑制剂及其用途 |
| CN104945315A (zh) * | 2015-07-19 | 2015-09-30 | 佛山市赛维斯医药科技有限公司 | 一类硝基二吡啶叔醇结构的11β-HSD1抑制剂及其用途 |
| CN104974080A (zh) * | 2015-07-19 | 2015-10-14 | 佛山市赛维斯医药科技有限公司 | 二吡啶叔醇结构的11β-HSD1抑制剂、制备方法及其用途 |
| WO2017083795A1 (en) | 2015-11-13 | 2017-05-18 | Pietro Paolo Sanna | Methods and compositions for treating alcohol use disorders |
| EA202092442A3 (ru) | 2016-06-07 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| KR102317480B1 (ko) | 2017-03-23 | 2021-10-25 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| WO2020063760A1 (en) | 2018-09-26 | 2020-04-02 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
| TW202523658A (zh) * | 2019-05-24 | 2025-06-16 | 美商賽吉醫療公司 | 化合物、組合物及使用方法 |
| WO2021062472A1 (en) * | 2019-09-30 | 2021-04-08 | Actinogen Medical Limited | Medicinal cognitive treatments |
| WO2022051565A1 (en) * | 2020-09-04 | 2022-03-10 | Ikena Oncology, Inc. | Substituted 4-piperidinyl-quinazolines, 4-piperidinyl-pyrimidine-2-amines, and related compounds and their use in treating medical conditions |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| KR20230154789A (ko) * | 2020-11-06 | 2023-11-09 | 액티노젠 메디컬 리미티드 | 헤테로고리 메탄온 화합물 및 그의 아자-비시클로 중간체의 제조 공정 |
| EP4251618A1 (en) * | 2020-11-25 | 2023-10-04 | Sage Therapeutics, Inc. | 4-fluoro-(4-(4-benzyl)piperidin-1-yl)(2-(pyrimidin-4-yl)pyridin-3-yl)methanone derivatives and similar compounds as cyp46a1 inhibitors for the treatment of neurodegenerative disorders |
| KR20250025629A (ko) * | 2022-06-10 | 2025-02-24 | 액티노젠 메디컬 리미티드 | 항우울제 저항성 대상체의 치료 |
| CN115073422A (zh) * | 2022-07-28 | 2022-09-20 | 成都普瑞熙药业有限公司 | 一种制备4-(1-甲基-1h-吡唑-5-基)哌啶及其盐的方法 |
| AU2023357033A1 (en) * | 2022-10-07 | 2025-05-01 | Actinogen Medical Limited | SUBJECT SELECTION FOR 11β-HSD1 INHIBITOR TREATMENT |
| CN120957989A (zh) * | 2023-03-02 | 2025-11-14 | 射线质医疗有限公司 | 用于制备氮杂双环杂芳基化合物的流动化学工艺 |
| WO2025073002A1 (en) * | 2023-10-03 | 2025-04-10 | Actinogen Medical Limited | Tablet formulation |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5087631A (en) | 1990-12-18 | 1992-02-11 | Glaxo Inc. | Oxathi(SIV)azol-5-one compounds |
| AR011913A1 (es) | 1997-03-06 | 2000-09-13 | Yamano Masaki | Derivados de 4,4-difluoro-2,3,4,5-tetrahidro-1h-1-benzoazepina y composiciones farmaceuticas de los mismos. |
| WO2000051608A1 (en) | 1999-03-02 | 2000-09-08 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
| MXPA04004837A (es) | 2001-11-22 | 2004-08-02 | Biovitrum Ab | Inhibidores de 11-??-hidroxiesteroide deshidrogenasa de tipo 1. |
| SE0202430D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | New Compounds |
| US7700583B2 (en) | 2003-04-11 | 2010-04-20 | High Point Pharmaceuticals, Llc | 11β-hydroxysteroid dehydrogenase type 1 active compounds |
| GB0325745D0 (en) | 2003-11-05 | 2003-12-10 | Astrazeneca Ab | Chemical compounds |
| GB0326029D0 (en) | 2003-11-07 | 2003-12-10 | Astrazeneca Ab | Chemical compounds |
| ES2297727T3 (es) | 2004-06-09 | 2008-05-01 | F. Hoffmann-La Roche Ag | Derivados de octahidropirrolo(3,4-c)pirrol y su empleo como agentes antiviricos. |
| WO2006132197A1 (ja) | 2005-06-07 | 2006-12-14 | Shionogi & Co., Ltd. | I型11βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物 |
| ZA200800142B (en) * | 2005-06-08 | 2009-05-27 | Japan Tobacco Inc | Heterocyclic compound |
| KR100970294B1 (ko) | 2005-06-08 | 2010-07-15 | 니뽄 다바코 산교 가부시키가이샤 | 복소환 화합물 |
| US7803806B2 (en) | 2005-11-03 | 2010-09-28 | Sgx Pharmaceuticals, Inc. | Pyrimidinyl-thiophene kinase modulators |
| CA2636826C (en) | 2006-01-18 | 2011-11-29 | F.Hoffmann-La Roche Ag | Thiazoles as 11 beta-hsd1 inhibitors |
| WO2007100851A1 (en) | 2006-02-28 | 2007-09-07 | Helicon Therapeutics, Inc. | Therapeutic compounds |
| CN101466691B (zh) | 2006-06-08 | 2011-07-27 | 伊莱利利公司 | 作为组ⅰ代谢型受体拮抗剂的取代的甲酰胺类化合物 |
| TW200811170A (en) * | 2006-06-27 | 2008-03-01 | Sanofi Aventis | Urea derivatives of tropane, their preparation and their therapeutic application |
| EP2051977A2 (en) | 2006-07-20 | 2009-04-29 | Amgen Inc. | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1 |
| CN101848910B (zh) | 2007-11-05 | 2013-12-04 | 默克专利股份公司 | 作为选择性11-β-羟基类固醇脱氢酶1型抑制剂的7-氮杂吲哚衍生物 |
| GB0724251D0 (en) | 2007-12-12 | 2008-02-06 | Univ Edinburgh | Therapeutic compounds and their use |
| US20100022590A1 (en) | 2008-01-17 | 2010-01-28 | Biovitrum Ab (Publ.) | Novel compounds |
| GB0804685D0 (en) * | 2008-03-13 | 2008-04-16 | Univ Edinburgh | Therapeutic compounds and their use |
| JP5586605B2 (ja) * | 2008-08-25 | 2014-09-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 置換ノルトロパンのアリール及びヘテロアリールカルボニル誘導体、該化合物を含有する医薬及びその使用 |
| EP2443113A1 (en) | 2009-06-15 | 2012-04-25 | The University Of Edinburgh | Amido-isothiazole compounds and their use as inhibitors of 11beta-hsd1 for the treatment of metabolic syndrome and related disorders |
| US8642621B2 (en) * | 2009-09-16 | 2014-02-04 | The University Of Edinburgh | (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use |
| CN102947295B (zh) | 2010-04-29 | 2016-01-20 | 爱丁堡大学 | 作为11β-HSD1抑制剂的3,3-二取代的-(8-氮杂双环[3.2.1]辛烷-8-基)-[5-(1H-吡唑-4基)-噻吩-3-基]-甲酮 |
-
2011
- 2011-03-10 CN CN201180031564.6A patent/CN102947295B/zh active Active
- 2011-03-10 RU RU2012143502/04A patent/RU2593753C2/ru active
- 2011-03-10 ES ES11709770.9T patent/ES2543692T3/es active Active
- 2011-03-10 AU AU2011247116A patent/AU2011247116B2/en active Active
- 2011-03-10 BR BR112012027640-9A patent/BR112012027640B1/pt active IP Right Grant
- 2011-03-10 KR KR1020127028597A patent/KR101714820B1/ko active Active
- 2011-03-10 JP JP2013506723A patent/JP5899202B2/ja active Active
- 2011-03-10 MX MX2012012413A patent/MX344142B/es active IP Right Grant
- 2011-03-10 WO PCT/GB2011/000345 patent/WO2011135276A1/en not_active Ceased
- 2011-03-10 US US13/642,963 patent/US9365564B2/en active Active
- 2011-03-10 DK DK11709770.9T patent/DK2563780T3/en active
- 2011-03-10 EP EP11709770.9A patent/EP2563780B1/en active Active
- 2011-03-10 CA CA2796297A patent/CA2796297C/en active Active
-
2012
- 2012-10-14 IL IL222417A patent/IL222417A/en active IP Right Grant
-
2016
- 2016-05-13 US US15/154,254 patent/US9834549B2/en active Active
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