RU2593753C2 - 3,3-дизамещенный-(8-азабицикло[3.2.1]окт-8-ил)-[5-(1н-пиразол-4-ил)-тиофен-3-ил]-метанон и родственные соединения и их применение - Google Patents

3,3-дизамещенный-(8-азабицикло[3.2.1]окт-8-ил)-[5-(1н-пиразол-4-ил)-тиофен-3-ил]-метанон и родственные соединения и их применение Download PDF

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RU2593753C2
RU2593753C2 RU2012143502/04A RU2012143502A RU2593753C2 RU 2593753 C2 RU2593753 C2 RU 2593753C2 RU 2012143502/04 A RU2012143502/04 A RU 2012143502/04A RU 2012143502 A RU2012143502 A RU 2012143502A RU 2593753 C2 RU2593753 C2 RU 2593753C2
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Скотт Питер ВЕБСТЕР
Джонатан Роберт СЕКЛ
Брайан Роберт ВОЛКЕР
Питер ВОРД
Томас Дэвид ПОЛЛИН
Хэйзел Джоан ДАЙК
Тревор Роберт ПЕРРИОР
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Зэ Юниверсити Оф Эдинбург
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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RU2012143502/04A 2010-04-29 2011-03-10 3,3-дизамещенный-(8-азабицикло[3.2.1]окт-8-ил)-[5-(1н-пиразол-4-ил)-тиофен-3-ил]-метанон и родственные соединения и их применение RU2593753C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32945310P 2010-04-29 2010-04-29
US61/329,453 2010-04-29
PCT/GB2011/000345 WO2011135276A1 (en) 2010-04-29 2011-03-10 3, 3 -disubstituted- ( 8 - aza - bicyclo [3.2.1] oct- 8 - yl) -[5- (1h - pyrazol - 4 -yl) -thiophen-3 -yl] methanones as inhibitors of 11 (beta) -hsd1

Publications (2)

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RU2012143502A RU2012143502A (ru) 2014-06-10
RU2593753C2 true RU2593753C2 (ru) 2016-08-10

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US (2) US9365564B2 (enExample)
EP (1) EP2563780B1 (enExample)
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KR (1) KR101714820B1 (enExample)
CN (1) CN102947295B (enExample)
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BR (1) BR112012027640B1 (enExample)
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
RU2868197C2 (ru) * 2020-11-06 2026-08-17 Актиноген Медикал Лимитед Способ получения гетероциклических метаноновых соединений и их промежуточных азабициклосоединений

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GB0724251D0 (en) 2007-12-12 2008-02-06 Univ Edinburgh Therapeutic compounds and their use
GB0804685D0 (en) 2008-03-13 2008-04-16 Univ Edinburgh Therapeutic compounds and their use
DK2477983T3 (en) 2009-09-16 2015-06-29 Univ Edinburgh (4-phenyl-piperidin-1-yl) - [5-1H-pyrazol-4-yl) -thiophene-3-yl] -METHANONFORBINDELSER AND THEIR USE
BR112012027640B1 (pt) 2010-04-29 2021-08-03 The University Of Edinburgh Composto, composição farmacêutica, e, métodos de preparar uma composição farmacêutica, de inibir a função da 11beta-hidroxiesteroide desidrogenase do tipo 1
FR2993563B1 (fr) * 2012-07-20 2015-12-18 Metabrain Res Derives de thiophenes utiles dans le traitement du diabete
WO2015131773A1 (zh) * 2014-03-06 2015-09-11 上海海雁医药科技有限公司 作为食欲素受体拮抗剂的哌啶衍生物
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