AR059037A1 - Compuestos para el tratamiento de trastornos inflamatorios - Google Patents
Compuestos para el tratamiento de trastornos inflamatoriosInfo
- Publication number
- AR059037A1 AR059037A1 ARP070100164A ARP070100164A AR059037A1 AR 059037 A1 AR059037 A1 AR 059037A1 AR P070100164 A ARP070100164 A AR P070100164A AR P070100164 A ARP070100164 A AR P070100164A AR 059037 A1 AR059037 A1 AR 059037A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- heteroaryl
- heterocyclyl
- alkyl
- cycloalkyl
- Prior art date
Links
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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Abstract
Estos compuestos pueden ser utiles para el tratamiento de enfermedades o afecciones mediadas por las MMP, ADAM, TACE, agrecanasa, TNF-a o combinaciones de las mismas. Reivindicacion 1: Un compuesto representado por la formula (1), o una de sus sales, solvatos, o ésteres aceptables para uso farmacéutico, donde: el anillo A se selecciona del grupo que consiste en arilo y heteroarilo, estando cada uno ellos substituido con -Y-R1 y -Z-R2 como se muestra; X se selecciona del grupo que consiste en of -S-, -O-, -S(O)2-, S(O)-, -(C(R3)2)m- y -N(R3)-; T está ausente o presente y, si está presente se selecciona del grupo que consiste en alquilo; arilo y heteroarilo, en donde cuando cada uno de dichos T arilo y heteroarilo contiene dos radicales en átomos de carbono adyacentes, dichos radicales pueden opcionalmente tomarse junto con los átomos de carbono a los cuales están unidos para formar un anillo arilo o heteroarilo de cinco a ocho miembros, en donde cada uno de los antes mencionados T arilo y heteroarilo, opcionalmente con dicho arilo o heteroarilo de cinco a ocho miembros está independientemente no substitutido o substituido con uno a cuatro restos R10 que pueden ser iguales o diferentes; U está ausente o presente y, si está presente se selecciona del grupo que consiste en -O-, -O-C(O)NH-, -OC(O)N(alquilo)-, -C(O)-, -C(O)O-, -C(O)NH-, -C(O)N(alquilo)-, -C(=N-OH)-alquilo-, y -C(=N-O-alquil)-alquilo-; V está ausente o presente y, si está presente, V se selecciona del grupo que consiste en alquilo, alquinilo, cicloalquilo, heterociclilo, arilo, heteroarilo y N-oxidos de dicho heterociclilo y heteroarilo, en donde cuando cada uno de dichos V cicloalquilo, heterociclilo, arilo, heteroarilo y N-oxidos de dicho heterociclilo y heteroarilo contiene dos radicales en átomos de carbono adyacentes, dichos radicales pueden estar opcionalmente tomados conjuntamente con los átomos de carbono a los cuales están unidos para formar un anillo cicloalquilo, arilo, heterociclilo o heteroarilo de cinco a ocho miembros, donde cada uno de dichos V alquilo, alquinilo, cicloalquilo, heterociclilo, arilo, heteroarilo y heterociclilo, opcionalmente con dichos cicloalquilo, arilo, heterociclilo, o heteroarilo de cinco a ocho miembros independientemente no substitutido o substituido con uno a cuatro restos R10 que pueden ser iguales o diferentes; Y se selecciona del grupo que consiste en una union covalente, -(C(R4)2)n-, -N(R4)-, -C(O)N(R4)-, -N(R4)C(O)-, -N(R4)C(O)N(R4)-, -S(O)2N(R4)-, -N(R4)-S(O)2-, -O-, -S-, -C(O)-, -S(O)-, y -S(O)2-; Z se selecciona del grupo que consiste en una union covalente, -(C(R4)2)n-, -N(R4)-, -C(O)N(R4)-, -N(R4)C(O)-, -N(R4)C(O)N(R4)-, -S(O)2N(R4)-, -N(R4)-S(O)2-, -O-, -S- , -C(O)-, -S(O)-, y -S(O)2-; m es 1 a 3: n es 1 a 3; R1 está seleccionado del grupo que consiste en H, ciano, -C(O)OH, -C(O)O-alquilo, -C(O)NH2, -C(O)NH(alquilo), -C(O)N(alquilo)2, -alquinilo, halogeno, alquilo, cicloalquilo, haloalquilo, arilo, heteroarilo, y heterociclilo, en donde cuando cada uno de dichos cicloalquilo, heterociclilo, arilo y heteroarilo contienen dos radicales en átomos de carbono adyacentes, dichos radicales pueden estar opcionalmente tomados conjuntamente con los átomos de carbono a los cuales están unidos para formar un anillo cicloalquilo, arilo, heterociclilo o heteroarilo de cinco a ocho miembros; donde cada uno de los R1 alquilo, alquinilo, arilo, heteroarilo, y heterociclilo, opcionalmente con el anillo cicloalquilo, arilo, heterociclilo o heteroarilo de cinco o seis miembros no substitutido o en forma opcional está substituido independientemente con uno a cuatro restos R20 los cuales pueden ser iguales o diferentes; con la salvedad de que cuando Y es -N(R4)-, -S- o -O-, entonces R1 no es halogeno o ciano; R2 se selecciona del grupo que consiste en H, ciano, -C(O)OH, -C(O)O-alquilo, -C(O)NH2, -C(O)NH(alquilo), -C(O)N(alquilo)2, alquinilo, halogeno, alquilo, cicloalquilo, haloalquilo, arilo, heteroarilo, y heterociclilo, donde cuando cada uno de dichos cicloalquilo, heterociclilo, arilo y heteroarilo contiene dos radicales en átomos de carbono adyacentes, dichos radicales pueden opcionalmente tomarse junto con los átomos de carbono a los cuales están unidos para formar un anillo cicloalquilo, arilo, heterociclilo o heteroarilo de cinco a ocho miembros; en donde cada uno de los R2 alquilo, cicloalquilo, arilo, heteroarilo, y heterociclilo, en forma opcional con el anillo cicloalquilo, arilo, heterociclilo o heteroarilo de cinco a seis miembros no substitutido o en forma opcional está substituido independientemente con uno a cuatro restos R20 que pueden ser iguales o diferentes; con la salvedad de que cuando Y es -N(R4)-, -S- o -O-, entonces R2 no es halogeno o ciano; cada R3 es igual o diferente y seleccionado en forma independiente del grupo que consiste en H, alquilo, y arilo; cada R4 es igual o diferente y seleccionado en forma independiente del grupo que consiste en H, alquilo, cicloalquilo, haloalquilo, hidroxi, -alquilcicloalquilo, -alquil-N(alquil)2, heterociclilo, arilo, y heteroarilo en donde cuando cada uno de dichos cicloalquilo, heterociclilo, arilo, y heteroarilo contiene dos radicales en átomos de carbono adyacentes, dichos radicales pueden opcionalmente tomarse junto con los átomos de carbono a los cuales están unidos para formar un anillo cicloalquilo, arilo, heterociclilo o heteroarilo de cinco a ocho miembros; R10 se selecciona del grupo que consiste en hidrogeno, ciano, nitro, -C(R4)=N-OR4, -OR4, -SR4, -N(R4)2, -S(O)R4, -S(O)2R4, -N(R4)S(O)2R4, -N(R4)-C(O)-R4, -N(R4)-C(O)-N(R4)2, -N(R4)-C(O)-OR4, -OC(O)N(R4)2, -C(O)N(R4)-S(O)2R4, -S(O)2N(R4)-C(O)-R4, - C(O)N(R4)C(O)R4, -C(O)N(R4)C(O)NR4, -S(O)2N(R4)2, -N(R4)-C(=NR4)-N(R4)2, -N(R4)-C(=N-CN)-N(R4)2, -haloalcoxi, -C(O)OR4, -C(O)R4, -C(O)N(R4)2, halogeno, alquilo, haloalquilo, arilo, heteroarilo, heterociclilo, y cicloalquilo, donde cada uno alquilo, arilo, heteroarilo, heterociclilo, y cicloalquilo, en donde cada uno de los R10 alquilo, arilo, heteroarilo, heterociclilo, y cicloalquilo no está substitutido o en forma opcional está substituido independientemente con uno a cuatro restos R30 que pueden ser iguales o diferentes; o donde dos restos R10, cuando están unidos al mismo átomo de carbono o átomos de carbono adyacentes pueden en forma opcional tomarse junto con el/los átomo(s) de carbono a los cuales están unidos para formar un anillo cicloalquilo, cicloalquenilo, heterociclilo, arilo, o heteroarilo; R20 se selecciona del grupo que consiste en of ciano, nitro, -C(R4)=N-OR4, -OR4, -SR4, -N(R4)2, -S(O)R4, -S(O)2R4, -N(R4)S(O)2R4, -N(R4)-C(O)-R4, -N(R4)-C(O)-N(R4)2, -N(R4)- C(O)-OR4, -OC(O)N(R4)2, -C(O)N(R4)-S(O)2R4, -S(O)2N(R4)-C(O)-R4, -C(O)N(R4)C(O)R4, -C(O)N(R4)C(O)NR4, -S(O)2N(R4)2, -N(R4)-C(=NR4)-N(R4)2, -N(R4)-C(=N-CN)-N(R4)2, -haloalcoxi, -C(O)OR4, -C(O)R4, -C(O)N(R4)2, halogeno, alquilo, haloalquilo, arilo, heteroarilo, heterociclilo, y cicloalquilo; en donde cuando cada uno de dichos R20 arilo, heteroarilo, heterociclilo y cicloalquilo contiene dos radicales en átomos de carbono adyacentes, dichos radicales pueden opcionalmente tomarse junto con los átomos de carbono a los cuales están unidos para formar un anillo cicloalquilo, arilo, heterociclilo o heteroarilo de cinco a ocho miembros; en donde cada uno dichos R20 alquilo, arilo, heteroarilo, heterociclilo, y cicloalquilo, en forma opcional con dicho anillo cicloalquilo, arilo, heterociclilo o heteroarilo de cinco a ocho miembros no substitutido o está substituido con uno a cuatro restos seleccionados independientemente del grupo que consiste en alquilo, halo, haloalquilo, hidroxi, alcoxi, haloalcoxi, hidroxialquilo, ciano, nitro, -NH2, -NH(alquil), y -N(alquil)2; o cuando dos restos R20 cuando están unidos al mismo átomo de carbono o átomos de carbono adyacentes pueden tomarse opcionalmente en forma conjunta con los átomos de carbono a los cuales están unidos para formar un anillo cicloalquilo, cicloalquenilo, heterociclilo, arilo, o heteroarilo; R30 se selecciona del grupo que consiste en of ciano, nitro, -C(R4)=N-OR4, -OR4, -SR4, -N(R4)2, -S(O)R4, -S(O)2R4, - N(R4)S(O)2R4, -N(R4)-C(O)-R4, -N(R4)-C(O)-N(R4)2, -N(R4)-C(O)-OR4, -OC(O)N(R4)2, -C(O)N(R4)-S(O)2R4, -S(O)2N(R4)-C(O)-R4, -C(O)N(R4)C(O)R4, -C(O)N(R4)C(O)NR4, -S(O)2N(R4)2, -N(R4)-C(=NR4)-N(R4)2, -N(R4)-C(=N-CN)-N(R4)2, -haloalcoxi, -C(O)OR4, - C(O)R4, -C(O)N(R4)2, halogeno, alquilo, haloalquilo, arilo, heteroarilo, heterociclilo, y cicloalquilo; en donde cuando cada uno de dichos R30 arilo, heteroarilo, heterociclilo y cicloalquilo contiene dos radicales en átomos de carbono adyacentes, dichos radicales pueden opcionalmente tomarse junto con los átomos de carbono a los cuales están unidos para formar un anillo cicloalquilo, arilo, heterociclilo o heteroarilo de cinco a ocho miembros; en donde cada uno dichos R30 alquilo, arilo, heteroarilo, heterociclilo, y cicloalquilo, en forma opcional con dicho anillo cicloalquilo, arilo, heterociclilo o heteroarilo de cinco a ocho miembros no está substitutido o está substituido con uno a cuatro restos seleccionados independientemente del grupo que consiste en alquilo, halo, haloalquilo, hidroxi, alcoxi, haloalcoxi, ciano, nitro, -NH2, -NH(alquilo), y -N(alquilo)2; o cuando dos restos R30 cuando están unidos al mismo átomo de carbono o átomos de carbono adyacentes pueden en forma opcional tomarse junto con el/los átomo(s) de carbono a los cuales están unidos para formar un anillo cicloalquilo, cicloalquenilo, heterociclilo, arilo, o heteroarilo; con la salvedad de que al menos uno de T, U, y V debe estar presente; y además que se hayan cumplido al menos una de las condiciones (a) - (e): (a) al menos uno de T y V está presente, y V es diferente de alquinilo; en donde dicho T o V está substituido con al menos un resto R10 seleccionado del grupo que consiste en ciano, - C(O)OR4, -C(O)R4, -C(O)N(R4)2, -C(O)N(R4)C(O)R4, -C(O)N(R4)C(O)NR4, -SR4, -S(O)2R4, -N(R4)-C(O)OR4, -OC(O)N(R4)2, -N(R4)C(O)N(R
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EP1546109A4 (en) * | 2002-10-04 | 2005-11-09 | Bristol Myers Squibb Co | HYDANTOIN DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND / OR TNF-ALPHA CONVERSION ENZYME (TACE) |
DE60329326D1 (de) | 2002-12-19 | 2009-10-29 | Vertex Pharma | Tace inhibitoren |
DE602005023172D1 (de) * | 2004-07-16 | 2010-10-07 | Schering Corp | Hydantoinderivate zur behandlung von entzündlichen erkrankungen |
US7488745B2 (en) * | 2004-07-16 | 2009-02-10 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
US7504424B2 (en) * | 2004-07-16 | 2009-03-17 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
AR059036A1 (es) * | 2006-01-17 | 2008-03-12 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
US7998961B2 (en) * | 2006-08-31 | 2011-08-16 | Schering Corporation | Hydantoin derivatives useful as antibacterial agents |
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2007
- 2007-01-15 AR ARP070100163A patent/AR059036A1/es not_active Application Discontinuation
- 2007-01-15 PE PE2007000036A patent/PE20071240A1/es not_active Application Discontinuation
- 2007-01-15 PE PE2007000041A patent/PE20071241A1/es not_active Application Discontinuation
- 2007-01-15 AR ARP070100164A patent/AR059037A1/es not_active Application Discontinuation
- 2007-01-16 WO PCT/US2007/001025 patent/WO2007084451A1/en active Application Filing
- 2007-01-16 JP JP2008551312A patent/JP2009523797A/ja not_active Withdrawn
- 2007-01-16 KR KR1020087019782A patent/KR20080085221A/ko not_active Application Discontinuation
- 2007-01-16 KR KR1020087019785A patent/KR20080085222A/ko not_active Application Discontinuation
- 2007-01-16 EP EP07716637.9A patent/EP1973900B1/en active Active
- 2007-01-16 RU RU2008133383/04A patent/RU2008133383A/ru not_active Application Discontinuation
- 2007-01-16 TW TW096101542A patent/TW200736247A/zh unknown
- 2007-01-16 RU RU2008133382/04A patent/RU2008133382A/ru not_active Application Discontinuation
- 2007-01-16 AU AU2007207711A patent/AU2007207711A1/en not_active Abandoned
- 2007-01-16 AU AU2007207707A patent/AU2007207707A1/en not_active Abandoned
- 2007-01-16 CA CA002637196A patent/CA2637196A1/en not_active Abandoned
- 2007-01-16 US US11/653,511 patent/US7524842B2/en active Active
- 2007-01-16 CA CA002637198A patent/CA2637198A1/en not_active Abandoned
- 2007-01-16 CN CNA2007800091850A patent/CN101405286A/zh active Pending
- 2007-01-16 BR BRPI0706598-1A patent/BRPI0706598A2/pt not_active IP Right Cessation
- 2007-01-16 CN CNA2007800091278A patent/CN101410390A/zh active Pending
- 2007-01-16 US US11/653,798 patent/US7683088B2/en active Active
- 2007-01-16 JP JP2008551310A patent/JP2009523796A/ja not_active Withdrawn
- 2007-01-16 TW TW096101540A patent/TW200738688A/zh unknown
- 2007-01-16 WO PCT/US2007/001030 patent/WO2007084455A1/en active Application Filing
- 2007-01-16 BR BRPI0706599-0A patent/BRPI0706599A2/pt not_active IP Right Cessation
- 2007-01-16 EP EP07716634.6A patent/EP1973901B1/en active Active
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2008
- 2008-07-08 IL IL192691A patent/IL192691A0/en unknown
- 2008-07-08 IL IL192690A patent/IL192690A0/en unknown
- 2008-07-11 ZA ZA200806072A patent/ZA200806072B/xx unknown
- 2008-07-16 EC EC2008008626A patent/ECSP088626A/es unknown
- 2008-07-16 EC EC2008008625A patent/ECSP088625A/es unknown
- 2008-08-15 NO NO20083567A patent/NO20083567L/no not_active Application Discontinuation
- 2008-08-15 NO NO20083568A patent/NO20083568L/no not_active Application Discontinuation
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2009
- 2009-02-03 US US12/364,845 patent/US7772263B2/en active Active
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2010
- 2010-01-20 US US12/690,633 patent/US8178553B2/en active Active
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