RU2016118528A - Лечение заболеваний, связанных с альфа-субъединицей потенциалзависимого натриевого канала (scna), путем ингибирования природного антисмыслового транскрипта гена scna - Google Patents
Лечение заболеваний, связанных с альфа-субъединицей потенциалзависимого натриевого канала (scna), путем ингибирования природного антисмыслового транскрипта гена scna Download PDFInfo
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- seq
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- sodium channel
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- scna
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 17
- 201000010099 disease Diseases 0.000 title claims 12
- 102000018674 Sodium Channels Human genes 0.000 title claims 9
- 108010052164 Sodium Channels Proteins 0.000 title claims 9
- 230000001419 dependent effect Effects 0.000 title claims 7
- 108090000623 proteins and genes Proteins 0.000 title claims 6
- 230000002401 inhibitory effect Effects 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 51
- 125000003729 nucleotide group Chemical group 0.000 claims 27
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- 102000040430 polynucleotide Human genes 0.000 claims 24
- 239000002157 polynucleotide Substances 0.000 claims 23
- 108010053752 Voltage-Gated Sodium Channels Proteins 0.000 claims 21
- 102000016913 Voltage-Gated Sodium Channels Human genes 0.000 claims 21
- 239000002773 nucleotide Substances 0.000 claims 20
- 238000000034 method Methods 0.000 claims 15
- 238000012986 modification Methods 0.000 claims 15
- 230000004048 modification Effects 0.000 claims 15
- 101000631760 Homo sapiens Sodium channel protein type 1 subunit alpha Proteins 0.000 claims 9
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- CXHHBNMLPJOKQD-UHFFFAOYSA-N methyl hydrogen carbonate Chemical compound COC(O)=O CXHHBNMLPJOKQD-UHFFFAOYSA-N 0.000 claims 3
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
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- YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 claims 1
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