EP1218411A4 - Secreted proteins and uses thereof - Google Patents
Secreted proteins and uses thereofInfo
- Publication number
- EP1218411A4 EP1218411A4 EP00965288A EP00965288A EP1218411A4 EP 1218411 A4 EP1218411 A4 EP 1218411A4 EP 00965288 A EP00965288 A EP 00965288A EP 00965288 A EP00965288 A EP 00965288A EP 1218411 A4 EP1218411 A4 EP 1218411A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- secreted proteins
- secreted
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39972399A | 1999-09-20 | 1999-09-20 | |
US399723 | 1999-09-20 | ||
PCT/US2000/025982 WO2001021631A2 (en) | 1999-09-20 | 2000-09-20 | Secreted proteins and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1218411A2 EP1218411A2 (en) | 2002-07-03 |
EP1218411A4 true EP1218411A4 (en) | 2004-09-01 |
Family
ID=23580710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00965288A Withdrawn EP1218411A4 (en) | 1999-09-20 | 2000-09-20 | Secreted proteins and uses thereof |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1218411A4 (en) |
AU (1) | AU7602400A (en) |
WO (1) | WO2001021631A2 (en) |
Families Citing this family (59)
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---|---|---|---|---|
CA2389722A1 (en) * | 1999-11-09 | 2001-05-17 | Human Genome Sciences, Inc. | 15 human secreted proteins |
EP3225632B1 (en) | 1999-11-30 | 2020-05-06 | Mayo Foundation for Medical Education and Research | Antibodies binding to b7-h1, a novel immunoregulatory molecule |
US6965018B2 (en) | 2000-06-06 | 2005-11-15 | Bristol-Myers Squibb Company | Antibodies directed to B7-related polypeptide, BSL-2 |
US20030031675A1 (en) | 2000-06-06 | 2003-02-13 | Mikesell Glen E. | B7-related nucleic acids and polypeptides useful for immunomodulation |
CA2448123C (en) * | 2001-05-24 | 2012-09-11 | Zymogenetics, Inc. | Taci-immunoglobulin fusion proteins |
LT2397156T (en) | 2005-06-08 | 2017-02-27 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (PD-1)pathway |
JP5713377B2 (en) | 2005-12-28 | 2015-05-07 | ザ スクリプス リサーチ インスティテュート | Natural antisense and non-coding RNA transcripts as drug targets |
CN102282265B (en) | 2008-11-28 | 2020-07-24 | 埃默里大学 | Methods for treating infectious diseases and tumors |
CN102317458B (en) | 2008-12-04 | 2018-01-02 | 库尔纳公司 | Pass through treatment of the suppression of erythropoietin(EPO) (EPO) natural antisense transcript to EPO relevant diseases |
US8927511B2 (en) | 2008-12-04 | 2015-01-06 | Curna, Inc. | Treatment of vascular endothelial growth factor (VEGF) related diseases by inhibition of natural antisense transcript to VEGF |
WO2010065787A2 (en) | 2008-12-04 | 2010-06-10 | Curna, Inc. | Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene |
CN102245640B (en) | 2008-12-09 | 2014-12-31 | 霍夫曼-拉罗奇有限公司 | Anti-PD-L1 antibodies and their use to enhance T-cell function |
CA2752239C (en) * | 2009-02-12 | 2021-03-30 | Opko Curna, Llc | Treatment of glial cell derived neurotrophic factor (gdnf) related diseases by inhibition of natural antisense transcript to gdnf |
JP5766126B2 (en) | 2009-02-12 | 2015-08-19 | クルナ・インコーポレーテッド | Treatment of brain-derived neurotrophic factor (BDNF) -related diseases by suppression of natural antisense transcripts against BDNF |
CN102482677B (en) | 2009-03-16 | 2017-10-17 | 库尔纳公司 | Nuclear factor (red blood cell derives 2) sample 2 (NRF2) relevant disease is treated by suppressing NRF2 natural antisense transcript |
CN102549159B (en) | 2009-03-17 | 2016-08-10 | 库尔纳公司 | By suppressing to treat the disease that DLK1 is correlated with for the natural antisense transcript of δ sample 1 congener (DLK1) |
WO2010129799A2 (en) | 2009-05-06 | 2010-11-11 | Curna, Inc. | Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene |
ES2609655T3 (en) | 2009-05-06 | 2017-04-21 | Curna, Inc. | Treatment of diseases related to tristetraproline (TTP) by inhibition of natural antisense transcript for TTP |
WO2010129861A2 (en) | 2009-05-08 | 2010-11-11 | Curna, Inc. | Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family |
EP2432881B1 (en) | 2009-05-18 | 2017-11-15 | CuRNA, Inc. | Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor |
WO2010135695A2 (en) | 2009-05-22 | 2010-11-25 | Curna, Inc. | TREATMENT OF TRANSCRIPTION FACTOR E3 (TFE3) and INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO TFE3 |
ES2618576T3 (en) | 2009-05-28 | 2017-06-21 | Curna, Inc. | Treatment of diseases related to an antiviral gene by inhibiting a natural antisense transcript to an antiviral gene |
WO2010148050A2 (en) | 2009-06-16 | 2010-12-23 | Curna, Inc. | Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene |
JP6128846B2 (en) | 2009-06-16 | 2017-05-17 | クルナ・インコーポレーテッド | Treatment of PON1 gene-related diseases by suppression of natural antisense transcripts against paraoxonase (PON1) |
WO2010151671A2 (en) | 2009-06-24 | 2010-12-29 | Curna, Inc. | Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2 |
CA2765815A1 (en) | 2009-06-26 | 2010-12-29 | Opko Curna, Llc | Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene |
CA2768947C (en) | 2009-07-24 | 2018-06-19 | Opko Curna, Llc | Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt) |
CA2769665A1 (en) | 2009-08-05 | 2011-02-10 | Opko Curna, Llc | Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins) |
ES2599986T3 (en) | 2009-08-11 | 2017-02-06 | Curna, Inc. | Treatment of adiponectin-related diseases (ADIPOQ) by inhibiting a natural antisense transcript of an adiponectin (ADIPOQ) |
EP2982755B1 (en) | 2009-08-21 | 2020-10-07 | CuRNA, Inc. | Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip |
KR101892760B1 (en) | 2009-08-25 | 2018-08-28 | 큐알엔에이, 인크. | Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap |
CA2775111C (en) | 2009-09-25 | 2019-12-31 | Opko Curna, Llc | Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity |
NO2513310T3 (en) | 2009-12-16 | 2018-03-31 | ||
US9068183B2 (en) | 2009-12-23 | 2015-06-30 | Curna, Inc. | Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2 |
CN102869776B (en) | 2009-12-23 | 2017-06-23 | 库尔纳公司 | HGF relevant diseases are treated by suppressing the natural antisense transcript of HGF (HGF) |
CA2785173A1 (en) | 2009-12-29 | 2011-07-28 | Curna, Inc. | Treatment of nuclear respiratory factor 1 (nrf1) related diseases by inhibition of natural antisense transcript to nrf1 |
KR101853508B1 (en) | 2009-12-29 | 2018-06-20 | 큐알엔에이, 인크. | TREATMENT OF TUMOR PROTEIN 63 (p63) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO p63 |
ES2677044T3 (en) | 2009-12-31 | 2018-07-27 | Curna, Inc. | Treatment of diseases related to insulin receptor substrate 2 (IRS2) by inhibition of natural antisense transcript for IRS2 and transcription factor E3 (TFE3) |
US8946181B2 (en) | 2010-01-04 | 2015-02-03 | Curna, Inc. | Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8 |
RU2612161C2 (en) | 2010-01-06 | 2017-03-02 | Курна, Инк. | Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to pancreatic developmental gene |
WO2011085347A2 (en) | 2010-01-11 | 2011-07-14 | Opko Curna, Llc | Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg |
CN102782135A (en) | 2010-01-25 | 2012-11-14 | 库尔纳公司 | Treatment of RNase H1 related diseases by inhibition of natural antisense transcript to RNase H1 |
CA2790506A1 (en) | 2010-02-22 | 2011-08-25 | Curna, Inc. | Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1 |
CN102869777B (en) | 2010-04-02 | 2018-11-02 | 库尔纳公司 | CSF3 relevant diseases are treated by inhibiting the natural antisense transcript of colony stimulating factor 3 (CSF3) |
TWI644675B (en) | 2010-04-09 | 2018-12-21 | 可娜公司 | Treatment of fibroblast growth factor 21 (fgf21) related diseases by inhibition of natural antisense transcript to fgf21 |
CN107988228B (en) | 2010-05-03 | 2022-01-25 | 库尔纳公司 | Treatment of Sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to Sirtuin (SIRT) |
TWI531370B (en) | 2010-05-14 | 2016-05-01 | 可娜公司 | Treatment of par4 related diseases by inhibition of natural antisense transcript to par4 |
DK2576784T3 (en) | 2010-05-26 | 2018-02-26 | Curna Inc | TREATMENT OF METHIONIN SULPHOXIDE REDUCTASE A (MSRA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTION TO MSRA |
DK2576783T3 (en) | 2010-05-26 | 2018-03-12 | Curna Inc | TREATMENT OF ATONAL HOMOLOGY 1- (ATOH1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTS AT ATOH1 |
CA2803882C (en) | 2010-06-23 | 2022-10-18 | Opko Curna, Llc | Treatment of sodium channel, voltage-gated, alpha subunit (scna) related diseases by inhibition of natural antisense transcript to scna |
NO2593547T3 (en) | 2010-07-14 | 2018-04-14 | ||
RU2624048C2 (en) | 2010-10-06 | 2017-06-30 | Курна, Инк. | Treatment of diseases associated with the sialidase 4 (neu4) gene, by gene neu4 natural antisense transcript inhibition |
JP6049623B2 (en) | 2010-10-22 | 2016-12-21 | カッパーアールエヌエー,インコーポレイテッド | Treatment of IDUA-related diseases by inhibition of natural antisense transcripts to α-L-iduronidase (IDUA) |
US10000752B2 (en) | 2010-11-18 | 2018-06-19 | Curna, Inc. | Antagonat compositions and methods of use |
JP6071893B2 (en) | 2010-11-23 | 2017-02-01 | カッパーアールエヌエー,インコーポレイテッド | Treatment of NANOG-related diseases by inhibition of natural antisense transcripts to NANOG |
CN103620036B (en) | 2011-06-09 | 2016-12-21 | 库尔纳公司 | FXN relevant disease is treated by the natural antisense transcript of suppression Frataxin (FXN) |
KR101991980B1 (en) | 2011-09-06 | 2019-06-21 | 큐알엔에이, 인크. | TREATMENT OF DISEASES RELATED TO ALPHA SUBUNITS OF SODIUM CHANNELS, VOLTAGE-GATED (SCNxA) WITH SMALL MOLECULES |
ES2694592T3 (en) | 2012-03-15 | 2018-12-21 | Curna, Inc. | Treatment of diseases related to brain-derived neurotrophic factor (BDNF) by inhibition of the natural antisense transcript of BDNF |
AU2013263076B2 (en) | 2012-05-15 | 2017-08-31 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999041284A1 (en) * | 1998-02-11 | 1999-08-19 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
WO1999042470A1 (en) * | 1998-02-18 | 1999-08-26 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
EP1130094A2 (en) * | 1999-07-08 | 2001-09-05 | Helix Research Institute | Primers for synthesizing full length cDNA clones and their use |
WO2001075067A2 (en) * | 2000-03-31 | 2001-10-11 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998046643A1 (en) * | 1997-04-16 | 1998-10-22 | Millennium Biotherapeutics, Inc. | TUMOR NECROSIS FACTOR RECEPTOR RELATED PROTEINS TANGO-63d AND TANGO-63e |
-
2000
- 2000-09-20 AU AU76024/00A patent/AU7602400A/en not_active Abandoned
- 2000-09-20 WO PCT/US2000/025982 patent/WO2001021631A2/en not_active Application Discontinuation
- 2000-09-20 EP EP00965288A patent/EP1218411A4/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999041284A1 (en) * | 1998-02-11 | 1999-08-19 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
WO1999042470A1 (en) * | 1998-02-18 | 1999-08-26 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
EP1130094A2 (en) * | 1999-07-08 | 2001-09-05 | Helix Research Institute | Primers for synthesizing full length cDNA clones and their use |
WO2001075067A2 (en) * | 2000-03-31 | 2001-10-11 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
Non-Patent Citations (3)
Title |
---|
CELIS J E ET AL: "SECRETED PROTEINS FROM NORMAL AND SV40 TRANSFORMED HUMAN MRC-5 FIBROBLASTS: TOWARD ESTABLISHING A DATABASE OF HUMAN SECRETED PROTEINS", LEUKEMIA, MACMILLAN PRESS LTD, US, vol. 1, no. 10, October 1987 (1987-10-01), pages 707 - 717, XP001118789, ISSN: 0887-6924 * |
HALVORSEN Y-D C ET AL: "Adipose as an endocrine organ: The characterization of secreted proteins from human cultured adipocytes", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 13, no. 4 part 11, 12 March 1999 (1999-03-12), pages A369, XP002146933, ISSN: 0892-6638 * |
See also references of WO0121631A3 * |
Also Published As
Publication number | Publication date |
---|---|
WO2001021631A2 (en) | 2001-03-29 |
AU7602400A (en) | 2001-04-24 |
WO2001021631A3 (en) | 2001-11-22 |
EP1218411A2 (en) | 2002-07-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20020410 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL;LT;LV;MK;RO;SI |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SHARP, JOHN, D. Inventor name: KIRST, SUSAN, J. Inventor name: FRASER, CHRISTOPHER, C. Inventor name: KINGSBURY, GILLIAN Inventor name: BARNES, THOMAS |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: KINGSBURY, GILLIAN Inventor name: KIRST, SUSAN, J. Inventor name: SHARP, JOHN, D. Inventor name: BARNES, THOMAS Inventor name: FRASER, CHRISTOPHER, C. |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7C 12N 15/63 B Ipc: 7C 12P 21/02 B Ipc: 7C 12N 1/21 B Ipc: 7C 07K 14/705 A Ipc: 7C 07K 14/47 B Ipc: 7C 07H 21/04 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040719 |
|
17Q | First examination report despatched |
Effective date: 20070326 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20070807 |