RU2010114056A - Терапевтическое применение пептидов интермедина 47 и 53 - Google Patents

Терапевтическое применение пептидов интермедина 47 и 53 Download PDF

Info

Publication number
RU2010114056A
RU2010114056A RU2010114056/15A RU2010114056A RU2010114056A RU 2010114056 A RU2010114056 A RU 2010114056A RU 2010114056/15 A RU2010114056/15 A RU 2010114056/15A RU 2010114056 A RU2010114056 A RU 2010114056A RU 2010114056 A RU2010114056 A RU 2010114056A
Authority
RU
Russia
Prior art keywords
gln
leu
ser
gly
pro
Prior art date
Application number
RU2010114056/15A
Other languages
English (en)
Inventor
Дориан БЕВЕК (DE)
Дориан БЕВЕК
Фабио КАВАЛЛИ (CH)
Фабио КАВАЛЛИ
Вера КАВАЛЛИ (CH)
Вера КАВАЛЛИ
Геральд БАХЕР (DE)
Геральд БАХЕР
Original Assignee
Мондобайотек Лабораториз Аг (Li)
Мондобайотек Лабораториз Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мондобайотек Лабораториз Аг (Li), Мондобайотек Лабораториз Аг filed Critical Мондобайотек Лабораториз Аг (Li)
Publication of RU2010114056A publication Critical patent/RU2010114056A/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)

Abstract

1. Комбинация пептидов His-Ser-Gly-Pro-Arg-Arg-Thr-Gln-Ala-Gln-Leu-Leu-Arg-Val-Gly-Cys-Val-Leu-Gly-Thr-Cys-Gln-Val-Gln-Asn-Leu-Ser-His-Arg-Leu-Trp-Gln-Leu-Met-Gly-Pro-Ala-Gly-Arg-Gln-Asp-Ser-Ala-Pro-Val-Asp-Pro-Ser-Ser-Pro-His-Ser-Tyr-NH2 и Thr-Gln-Ala-Gln-Leu-Leu-Arg-Val-Gly-Cys-Val-Leu-Gly-Thr-Cys-Gln-Val-Gln-Asn-Leu-Ser-His-Arg-Leu-Trp-Gln-Leu-Met-Gly-Pro-Ala-Gly-Arg-Gln-Asp-Ser-Ala-Pro-Val-Asp-Pro-Ser-Ser-Pro-His-Ser-Tyr-NH2 или их солей или гидратов. ! 2. Комбинация по п.1, где пептиды содержатся в комбинации в количестве от 30% по массе к 70% по массе до 70% по массе к 30% по массе. ! 3. Комбинация по п.1 для применения в лекарственном средстве. ! 4. Применение пептида His-Ser-Gly-Pro-Arg-Arg-Thr-Gln-Ala-Gln-Leu-Leu-Arg-Val-Gly-Cys-Val-Leu-Gly-Thr-Cys-Gln-Val-Gln-Asn-Leu-Ser-His-Arg-Leu-Trp-Gln-Leu-Met-Gly-Pro-Ala-Gly-Arg-Gln-Asp-Ser-Ala-Pro-Val-Asp-Pro-Ser-Ser-Pro-His-Ser-Tyr-NH2 или комбинации по п.1 или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ. ! 5. Применение пептида по п.4, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из СПИД, ассоциированных со СПИД заболеваний, ВИЧ, болезни Крона, индуцированной Helicobacter pylori язвенной болезни, острого отторжения аллотрансплантата почки, необъяснимого привычного выкидыша, туберкулеза, астмы, рассеянного склероза, склеродермии, диабета типа 1, ревматоидного артрита, саркоидоза, аутоиммунного тиреоидита, увеита, синдрома Оменна, идиопатического фиброза легких и атопических нарушений у генетически восприимчивых и

Claims (13)

1. Комбинация пептидов His-Ser-Gly-Pro-Arg-Arg-Thr-Gln-Ala-Gln-Leu-Leu-Arg-Val-Gly-Cys-Val-Leu-Gly-Thr-Cys-Gln-Val-Gln-Asn-Leu-Ser-His-Arg-Leu-Trp-Gln-Leu-Met-Gly-Pro-Ala-Gly-Arg-Gln-Asp-Ser-Ala-Pro-Val-Asp-Pro-Ser-Ser-Pro-His-Ser-Tyr-NH2 и Thr-Gln-Ala-Gln-Leu-Leu-Arg-Val-Gly-Cys-Val-Leu-Gly-Thr-Cys-Gln-Val-Gln-Asn-Leu-Ser-His-Arg-Leu-Trp-Gln-Leu-Met-Gly-Pro-Ala-Gly-Arg-Gln-Asp-Ser-Ala-Pro-Val-Asp-Pro-Ser-Ser-Pro-His-Ser-Tyr-NH2 или их солей или гидратов.
2. Комбинация по п.1, где пептиды содержатся в комбинации в количестве от 30% по массе к 70% по массе до 70% по массе к 30% по массе.
3. Комбинация по п.1 для применения в лекарственном средстве.
4. Применение пептида His-Ser-Gly-Pro-Arg-Arg-Thr-Gln-Ala-Gln-Leu-Leu-Arg-Val-Gly-Cys-Val-Leu-Gly-Thr-Cys-Gln-Val-Gln-Asn-Leu-Ser-His-Arg-Leu-Trp-Gln-Leu-Met-Gly-Pro-Ala-Gly-Arg-Gln-Asp-Ser-Ala-Pro-Val-Asp-Pro-Ser-Ser-Pro-His-Ser-Tyr-NH2 или комбинации по п.1 или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ.
5. Применение пептида по п.4, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из СПИД, ассоциированных со СПИД заболеваний, ВИЧ, болезни Крона, индуцированной Helicobacter pylori язвенной болезни, острого отторжения аллотрансплантата почки, необъяснимого привычного выкидыша, туберкулеза, астмы, рассеянного склероза, склеродермии, диабета типа 1, ревматоидного артрита, саркоидоза, аутоиммунного тиреоидита, увеита, синдрома Оменна, идиопатического фиброза легких и атопических нарушений у генетически восприимчивых индивидуумов.
6. Применение пептида по п.4, где аутоиммунное заболевание выбрано из рассеянного склероза, артрита Лайма, диабета типа I, ревматоидного артрита, волчаночного эритематоза, миокардита, ревматической лихорадки, болезни Чагаса и миастении gravis, вызываемых инфекцией вирусом Эпштейна-Барр (EBV), вирусом кори, Borrelia burgdorferi, вирусом коксаки B4, вирусом краснухи, цитомегаловирусом (CMV), вирусом эпидемического паротита, Escherichia coli, микобактериями, вирусом гепатита C (HCV), CB3, хламидиями, Streptococci, Trypanosoma cruz или вирусом простого герпеса.
7. Применение пептида His-Ser-Gly-Pro-Arg-Arg-Thr-Gln-Ala-Gln-Leu-Leu-Arg-Val-Gly-Cys-Val-Leu-Gly-Thr-Cys-Gln-Val-Gln-Asn-Leu-Ser-His-Arg-Leu-Trp-Gln-Leu-Met-Gly-Pro-Ala-Gly-Arg-Gln-Asp-Ser-Ala-Pro-Val-Asp-Pro-Ser-Ser-Pro-His-Ser-Tyr-NH2 для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
8. Применение пептида His-Ser-Gly-Pro-Arg-Arg-Thr-Gln-Ala-Gln-Leu-Leu-Arg-Val-Gly-Cys-Val-Leu-Gly-Thr-Cys-Gln-Val-Gln-Asn-Leu-Ser-His-Arg-Leu-Trp-Gln-Leu-Met-Gly-Pro-Ala-Gly-Arg-Gln-Asp-Ser-Ala-Pro-Val-Asp-Pro-Ser-Ser-Pro-His-Ser-Tyr-NH2 для получения лиофилизированного состава или буферного жидкого состава.
9. Фармацевтическая композиция, содержащая комбинацию по п.1, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем.
10. Фармацевтическая композиция по п.9 в форме лиофилизата или жидкого буферного раствора.
11. Фармацевтическая композиция по п.9 или 10, пригодная для внутривенного введения, перорального введения или для введения посредством ингаляции.
12. Фармацевтическая композиция по п.9 или 10 в форме состава искусственного материнского молока или заменителя материнского молока, пригодная для пероральной доставки новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
13. Фармацевтическая композиция по п.9 или 10, пригодная для лечения и/или профилактики злокачественной опухоли, аутоиммунного заболевания, фиброза, воспалительного заболевания, нейродегенеративного заболевания, инфекционного заболевания, заболевания легких, заболевания сердца и сосудов или болезни обмена веществ.
RU2010114056/15A 2007-09-11 2008-09-09 Терапевтическое применение пептидов интермедина 47 и 53 RU2010114056A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07017755 2007-09-11
EP07017755.5 2007-09-11

Publications (1)

Publication Number Publication Date
RU2010114056A true RU2010114056A (ru) 2011-10-20

Family

ID=40130545

Family Applications (8)

Application Number Title Priority Date Filing Date
RU2010114004/15A RU2010114004A (ru) 2007-09-11 2008-09-09 Применение меланиноконцентрирующего гормона и met-энкефалина в качестве терапевтических средств
RU2010114013/15A RU2010114013A (ru) 2007-09-11 2008-09-09 Применение нейротрофического фактора для холинергических нейронов сетчатки (nfrcn) и хорионического гонадотропина бета (109-145) в качестве терапевтических средств
RU2010113985/15A RU2010113985A (ru) 2007-09-11 2008-09-09 Применение уродилатина в качестве терапевтического средства
RU2010114056/15A RU2010114056A (ru) 2007-09-11 2008-09-09 Терапевтическое применение пептидов интермедина 47 и 53
RU2010113972/15A RU2010113972A (ru) 2007-09-11 2008-09-09 Применение cnp-22 отдельно или в сочетании с физалемином в качестве терапевтического средства
RU2010114043/15A RU2010114043A (ru) 2007-09-11 2008-09-09 Применение бета-меланотропина в качестве терапевтического средства, например, для лечения спид или болезни альцгеймера
RU2010114024/10A RU2010114024A (ru) 2007-09-11 2008-09-09 Применение гонадорелина в качестве терапевтического средства
RU2010114057/15A RU2010114057A (ru) 2007-09-11 2008-09-09 Применение натрийуретического пептида с-типа индивидуально или в сочетании с нейропептидом af в качестве терапевтического средства

Family Applications Before (3)

Application Number Title Priority Date Filing Date
RU2010114004/15A RU2010114004A (ru) 2007-09-11 2008-09-09 Применение меланиноконцентрирующего гормона и met-энкефалина в качестве терапевтических средств
RU2010114013/15A RU2010114013A (ru) 2007-09-11 2008-09-09 Применение нейротрофического фактора для холинергических нейронов сетчатки (nfrcn) и хорионического гонадотропина бета (109-145) в качестве терапевтических средств
RU2010113985/15A RU2010113985A (ru) 2007-09-11 2008-09-09 Применение уродилатина в качестве терапевтического средства

Family Applications After (4)

Application Number Title Priority Date Filing Date
RU2010113972/15A RU2010113972A (ru) 2007-09-11 2008-09-09 Применение cnp-22 отдельно или в сочетании с физалемином в качестве терапевтического средства
RU2010114043/15A RU2010114043A (ru) 2007-09-11 2008-09-09 Применение бета-меланотропина в качестве терапевтического средства, например, для лечения спид или болезни альцгеймера
RU2010114024/10A RU2010114024A (ru) 2007-09-11 2008-09-09 Применение гонадорелина в качестве терапевтического средства
RU2010114057/15A RU2010114057A (ru) 2007-09-11 2008-09-09 Применение натрийуретического пептида с-типа индивидуально или в сочетании с нейропептидом af в качестве терапевтического средства

Country Status (8)

Country Link
US (9) US20100323950A1 (ru)
EP (9) EP2187944A1 (ru)
JP (8) JP2010539051A (ru)
KR (8) KR20100058554A (ru)
AU (8) AU2008297891A1 (ru)
CA (8) CA2698828A1 (ru)
RU (8) RU2010114004A (ru)
WO (21) WO2009043466A2 (ru)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2365023T3 (es) 2004-04-21 2011-09-20 Enobia Pharma Inc. Conjugados de administración ósea y método de uso de los mismos para dirigir proteínas a hueso.
ES2554713T3 (es) 2005-04-07 2015-12-22 Cardiorentis Ag Uso de un péptido natriurético para tratar insuficiencia cardiaca
JP4593639B2 (ja) 2008-03-04 2010-12-08 株式会社マルハニチロ食品 ペプチド含有摂食調節剤
HUE057174T2 (hu) 2009-05-20 2022-04-28 Biomarin Pharm Inc A C-típusú nátriuretikus peptid variánsai
DK2457581T3 (da) * 2009-07-23 2014-03-31 Igisu Co Ltd Sammensætning omfattende CNP eller BNP for et udvendigt præparat til hud til behandling af dermatitis
BR112012004058A2 (pt) 2009-08-27 2021-08-17 Kyoko Endo preparação terapêutica para rinite
WO2011153531A1 (en) 2010-06-04 2011-12-08 University Of South Florida Method of treating skeletal dysplasias using vessel dilator
US9585935B2 (en) * 2010-07-30 2017-03-07 The Regents Of The University Of California Intranasal oxytocin treatment to improve schizophrenia
EP2658979B1 (en) 2010-12-27 2018-02-14 Alexion Pharmaceuticals, Inc. Compositions comprising natriuretic peptides and methods of use thereof
HUE035584T2 (en) 2011-01-21 2018-05-28 Igisu Co Ltd A therapeutic agent for the treatment of allopathy
EP2678002A2 (en) 2011-02-25 2014-01-01 Medtronic, Inc. Therapy for kidney disease and/or heart failure
WO2012118042A1 (ja) * 2011-02-28 2012-09-07 独立行政法人国立循環器病研究センター 悪性腫瘍転移抑制用医薬
US9233143B2 (en) * 2011-08-19 2016-01-12 National Cerebral And Cardiovascular Center Medicinal agent for preventing exacerbation of malignant tumor, comprising combination of natriuretic peptide receptor GC-A and GC-B agonists
WO2013033675A1 (en) 2011-09-02 2013-03-07 Medtronic, Inc. Chimeric natriuretic peptide compositions and methods of preparation
CN102380089A (zh) * 2011-11-14 2012-03-21 北京大学 中介素1-53在制备糖代谢紊乱治疗药物中的新用途
CN102389567A (zh) * 2011-11-14 2012-03-28 北京大学 中介素1-53在制备脂代谢紊乱治疗药物中的新用途
CN102441159B (zh) * 2011-12-08 2013-12-25 赵海潞 一种人类多肽在制备免疫调节剂中的应用
US20150045301A1 (en) * 2011-12-16 2015-02-12 Kalos Therapeutics, Inc. Methods and uses of anp (atrial natriuretic peptide), bnp (brain natriuretic peptide) and cnp (c-type natriuretic peptide)-related peptides and derivatives thereof for treatment of retinal disorders and diseases
ES2425448B8 (es) * 2012-03-12 2015-03-17 Universidade De Santiago De Compostela Uso de la obestatina para la regeneración muscular
RU2496504C1 (ru) * 2012-03-22 2013-10-27 Федеральное государственное бюджетное учреждение "Научный центр биомедицинских технологий" Российской академии медицинских наук Средство для стимуляции работы в экстремальных условиях, способ его получения и его применения
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
WO2014116786A1 (en) * 2013-01-25 2014-07-31 Zietchick Research Institute,Llc Use of human chorionic gonadotropin to treat cerebral palsy and/or its co-morbidities
RU2521197C1 (ru) * 2013-03-22 2014-06-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО РостГМУ Минздрава России) Способ лечения больных деструктивными формами туберкулеза легких
JP2017518373A (ja) * 2014-05-29 2017-07-06 グリーン・クロス・コーポレイションＧｒｅｅｎ Ｃｒｏｓｓ Ｃｏｒｐ． スタフィロコッカス・アウレウス感染疾患の予防または治療用組成物
WO2016007873A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
CN112773765A (zh) 2014-09-19 2021-05-11 辉凌公司 治疗普拉德-威利综合征的方法
EP3212212B1 (en) 2014-10-31 2020-09-23 Monash University Powder formulation
US10449236B2 (en) 2014-12-05 2019-10-22 Alexion Pharmaceuticals, Inc. Treating seizure with recombinant alkaline phosphatase
CA2973883A1 (en) 2015-01-28 2016-08-04 Alexion Pharmaceuticals, Inc. Methods of treating a subject with an alkaline phosphatase deficiency
EP3307283B1 (en) * 2015-06-10 2020-09-02 Cellphire Inc. Composition and methods for treatment of loss of fluids leading to hypotension and/or hypovolemia
RU2587332C1 (ru) * 2015-07-01 2016-06-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Ростовский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО РостГМУ Минздрава России) Способ лечения больных деструктивными формами туберкулеза легких
WO2017010845A1 (ko) * 2015-07-15 2017-01-19 재단법인 목암생명과학연구소 포도상구균 감염 질환의 예방 또는 치료용 조성물
US11352612B2 (en) 2015-08-17 2022-06-07 Alexion Pharmaceuticals, Inc. Manufacturing of alkaline phosphatases
KR101727397B1 (ko) 2015-09-15 2017-04-17 경희대학교 산학협력단 멜라닌 응집 호르몬을 유효성분으로 포함하는 통증 억제용 조성물
WO2017058822A1 (en) 2015-09-28 2017-04-06 Alexion Pharmaceuticals, Inc. Identifying effective dosage regimens for tissue non-specific alkaline phosphatase (tnsalp)-enzyme replacement therapy of hypophosphatasia
WO2017064302A1 (en) * 2015-10-16 2017-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
EP3368062A4 (en) 2015-10-30 2019-07-03 Alexion Pharmaceuticals, Inc. METHODS OF TREATING CRANIOSYNOSTOSIS IN A PATIENT
WO2017155569A1 (en) 2016-03-08 2017-09-14 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
CA3019726A1 (en) 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Treating muscle weakness with alkaline phosphatases
WO2017173395A1 (en) 2016-04-01 2017-10-05 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in adolescents and adults
US10988744B2 (en) 2016-06-06 2021-04-27 Alexion Pharmaceuticals, Inc. Method of producing alkaline phosphatase
EP3500289B1 (en) 2016-08-18 2024-10-09 Alexion Pharmaceuticals, Inc. Asfotase alfa for use in treating tracheobronchomalacia
KR20190117541A (ko) 2017-01-20 2019-10-16 이뮨 시스템 레귤레이션 홀딩 에이비 신규 화합물 (이뮤노렐린)
WO2018134373A1 (en) 2017-01-20 2018-07-26 Immune System Regulation Holding Ab Novel compounds (immunorhelins- intracellular infections)
CN110381977A (zh) * 2017-01-20 2019-10-25 免疫系统调节控股有限公司 已知化合物的治疗细胞内感染的新用途
EP3585414A1 (en) 2017-02-22 2020-01-01 Immune System Regulation Holding AB Gonadotropin-releasing hormones for use as adjuvant immunotherapeutics
CN110719786A (zh) 2017-03-31 2020-01-21 阿雷克森制药公司 用于治疗成人和青少年的低磷酸酯酶症(hpp)的方法
CN108186583A (zh) * 2018-03-28 2018-06-22 宁波第二激素厂 一种兽用戈那瑞林注射剂的制备方法
EP3773684A1 (en) 2018-03-30 2021-02-17 Alexion Pharmaceuticals, Inc. Manufacturing of glycoproteins
CN112969450B (zh) 2018-09-20 2023-05-30 阿卡蒂亚药品公司 卡贝缩宫素药物产品及用于制备其的方法
CN112839632A (zh) 2018-09-20 2021-05-25 莱沃疗法公司 稳定的鼻内卡贝缩宫素制剂
CA3121200A1 (en) 2018-11-30 2020-06-04 Cellphire, Inc. Platelets as delivery agents
US11767511B2 (en) 2018-11-30 2023-09-26 Cellphire, Inc. Platelets as delivery agents
CN109893646A (zh) * 2019-03-19 2019-06-18 南京星银药业集团有限公司 一种治疗抑郁症的组合物
US11529587B2 (en) 2019-05-03 2022-12-20 Cellphire, Inc. Materials and methods for producing blood products
FR3099056B1 (fr) * 2019-07-26 2022-08-12 Univ Rouen Normandie Utilisation de l’ANP pour détruire les biofilms bactériens
AU2020334903B2 (en) 2019-08-16 2023-12-21 Cellphire, Inc. Thrombosomes as an antiplatelet agent reversal agent
CN112641928A (zh) * 2019-10-11 2021-04-13 田中纯美 一种用于血管新生、淋巴管新生相关疾病的多肽及其用途
CA3170201A1 (en) 2020-02-04 2021-08-12 Cellphire, Inc. Methods of treating congenital hemophilia with anti-fibrinolytic loaded platelets
US11419917B2 (en) 2020-04-07 2022-08-23 Drora Shevy Treatment for SARS-CoV-2 and other coronaviruses
WO2022029499A1 (en) * 2020-08-06 2022-02-10 Ads Aiphia Development Services Ag Methods of treating refractory ascites
CN112212178B (zh) * 2020-09-11 2022-04-01 山东中科诺亚科技有限公司 一种基于自转向的森林火灾监控装置
CA3173631A1 (en) 2021-02-12 2022-08-18 Walter C. Voegtli Alkaline phosphatase polypeptides and methods of use thereof
CN114940990B (zh) * 2022-06-20 2023-03-14 北京市神经外科研究所 与颅内动脉瘤相关的基因突变位点及其应用
EP4434579A1 (en) * 2023-03-23 2024-09-25 Servizo Galego de Saude Obestatin for use as antineoplastic agent in the treatment of pancreatic cancer

Family Cites Families (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188373A (en) 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4100271A (en) 1976-02-26 1978-07-11 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4235988A (en) 1976-12-13 1980-11-25 Imperial Chemical Industries Limited Delivery means for biologically active agents
US4321260A (en) * 1980-05-22 1982-03-23 Ayerst, Mckenna & Harrison Inc. Method of using gonadorelin for the treatment of benign prostatic hyperplasia
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4474752A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474753A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Topical drug delivery system utilizing thermosetting gels
US4496521A (en) * 1983-07-15 1985-01-29 The Whittier Institute For Diabetes And Endocrinology Insulin-potentiating peptides
US5432176A (en) * 1988-11-29 1995-07-11 The John Hopkins University Method of retarding the progression of chronic renal failure
US5324510A (en) * 1989-09-01 1994-06-28 Boehringer Ingelheim Pharmaceuticals, Inc. Use of antibodies to intercellular adhesion molecule-1 (ICAM-1) in the treatment of asthma
US5262520A (en) * 1989-12-01 1993-11-16 The Scripps Research Institute Peptides and antibodies that inhibit integrin-ligand binding
WO1991018010A1 (en) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition of viral infection using intercellular adhesion molecule-1-like peptides and/or analogues thereof
JP2977159B2 (ja) * 1990-09-07 1999-11-10 壽之 松尾 カエル由来新規生理活性ペプチド（カエルｃｎｐ）
JP3130080B2 (ja) * 1990-12-27 2001-01-31 日清製粉株式会社 ペプチドおよびその製造方法
US5256766A (en) * 1991-02-19 1993-10-26 The Regents Of The University Of California Recombinant thrombin receptor and related pharmaceuticals
WO1992019254A1 (en) * 1991-04-24 1992-11-12 Warner-Lambert Company α-SUBSTITUTED POLYPEPTIDES HAVING THERAPEUTIC ACTIVITY
DE69128283T2 (de) 1991-08-12 1998-03-19 Nestle Sa Nahrungsmittelzusammensetzung
IL106998A0 (en) * 1992-09-17 1993-12-28 Univ Florida Brain-enhanced delivery of neuroactive peptides by sequential metabolism
DE4310632A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Lineare Adhäsionsinhibitoren
CN1096862C (zh) 1994-05-06 2002-12-25 辉瑞大药厂 阿齐霉素的控释剂型
AU2473695A (en) * 1994-05-09 1995-11-29 Johns Hopkins University, The Method of slowing the progression of hiv infection
US5677275A (en) * 1994-08-05 1997-10-14 The United States Of America As Represented By The Department Of Health And Human Services Treatment of cancer with human chorionic gonadotropin
US5849708A (en) * 1995-06-06 1998-12-15 Joslin Diabetes Center, Inc. Promotion of eating behavior
EA000900B1 (ru) 1996-02-19 2000-06-26 Никомед Имеджинг Ас Термически стабилизированный контрастный агент
JPH09227590A (ja) * 1996-02-27 1997-09-02 Nisshin Flour Milling Co Ltd ペプチド
DE69722594T2 (de) * 1996-03-06 2004-04-29 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Pulverförmiges arzneimittel enthaltend interzelluläres adhäsionsmolekül
US6136780A (en) * 1996-03-29 2000-10-24 The Penn State Research Foundation Control of cancer growth through the interaction of [Met5 ]-enkephalin and the zeta (ζ) receptor
US20040063790A1 (en) * 1996-05-31 2004-04-01 The Scripps Research Institute Methods for inhibition of angiogenesis
WO1997049721A1 (en) * 1996-06-24 1997-12-31 University Of Maryland Biotechnology Institute Methods of treatment of wasting syndrome based on administration of derivatives of human chorionic gonadotropin
TW360501B (en) 1996-06-27 1999-06-11 Nestle Sa Dietetically balanced milk product
GB9613705D0 (en) 1996-06-29 1996-08-28 Mini Agriculture & Fisheries Novel peptides
ATE193636T1 (de) 1996-09-24 2000-06-15 Nestle Sa Milchaustauschprodukt und verfahren zu dessen herstellung
SE9701162D0 (sv) * 1997-03-27 1997-03-27 Karolinska Innovations Ab New use II
US6583109B1 (en) * 1997-06-24 2003-06-24 Robert C. Gallo Therapeutic polypeptides from β-hCG and derivatives
IL123349A0 (en) * 1998-02-18 1998-09-24 Hadasit Med Res Service Agents for the prevention of damages caused by stress conditions
US7175679B2 (en) * 2001-03-29 2007-02-13 Biotempt B.V. Oligopeptide treatment of NF-κB mediated inflammation
GB9816234D0 (en) * 1998-07-24 1998-09-23 William Harvey Research Limite Compounds for use in the treatment of inflammation
US6333313B1 (en) * 1998-10-29 2001-12-25 Board Of Regents, The University Of Texas System Clinical use of oxytocin alone or in combination to treat bone disorders
ES2226466T3 (es) 1998-11-24 2005-03-16 Societe Des Produits Nestle S.A. Procedimiento de preparacion de una composicion proteinica y de una formula infantil que la contiene.
WO2000041717A2 (en) * 1998-12-18 2000-07-20 Avi Biopharma, Inc. Chorionic gonadotropin dna vaccines and methods
DE19903087A1 (de) * 1999-01-27 2000-08-10 Forssmann Wolf Georg Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern
US20040259803A1 (en) * 1999-04-15 2004-12-23 Monash University Disease prevention by reactivation of the thymus
US20040013641A1 (en) * 1999-04-15 2004-01-22 Monash University Disease prevention by reactivation of the thymus
EP1173195B1 (en) 1999-04-21 2007-10-10 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES UTEROGLOBIN IN THE TREATMENT OF IgA MEDIATED AUTOIMMUNE DISORDERS
DE60026300T2 (de) * 1999-05-17 2006-11-16 Conjuchem, Inc., Montreal Schutz endogener, therapeutisch aktiver peptide vor peptidaseaktivität durch konjugation an blutbestandteile
DE19942230C2 (de) * 1999-09-03 2003-09-25 Wolf-Georg Forssmann Verwendung natriuretischer Peptide als antibiotisch wirksame Subsanzen zur Behandlung von bakteriellen Infektionen
WO2001017958A2 (en) * 1999-09-10 2001-03-15 Merck & Co., Inc. Neuropeptide sf receptor assays, compounds and therapeutic methods
US7235531B2 (en) * 1999-12-21 2007-06-26 Takeda Pharmaceutical Company Tachykinin-like polypeptides and use thereof
US6894026B1 (en) * 2000-01-11 2005-05-17 Atossa Healthcare, Inc. Long-acting oxytocin analogues for the treatment and prevention of breast cancer and psychiatric disorders
US20010046968A1 (en) * 2000-03-23 2001-11-29 Zagon Ian S. Opioid growth factor modulates angiogenesis
JP4237375B2 (ja) * 2000-03-31 2009-03-11 アスビオファーマ株式会社 虚血性疾患の処置又は予防に用いる医薬組成物
SE0001440D0 (sv) * 2000-04-18 2000-04-18 Entretech Medical Ab A drug against climacteric disorders
DE50201566D1 (de) * 2001-02-24 2004-12-23 Mologen Ag Beta-endorphin / crf - gentherapie zur lokalen schmerzbekämpfung
SE0100684D0 (sv) * 2001-02-28 2001-02-28 Kerstin Uvnaes Moberg New subject-matter
WO2002085401A1 (en) * 2001-04-18 2002-10-31 The Regents Of The University Of California Retrocyclins: antiviral and antimicrobial peptides
KR100411828B1 (ko) * 2001-04-21 2003-12-24 김수열 항 염증 효과가 있는 새로운 합성 펩타이드
CN1541103A (zh) * 2001-05-16 2004-10-27 �����˹��P����������Ʒ� 诱导持续免疫应答的方法
GB0115515D0 (en) * 2001-06-25 2001-08-15 Ferring Bv Oxytocin agonisys
SE0102910D0 (sv) * 2001-08-31 2001-08-31 Moberg Kerstin Uvnaes New use
US6770625B2 (en) * 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
PT1314357E (pt) 2001-11-23 2007-09-05 Nestle Sa Processo de preparação de leites em pó e produtos lácteos concentrados
WO2003063889A1 (en) * 2002-01-31 2003-08-07 Joslin Diabetes Center, Inc. METHODS OF MODULATING β CELL FUNCTION
DE10209072A1 (de) * 2002-02-28 2003-09-18 Universitaetsklinikum Charite Mittel zur Reduktion des Körpergewichts
US20050232925A1 (en) * 2002-03-18 2005-10-20 Sukhatme Vikas P Protease activity of thrombin inhibits angiogenesis
CA2391118A1 (en) * 2002-06-21 2003-12-21 Universite Du Quebec A Montreal Oxytocin as cardiomyogenesis inducer and uses thereof
JP4249970B2 (ja) * 2002-10-17 2009-04-08 扶桑薬品工業株式会社 Ｐａｒ−１を介する消化器系疾患の予防および／または治療用組成物
US8168233B2 (en) * 2002-10-18 2012-05-01 Amylin Pharmaceuticals, Inc. Treatment of pancreatitis with amylin
US6969702B2 (en) * 2002-11-20 2005-11-29 Neuronova Ab Compounds and methods for increasing neurogenesis
EP1583541B1 (en) * 2002-11-20 2011-01-12 NeuroNova AB Compounds and methods for increasing neurogenesis
AU2003298739A1 (en) * 2002-11-26 2004-06-18 The Board Of Trustees Of The Leland Stanford Junior University Intermedin and its uses
WO2004069175A2 (en) 2003-02-02 2004-08-19 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON’S DISEASE AND OTHER α-SYNUCLEINOPATHIES
GB0323378D0 (en) * 2003-10-07 2003-11-05 Univ Leicester Therapeutic agent
EP1522856A1 (en) * 2003-10-09 2005-04-13 BioVisioN AG Method for the detection of a neurological or psychiatric, demential disease, especially Alzheimer's disease by use of cholecystokinin (CCK)-molecules, corresponding substances and detection reagents
US20070053954A1 (en) * 2003-10-24 2007-03-08 Rowe Stephen C Macromer-melt formulations
EP1529535A1 (en) * 2003-11-06 2005-05-11 IPF PharmaCeuticals GmbH Isolation of a circulating human lipolytic peptide
US20050143303A1 (en) * 2003-12-26 2005-06-30 Nastech Pharmaceutical Company Inc. Intranasal administration of glucose-regulating peptides
US8076288B2 (en) * 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
WO2005082397A1 (en) * 2004-02-26 2005-09-09 The Penn State Research Foundation Combinatorial therapies for the treatment of neoplasias using the opioid growth factor receptor
US7399744B2 (en) * 2004-03-04 2008-07-15 Amylin Pharmaceuticals, Inc. Methods for affecting body composition
EP3620530A1 (en) * 2004-03-31 2020-03-11 Kazuwa Nakao Composition for increasing body height
CA2561530C (en) * 2004-03-31 2014-04-22 Kazuwa Nakao Therapeutic or prophylactic agent for arthritis
EP2631244A1 (en) * 2004-10-08 2013-08-28 Amylin Pharmaceuticals, Inc. Amylin family polypeptide-6 (AFP-6) analogs and methods of making and using them
WO2006060873A1 (en) * 2004-12-09 2006-06-15 Prince Henry's Institute Of Medical Research Method for restoring reproductive function
JP5317318B2 (ja) * 2004-12-24 2013-10-16 武田薬品工業株式会社 新規ポリペプチドおよびその用途
US20060177438A1 (en) * 2005-02-08 2006-08-10 New England Medical Center Methods of altering absorption of hydrophobic compounds
CA2595526A1 (en) * 2005-02-09 2006-08-17 Da Volterra Colonic delivery of active agents
AU2006213607A1 (en) * 2005-02-11 2006-08-17 Amylin Pharmaceuticals, Llc GIP analog and hybrid polypeptides with selectable properties
WO2007022123A2 (en) * 2005-08-11 2007-02-22 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
US20060229250A1 (en) * 2005-03-09 2006-10-12 Jian Zhang Ghrelin associated peptide and its uses
WO2006135783A2 (en) * 2005-06-10 2006-12-21 Wisconsin Alumni Research Foundation Compositions and methods for modulating angiogenesis
EP1912666A2 (en) * 2005-07-22 2008-04-23 Amylin Pharmaceuticals, Inc. Use of amylin and amylin agonists as cardioprotective or myoprotective agents
GB0516091D0 (en) * 2005-08-04 2005-09-14 Haemostatix Ltd Therapeutic agent
WO2007027910A2 (en) * 2005-09-01 2007-03-08 The Feinstein Institute For Medical Research Peptide mimics of melanocyte stimulating hormone
WO2007034498A1 (en) * 2005-09-26 2007-03-29 Compugen Ltd. Atrial natriuretic peptide (anp) splice variants and methods of using same
WO2007044998A1 (en) * 2005-10-12 2007-04-19 The Regents Of The University Of California Retrocyclins: antiviral and antimicrobial peptides
WO2007055743A2 (en) * 2005-11-01 2007-05-18 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
JP2009519949A (ja) * 2005-12-16 2009-05-21 アミリン・ファーマシューティカルズ，インコーポレイテッド 肥満症および関連する代謝性疾患の治療のための組成物および方法
MX2008009654A (es) * 2006-01-24 2009-01-15 Univ British Columbia Polimorfismos de vias de vasopresina como indicadores del resultado expuesto en sujetos criticamente enfermos.
BRPI0708773B1 (pt) 2006-03-10 2021-10-19 Laboswiss Ag Método para solubilização, dispersão e estabilização de substâncias, produtos manufaturados de acordo com o método, bem como uso dos mesmos
ATE516300T1 (de) * 2006-03-20 2011-07-15 Merck Sharp & Dohme Neuromedin-u-rezeptoragonisten und ihre verwendung
JP2009538824A (ja) * 2006-03-31 2009-11-12 アミリン・ファーマシューティカルズ，インコーポレイテッド 精神疾患及び障害治療用アミリン及びアミリンアゴニスト
WO2007134151A2 (en) * 2006-05-10 2007-11-22 Smithkline Beecham Corporation Composition and method for increasing cell permeability of a compound
JPWO2008029601A1 (ja) * 2006-08-16 2010-01-21 株式会社 未来創薬研究所 ニューロメジンｕ受容体２（ｆｍ４）分子に対するリガンドを有効成分として含む癌治療剤
JP2010510196A (ja) * 2006-11-17 2010-04-02 ダ・ボルテラ オイドラギット被覆を施した亜鉛／ペクチンビーズを使用する結腸送達
EP2120985B1 (en) * 2007-02-05 2012-06-27 Amylin Pharmaceuticals, Inc. FN-38 peptides for use in the treatment of psychotic and anxiety disorders
ES2854674T3 (es) * 2007-03-14 2021-09-22 Arch Biosurgery Inc Tratamiento de uniones estrechas con fugas o dañadas y mejora de la matriz extracelular
WO2009042053A2 (en) * 2007-09-21 2009-04-02 Merck & Co., Inc. Neuromedin u receptor agonists and uses thereof

Also Published As

Publication number Publication date
WO2009043458A2 (en) 2009-04-09
RU2010113972A (ru) 2011-10-20
CA2699169A1 (en) 2009-04-16
KR20100056510A (ko) 2010-05-27
WO2009033717A3 (en) 2009-06-11
WO2009033707A3 (en) 2009-12-17
EP2197466A2 (en) 2010-06-23
JP2010539022A (ja) 2010-12-16
US20100204107A1 (en) 2010-08-12
WO2009046844A1 (en) 2009-04-16
WO2009033795A2 (en) 2009-03-19
KR20100059859A (ko) 2010-06-04
RU2010114043A (ru) 2011-10-20
JP2010539051A (ja) 2010-12-16
WO2009033744A1 (en) 2009-03-19
AU2008306217A1 (en) 2009-04-09
WO2009043527A2 (en) 2009-04-09
CA2699084A1 (en) 2009-04-16
WO2009043448A2 (en) 2009-04-09
WO2009043450A3 (en) 2009-07-30
RU2010114057A (ru) 2011-10-20
WO2009043527A3 (en) 2009-05-28
RU2010114004A (ru) 2011-10-20
CA2699104A1 (en) 2009-04-09
WO2009043448A3 (en) 2009-06-18
WO2009043450A8 (en) 2010-04-22
WO2009046865A2 (en) 2009-04-16
WO2009043466A3 (en) 2009-09-03
KR20100057057A (ko) 2010-05-28
WO2009043439A3 (en) 2009-12-17
WO2009043439A2 (en) 2009-04-09
AU2008306255A1 (en) 2009-04-09
AU2008297891A1 (en) 2009-03-19
WO2009033701A1 (en) 2009-03-19
JP2010539008A (ja) 2010-12-16
WO2009043458A3 (en) 2009-11-26
WO2009040020A1 (en) 2009-04-02
WO2009046852A1 (en) 2009-04-16
JP5385279B2 (ja) 2014-01-08
KR20100057049A (ko) 2010-05-28
US20100190717A1 (en) 2010-07-29
JP2010539028A (ja) 2010-12-16
US20100249017A1 (en) 2010-09-30
KR20100058554A (ko) 2010-06-03
US20100323950A1 (en) 2010-12-23
US20100210538A1 (en) 2010-08-19
JP2010539016A (ja) 2010-12-16
EP2190459A1 (en) 2010-06-02
US20100204090A1 (en) 2010-08-12
WO2009033707A2 (en) 2009-03-19
JP2010539059A (ja) 2010-12-16
CA2698778A1 (en) 2009-03-19
KR20100057642A (ko) 2010-05-31
RU2010114013A (ru) 2011-10-20
WO2009043466A2 (en) 2009-04-09
WO2009039990A2 (en) 2009-04-02
WO2009043457A2 (en) 2009-04-09
WO2009033735A2 (en) 2009-03-19
WO2009033795A3 (en) 2009-08-06
AU2008309993A1 (en) 2009-04-16
EP2190456A2 (en) 2010-06-02
EP2185171A2 (en) 2010-05-19
WO2009043450A2 (en) 2009-04-09
AU2008297898A1 (en) 2009-03-19
JP2010539056A (ja) 2010-12-16
US20100204139A1 (en) 2010-08-12
EP2187921A2 (en) 2010-05-26
WO2009033735A3 (en) 2009-05-22
WO2009043505A3 (en) 2009-10-29
EP2185177A1 (en) 2010-05-19
RU2010113985A (ru) 2011-10-20
CA2698971A1 (en) 2009-03-19
WO2009033724A1 (en) 2009-03-19
RU2010114024A (ru) 2011-10-20
EP2187944A1 (en) 2010-05-26
AU2008297909A1 (en) 2009-03-19
WO2009046861A1 (en) 2009-04-16
CA2698977A1 (en) 2009-03-19
EP2190450A2 (en) 2010-06-02
EP2205269A1 (en) 2010-07-14
KR20100059865A (ko) 2010-06-04
US8349805B2 (en) 2013-01-08
JP2010539002A (ja) 2010-12-16
AU2008310078A1 (en) 2009-04-16
WO2009039990A3 (en) 2009-07-16
US20100204108A1 (en) 2010-08-12
AU2008297875A1 (en) 2009-03-19
CA2698828A1 (en) 2009-03-19
KR20100057641A (ko) 2010-05-31
WO2009043457A3 (en) 2009-11-26
CA2698687A1 (en) 2009-04-09
WO2009046865A3 (en) 2009-09-11
WO2009033717A2 (en) 2009-03-19
WO2009043505A2 (en) 2009-04-09
US20100204109A1 (en) 2010-08-12

Similar Documents

Publication Publication Date Title
RU2010114056A (ru) Терапевтическое применение пептидов интермедина 47 и 53
RU2010114049A (ru) Cgrp в качестве терапевтического средства
RU2010113964A (ru) Применение соматостатина-14 в качестве терапевтического средства
RU2010113978A (ru) ПРИМЕНЕНИЕ Gly-Pro-Glu-OH (GPE) В КАЧЕСТВЕ ТЕРАПЕВТИЧЕСКОГО СРЕДСТВА
RU2010114018A (ru) Применение пептид тимозина бета 4 индивидуально или в сочетании с цекропином а в качестве терапевтического средства
RU2010113979A (ru) Применение bubuc и необязательно eaa-marti (26-35) в качестве терапевтического средства для лечения инфекций hcmv
RU2010113986A (ru) Применение пептида в качестве терапевтического средства
RU2010114000A (ru) Применение нейропептида sf индивидуально или в сочетании с glp-2 в качестве терапевтического средства
RU2010114051A (ru) Применение grf-1(1-29) и кортиколиберина в качестве терапевтических средств
RU2010114042A (ru) Применение пептида в качестве терапевтического средства
RU2010113994A (ru) Применение панкреатического полипептида человека в качестве терапевтического средства
RU2010114014A (ru) Применение глюкагона (1-29) отдельно или в сочетании с нейропептидом w30 в качестве терапевтического средства
RU2010114031A (ru) Проадреномедуллин индивидуально или в сочетании с большим гастрином i в качестве терапевтического средства
RU2010114030A (ru) Применение пептида в качестве терапевтического средства
RU2010113989A (ru) Применение пептида в качестве терапевтического средства
RU2010113998A (ru) Применение пептида rfmwmr в качестве терапевтического средства
RU2010114039A (ru) Применение октреотида в качестве терапевтического средства
RU2010114005A (ru) Применение сочетания пептидов тимозина бета4 и индуцирующего дельта-сон пептида в качестве терапевтического средства
RU2010114035A (ru) Применение rfrp индивидуально или в комбинации с нейрокинином в в качестве терапевтического средства
RU2010114037A (ru) Применение белка полосы 3 и расар-27 в качестве терапевтического средства
RU2010114060A (ru) Применение пептида в качестве терапевтического средства

Legal Events

Date Code Title Description
FA93 Acknowledgement of application withdrawn (no request for examination)

Effective date: 20110912