RU2010114035A - Применение rfrp индивидуально или в комбинации с нейрокинином в в качестве терапевтического средства - Google Patents

Применение rfrp индивидуально или в комбинации с нейрокинином в в качестве терапевтического средства Download PDF

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RU2010114035A
RU2010114035A RU2010114035/15A RU2010114035A RU2010114035A RU 2010114035 A RU2010114035 A RU 2010114035A RU 2010114035/15 A RU2010114035/15 A RU 2010114035/15A RU 2010114035 A RU2010114035 A RU 2010114035A RU 2010114035 A RU2010114035 A RU 2010114035A
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phe
leu
disease
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diseases
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RU2010114035/15A
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Дориан БЕВЕК (DE)
Дориан БЕВЕК
Фабио КАВАЛЛИ (CH)
Фабио КАВАЛЛИ
Вера КАВАЛЛИ (CH)
Вера КАВАЛЛИ
Геральд БАХЕР (DE)
Геральд БАХЕР
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Мондобайотек Лабораториз Аг (Li)
Мондобайотек Лабораториз Аг
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Abstract

1. Комбинация пептидов Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2 и Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 или их солей или гидратов. ! 2. Комбинация по п.1, где пептиды содержатся в комбинации в количестве от 30 мас.% к 70 мас.% до 70 мас.% к 30 мас.%. ! 3. Комбинация по п.1 для применения в лекарственном средстве. ! 4. Применение пептида Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2 или комбинации по п.1, или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ. ! 5. Применение пептида по п.4, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции вирусом гепатита B, заболеваний, вызываемых инфекцией вирусом гепатита B, а именно острого гепатита, хронического гепатита, острой печеночной недостаточности, цирроза печени, злокачественной опухоли, ассоциированной с инфекцией вирусом гепатита B. ! 6. Применение пептида Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2 для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста. ! 7. Применение пептида Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2 для получения лиофилизированного состава или буферного жидкого состава. ! 8. Фармацевтическая композиция, содержащая комбинацию по п.1, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротекторо

Claims (12)

1. Комбинация пептидов Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2 и Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 или их солей или гидратов.
2. Комбинация по п.1, где пептиды содержатся в комбинации в количестве от 30 мас.% к 70 мас.% до 70 мас.% к 30 мас.%.
3. Комбинация по п.1 для применения в лекарственном средстве.
4. Применение пептида Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2 или комбинации по п.1, или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ.
5. Применение пептида по п.4, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции вирусом гепатита B, заболеваний, вызываемых инфекцией вирусом гепатита B, а именно острого гепатита, хронического гепатита, острой печеночной недостаточности, цирроза печени, злокачественной опухоли, ассоциированной с инфекцией вирусом гепатита B.
6. Применение пептида Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2 для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
7. Применение пептида Met-Pro-His-Ser-Phe-Ala-Asn-Leu-Pro-Leu-Arg-Phe-NH2 для получения лиофилизированного состава или буферного жидкого состава.
8. Фармацевтическая композиция, содержащая комбинацию по п.1, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем.
9. Фармацевтическая композиция по п.8 в форме лиофилизата или жидкого буферного раствора.
10. Фармацевтическая композиция по п.8 или 9, пригодная для внутривенного введения, перорального введения или для введения посредством ингаляции.
11. Фармацевтическая композиция по п.8 или 9 в форме состава искусственного материнского молока или заменителя материнского молока, пригодная для пероральной доставки новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
12. Фармацевтическая композиция по п.8 или 9, пригодная для лечения и/или профилактики злокачественной опухоли, аутоиммунного заболевания, фиброза, воспалительного заболевания, нейродегенеративного заболевания, инфекционного заболевания, заболевания легких, заболевания сердца и сосудов или болезни обмена веществ.
RU2010114035/15A 2007-09-11 2008-09-09 Применение rfrp индивидуально или в комбинации с нейрокинином в в качестве терапевтического средства RU2010114035A (ru)

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