RU2010114045A - Применение пептида sfllr-oh и мурамилдипептида в качестве терапевтических средств - Google Patents

Применение пептида sfllr-oh и мурамилдипептида в качестве терапевтических средств Download PDF

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RU2010114045A
RU2010114045A RU2010114045/15A RU2010114045A RU2010114045A RU 2010114045 A RU2010114045 A RU 2010114045A RU 2010114045/15 A RU2010114045/15 A RU 2010114045/15A RU 2010114045 A RU2010114045 A RU 2010114045A RU 2010114045 A RU2010114045 A RU 2010114045A
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Russia
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leu
disease
diseases
phe
arg
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RU2010114045/15A
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Дориан БЕВЕК (DE)
Дориан БЕВЕК
Фабио КАВАЛЛИ (CH)
Фабио КАВАЛЛИ
Вера КАВАЛЛИ (CH)
Вера КАВАЛЛИ
Геральд БАХЕР (DE)
Геральд БАХЕР
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Мондобайотек Лабораториз Аг (Li)
Мондобайотек Лабораториз Аг
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Publication of RU2010114045A publication Critical patent/RU2010114045A/ru

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Abstract

1. Комбинация пептидов Ser-Phe-Leu-Leu-Arg-OH и Ac-мурамил-Ala-D-Glu-NH2 или их солей, гидратов или деацетилированной формы. ! 2. Комбинация по п.1, где пептиды содержатся в комбинации в количестве от 30% по массе к 70% по массе до 70% по массе к 30% по массе. ! 3. Комбинация по п.1 для применения в лекарственном средстве. ! 4. Применение пептида Ser-Phe-Leu-Leu-Arg-OH 2 или комбинации по п.1, или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ. ! 5. Применение пептида по п.4, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции вирусом гепатита B, заболеваний, вызываемых инфекцией вирусом гепатита B, острого гепатита, хронического гепатита, острой печеночной недостаточности, цирроза печени, злокачественной опухоли, ассоциированной с инфекцией вирусом гепатита B. ! 6. Применение пептида Ser-Phe-Leu-Leu-Arg-OH для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста. ! 7. Применение пептида Ser-Phe-Leu-Leu-Arg-OH для получения лиофилизированного состава или буферного жидкого состава. ! 8. Фармацевтическая композиция, содержащая пептид Ser-Phe-Leu-Leu-Arg-OH или комбинацию по п.1, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопроте

Claims (12)

1. Комбинация пептидов Ser-Phe-Leu-Leu-Arg-OH и Ac-мурамил-Ala-D-Glu-NH2 или их солей, гидратов или деацетилированной формы.
2. Комбинация по п.1, где пептиды содержатся в комбинации в количестве от 30% по массе к 70% по массе до 70% по массе к 30% по массе.
3. Комбинация по п.1 для применения в лекарственном средстве.
4. Применение пептида Ser-Phe-Leu-Leu-Arg-OH 2 или комбинации по п.1, или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ.
5. Применение пептида по п.4, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции вирусом гепатита B, заболеваний, вызываемых инфекцией вирусом гепатита B, острого гепатита, хронического гепатита, острой печеночной недостаточности, цирроза печени, злокачественной опухоли, ассоциированной с инфекцией вирусом гепатита B.
6. Применение пептида Ser-Phe-Leu-Leu-Arg-OH для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
7. Применение пептида Ser-Phe-Leu-Leu-Arg-OH для получения лиофилизированного состава или буферного жидкого состава.
8. Фармацевтическая композиция, содержащая пептид Ser-Phe-Leu-Leu-Arg-OH или комбинацию по п.1, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем.
9. Фармацевтическая композиция по п.8 в форме лиофилизата или жидкого буферного раствора.
10. Фармацевтическая композиция по п.8 или 9, пригодная для внутривенного введения, перорального введения или для введения посредством ингаляции.
11. Фармацевтическая композиция по п.8 или 9 в форме состава искусственного материнского молока или заменителя материнского молока, пригодная для пероральной доставки новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
12. Фармацевтическая композиция по п.8 или 9, пригодная для лечения и/или профилактики злокачественной опухоли, аутоиммунного заболевания, фиброза, воспалительного заболевания, нейродегенеративного заболевания, инфекционного заболевания, заболевания легких, заболевания сердца и сосудов или болезни обмена веществ.
RU2010114045/15A 2007-09-11 2008-09-09 Применение пептида sfllr-oh и мурамилдипептида в качестве терапевтических средств RU2010114045A (ru)

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