EP1888618A4 - Analogs of glycyl-prolyl-glutamate - Google Patents

Analogs of glycyl-prolyl-glutamate

Info

Publication number
EP1888618A4
EP1888618A4 EP06770950A EP06770950A EP1888618A4 EP 1888618 A4 EP1888618 A4 EP 1888618A4 EP 06770950 A EP06770950 A EP 06770950A EP 06770950 A EP06770950 A EP 06770950A EP 1888618 A4 EP1888618 A4 EP 1888618A4
Authority
EP
European Patent Office
Prior art keywords
glycyl
prolyl
glutamate
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06770950A
Other languages
German (de)
French (fr)
Other versions
EP1888618A2 (en
Inventor
Margaret Anne Brimble
Paul William Richard Harris
Frank Sieg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuren Pharmaceuticals Ltd
Original Assignee
Neuren Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuren Pharmaceuticals Ltd filed Critical Neuren Pharmaceuticals Ltd
Publication of EP1888618A2 publication Critical patent/EP1888618A2/en
Publication of EP1888618A4 publication Critical patent/EP1888618A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
EP06770950A 2005-05-23 2006-05-23 Analogs of glycyl-prolyl-glutamate Withdrawn EP1888618A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68381305P 2005-05-23 2005-05-23
PCT/US2006/019909 WO2006127702A2 (en) 2005-05-23 2006-05-23 Analogs of glycyl-prolyl-glutamate

Publications (2)

Publication Number Publication Date
EP1888618A2 EP1888618A2 (en) 2008-02-20
EP1888618A4 true EP1888618A4 (en) 2009-07-15

Family

ID=37452742

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06770950A Withdrawn EP1888618A4 (en) 2005-05-23 2006-05-23 Analogs of glycyl-prolyl-glutamate

Country Status (3)

Country Link
EP (1) EP1888618A4 (en)
JP (1) JP2008545697A (en)
WO (1) WO2006127702A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007106555A2 (en) * 2006-03-14 2007-09-20 Neuren Pharmaceuticals Limited Oral formulations of glycyl-2-methylprolyl-glutamate
EP2170312A1 (en) * 2007-07-06 2010-04-07 University Of Zurich Method of preventing and treating acute brain pathologies
JP2010539067A (en) * 2007-09-11 2010-12-16 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト Use of Gly-Pro-Glu-OH (GPE) as a therapeutic agent
KR20100056509A (en) 2007-09-11 2010-05-27 몬도바이오테크 래보래토리즈 아게 Use of a peptide as a therapeutic agent
AU2012208693B2 (en) * 2011-01-19 2015-02-26 Galapagos Nv Azetidine derivatives useful for the treatment of metabolic and inflammatory diseases
HUE036637T2 (en) * 2011-01-27 2018-07-30 Neuren Pharmaceuticals Ltd Treatment of autism spectrum disorders using glycyl-l-2-methylprolyl-l-glutamic acid
SG187271A1 (en) * 2011-07-07 2013-02-28 Agency Science Tech & Res Anti-amyloidogenic, alpha-helix breaking ultra-small peptide therapeutic
JP2016506380A (en) * 2012-11-28 2016-03-03 ニューレン ファーマシューティカルズ リミテッド Treatment of autism spectrum disorder using glycyl-L-2-methylprolyl-L-glutamic acid
CN103275106B (en) * 2013-04-19 2015-09-30 暨南大学 A kind of indole alkaloid adduct and preparation method thereof and preparing the application in antitumor drug
JOP20220027A1 (en) * 2019-08-05 2023-01-30 Neuren Pharmaceuticals Ltd Compositions of trofinetide
GB202102709D0 (en) * 2021-02-25 2021-04-14 Univ Southampton Compounds
CN113135983B (en) * 2021-04-12 2022-06-24 四川大学华西医院 Antitumor compound and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094856A2 (en) * 2001-05-24 2002-11-28 Neuronz Limited Gpe analogs and peptidomimetics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187906B1 (en) * 1997-08-11 2001-02-13 Aukland Uniservices Limited Methods to improve neural outcome

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002094856A2 (en) * 2001-05-24 2002-11-28 Neuronz Limited Gpe analogs and peptidomimetics

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ALONSO DE DIEGO S A ET AL: "Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 9, 2 May 2005 (2005-05-02), pages 2279 - 2283, XP025313633, ISSN: 0960-894X, [retrieved on 20050502] *
ALONSO DE DIEGO S A ET AL: "The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 16, no. 13, 1 July 2006 (2006-07-01), pages 3396 - 3400, XP025107379, ISSN: 0960-894X, [retrieved on 20060701] *
BRIMBLE MARGARET A ET AL: "Synthesis and pharmacological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE).", BIOORGANIC & MEDICINAL CHEMISTRY 17 JAN 2005, vol. 13, no. 2, 17 January 2005 (2005-01-17), pages 519 - 532, XP002528279, ISSN: 0968-0896 *
GILLESSEN D ET AL: "[Syntheses of thyrotropin-releasing hormones (TRH) (Schaf) and related peptides]", HELVETICA CHIMICA ACTA 1970, vol. 53, no. 1, 1970, pages 63 - 72, XP002528278, ISSN: 0018-019X *
LAI MICHELLE Y H ET AL: "Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-L-prolyl-L-glutamic acid (GPE).", BIOORGANIC & MEDICINAL CHEMISTRY 17 JAN 2005, vol. 13, no. 2, 17 January 2005 (2005-01-17), pages 533 - 548, XP002528274, ISSN: 0968-0896 *
MAEHASHI K ET AL: "Isolation of peptides from an enzymatic hydrolysate of food proteins and characterization of their taste properties.", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY MAR 1999, vol. 63, no. 3, March 1999 (1999-03-01), pages 555 - 559, XP002528276, ISSN: 0916-8451 *
PARK JUNG-NIM ET AL: "Taste effects of oligopeptides in a Vietnamese fish sauce", FISHERIES SCIENCE (TOKYO), vol. 68, no. 4, August 2002 (2002-08-01), pages 921 - 928, XP002528277, ISSN: 0919-9268 *
SLOOTSTRA J W ET AL: "STRUCTURAL ASPECTS OF ANTIBODY-ANTIGEN INTERACTION REVEALED THROUGH SMALL RANDOM PEPTIDE LIBRARIES", MOLECULAR DIVERSITY, ESCOM SCIENCE PUBLISHERS, LEIDEN, NL, vol. 1, no. 2, 1 January 1995 (1995-01-01), pages 87 - 96, XP008065429, ISSN: 1381-1991 *
TROTTER NICHOLAS S ET AL: "Synthesis and neuroprotective activity of analogues of glycyl-L-prolyl-L-glutamic acid (GPE) modified at the alpha-carboxylic acid.", BIOORGANIC & MEDICINAL CHEMISTRY 17 JAN 2005, vol. 13, no. 2, 17 January 2005 (2005-01-17), pages 501 - 517, XP002528275, ISSN: 0968-0896 *

Also Published As

Publication number Publication date
EP1888618A2 (en) 2008-02-20
WO2006127702A3 (en) 2007-06-14
WO2006127702A2 (en) 2006-11-30
JP2008545697A (en) 2008-12-18

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