RU2010114000A - Применение нейропептида sf индивидуально или в сочетании с glp-2 в качестве терапевтического средства - Google Patents

Применение нейропептида sf индивидуально или в сочетании с glp-2 в качестве терапевтического средства Download PDF

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RU2010114000A
RU2010114000A RU2010114000/15A RU2010114000A RU2010114000A RU 2010114000 A RU2010114000 A RU 2010114000A RU 2010114000/15 A RU2010114000/15 A RU 2010114000/15A RU 2010114000 A RU2010114000 A RU 2010114000A RU 2010114000 A RU2010114000 A RU 2010114000A
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phe
gln
disease
diseases
leu
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RU2010114000/15A
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Дориан БЕВЕК (DE)
Дориан БЕВЕК
Фабио КАВАЛЛИ (CH)
Фабио КАВАЛЛИ
Вера КАВАЛЛИ (CH)
Вера КАВАЛЛИ
Геральд БАХЕР (DE)
Геральд БАХЕР
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Мондобайотек Лабораториз Аг (Li)
Мондобайотек Лабораториз Аг
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Publication of RU2010114000A publication Critical patent/RU2010114000A/ru

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Abstract

1. Комбинация пептидов Ser-Gln-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 и His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-OH или их солей или гидратов. ! 2. Комбинация по п.1, где пептиды содержатся в сочетании в количестве от 30 мас.% к 70 мас.% до 70 мас.% к 30 мас.%. ! 3. Комбинация по п.1 для применения в медицине. ! 4. Применение пептида Ser-Gln-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 или комбинации по п.1, или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ. ! 5. Применение пептида по п.4, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции цитомегаловирусом человека, инфекции HBV, заболеваний, ассоциированных с инфекцией цитомегаловирусом человека, пневмонии, желудочно-кишечного заболевания, заболевания сетчатки, неврологического заболевания, потери слуха, ухудшения зрения, печеночной недостаточности, колита, указанных выше заболеваний у пациентов с иммунной недостаточностью, у реципиентов трансплантированных органов, у пациентов, прошедших гемодиализ, у пациентов со злокачественной опухолью, у пациентов, получающих иммуносупрессорные лекарственные средства, и у ВИЧ-инфицированных пациентов. ! 6. Применение пептида Ser-Gln-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 для получения состава для перорального введения н�

Claims (12)

1. Комбинация пептидов Ser-Gln-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 и His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-OH или их солей или гидратов.
2. Комбинация по п.1, где пептиды содержатся в сочетании в количестве от 30 мас.% к 70 мас.% до 70 мас.% к 30 мас.%.
3. Комбинация по п.1 для применения в медицине.
4. Применение пептида Ser-Gln-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 или комбинации по п.1, или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ.
5. Применение пептида по п.4, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции цитомегаловирусом человека, инфекции HBV, заболеваний, ассоциированных с инфекцией цитомегаловирусом человека, пневмонии, желудочно-кишечного заболевания, заболевания сетчатки, неврологического заболевания, потери слуха, ухудшения зрения, печеночной недостаточности, колита, указанных выше заболеваний у пациентов с иммунной недостаточностью, у реципиентов трансплантированных органов, у пациентов, прошедших гемодиализ, у пациентов со злокачественной опухолью, у пациентов, получающих иммуносупрессорные лекарственные средства, и у ВИЧ-инфицированных пациентов.
6. Применение пептида Ser-Gln-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
7. Применение пептида Ser-Gln-Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 для получения лиофилизированного состава или буферного жидкого состава.
8. Фармацевтическая композиция, содержащая комбинации по п.1 совместно с по меньшей мере одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем.
9. Фармацевтическая композиция по п.8 в форме лиофилизата или жидкого буферного раствора.
10. Фармацевтическая композиция по п.8 или 9, пригодная для внутривенного введения, перорального введения или для введения посредством ингаляции.
11. Фармацевтическая композиция по п.8 или 9 в форме состава искусственного материнского молока или заменителя материнского молока, пригодная для пероральной доставки новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
12. Фармацевтическая композиция по п.8 или 9, пригодная для лечения и/или профилактики злокачественной опухоли, аутоиммунного заболевания, фиброза, воспалительного заболевания, нейродегенеративного заболевания, инфекционного заболевания, заболевания легких, заболевания сердца и сосудов или болезни обмена веществ.
RU2010114000/15A 2007-09-11 2008-09-09 Применение нейропептида sf индивидуально или в сочетании с glp-2 в качестве терапевтического средства RU2010114000A (ru)

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