RU2010113979A - Применение bubuc и необязательно eaa-marti (26-35) в качестве терапевтического средства для лечения инфекций hcmv - Google Patents

Применение bubuc и необязательно eaa-marti (26-35) в качестве терапевтического средства для лечения инфекций hcmv Download PDF

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RU2010113979A
RU2010113979A RU2010113979/15A RU2010113979A RU2010113979A RU 2010113979 A RU2010113979 A RU 2010113979A RU 2010113979/15 A RU2010113979/15 A RU 2010113979/15A RU 2010113979 A RU2010113979 A RU 2010113979A RU 2010113979 A RU2010113979 A RU 2010113979A
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Russia
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disease
diseases
patients
tbu
gly
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RU2010113979/15A
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Дориан БЕВЕК (DE)
Дориан БЕВЕК
Фабио КАВАЛЛИ (CH)
Фабио КАВАЛЛИ
Вера КАВАЛЛИ (CH)
Вера КАВАЛЛИ
Геральд БАХЕР (DE)
Геральд БАХЕР
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Мондобайотек Лабораториз Аг (Li)
Мондобайотек Лабораториз Аг
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Publication of RU2010113979A publication Critical patent/RU2010113979A/ru

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Abstract

1. Сочетание пептидов Tyr-D-Cys(tBu)-Gly-Phe-Leu-Thr(tBu)-OH и Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val-OH или их солей или гидратов. ! 2. Сочетание по п.1, где пептиды содержатся в сочетании в количестве от 30 мас.% к 70 мас.% до 70 мас.% к 30 мас.%. ! 3. Сочетание по п.1 для применения в медицине. !4. Применение пептида Tyr-D-Cys(tBu)-Gly-Phe-Leu-Thr(tBu)-OH или сочетания по п.1, или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ. ! 5. Применение пептида по п.4, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции HBV, инфекции цитомегаловирусом человека, заболеваний, ассоциированных с инфекцией цитомегаловирусом человека, а также вследствие инфекции HCMV у пациентов с иммунной недостаточностью, у реципиентов трансплантированных органов, у пациентов, проходящих гемодиализ, у пациентов со злокачественной опухолью, у пациентов, получающих иммуносупрессорные лекарственные средства, и у ВИЧ-инфицированных пациентов и у пациентов, страдающих от пневмонии, желудочно-кишечного заболевания, заболевания сетчатки, неврологического заболевания, потери слуха, ухудшения зрения, печеночной недостаточности и колита, указанных выше заболеваний у пациентов с иммунной недостаточностью, у реципиентов трансплантированных органов, у пациентов, прохо�

Claims (12)

1. Сочетание пептидов Tyr-D-Cys(tBu)-Gly-Phe-Leu-Thr(tBu)-OH и Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val-OH или их солей или гидратов.
2. Сочетание по п.1, где пептиды содержатся в сочетании в количестве от 30 мас.% к 70 мас.% до 70 мас.% к 30 мас.%.
3. Сочетание по п.1 для применения в медицине.
4. Применение пептида Tyr-D-Cys(tBu)-Gly-Phe-Leu-Thr(tBu)-OH или сочетания по п.1, или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ.
5. Применение пептида по п.4, где злокачественная опухоль, аутоиммунное заболевание, фиброз, воспалительное заболевание, нейродегенеративное заболевание, инфекционное заболевание, заболевание легких, заболевание сердца и сосудов или болезнь обмена веществ выбраны из инфекции HBV, инфекции цитомегаловирусом человека, заболеваний, ассоциированных с инфекцией цитомегаловирусом человека, а также вследствие инфекции HCMV у пациентов с иммунной недостаточностью, у реципиентов трансплантированных органов, у пациентов, проходящих гемодиализ, у пациентов со злокачественной опухолью, у пациентов, получающих иммуносупрессорные лекарственные средства, и у ВИЧ-инфицированных пациентов и у пациентов, страдающих от пневмонии, желудочно-кишечного заболевания, заболевания сетчатки, неврологического заболевания, потери слуха, ухудшения зрения, печеночной недостаточности и колита, указанных выше заболеваний у пациентов с иммунной недостаточностью, у реципиентов трансплантированных органов, у пациентов, проходящих гемодиализ, у пациентов со злокачественной опухолью, у пациентов, получающих иммуносупрессорные лекарственные средства, и у ВИЧ-инфицированных пациентов.
6. Применение пептида Tyr-D-Cys(tBu)-Gly-Phe-Leu-Thr(tBu)-OH для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
7. Применение пептида Tyr-D-Cys(tBu)-Gly-Phe-Leu-Thr(tBu)-OH для получения лиофилизированного состава или буферного жидкого состава.
8. Фармацевтическая композиция, содержащая сочетание по п.1, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем.
9. Фармацевтическая композиция по п.8 в форме лиофилизата или жидкого буферного раствора.
10. Фармацевтическая композиция по п.8 или 9, пригодная для внутривенного введения, перорального введения или для введения посредством ингаляции.
11. Фармацевтическая композиция по п.8 или 9 в форме состава искусственного материнского молока или заменителя материнского молока, пригодная для пероральной доставки новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
12. Фармацевтическая композиция по п.8 или 9, пригодная для лечения и/или профилактики злокачественной опухоли, аутоиммунного заболевания, фиброза, воспалительного заболевания, нейродегенеративного заболевания, инфекционного заболевания, заболевания легких, заболевания сердца и сосудов или болезни обмена веществ.
RU2010113979/15A 2007-09-11 2008-09-09 Применение bubuc и необязательно eaa-marti (26-35) в качестве терапевтического средства для лечения инфекций hcmv RU2010113979A (ru)

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