RU2005104818A - Азаиндольные ингибиторы киназ - Google Patents
Азаиндольные ингибиторы киназ Download PDFInfo
- Publication number
- RU2005104818A RU2005104818A RU2005104818/04A RU2005104818A RU2005104818A RU 2005104818 A RU2005104818 A RU 2005104818A RU 2005104818/04 A RU2005104818/04 A RU 2005104818/04A RU 2005104818 A RU2005104818 A RU 2005104818A RU 2005104818 A RU2005104818 A RU 2005104818A
- Authority
- RU
- Russia
- Prior art keywords
- substituted
- pyrrolo
- yloxy
- fluoro
- methyl
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 241000124008 Mammalia Species 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000000547 substituted alkyl group Chemical group 0.000 claims 5
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 4
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 4
- -1 R 31 Chemical compound 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 230000001093 anti-cancer Effects 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
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- 239000002254 cytotoxic agent Substances 0.000 claims 3
- 231100000599 cytotoxic agent Toxicity 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
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- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
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- NTKPIEALXMYDOX-SECBINFHSA-N (2r)-1-[4-[(4-fluoro-1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-amine Chemical compound N1=C2NC=CC2=C(F)C(OC2=NC=NN3C=C(C(=C32)C)OC[C@H](N)C)=C1 NTKPIEALXMYDOX-SECBINFHSA-N 0.000 claims 1
- ACPWZRGLIIWDAZ-SECBINFHSA-N (2r)-1-[4-[(4-fluoro-1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-ol Chemical compound N1=C2NC=CC2=C(F)C(OC2=NC=NN3C=C(C(=C32)C)OC[C@H](O)C)=C1 ACPWZRGLIIWDAZ-SECBINFHSA-N 0.000 claims 1
- IEVVBXWLVDGZEQ-SECBINFHSA-N (2r)-1-[4-[(4-fluoro-2-methyl-1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-amine Chemical compound N1=C2NC(C)=CC2=C(F)C(OC2=NC=NN3C=C(C(=C32)C)OC[C@H](N)C)=C1 IEVVBXWLVDGZEQ-SECBINFHSA-N 0.000 claims 1
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- ACPWZRGLIIWDAZ-VIFPVBQESA-N (2s)-1-[4-[(4-fluoro-1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxypropan-2-ol Chemical compound N1=C2NC=CC2=C(F)C(OC2=NC=NN3C=C(C(=C32)C)OC[C@@H](O)C)=C1 ACPWZRGLIIWDAZ-VIFPVBQESA-N 0.000 claims 1
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- LHMXHXQYVFYCCQ-UHFFFAOYSA-N 2-[4-[(4-fluoro-1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxyethanamine Chemical compound N1=C2NC=CC2=C(F)C(OC2=NC=NN3C=C(OCCN)C(=C23)C)=C1 LHMXHXQYVFYCCQ-UHFFFAOYSA-N 0.000 claims 1
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- YYOLIACIIOCPPM-UHFFFAOYSA-N 4-[(4-fluoro-1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol Chemical compound N1=C2NC=CC2=C(F)C(OC2=NC=NN3C=C(O)C(=C23)C)=C1 YYOLIACIIOCPPM-UHFFFAOYSA-N 0.000 claims 1
- SGOOQMRIPALTEL-UHFFFAOYSA-N 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide Chemical group OC=1C2=CC=CC=C2N(C)C(=O)C=1C(=O)N(C)C1=CC=CC=C1 SGOOQMRIPALTEL-UHFFFAOYSA-N 0.000 claims 1
- OOQXPATWSOGSAV-UHFFFAOYSA-N 6-(5-methyl-1,3,4-oxadiazol-2-yl)-n-(2-methyl-1h-pyrrolo[2,3-b]pyridin-5-yl)-5-propan-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine Chemical compound C=1N2N=CN=C(NC=3C=C4C=C(C)NC4=NC=3)C2=C(C(C)C)C=1C1=NN=C(C)O1 OOQXPATWSOGSAV-UHFFFAOYSA-N 0.000 claims 1
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- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 1
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Classifications
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|---|---|---|---|---|
| RU2404765C2 (ru) * | 2005-08-26 | 2010-11-27 | Антисома Рисерч Лимитед | Комбинации (составы), включающие dmxaa для лечения рака |
| CN116813526A (zh) * | 2023-05-22 | 2023-09-29 | 四川省医学科学院·四川省人民医院 | 异吲哚啉酮类化合物、其制备方法及其应用 |
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