RS56972B1 - Postupak za pripremu visoko-čistog i kristalnog dimetil fumarata - Google Patents
Postupak za pripremu visoko-čistog i kristalnog dimetil fumarataInfo
- Publication number
- RS56972B1 RS56972B1 RS20180175A RSP20180175A RS56972B1 RS 56972 B1 RS56972 B1 RS 56972B1 RS 20180175 A RS20180175 A RS 20180175A RS P20180175 A RSP20180175 A RS P20180175A RS 56972 B1 RS56972 B1 RS 56972B1
- Authority
- RS
- Serbia
- Prior art keywords
- dimethyl fumarate
- reaction
- methanol
- dimethyl
- fumaric acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/62—Use of additives, e.g. for stabilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
- C07C69/60—Maleic acid esters; Fumaric acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/604—Polycarboxylic acid esters, the acid moiety containing more than two carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494775P | 2011-06-08 | 2011-06-08 | |
| EP12796164.7A EP2718257B1 (en) | 2011-06-08 | 2012-06-08 | Process for preparing high purity and crystalline dimethyl fumarate |
| PCT/US2012/041715 WO2012170923A1 (en) | 2011-06-08 | 2012-06-08 | Process for preparing high purity and crystalline dimethyl fumarate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS56972B1 true RS56972B1 (sr) | 2018-05-31 |
Family
ID=47296498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20180175A RS56972B1 (sr) | 2011-06-08 | 2012-06-08 | Postupak za pripremu visoko-čistog i kristalnog dimetil fumarata |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9422226B2 (OSRAM) |
| EP (1) | EP2718257B1 (OSRAM) |
| JP (3) | JP6385273B6 (OSRAM) |
| KR (2) | KR20140035995A (OSRAM) |
| CN (1) | CN103649041A (OSRAM) |
| AU (1) | AU2012267524A1 (OSRAM) |
| BR (1) | BR112013031616A2 (OSRAM) |
| CA (1) | CA2838271A1 (OSRAM) |
| CL (1) | CL2013003483A1 (OSRAM) |
| CO (1) | CO6821956A2 (OSRAM) |
| CY (1) | CY1119920T1 (OSRAM) |
| DK (1) | DK2718257T3 (OSRAM) |
| EA (1) | EA201391638A1 (OSRAM) |
| EC (1) | ECSP14013123A (OSRAM) |
| ES (1) | ES2659771T3 (OSRAM) |
| HR (1) | HRP20180203T1 (OSRAM) |
| HU (1) | HUE036085T2 (OSRAM) |
| IL (1) | IL229656A0 (OSRAM) |
| LT (1) | LT2718257T (OSRAM) |
| ME (1) | ME02960B (OSRAM) |
| MX (1) | MX355421B (OSRAM) |
| NO (1) | NO2820009T3 (OSRAM) |
| NZ (1) | NZ618178A (OSRAM) |
| PE (1) | PE20141639A1 (OSRAM) |
| PH (1) | PH12013502498A1 (OSRAM) |
| PL (1) | PL2718257T3 (OSRAM) |
| PT (1) | PT2718257T (OSRAM) |
| RS (1) | RS56972B1 (OSRAM) |
| SG (1) | SG195227A1 (OSRAM) |
| SI (1) | SI2718257T1 (OSRAM) |
| SM (1) | SMT201800098T1 (OSRAM) |
| WO (1) | WO2012170923A1 (OSRAM) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0410805A (pt) | 2003-09-09 | 2006-06-27 | Fumapharm Ag | uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma |
| PL2801354T3 (pl) | 2004-10-08 | 2017-08-31 | Forward Pharma A/S | Kompozycje farmaceutyczne o kontrolowanym uwalnianiu zawierające ester kwasu fumarowego |
| ES2477884T3 (es) | 2008-08-19 | 2014-07-18 | Xenoport, Inc. | Profármacos de hidrogenofumarato de metilo, composiciones farmacéuticas de los mismos y procedimientos de uso |
| PH12013502498A1 (en) | 2011-06-08 | 2014-01-20 | Biogen Ma Inc | Process for preparing high purity and crystalline dimethyl fumarate |
| WO2014031844A1 (en) | 2012-08-22 | 2014-02-27 | Xenoport, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| WO2014031892A1 (en) | 2012-08-22 | 2014-02-27 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| CN105142628A (zh) | 2012-12-21 | 2015-12-09 | 比奥根玛公司 | 氘取代的富马酸盐衍生物 |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| EP3366668B1 (en) | 2013-03-14 | 2023-06-21 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various deseases |
| US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
| CN104098471A (zh) * | 2013-04-03 | 2014-10-15 | 南京卡文迪许生物工程技术有限公司 | 富马酸二甲酯多晶型物及其制备方法和药物组合物 |
| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| TW201516020A (zh) | 2013-09-06 | 2015-05-01 | Xenoport Inc | （ｎ，ｎ－二乙基胺甲醯基）甲基（２ｅ）丁－２－烯－１，４－二酸甲酯之晶形、合成方法及用途 |
| WO2015044853A2 (en) * | 2013-09-25 | 2015-04-02 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for preparation of dimethyl fumarate |
| WO2014203231A2 (en) * | 2014-01-24 | 2014-12-24 | Shilpa Medicare Limited | Process for preparation of dimethyl-(e)-butenedioate |
| CA2940845C (en) | 2014-02-24 | 2019-09-24 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| EP3501510B1 (en) | 2014-02-28 | 2020-07-01 | Banner Life Sciences LLC | Controlled release enteric soft capsules of fumarate esters |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| US10626076B2 (en) * | 2014-03-17 | 2020-04-21 | Biophore India Pharmaeuticals Pvt. Ltd. | Process for the synthesis of dimethyl fumarate |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016001093A1 (en) * | 2014-07-03 | 2016-01-07 | Synthon B.V. | Process for making microcrystalline dimethyl fumarate |
| CN104151165B (zh) * | 2014-08-11 | 2016-08-24 | 广东东阳光药业有限公司 | 制备富马酸二甲酯的方法 |
| CN104761453A (zh) * | 2015-04-22 | 2015-07-08 | 河南中帅医药科技股份有限公司 | 一种富马酸二甲酯晶型及其制备方法 |
| EP3302461A4 (en) * | 2015-06-01 | 2019-02-13 | Sun Pharmaceutical Industries Ltd | PHARMACEUTICAL COMPOSITIONS OF DIMETHYLFUMARATE |
| EA201890068A1 (ru) | 2015-06-17 | 2018-09-28 | Байоджен Ма Инк. | Частицы диметилфумарата и фармацевтические композиции на их основе |
| CN106316841A (zh) * | 2015-06-30 | 2017-01-11 | 深圳翰宇药业股份有限公司 | 一种富马酸二甲酯的制备方法 |
| WO2017013672A1 (en) * | 2015-07-23 | 2017-01-26 | Natco Pharma Ltd | Process for the preparation of pharmaceutical grade dimethyl fumarate |
| US10011663B2 (en) | 2016-02-04 | 2018-07-03 | Eastman Chemical Company | Vulcanizing composition containing cyclododecasulfur and improved cyclododecasulfur compound |
| RU2616605C1 (ru) * | 2016-04-07 | 2017-04-18 | Олег Ростиславович Михайлов | Кристаллическая бета - модификация (Е)-диметилбутендиоата, способ её получения и фармацевтическая композиция на её основе |
| CN107285320A (zh) * | 2017-08-02 | 2017-10-24 | 内蒙古新福地科技有限公司 | 一种氟硅酸钠的结晶方法及装置 |
| HUE062926T2 (hu) | 2017-10-10 | 2023-12-28 | Pfizer | Lorlatinib mint szabad bázis hidrátjának kristályos formája |
| US11903918B2 (en) | 2020-01-10 | 2024-02-20 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
| KR102271575B1 (ko) * | 2020-09-16 | 2021-07-01 | 김갑용 | 염의 이온교환법을 이용한 친환경 고효율 에스터화반응 기반의 에스터화합물 제조방법 및 이의 화합물 |
| JP6865489B1 (ja) * | 2020-10-20 | 2021-04-28 | 株式会社エス・ディー・エス バイオテック | ２，３，５，６−テトラクロロ−１，４−ベンゼンジカルボン酸ジメチルの製造方法 |
| CN117550970A (zh) * | 2023-10-30 | 2024-02-13 | 寿光金远东变性淀粉有限公司 | 一种高纯度衣康酸二甲酯的生产方法 |
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