RO69984A - Procedeu de obtinere a acidului clavulanic - Google Patents

Procedeu de obtinere a acidului clavulanic

Info

Publication number
RO69984A
RO69984A RO7582037A RO8203775A RO69984A RO 69984 A RO69984 A RO 69984A RO 7582037 A RO7582037 A RO 7582037A RO 8203775 A RO8203775 A RO 8203775A RO 69984 A RO69984 A RO 69984A
Authority
RO
Romania
Prior art keywords
clavulian
processing procedure
acid processing
acid
procedure
Prior art date
Application number
RO7582037A
Other languages
English (en)
French (fr)
Inventor
Martin Cole
Thomas T Howarth
Christopher Reading
Original Assignee
Beecham Group Ltd,Gb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27448389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO69984(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB17410/74A external-priority patent/GB1508977A/en
Application filed by Beecham Group Ltd,Gb filed Critical Beecham Group Ltd,Gb
Publication of RO69984A publication Critical patent/RO69984A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
RO7582037A 1974-04-20 1975-04-19 Procedeu de obtinere a acidului clavulanic RO69984A (ro)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB17410/74A GB1508977A (en) 1974-04-20 1974-04-20 Beta-lactam antibiotic from streptomyces clavuligerus
GB2771574 1974-06-21
GB4365174 1974-10-09
GB5352574 1974-12-11

Publications (1)

Publication Number Publication Date
RO69984A true RO69984A (ro) 1980-12-30

Family

ID=27448389

Family Applications (2)

Application Number Title Priority Date Filing Date
RO7595311A RO77320A (ro) 1974-04-20 1975-04-19 Procedeu pentru purificarea sarurilor acidului clavulanic
RO7582037A RO69984A (ro) 1974-04-20 1975-04-19 Procedeu de obtinere a acidului clavulanic

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO7595311A RO77320A (ro) 1974-04-20 1975-04-19 Procedeu pentru purificarea sarurilor acidului clavulanic

Country Status (26)

Country Link
US (5) US4427690A (ro)
JP (7) JPS521996B2 (ro)
AR (3) AR206627A1 (ro)
CA (1) CA1059050A (ro)
CH (2) CH629252A5 (ro)
CY (1) CY1078A (ro)
DD (2) DD132297A5 (ro)
DE (4) DE2560074C2 (ro)
DK (1) DK141254B (ro)
FI (1) FI54144C (ro)
FR (1) FR2267778B1 (ro)
HK (1) HK54780A (ro)
IE (1) IE41109B1 (ro)
IL (1) IL47087A (ro)
IN (1) IN140042B (ro)
KE (1) KE3076A (ro)
LU (1) LU72322A1 (ro)
MY (1) MY8100195A (ro)
NL (1) NL163824C (ro)
NO (3) NO145247C (ro)
NZ (1) NZ177159A (ro)
OA (1) OA05203A (ro)
PH (1) PH16474A (ro)
RO (2) RO77320A (ro)
SE (8) SE422063B (ro)
YU (3) YU39941B (ro)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
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JPS596796Y2 (ja) * 1975-04-04 1984-03-01 株式会社東芝 脱水兼用洗濯機
US6218380B1 (en) * 1975-04-17 2001-04-17 Smithkline Beecham P.L.C. Pharmaceutical compositions
US6051703C1 (en) * 1975-04-17 2001-10-06 Smithkline Beecham Plc Purified clavulanic acid and salts thereof
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Family Cites Families (7)

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US3801464A (en) 1972-02-09 1974-04-02 Lilly Co Eli Antibiotic a16886 and process for production thereof
NZ177159A (en) 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
US4140764A (en) * 1974-12-18 1979-02-20 Beecham Group Limited β-Lactamase inhibitors and process for their preparation
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US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
YU40452B (en) * 1975-02-07 1986-02-28 Beecham Group Plc Process for the elimination of contaminating impurities from clavulinic acid
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration

Also Published As

Publication number Publication date
HK54780A (en) 1980-10-03
CY1078A (en) 1980-12-27
JPS5549833B2 (ro) 1980-12-15
NO145247B (no) 1981-11-02
US4560552A (en) 1985-12-24
IE41109B1 (en) 1979-10-24
DK167275A (ro) 1975-10-21
JPS5549830B2 (ro) 1980-12-15
SE8605405L (sv) 1986-12-16
FI54144B (fi) 1978-06-30
JPS532494A (en) 1978-01-11
LU72322A1 (ro) 1975-08-20
US4560552C1 (en) 2001-10-16
SE435286B (sv) 1984-09-17
US4427690A (en) 1984-01-24
SE7504541L (ro) 1975-10-18
NL7504621A (nl) 1975-10-22
JPS5549831B2 (ro) 1980-12-15
SE446687B (sv) 1986-10-06
DE2559410A1 (de) 1976-09-23
YU90875A (en) 1982-05-31
NO145247C (no) 1982-02-10
NO791956L (no) 1975-10-21
US4525352A (en) 1985-06-25
SE443562B (sv) 1986-03-03
SE453600B (sv) 1988-02-15
NO150838C (no) 1985-01-09
SE8306328D0 (sv) 1983-11-16
JPS533589A (en) 1978-01-13
SE8306328L (sv) 1983-11-16
DE2517316C2 (de) 1985-03-07
YU42745B (en) 1988-12-31
US4556559A (en) 1985-12-03
CH630631A5 (de) 1982-06-30
JPS50142591A (ro) 1975-11-17
JPS533588A (en) 1978-01-13
AR206627A1 (es) 1976-08-06
SE7811202L (sv) 1978-10-27
IN140042B (ro) 1976-09-04
JPS5549832B2 (ro) 1980-12-15
KE3076A (en) 1980-10-03
OA05203A (fr) 1981-02-28
DK141254B (da) 1980-02-11
JPS533590A (en) 1978-01-13
NL163824C (nl) 1980-10-15
NZ177159A (en) 1978-03-06
DK141254C (ro) 1980-08-11
SE7811201L (sv) 1978-10-27
DD132297A5 (de) 1978-09-20
MY8100195A (en) 1981-12-31
NO801852L (no) 1975-10-21
SE7811203L (sv) 1978-10-27
JPS50142789A (ro) 1975-11-17
YU274381A (en) 1983-06-30
JPS532495A (en) 1978-01-11
IE41109L (en) 1975-10-20
AR219050A1 (es) 1980-07-31
DE2560074C2 (de) 1985-03-28
YU39941B (en) 1985-06-30
NL163824B (nl) 1980-05-16
JPS5246957B2 (ro) 1977-11-29
IL47087A (en) 1979-07-25
RO77320A (ro) 1981-08-17
FI751133A (ro) 1975-10-21
DE2559411A1 (de) 1976-10-21
NO751407L (ro) 1975-10-21
YU274481A (en) 1983-06-30
YU42744B (en) 1988-12-31
SE435287B (sv) 1984-09-17
PH16474A (en) 1983-10-25
IL47087A0 (en) 1975-06-25
FR2267778B1 (ro) 1978-11-17
US4526783A (en) 1985-07-02
SE7811200L (sv) 1978-10-27
SE8105829L (sv) 1981-10-02
CH629252A5 (de) 1982-04-15
FI54144C (fi) 1978-10-10
DE2559411C2 (de) 1982-07-01
AR216430A1 (es) 1979-12-28
CA1059050A (en) 1979-07-24
FR2267778A1 (ro) 1975-11-14
SE8605405D0 (sv) 1986-12-16
SE422063B (sv) 1982-02-15
NO150838B (no) 1984-09-17
DD121799A5 (ro) 1976-08-20
JPS521996B2 (ro) 1977-01-19
DE2517316A1 (de) 1975-10-23

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