JPS533588A - Production of antibiotic - Google Patents

Production of antibiotic

Info

Publication number
JPS533588A
JPS533588A JP4025977A JP4025977A JPS533588A JP S533588 A JPS533588 A JP S533588A JP 4025977 A JP4025977 A JP 4025977A JP 4025977 A JP4025977 A JP 4025977A JP S533588 A JPS533588 A JP S533588A
Authority
JP
Japan
Prior art keywords
antibiotic
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4025977A
Other languages
English (en)
Other versions
JPS5549832B2 (ja
Inventor
Kooru Maachin
Toreboo Howaasu Toomasu
Riidengu Kurisutofuaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27448389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS533588(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB17410/74A external-priority patent/GB1508977A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of JPS533588A publication Critical patent/JPS533588A/ja
Publication of JPS5549832B2 publication Critical patent/JPS5549832B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
JP4025977A 1974-04-20 1977-04-05 Production of antibiotic Granted JPS533588A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB17410/74A GB1508977A (en) 1974-04-20 1974-04-20 Beta-lactam antibiotic from streptomyces clavuligerus
GB2771574 1974-06-21
GB4365174 1974-10-09
GB5352574 1974-12-11

Publications (2)

Publication Number Publication Date
JPS533588A true JPS533588A (en) 1978-01-13
JPS5549832B2 JPS5549832B2 (ja) 1980-12-15

Family

ID=27448389

Family Applications (7)

Application Number Title Priority Date Filing Date
JP50048087A Expired JPS5246957B2 (ja) 1974-04-20 1975-04-19
JP50048086A Expired JPS521996B2 (ja) 1974-04-20 1975-04-19
JP4025877A Granted JPS532495A (en) 1974-04-20 1977-04-05 Method of purifying antibiotics
JP4026177A Pending JPS533590A (en) 1974-04-20 1977-04-05 Purification of antibiotic
JP4026077A Granted JPS533589A (en) 1974-04-20 1977-04-05 Purification of antibiotic
JP4025777A Granted JPS532494A (en) 1974-04-20 1977-04-05 Process for preparing antibiotics
JP4025977A Granted JPS533588A (en) 1974-04-20 1977-04-05 Production of antibiotic

Family Applications Before (6)

Application Number Title Priority Date Filing Date
JP50048087A Expired JPS5246957B2 (ja) 1974-04-20 1975-04-19
JP50048086A Expired JPS521996B2 (ja) 1974-04-20 1975-04-19
JP4025877A Granted JPS532495A (en) 1974-04-20 1977-04-05 Method of purifying antibiotics
JP4026177A Pending JPS533590A (en) 1974-04-20 1977-04-05 Purification of antibiotic
JP4026077A Granted JPS533589A (en) 1974-04-20 1977-04-05 Purification of antibiotic
JP4025777A Granted JPS532494A (en) 1974-04-20 1977-04-05 Process for preparing antibiotics

Country Status (26)

Country Link
US (5) US4427690A (ja)
JP (7) JPS5246957B2 (ja)
AR (3) AR206627A1 (ja)
CA (1) CA1059050A (ja)
CH (2) CH629252A5 (ja)
CY (1) CY1078A (ja)
DD (2) DD121799A5 (ja)
DE (4) DE2559411C2 (ja)
DK (1) DK141254B (ja)
FI (1) FI54144C (ja)
FR (1) FR2267778B1 (ja)
HK (1) HK54780A (ja)
IE (1) IE41109B1 (ja)
IL (1) IL47087A (ja)
IN (1) IN140042B (ja)
KE (1) KE3076A (ja)
LU (1) LU72322A1 (ja)
MY (1) MY8100195A (ja)
NL (1) NL163824C (ja)
NO (3) NO145247C (ja)
NZ (1) NZ177159A (ja)
OA (1) OA05203A (ja)
PH (1) PH16474A (ja)
RO (2) RO77320A (ja)
SE (8) SE422063B (ja)
YU (3) YU39941B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5545906U (ja) * 1978-09-21 1980-03-26

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
DK141099B (da) * 1975-02-07 1980-01-14 Glaxo Lab Ltd Fremgangsmåde til rensning af clavulansyre eller et salt deraf med en base.
JPS596796Y2 (ja) * 1975-04-04 1984-03-01 株式会社東芝 脱水兼用洗濯機
US6051703C1 (en) * 1975-04-17 2001-10-06 Smithkline Beecham Plc Purified clavulanic acid and salts thereof
US6218380B1 (en) * 1975-04-17 2001-04-17 Smithkline Beecham P.L.C. Pharmaceutical compositions
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
US4230622A (en) * 1975-12-17 1980-10-28 Glaxo Laboratories Limited Halogen derivatives of clavulaic acid
GB1515241A (en) * 1976-01-27 1978-06-21 Beecham Group Ltd Beta-lactam antibiotics
DE2725690A1 (de) * 1976-06-08 1977-12-22 Glaxo Lab Ltd Neue clavulansaeurederivate, verfahren zu deren herstellung und diese enthaltende zusammensetzungen
GB1562802A (en) * 1976-06-26 1980-03-19 Beecham Group Ltd Pharmaceutical compositions containing containing clavulanic acid
GB1562902A (en) * 1976-06-30 1980-03-19 Beecham Group Ltd Pharmaceutical compositions containing clavulanic acid
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB1594001A (en) * 1977-03-16 1981-07-30 Beecham Group Ltd Pellets suitable for use in the testing of microorganisms
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DE2912511C2 (de) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmazeutische Zusammensetzung, enthaltend Penicillansäure
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
JPS54126735A (en) * 1978-03-24 1979-10-02 Toyama Chem Co Ltd Bactericidal composition for medical use
EP0008905B1 (en) * 1978-09-06 1983-02-16 Beecham Group Plc Pharmaceutical compositions containing two beta-lactam derivatives
US4202819A (en) * 1979-05-04 1980-05-13 Hoffman-La Roche Inc. 2-(3-Alanyl)clavam antibiotic
ZA804670B (en) * 1979-08-03 1981-07-29 Beecham Group Ltd Derivatives of clavulanic acid, a process for their preparation and their use
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
DE3169452D1 (en) * 1980-12-09 1985-04-25 Beecham Group Plc Derivatives of clavulanic acid, their preparation and their use
US4562182A (en) * 1980-12-23 1985-12-31 Beecham Group P.L.C. Compounds containing beta-lactams
JPS58361A (ja) * 1981-06-22 1983-01-05 Kurosaki Refract Co Ltd 溶融金属鋳造用ノズル
US4533542A (en) * 1983-08-22 1985-08-06 Eli Lilly And Company Pharmaceutical compositions for storage in plastic containers and process therefor
US4684643A (en) * 1983-08-22 1987-08-04 Eli Lilly And Company Pharmaceutical compositions for storage in plastic containers and process therefor
IT1207982B (it) * 1983-10-07 1989-06-01 Lisapharma Spa Composizioni farmaceutiche adattivita' antibiotica.
JPS60151610U (ja) * 1984-03-22 1985-10-08 住友重機械工業株式会社 回転ホイ−ル式連続金属押出装置におけるアバツトメント
JPS6155889A (ja) * 1984-08-28 1986-03-20 松下電器産業株式会社 高周波加熱装置
US4757066A (en) * 1984-10-15 1988-07-12 Sankyo Company Limited Composition containing a penem or carbapenem antibiotic and the use of the same
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
GB9009446D0 (en) * 1990-04-26 1990-06-20 Beecham Group Plc Veterinary composition
DE4027928A1 (de) * 1990-09-04 1992-03-05 Bayer Ag Neue 2-tert.substituierte methyl-oxapenem-3-carbonsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung
DE4030706A1 (de) * 1990-09-28 1992-04-02 Bayer Ag Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB9201639D0 (en) * 1992-01-25 1992-03-11 Smithkline Beecham Plc Pharmaceutical formulations
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
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US5760218A (en) * 1993-03-26 1998-06-02 Gist-Brocades N.V. Diamine salts of clavulanic acid
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US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
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NZ318282A (en) * 1995-09-07 2000-01-28 Smithkline Beecham Corp Pharmaceutical formulation containing amoxycillin and clavulanate in a weight ratio of 12:1 and 20:1
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US20030124187A1 (en) * 1997-02-14 2003-07-03 Smithkline Beecham Laboratoires Pharmaceutiques, Pharmaceutical formulations comprising amoxycillin and clavulanate
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AR015825A1 (es) * 1997-05-28 2001-05-30 Gist Brocades Bv Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato
CN1308682A (zh) * 1998-07-03 2001-08-15 Dsm公司 在低浓度游离氨基酸下生产棒酸的发酵工艺
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US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
US6294199B1 (en) 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
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US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
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US3801464A (en) 1972-02-09 1974-04-02 Lilly Co Eli Antibiotic a16886 and process for production thereof
IE41109B1 (en) 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4123540A (en) * 1974-12-18 1978-10-31 Beecham Group Limited Isoclavulanic acid as an antibacterial and a β-lactamase inhibitor
US4140764A (en) * 1974-12-18 1979-02-20 Beecham Group Limited β-Lactamase inhibitors and process for their preparation
DK141099B (da) * 1975-02-07 1980-01-14 Glaxo Lab Ltd Fremgangsmåde til rensning af clavulansyre eller et salt deraf med en base.
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5545906U (ja) * 1978-09-21 1980-03-26

Also Published As

Publication number Publication date
AR206627A1 (es) 1976-08-06
NL7504621A (nl) 1975-10-22
SE422063B (sv) 1982-02-15
YU42745B (en) 1988-12-31
CH629252A5 (de) 1982-04-15
FI751133A (ja) 1975-10-21
YU39941B (en) 1985-06-30
JPS5549832B2 (ja) 1980-12-15
JPS521996B2 (ja) 1977-01-19
FI54144C (fi) 1978-10-10
NL163824B (nl) 1980-05-16
OA05203A (fr) 1981-02-28
SE435286B (sv) 1984-09-17
FI54144B (fi) 1978-06-30
NZ177159A (en) 1978-03-06
NO150838B (no) 1984-09-17
IN140042B (ja) 1976-09-04
SE8605405D0 (sv) 1986-12-16
HK54780A (en) 1980-10-03
AR219050A1 (es) 1980-07-31
IL47087A0 (en) 1975-06-25
SE7811202L (sv) 1978-10-27
NO791956L (no) 1975-10-21
DE2559411A1 (de) 1976-10-21
DE2559410A1 (de) 1976-09-23
JPS5549830B2 (ja) 1980-12-15
YU274381A (en) 1983-06-30
DD132297A5 (de) 1978-09-20
US4525352A (en) 1985-06-25
SE8605405L (sv) 1986-12-16
IE41109B1 (en) 1979-10-24
LU72322A1 (ja) 1975-08-20
US4560552C1 (en) 2001-10-16
DE2517316C2 (de) 1985-03-07
CA1059050A (en) 1979-07-24
JPS532495A (en) 1978-01-11
DK167275A (ja) 1975-10-21
NO145247C (no) 1982-02-10
US4560552A (en) 1985-12-24
YU274481A (en) 1983-06-30
US4427690A (en) 1984-01-24
SE7504541L (ja) 1975-10-18
DD121799A5 (ja) 1976-08-20
SE453600B (sv) 1988-02-15
PH16474A (en) 1983-10-25
IL47087A (en) 1979-07-25
JPS533590A (en) 1978-01-13
SE7811200L (sv) 1978-10-27
SE435287B (sv) 1984-09-17
SE8105829L (sv) 1981-10-02
NL163824C (nl) 1980-10-15
NO150838C (no) 1985-01-09
NO751407L (ja) 1975-10-21
JPS533589A (en) 1978-01-13
JPS532494A (en) 1978-01-11
JPS50142591A (ja) 1975-11-17
YU90875A (en) 1982-05-31
CY1078A (en) 1980-12-27
DE2517316A1 (de) 1975-10-23
SE446687B (sv) 1986-10-06
RO69984A (ro) 1980-12-30
CH630631A5 (de) 1982-06-30
JPS5549831B2 (ja) 1980-12-15
JPS50142789A (ja) 1975-11-17
US4556559A (en) 1985-12-03
SE7811203L (sv) 1978-10-27
SE443562B (sv) 1986-03-03
RO77320A (ro) 1981-08-17
SE8306328L (sv) 1983-11-16
IE41109L (en) 1975-10-20
JPS5549833B2 (ja) 1980-12-15
AR216430A1 (es) 1979-12-28
US4526783A (en) 1985-07-02
SE7811201L (sv) 1978-10-27
MY8100195A (en) 1981-12-31
FR2267778A1 (ja) 1975-11-14
JPS5246957B2 (ja) 1977-11-29
NO801852L (no) 1975-10-21
DE2560074C2 (de) 1985-03-28
SE8306328D0 (sv) 1983-11-16
YU42744B (en) 1988-12-31
DE2559411C2 (de) 1982-07-01
FR2267778B1 (ja) 1978-11-17
DK141254C (ja) 1980-08-11
KE3076A (en) 1980-10-03
NO145247B (no) 1981-11-02
DK141254B (da) 1980-02-11

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