NO145247C - Fremgangsmaate for fremstilling av clavulansyre - Google Patents

Fremgangsmaate for fremstilling av clavulansyre

Info

Publication number
NO145247C
NO145247C NO751407A NO751407A NO145247C NO 145247 C NO145247 C NO 145247C NO 751407 A NO751407 A NO 751407A NO 751407 A NO751407 A NO 751407A NO 145247 C NO145247 C NO 145247C
Authority
NO
Norway
Prior art keywords
procedure
preparation
clavulanic acid
clavulanic
acid
Prior art date
Application number
NO751407A
Other languages
English (en)
Other versions
NO751407L (no
NO145247B (no
Inventor
Martin Cole
Thomas Trevor Howarth
Christopher Reading
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27448389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO145247(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB17410/74A external-priority patent/GB1508977A/en
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of NO751407L publication Critical patent/NO751407L/no
Publication of NO145247B publication Critical patent/NO145247B/no
Publication of NO145247C publication Critical patent/NO145247C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO751407A 1974-04-20 1975-04-18 Fremgangsmaate for fremstilling av clavulansyre NO145247C (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB17410/74A GB1508977A (en) 1974-04-20 1974-04-20 Beta-lactam antibiotic from streptomyces clavuligerus
GB2771574 1974-06-21
GB4365174 1974-10-09
GB5352574 1974-12-11

Publications (3)

Publication Number Publication Date
NO751407L NO751407L (no) 1975-10-21
NO145247B NO145247B (no) 1981-11-02
NO145247C true NO145247C (no) 1982-02-10

Family

ID=27448389

Family Applications (3)

Application Number Title Priority Date Filing Date
NO751407A NO145247C (no) 1974-04-20 1975-04-18 Fremgangsmaate for fremstilling av clavulansyre
NO791956A NO150838C (no) 1974-04-20 1979-06-12 Analogifremgangsmaate for fremstilling av nye klavulansyreforbindelser med antibakterielle og beta-laktamase-inhiberende egenskaper
NO801852A NO801852L (no) 1974-04-20 1980-06-20 Farmasoeytisk clavulansyrepreparat.

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO791956A NO150838C (no) 1974-04-20 1979-06-12 Analogifremgangsmaate for fremstilling av nye klavulansyreforbindelser med antibakterielle og beta-laktamase-inhiberende egenskaper
NO801852A NO801852L (no) 1974-04-20 1980-06-20 Farmasoeytisk clavulansyrepreparat.

Country Status (26)

Country Link
US (5) US4427690A (no)
JP (7) JPS5246957B2 (no)
AR (3) AR206627A1 (no)
CA (1) CA1059050A (no)
CH (2) CH629252A5 (no)
CY (1) CY1078A (no)
DD (2) DD132297A5 (no)
DE (4) DE2560074C2 (no)
DK (1) DK141254B (no)
FI (1) FI54144C (no)
FR (1) FR2267778B1 (no)
HK (1) HK54780A (no)
IE (1) IE41109B1 (no)
IL (1) IL47087A (no)
IN (1) IN140042B (no)
KE (1) KE3076A (no)
LU (1) LU72322A1 (no)
MY (1) MY8100195A (no)
NL (1) NL163824C (no)
NO (3) NO145247C (no)
NZ (1) NZ177159A (no)
OA (1) OA05203A (no)
PH (1) PH16474A (no)
RO (2) RO77320A (no)
SE (8) SE422063B (no)
YU (3) YU39941B (no)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
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IE41109B1 (en) 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
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US6051703C1 (en) * 1975-04-17 2001-10-06 Smithkline Beecham Plc Purified clavulanic acid and salts thereof
US6218380B1 (en) * 1975-04-17 2001-04-17 Smithkline Beecham P.L.C. Pharmaceutical compositions
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
US4230622A (en) * 1975-12-17 1980-10-28 Glaxo Laboratories Limited Halogen derivatives of clavulaic acid
GB1515241A (en) * 1976-01-27 1978-06-21 Beecham Group Ltd Beta-lactam antibiotics
NL7706242A (nl) * 1976-06-08 1977-12-12 Glaxo Lab Ltd Werkwijze voor de bereiding van clavamderivaten.
GB1562802A (en) * 1976-06-26 1980-03-19 Beecham Group Ltd Pharmaceutical compositions containing containing clavulanic acid
GB1562902A (en) * 1976-06-30 1980-03-19 Beecham Group Ltd Pharmaceutical compositions containing clavulanic acid
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB1594001A (en) * 1977-03-16 1981-07-30 Beecham Group Ltd Pellets suitable for use in the testing of microorganisms
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DE2912511C2 (de) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmazeutische Zusammensetzung, enthaltend Penicillansäure
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
JPS54126735A (en) * 1978-03-24 1979-10-02 Toyama Chem Co Ltd Bactericidal composition for medical use
DE2964817D1 (en) * 1978-09-06 1983-03-24 Beecham Group Plc Pharmaceutical compositions containing two beta-lactam derivatives
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US4202819A (en) * 1979-05-04 1980-05-13 Hoffman-La Roche Inc. 2-(3-Alanyl)clavam antibiotic
DK330880A (da) * 1979-08-03 1981-02-04 Beecham Group Ltd Fremgangsmaade til fremstilling af clavulansyrederivater
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US4757066A (en) * 1984-10-15 1988-07-12 Sankyo Company Limited Composition containing a penem or carbapenem antibiotic and the use of the same
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GB9009446D0 (en) * 1990-04-26 1990-06-20 Beecham Group Plc Veterinary composition
DE4027928A1 (de) * 1990-09-04 1992-03-05 Bayer Ag Neue 2-tert.substituierte methyl-oxapenem-3-carbonsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung
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US20030219867A1 (en) * 1993-07-24 2003-11-27 Smithkline Beecham Plc Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid
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US20030124187A1 (en) * 1997-02-14 2003-07-03 Smithkline Beecham Laboratoires Pharmaceutiques, Pharmaceutical formulations comprising amoxycillin and clavulanate
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US3801464A (en) 1972-02-09 1974-04-02 Lilly Co Eli Antibiotic a16886 and process for production thereof
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4123540A (en) * 1974-12-18 1978-10-31 Beecham Group Limited Isoclavulanic acid as an antibacterial and a β-lactamase inhibitor
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YU40452B (en) * 1975-02-07 1986-02-28 Beecham Group Plc Process for the elimination of contaminating impurities from clavulinic acid
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration

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Publication number Publication date
DK141254C (no) 1980-08-11
NO150838B (no) 1984-09-17
US4526783A (en) 1985-07-02
JPS533588A (en) 1978-01-13
DD121799A5 (no) 1976-08-20
RO77320A (ro) 1981-08-17
US4560552A (en) 1985-12-24
JPS533589A (en) 1978-01-13
SE7811200L (sv) 1978-10-27
OA05203A (fr) 1981-02-28
AR206627A1 (es) 1976-08-06
NO751407L (no) 1975-10-21
HK54780A (en) 1980-10-03
LU72322A1 (no) 1975-08-20
PH16474A (en) 1983-10-25
AR216430A1 (es) 1979-12-28
DE2560074C2 (de) 1985-03-28
NL7504621A (nl) 1975-10-22
SE8105829L (sv) 1981-10-02
DK141254B (da) 1980-02-11
DK167275A (no) 1975-10-21
SE8306328L (sv) 1983-11-16
SE435286B (sv) 1984-09-17
IL47087A0 (en) 1975-06-25
SE7811203L (sv) 1978-10-27
CH630631A5 (de) 1982-06-30
SE8605405L (sv) 1986-12-16
IE41109B1 (en) 1979-10-24
JPS532495A (en) 1978-01-11
SE422063B (sv) 1982-02-15
DE2559411A1 (de) 1976-10-21
IL47087A (en) 1979-07-25
FR2267778A1 (no) 1975-11-14
YU90875A (en) 1982-05-31
YU42744B (en) 1988-12-31
NL163824C (nl) 1980-10-15
US4427690A (en) 1984-01-24
NL163824B (nl) 1980-05-16
IN140042B (no) 1976-09-04
JPS50142789A (no) 1975-11-17
JPS5549832B2 (no) 1980-12-15
JPS50142591A (no) 1975-11-17
AR219050A1 (es) 1980-07-31
SE446687B (sv) 1986-10-06
NO801852L (no) 1975-10-21
FI54144C (fi) 1978-10-10
KE3076A (en) 1980-10-03
JPS532494A (en) 1978-01-11
SE8605405D0 (sv) 1986-12-16
DD132297A5 (de) 1978-09-20
SE443562B (sv) 1986-03-03
RO69984A (ro) 1980-12-30
SE435287B (sv) 1984-09-17
MY8100195A (en) 1981-12-31
YU274481A (en) 1983-06-30
JPS533590A (en) 1978-01-13
DE2517316C2 (de) 1985-03-07
NO145247B (no) 1981-11-02
US4560552C1 (en) 2001-10-16
FR2267778B1 (no) 1978-11-17
CY1078A (en) 1980-12-27
IE41109L (en) 1975-10-20
US4525352A (en) 1985-06-25
YU274381A (en) 1983-06-30
SE7811202L (sv) 1978-10-27
YU39941B (en) 1985-06-30
SE7504541L (no) 1975-12-19
JPS521996B2 (no) 1977-01-19
FI751133A (no) 1975-10-21
YU42745B (en) 1988-12-31
JPS5246957B2 (no) 1977-11-29
JPS5549830B2 (no) 1980-12-15
JPS5549833B2 (no) 1980-12-15
SE453600B (sv) 1988-02-15
SE7811201L (sv) 1978-10-27
JPS5549831B2 (no) 1980-12-15
US4556559A (en) 1985-12-03
DE2559410A1 (de) 1976-09-23
NO150838C (no) 1985-01-09
NZ177159A (en) 1978-03-06
DE2517316A1 (de) 1975-10-23
DE2559411C2 (de) 1982-07-01
SE8306328D0 (sv) 1983-11-16
FI54144B (fi) 1978-06-30
CH629252A5 (de) 1982-04-15
CA1059050A (en) 1979-07-24
NO791956L (no) 1975-10-21

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