JPS5549832B2 - - Google Patents

Info

Publication number
JPS5549832B2
JPS5549832B2 JP4025977A JP4025977A JPS5549832B2 JP S5549832 B2 JPS5549832 B2 JP S5549832B2 JP 4025977 A JP4025977 A JP 4025977A JP 4025977 A JP4025977 A JP 4025977A JP S5549832 B2 JPS5549832 B2 JP S5549832B2
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP4025977A
Other versions
JPS533588A (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27448389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5549832(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB17410/74A external-priority patent/GB1508977A/en
Application filed filed Critical
Publication of JPS533588A publication Critical patent/JPS533588A/ja
Publication of JPS5549832B2 publication Critical patent/JPS5549832B2/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D503/00Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465Streptomyces
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
JP4025977A 1974-04-20 1977-04-05 Production of antibiotic Granted JPS533588A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB17410/74A GB1508977A (en) 1974-04-20 1974-04-20 Beta-lactam antibiotic from streptomyces clavuligerus
GB2771574 1974-06-21
GB4365174 1974-10-09
GB5352574 1974-12-11

Publications (2)

Publication Number Publication Date
JPS533588A JPS533588A (en) 1978-01-13
JPS5549832B2 true JPS5549832B2 (ja) 1980-12-15

Family

ID=27448389

Family Applications (7)

Application Number Title Priority Date Filing Date
JP50048086A Expired JPS521996B2 (ja) 1974-04-20 1975-04-19
JP50048087A Expired JPS5246957B2 (ja) 1974-04-20 1975-04-19
JP4026177A Pending JPS533590A (en) 1974-04-20 1977-04-05 Purification of antibiotic
JP4025877A Granted JPS532495A (en) 1974-04-20 1977-04-05 Method of purifying antibiotics
JP4026077A Granted JPS533589A (en) 1974-04-20 1977-04-05 Purification of antibiotic
JP4025777A Granted JPS532494A (en) 1974-04-20 1977-04-05 Process for preparing antibiotics
JP4025977A Granted JPS533588A (en) 1974-04-20 1977-04-05 Production of antibiotic

Family Applications Before (6)

Application Number Title Priority Date Filing Date
JP50048086A Expired JPS521996B2 (ja) 1974-04-20 1975-04-19
JP50048087A Expired JPS5246957B2 (ja) 1974-04-20 1975-04-19
JP4026177A Pending JPS533590A (en) 1974-04-20 1977-04-05 Purification of antibiotic
JP4025877A Granted JPS532495A (en) 1974-04-20 1977-04-05 Method of purifying antibiotics
JP4026077A Granted JPS533589A (en) 1974-04-20 1977-04-05 Purification of antibiotic
JP4025777A Granted JPS532494A (en) 1974-04-20 1977-04-05 Process for preparing antibiotics

Country Status (26)

Country Link
US (5) US4427690A (ja)
JP (7) JPS521996B2 (ja)
AR (3) AR206627A1 (ja)
CA (1) CA1059050A (ja)
CH (2) CH629252A5 (ja)
CY (1) CY1078A (ja)
DD (2) DD132297A5 (ja)
DE (4) DE2560074C2 (ja)
DK (1) DK141254B (ja)
FI (1) FI54144C (ja)
FR (1) FR2267778B1 (ja)
HK (1) HK54780A (ja)
IE (1) IE41109B1 (ja)
IL (1) IL47087A (ja)
IN (1) IN140042B (ja)
KE (1) KE3076A (ja)
LU (1) LU72322A1 (ja)
MY (1) MY8100195A (ja)
NL (1) NL163824C (ja)
NO (3) NO145247C (ja)
NZ (1) NZ177159A (ja)
OA (1) OA05203A (ja)
PH (1) PH16474A (ja)
RO (2) RO77320A (ja)
SE (8) SE422063B (ja)
YU (3) YU39941B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6353900B2 (ja) * 1981-06-22 1988-10-26 Kurosaki Refractories Co

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
YU40452B (en) * 1975-02-07 1986-02-28 Beecham Group Plc Process for the elimination of contaminating impurities from clavulinic acid
JPS596796Y2 (ja) * 1975-04-04 1984-03-01 株式会社東芝 脱水兼用洗濯機
US6218380B1 (en) * 1975-04-17 2001-04-17 Smithkline Beecham P.L.C. Pharmaceutical compositions
US6051703C1 (en) * 1975-04-17 2001-10-06 Smithkline Beecham Plc Purified clavulanic acid and salts thereof
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
US4230622A (en) * 1975-12-17 1980-10-28 Glaxo Laboratories Limited Halogen derivatives of clavulaic acid
GB1515241A (en) * 1976-01-27 1978-06-21 Beecham Group Ltd Beta-lactam antibiotics
DK250477A (da) * 1976-06-08 1977-12-09 Glaxo Lab Ltd Fremgangsmade til fremstilling af clavamforbindelser
GB1562802A (en) * 1976-06-26 1980-03-19 Beecham Group Ltd Pharmaceutical compositions containing containing clavulanic acid
GB1562902A (en) * 1976-06-30 1980-03-19 Beecham Group Ltd Pharmaceutical compositions containing clavulanic acid
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB1594001A (en) * 1977-03-16 1981-07-30 Beecham Group Ltd Pellets suitable for use in the testing of microorganisms
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DE2912511C2 (de) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmazeutische Zusammensetzung, enthaltend Penicillansäure
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
JPS54126735A (en) * 1978-03-24 1979-10-02 Toyama Chem Co Ltd Bactericidal composition for medical use
DE2964817D1 (en) * 1978-09-06 1983-03-24 Beecham Group Plc Pharmaceutical compositions containing two beta-lactam derivatives
JPS5545906U (ja) * 1978-09-21 1980-03-26
US4202819A (en) * 1979-05-04 1980-05-13 Hoffman-La Roche Inc. 2-(3-Alanyl)clavam antibiotic
DK330880A (da) * 1979-08-03 1981-02-04 Beecham Group Ltd Fremgangsmaade til fremstilling af clavulansyrederivater
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
NZ199061A (en) * 1980-12-09 1984-10-19 Beecham Group Ltd 9-(n-tetrazolyl)-deoxyclavulanic acids,salts,esters,and pharmaceutical compositions
US4562182A (en) * 1980-12-23 1985-12-31 Beecham Group P.L.C. Compounds containing beta-lactams
US4533542A (en) * 1983-08-22 1985-08-06 Eli Lilly And Company Pharmaceutical compositions for storage in plastic containers and process therefor
US4684643A (en) * 1983-08-22 1987-08-04 Eli Lilly And Company Pharmaceutical compositions for storage in plastic containers and process therefor
IT1207982B (it) * 1983-10-07 1989-06-01 Lisapharma Spa Composizioni farmaceutiche adattivita' antibiotica.
JPS60151610U (ja) * 1984-03-22 1985-10-08 住友重機械工業株式会社 回転ホイ−ル式連続金属押出装置におけるアバツトメント
JPS6155889A (ja) * 1984-08-28 1986-03-20 松下電器産業株式会社 高周波加熱装置
US4757066A (en) * 1984-10-15 1988-07-12 Sankyo Company Limited Composition containing a penem or carbapenem antibiotic and the use of the same
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
GB9009446D0 (en) * 1990-04-26 1990-06-20 Beecham Group Plc Veterinary composition
DE4027928A1 (de) * 1990-09-04 1992-03-05 Bayer Ag Neue 2-tert.substituierte methyl-oxapenem-3-carbonsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung
DE4030706A1 (de) * 1990-09-28 1992-04-02 Bayer Ag Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB9201639D0 (en) * 1992-01-25 1992-03-11 Smithkline Beecham Plc Pharmaceutical formulations
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
AU5863894A (en) * 1993-01-22 1994-08-15 Smithkline Beecham Plc Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
US5760218A (en) * 1993-03-26 1998-06-02 Gist-Brocades N.V. Diamine salts of clavulanic acid
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
US5741903A (en) * 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
DE647229T1 (de) * 1993-03-26 1996-01-18 Gist Brocades Nv Diaminsalze von clavulansäure.
GB9315393D0 (en) * 1993-07-24 1993-09-08 Smithkline Beecham Plc Novel product
US20030219867A1 (en) * 1993-07-24 2003-11-27 Smithkline Beecham Plc Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
US20030109503A1 (en) * 1995-06-06 2003-06-12 Smithkline Beecham P.L.C. Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
DE69617036T2 (de) * 1995-09-07 2002-07-11 Smithkline Beecham Corp Verwendung einer amoxicillin und clavulanat enthaltenden paediatrischen pharmazeutischen formulierung
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
US20030124187A1 (en) * 1997-02-14 2003-07-03 Smithkline Beecham Laboratoires Pharmaceutiques, Pharmaceutical formulations comprising amoxycillin and clavulanate
PL335227A1 (en) * 1997-02-20 2000-04-10 Dsm Nv Industrial-scale production of valuable compounds by fermentation in a chemically defined medium
AR015825A1 (es) * 1997-05-28 2001-05-30 Gist Brocades Bv Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato
EP1097238A1 (en) * 1998-07-03 2001-05-09 Dsm N.V. Fermentation process to produce clavulanic acid at a low concentration of free amino acids
US7250176B1 (en) * 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
US6294199B1 (en) 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
EP1330236A2 (en) 2000-10-12 2003-07-30 Beecham Pharmaceuticals (Pte) Limited Formulation containing amoxicillin
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
CA2533292C (en) 2003-07-21 2013-12-31 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
CA2533178C (en) 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005009364A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005016311A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
AU2004264356B2 (en) 2003-08-12 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
JP5686494B2 (ja) 2003-08-29 2015-03-18 シオノギ インコーポレイテッド 抗生物質製剤、その使用法及び作成方法
EP1663169A4 (en) 2003-09-15 2010-11-24 Middlebrook Pharmaceuticals In ANTIBIOTICS, ITS USE AND FORMULATION
JP2008505124A (ja) 2004-07-02 2008-02-21 アドバンシス ファーマスーティカル コーポレイション パルス送達用錠剤
US20060194285A1 (en) * 2005-02-08 2006-08-31 Wei Lian Biological production of clavulanic acid and related compounds
DE102005009277B4 (de) * 2005-02-25 2008-07-31 Johnson Controls Interiors Gmbh & Co. Kg Halterung für eine Komponente
DK2484680T3 (da) * 2005-12-07 2013-09-08 Basilea Pharmaceutica Ag Nyttige kombinationer af monolactam-antibiotika med beta-lactamase-inhibitorer
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US20070218038A1 (en) 2006-03-17 2007-09-20 Pegasus Biologics, Inc. Stabilized, sterilized collagen scaffolds with active adjuncts attached
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
WO2011152806A1 (en) 2010-06-03 2011-12-08 Mahmut Bilgic Production method for the effervescent formulation comprising cephalosporin and potassium clavulanate
US9422314B2 (en) 2012-12-07 2016-08-23 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
CN105101970B (zh) 2013-01-10 2018-11-20 维纳拓尔斯制药公司 β-内酰胺酶抑制剂
EP2970340B1 (en) 2013-03-14 2020-02-12 Venatorx Pharmaceuticals, Inc. Beta-lactamase inhibitors
US20150361108A1 (en) * 2014-06-11 2015-12-17 VenatoRx Pharmaceuticals, Inc. Orally bioavailable beta-lactamase inhibitors
US9511142B2 (en) 2014-06-11 2016-12-06 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
CN106687465B (zh) 2014-06-11 2019-04-16 维纳拓尔斯制药公司 β-内酰胺酶抑制剂
US10399996B2 (en) 2015-09-11 2019-09-03 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
WO2017100537A1 (en) 2015-12-10 2017-06-15 VenatoRx Pharmaceuticals, Inc. Beta-lactamase inhibitors
WO2018013870A1 (en) 2016-07-14 2018-01-18 Achaogen, Inc. Combination of ceftibuten and clavulanic acid for use in the treatment of bacterial infections
WO2018027062A1 (en) 2016-08-04 2018-02-08 VenatoRx Pharmaceuticals, Inc. Boron-containing compounds
WO2018218154A1 (en) 2017-05-26 2018-11-29 VenatoRx Pharmaceuticals, Inc. Penicillin-binding protein inhibitors
WO2018218190A1 (en) 2017-05-26 2018-11-29 VenatoRx Pharmaceuticals, Inc. Penicillin-binding protein inhibitors
EP4049036A1 (en) 2019-10-25 2022-08-31 Instrumentation Laboratory Company Biocide compositions compatible with enzyme biosensors and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3801464A (en) 1972-02-09 1974-04-02 Lilly Co Eli Antibiotic a16886 and process for production thereof
NZ177159A (en) 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
US4140764A (en) * 1974-12-18 1979-02-20 Beecham Group Limited β-Lactamase inhibitors and process for their preparation
US4123540A (en) * 1974-12-18 1978-10-31 Beecham Group Limited Isoclavulanic acid as an antibacterial and a β-lactamase inhibitor
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
YU40452B (en) * 1975-02-07 1986-02-28 Beecham Group Plc Process for the elimination of contaminating impurities from clavulinic acid
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6353900B2 (ja) * 1981-06-22 1988-10-26 Kurosaki Refractories Co

Also Published As

Publication number Publication date
HK54780A (en) 1980-10-03
CY1078A (en) 1980-12-27
JPS5549833B2 (ja) 1980-12-15
NO145247B (no) 1981-11-02
US4560552A (en) 1985-12-24
IE41109B1 (en) 1979-10-24
DK167275A (ja) 1975-10-21
JPS5549830B2 (ja) 1980-12-15
SE8605405L (sv) 1986-12-16
FI54144B (fi) 1978-06-30
JPS532494A (en) 1978-01-11
LU72322A1 (ja) 1975-08-20
US4560552C1 (en) 2001-10-16
SE435286B (sv) 1984-09-17
US4427690A (en) 1984-01-24
SE7504541L (ja) 1975-10-18
NL7504621A (nl) 1975-10-22
JPS5549831B2 (ja) 1980-12-15
SE446687B (sv) 1986-10-06
DE2559410A1 (de) 1976-09-23
YU90875A (en) 1982-05-31
NO145247C (no) 1982-02-10
NO791956L (no) 1975-10-21
US4525352A (en) 1985-06-25
SE443562B (sv) 1986-03-03
RO69984A (ro) 1980-12-30
SE453600B (sv) 1988-02-15
NO150838C (no) 1985-01-09
SE8306328D0 (sv) 1983-11-16
JPS533589A (en) 1978-01-13
SE8306328L (sv) 1983-11-16
DE2517316C2 (de) 1985-03-07
YU42745B (en) 1988-12-31
US4556559A (en) 1985-12-03
CH630631A5 (de) 1982-06-30
JPS50142591A (ja) 1975-11-17
JPS533588A (en) 1978-01-13
AR206627A1 (es) 1976-08-06
SE7811202L (sv) 1978-10-27
IN140042B (ja) 1976-09-04
KE3076A (en) 1980-10-03
OA05203A (fr) 1981-02-28
DK141254B (da) 1980-02-11
JPS533590A (en) 1978-01-13
NL163824C (nl) 1980-10-15
NZ177159A (en) 1978-03-06
DK141254C (ja) 1980-08-11
SE7811201L (sv) 1978-10-27
DD132297A5 (de) 1978-09-20
MY8100195A (en) 1981-12-31
NO801852L (no) 1975-10-21
SE7811203L (sv) 1978-10-27
JPS50142789A (ja) 1975-11-17
YU274381A (en) 1983-06-30
JPS532495A (en) 1978-01-11
IE41109L (en) 1975-10-20
AR219050A1 (es) 1980-07-31
DE2560074C2 (de) 1985-03-28
YU39941B (en) 1985-06-30
NL163824B (nl) 1980-05-16
JPS5246957B2 (ja) 1977-11-29
IL47087A (en) 1979-07-25
RO77320A (ro) 1981-08-17
FI751133A (ja) 1975-10-21
DE2559411A1 (de) 1976-10-21
NO751407L (ja) 1975-10-21
YU274481A (en) 1983-06-30
YU42744B (en) 1988-12-31
SE435287B (sv) 1984-09-17
PH16474A (en) 1983-10-25
IL47087A0 (en) 1975-06-25
FR2267778B1 (ja) 1978-11-17
US4526783A (en) 1985-07-02
SE7811200L (sv) 1978-10-27
SE8105829L (sv) 1981-10-02
CH629252A5 (de) 1982-04-15
FI54144C (fi) 1978-10-10
DE2559411C2 (de) 1982-07-01
AR216430A1 (es) 1979-12-28
CA1059050A (en) 1979-07-24
FR2267778A1 (ja) 1975-11-14
SE8605405D0 (sv) 1986-12-16
SE422063B (sv) 1982-02-15
NO150838B (no) 1984-09-17
DD121799A5 (ja) 1976-08-20
JPS521996B2 (ja) 1977-01-19
DE2517316A1 (de) 1975-10-23

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