IL47087A - Antibiotic compounds obtained from streptomyces clavuligerus their preparation and pharmaceutical compositions containig them - Google Patents

Antibiotic compounds obtained from streptomyces clavuligerus their preparation and pharmaceutical compositions containig them

Info

Publication number
IL47087A
IL47087A IL47087A IL4708775A IL47087A IL 47087 A IL47087 A IL 47087A IL 47087 A IL47087 A IL 47087A IL 4708775 A IL4708775 A IL 4708775A IL 47087 A IL47087 A IL 47087A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compounds obtained
antibiotic compounds
streptomyces clavuligerus
Prior art date
Application number
IL47087A
Other languages
English (en)
Other versions
IL47087A0 (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27448389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL47087(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB17410/74A external-priority patent/GB1508977A/en
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of IL47087A0 publication Critical patent/IL47087A0/xx
Publication of IL47087A publication Critical patent/IL47087A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL47087A 1974-04-20 1975-04-14 Antibiotic compounds obtained from streptomyces clavuligerus their preparation and pharmaceutical compositions containig them IL47087A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB17410/74A GB1508977A (en) 1974-04-20 1974-04-20 Beta-lactam antibiotic from streptomyces clavuligerus
GB2771574 1974-06-21
GB4365174 1974-10-09
GB5352574 1974-12-11

Publications (2)

Publication Number Publication Date
IL47087A0 IL47087A0 (en) 1975-06-25
IL47087A true IL47087A (en) 1979-07-25

Family

ID=27448389

Family Applications (1)

Application Number Title Priority Date Filing Date
IL47087A IL47087A (en) 1974-04-20 1975-04-14 Antibiotic compounds obtained from streptomyces clavuligerus their preparation and pharmaceutical compositions containig them

Country Status (26)

Country Link
US (5) US4427690A (ro)
JP (7) JPS5246957B2 (ro)
AR (3) AR206627A1 (ro)
CA (1) CA1059050A (ro)
CH (2) CH629252A5 (ro)
CY (1) CY1078A (ro)
DD (2) DD121799A5 (ro)
DE (4) DE2560074C2 (ro)
DK (1) DK141254B (ro)
FI (1) FI54144C (ro)
FR (1) FR2267778B1 (ro)
HK (1) HK54780A (ro)
IE (1) IE41109B1 (ro)
IL (1) IL47087A (ro)
IN (1) IN140042B (ro)
KE (1) KE3076A (ro)
LU (1) LU72322A1 (ro)
MY (1) MY8100195A (ro)
NL (1) NL163824C (ro)
NO (3) NO145247C (ro)
NZ (1) NZ177159A (ro)
OA (1) OA05203A (ro)
PH (1) PH16474A (ro)
RO (2) RO69984A (ro)
SE (8) SE422063B (ro)
YU (3) YU39941B (ro)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
SE421796B (sv) * 1975-02-07 1982-02-01 Glaxo Lab Ltd Forfarande for rening av klavulansyra och dess salter
JPS596796Y2 (ja) * 1975-04-04 1984-03-01 株式会社東芝 脱水兼用洗濯機
US6031093C1 (en) * 1975-04-17 2001-10-16 Smithkline Beecham Plc Solid salts of clavulanic acid
US6218380B1 (en) * 1975-04-17 2001-04-17 Smithkline Beecham P.L.C. Pharmaceutical compositions
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
US4230622A (en) * 1975-12-17 1980-10-28 Glaxo Laboratories Limited Halogen derivatives of clavulaic acid
GB1515241A (en) * 1976-01-27 1978-06-21 Beecham Group Ltd Beta-lactam antibiotics
DK250477A (da) * 1976-06-08 1977-12-09 Glaxo Lab Ltd Fremgangsmade til fremstilling af clavamforbindelser
GB1562802A (en) * 1976-06-26 1980-03-19 Beecham Group Ltd Pharmaceutical compositions containing containing clavulanic acid
GB1562902A (en) * 1976-06-30 1980-03-19 Beecham Group Ltd Pharmaceutical compositions containing clavulanic acid
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB1594001A (en) * 1977-03-16 1981-07-30 Beecham Group Ltd Pellets suitable for use in the testing of microorganisms
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DE2912511C2 (de) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmazeutische Zusammensetzung, enthaltend Penicillansäure
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
JPS54126735A (en) * 1978-03-24 1979-10-02 Toyama Chem Co Ltd Bactericidal composition for medical use
DE2964817D1 (en) * 1978-09-06 1983-03-24 Beecham Group Plc Pharmaceutical compositions containing two beta-lactam derivatives
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DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
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ATE327340T1 (de) * 1997-02-20 2006-06-15 Dsm Ip Assets Bv Fermentative herstellung von wertstoffen in industriellem umfang durch verwendung von chemisch definierten media
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JP2008505124A (ja) 2004-07-02 2008-02-21 アドバンシス ファーマスーティカル コーポレイション パルス送達用錠剤
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CN114846332A (zh) 2019-10-25 2022-08-02 仪器实验室公司 与酶生物传感器相容的杀生物剂组合物及其使用方法

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US3801464A (en) 1972-02-09 1974-04-02 Lilly Co Eli Antibiotic a16886 and process for production thereof
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4140764A (en) * 1974-12-18 1979-02-20 Beecham Group Limited β-Lactamase inhibitors and process for their preparation
US4123540A (en) * 1974-12-18 1978-10-31 Beecham Group Limited Isoclavulanic acid as an antibacterial and a β-lactamase inhibitor
SE421796B (sv) * 1975-02-07 1982-02-01 Glaxo Lab Ltd Forfarande for rening av klavulansyra och dess salter
US4144242A (en) * 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration

Also Published As

Publication number Publication date
JPS533590A (en) 1978-01-13
US4556559A (en) 1985-12-03
IN140042B (ro) 1976-09-04
SE8306328L (sv) 1983-11-16
SE8105829L (sv) 1981-10-02
YU39941B (en) 1985-06-30
JPS532495A (en) 1978-01-11
FR2267778A1 (ro) 1975-11-14
JPS5549831B2 (ro) 1980-12-15
YU42745B (en) 1988-12-31
NO791956L (no) 1975-10-21
US4560552A (en) 1985-12-24
SE7811202L (sv) 1978-10-27
SE453600B (sv) 1988-02-15
JPS521996B2 (ro) 1977-01-19
SE7811203L (sv) 1978-10-27
IL47087A0 (en) 1975-06-25
DE2517316A1 (de) 1975-10-23
DD132297A5 (de) 1978-09-20
SE7504541L (ro) 1975-10-18
IE41109L (en) 1975-10-20
DE2560074C2 (de) 1985-03-28
CY1078A (en) 1980-12-27
YU90875A (en) 1982-05-31
RO69984A (ro) 1980-12-30
KE3076A (en) 1980-10-03
US4560552C1 (en) 2001-10-16
DE2559410A1 (de) 1976-09-23
JPS5549830B2 (ro) 1980-12-15
YU274381A (en) 1983-06-30
CA1059050A (en) 1979-07-24
DE2559411C2 (de) 1982-07-01
DK167275A (ro) 1975-10-21
DK141254C (ro) 1980-08-11
DE2559411A1 (de) 1976-10-21
CH629252A5 (de) 1982-04-15
NL163824C (nl) 1980-10-15
SE435286B (sv) 1984-09-17
US4427690A (en) 1984-01-24
AR216430A1 (es) 1979-12-28
SE7811200L (sv) 1978-10-27
DD121799A5 (ro) 1976-08-20
SE443562B (sv) 1986-03-03
DK141254B (da) 1980-02-11
NO801852L (no) 1975-10-21
NZ177159A (en) 1978-03-06
NO751407L (ro) 1975-10-21
YU274481A (en) 1983-06-30
JPS50142591A (ro) 1975-11-17
US4525352A (en) 1985-06-25
NO150838B (no) 1984-09-17
MY8100195A (en) 1981-12-31
SE8605405D0 (sv) 1986-12-16
FI54144B (fi) 1978-06-30
US4526783A (en) 1985-07-02
YU42744B (en) 1988-12-31
CH630631A5 (de) 1982-06-30
NO150838C (no) 1985-01-09
RO77320A (ro) 1981-08-17
SE435287B (sv) 1984-09-17
HK54780A (en) 1980-10-03
JPS533589A (en) 1978-01-13
OA05203A (fr) 1981-02-28
JPS532494A (en) 1978-01-11
NL7504621A (nl) 1975-10-22
JPS5549832B2 (ro) 1980-12-15
FI751133A (ro) 1975-10-21
FR2267778B1 (ro) 1978-11-17
AR219050A1 (es) 1980-07-31
SE7811201L (sv) 1978-10-27
DE2517316C2 (de) 1985-03-07
FI54144C (fi) 1978-10-10
SE8306328D0 (sv) 1983-11-16
LU72322A1 (ro) 1975-08-20
SE446687B (sv) 1986-10-06
NL163824B (nl) 1980-05-16
SE422063B (sv) 1982-02-15
SE8605405L (sv) 1986-12-16
JPS50142789A (ro) 1975-11-17
IE41109B1 (en) 1979-10-24
JPS5246957B2 (ro) 1977-11-29
NO145247B (no) 1981-11-02
JPS5549833B2 (ro) 1980-12-15
AR206627A1 (es) 1976-08-06
JPS533588A (en) 1978-01-13
NO145247C (no) 1982-02-10
PH16474A (en) 1983-10-25

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