PL369107A1 - Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same - Google Patents

Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Info

Publication number
PL369107A1
PL369107A1 PL02369107A PL36910702A PL369107A1 PL 369107 A1 PL369107 A1 PL 369107A1 PL 02369107 A PL02369107 A PL 02369107A PL 36910702 A PL36910702 A PL 36910702A PL 369107 A1 PL369107 A1 PL 369107A1
Authority
PL
Poland
Prior art keywords
sub
hydrogen
stands
alkyl
carbon atoms
Prior art date
Application number
PL02369107A
Other languages
English (en)
Polish (pl)
Inventor
Jozsef Barkoczy
Gyula Simig
Nagy Peter Kotay
György Levay
Istvan Gacsalyi
Marko Bernadett Martonne
Eva Schmidt
Andras Egyed
Hajnalka Kompagne
Csilla Leveleki
Kovacs Aniko Miklosne
Gabor Szenasi
Janos Wellmann
Laszlo Gabor Harsing
Original Assignee
Egis Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.
Publication of PL369107A1 publication Critical patent/PL369107A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL02369107A 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same PL369107A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0103912A HU227237B1 (en) 2001-09-27 2001-09-27 Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
PL369107A1 true PL369107A1 (en) 2005-04-18

Family

ID=89979721

Family Applications (2)

Application Number Title Priority Date Filing Date
PL02369256A PL369256A1 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
PL02369107A PL369107A1 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL02369256A PL369256A1 (en) 2001-09-27 2002-09-26 Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Country Status (25)

Country Link
US (2) US6930110B2 (enExample)
EP (2) EP1430034B1 (enExample)
JP (2) JP4472337B2 (enExample)
KR (2) KR100911069B1 (enExample)
CN (3) CN1325489C (enExample)
AT (2) ATE288899T1 (enExample)
AU (2) AU2002328166B2 (enExample)
BR (2) BR0212839A (enExample)
CA (2) CA2461510C (enExample)
CZ (2) CZ2004528A3 (enExample)
DE (2) DE60202969T2 (enExample)
DK (2) DK1430034T3 (enExample)
EA (2) EA006392B1 (enExample)
ES (2) ES2237696T3 (enExample)
HU (1) HU227237B1 (enExample)
MA (2) MA27137A1 (enExample)
MX (2) MXPA04002838A (enExample)
NO (2) NO326370B1 (enExample)
NZ (2) NZ532103A (enExample)
PL (2) PL369256A1 (enExample)
PT (2) PT1430047E (enExample)
SI (2) SI1430034T1 (enExample)
SK (2) SK1892004A3 (enExample)
WO (2) WO2003027097A1 (enExample)
ZA (2) ZA200402544B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60231507D1 (de) 2001-07-20 2010-07-01 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
HU227592B1 (en) * 2002-11-13 2011-09-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
KR20100049500A (ko) * 2007-03-15 2010-05-12 쉐링 코포레이션 글루칸 신타제 억제제로서 유용한 피리다지논 유도체
JP6942896B2 (ja) * 2018-04-30 2021-09-29 ライボン・セラピューティクス・インコーポレイテッドＲｉｂｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｐａｒｐ７阻害剤としてのピリダジノン
CN109053693B (zh) 2018-09-20 2021-02-05 顺毅股份有限公司 哒嗪胺类化合物的制备及其应用
US12371421B2 (en) 2019-04-29 2025-07-29 Ribon Therapeutics, Inc. Solid forms of a PARP7 inhibitor
WO2022188889A1 (zh) * 2021-03-12 2022-09-15 杭州英创医药科技有限公司 作为parp7抑制剂的化合物
CN115490671B (zh) * 2022-10-21 2024-05-14 水木未来(北京)科技有限公司 Parp7抑制剂及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH557820A (de) * 1970-11-12 1975-01-15 Sandoz Ag Verfahren zur herstellung von neuen 2-(2-hydroxyalkyl)4,5-dihydro-pyridazin (2h)-3-onen.
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
PL164079B1 (pl) * 1990-06-15 1994-06-30 Akad Medyczna posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu
HU209388B (en) * 1990-12-27 1994-05-30 Richter Gedeon Vegyeszet Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
HU224067B1 (hu) * 1995-05-29 2005-05-30 Gyógyszerkutató Intézet Kft. 3(2H)-Piridazinon-származékok és e vegyületeket tartalmazó gyógyszerkészítmények
CN1205190C (zh) * 1998-06-05 2005-06-08 埃吉斯药物工厂 制备3(2h)－哒嗪酮－4－取代氨基－5－氯－衍生物的方法

Also Published As

Publication number Publication date
SI1430034T1 (en) 2005-08-31
NZ532103A (en) 2005-08-26
ES2237690T3 (es) 2005-08-01
CA2461510C (en) 2009-07-07
CZ2004528A3 (cs) 2004-08-18
MA27068A1 (fr) 2004-12-20
CA2461467A1 (en) 2003-04-03
HU0103912D0 (en) 2001-12-28
HK1069816A1 (en) 2005-06-03
US6930110B2 (en) 2005-08-16
DK1430047T3 (da) 2005-06-06
EP1430047A1 (en) 2004-06-23
NZ532104A (en) 2005-10-28
ZA200402544B (en) 2005-04-26
SI1430047T1 (en) 2005-08-31
EA006942B1 (ru) 2006-06-30
US20050043314A1 (en) 2005-02-24
BR0212932A (pt) 2004-10-13
CA2461510A1 (en) 2003-04-03
WO2003027078A1 (en) 2003-04-03
MXPA04002838A (es) 2004-07-05
CN1571783A (zh) 2005-01-26
DE60202970T2 (de) 2006-02-16
SK1892004A3 (en) 2004-10-05
ZA200402545B (en) 2005-04-26
DE60202969T2 (de) 2006-01-19
ATE288899T1 (de) 2005-02-15
WO2003027097A1 (en) 2003-04-03
NO20041551L (no) 2004-06-10
NO20041704L (no) 2004-04-26
DE60202970D1 (de) 2005-03-17
CN100368404C (zh) 2008-02-13
MA27137A1 (fr) 2005-01-03
DK1430034T3 (da) 2005-05-30
JP4472337B2 (ja) 2010-06-02
EA200400470A1 (ru) 2004-08-26
EP1430034B1 (en) 2005-02-09
US20040242873A1 (en) 2004-12-02
HU227237B1 (en) 2010-12-28
HUP0103912A3 (en) 2004-03-01
ES2237696T3 (es) 2005-08-01
EA006392B1 (ru) 2005-12-29
CN101099740A (zh) 2008-01-09
NO325080B1 (no) 2008-01-28
JP2005508914A (ja) 2005-04-07
HUP0103912A2 (hu) 2003-07-28
SK1902004A3 (en) 2004-10-05
AU2002330656B2 (en) 2009-04-09
KR20040039445A (ko) 2004-05-10
AU2002330656B9 (en) 2009-09-03
BR0212839A (pt) 2004-10-13
KR100911069B1 (ko) 2009-08-06
PT1430034E (pt) 2005-06-30
HK1069817A1 (en) 2005-06-03
NO326370B1 (no) 2008-11-17
KR20040039446A (ko) 2004-05-10
EP1430047B1 (en) 2005-02-09
HK1115728A1 (en) 2008-12-05
CN101099740B (zh) 2010-09-08
AU2002330656A2 (en) 2003-04-07
PL369256A1 (en) 2005-04-18
DE60202969D1 (de) 2005-03-17
EP1430034A1 (en) 2004-06-23
CN1325489C (zh) 2007-07-11
EA200400469A1 (ru) 2004-08-26
ATE288910T1 (de) 2005-02-15
AU2002328166B2 (en) 2008-04-17
AU2002328166A2 (en) 2003-04-07
CN1558904A (zh) 2004-12-29
PT1430047E (pt) 2005-06-30
CZ2004532A3 (cs) 2004-08-18
KR100890667B1 (ko) 2009-03-26
JP2005503437A (ja) 2005-02-03
MXPA04002836A (es) 2004-07-05

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Legal Events

Date Code Title Description
VOID Decisions declaring the decisions on the grant of the patent lapsed