PL353092A1 - Sposób wytwarzania estrów nitroksyalkilowych naproksenu - Google Patents

Sposób wytwarzania estrów nitroksyalkilowych naproksenu

Info

Publication number
PL353092A1
PL353092A1 PL00353092A PL35309200A PL353092A1 PL 353092 A1 PL353092 A1 PL 353092A1 PL 00353092 A PL00353092 A PL 00353092A PL 35309200 A PL35309200 A PL 35309200A PL 353092 A1 PL353092 A1 PL 353092A1
Authority
PL
Poland
Prior art keywords
preparation
nitroxyalkylesters
naproxene
naproxene nitroxyalkylesters
naphthyl
Prior art date
Application number
PL00353092A
Other languages
English (en)
Other versions
PL200165B1 (pl
Inventor
Francesca Benedini
Erminio Oldani
Graziano Castaldi
Antonio Tarquini
Original Assignee
Nicox S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox S.A. filed Critical Nicox S.A.
Publication of PL353092A1 publication Critical patent/PL353092A1/pl
Publication of PL200165B1 publication Critical patent/PL200165B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PL353092A 1999-08-04 2000-07-27 Sposób wytwarzania estrów nitroksyalkilowych naproksenu oraz ester nitroksybutylowy kwasu 2-(S)-(6-metoksy-2-naftylo)propanowego o wysokim nadmiarze enancjomerycznym PL200165B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI001753A IT1313596B1 (it) 1999-08-04 1999-08-04 Processo per la preparazione di nitrossialchil esteri del naproxene
PCT/EP2000/007222 WO2001010814A1 (en) 1999-08-04 2000-07-27 Process for the preparation of naproxene nitroxyalkylesters

Publications (2)

Publication Number Publication Date
PL353092A1 true PL353092A1 (pl) 2003-10-06
PL200165B1 PL200165B1 (pl) 2008-12-31

Family

ID=11383500

Family Applications (1)

Application Number Title Priority Date Filing Date
PL353092A PL200165B1 (pl) 1999-08-04 2000-07-27 Sposób wytwarzania estrów nitroksyalkilowych naproksenu oraz ester nitroksybutylowy kwasu 2-(S)-(6-metoksy-2-naftylo)propanowego o wysokim nadmiarze enancjomerycznym

Country Status (23)

Country Link
US (2) US6700011B1 (pl)
EP (2) EP1200386B1 (pl)
JP (2) JP4667691B2 (pl)
KR (1) KR100687820B1 (pl)
CN (1) CN1198786C (pl)
AT (2) ATE251109T1 (pl)
AU (1) AU778694B2 (pl)
BR (1) BRPI0012915B1 (pl)
CA (1) CA2380116C (pl)
DE (2) DE60020753T2 (pl)
DK (2) DK1384707T3 (pl)
ES (2) ES2208390T3 (pl)
HU (1) HU227109B1 (pl)
IL (1) IL147639A0 (pl)
IT (1) IT1313596B1 (pl)
MX (1) MXPA02001256A (pl)
NO (1) NO327669B1 (pl)
PL (1) PL200165B1 (pl)
PT (2) PT1384707E (pl)
RU (1) RU2248348C2 (pl)
TR (1) TR200200290T2 (pl)
WO (1) WO2001010814A1 (pl)
ZA (2) ZA200200478B (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6297260B1 (en) 1998-10-30 2001-10-02 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
JP4092203B2 (ja) 2000-12-21 2008-05-28 ニトロメッド，インク． 新規のシクロオキシゲナーゼ２選択的阻害剤としての置換アリール化合物、組成物、および使用方法
US20050234123A1 (en) * 2001-11-27 2005-10-20 Aldo Belli Process
AU2003248642A1 (en) 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2004004648A2 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
EP1542972A4 (en) 2002-07-29 2008-01-23 Nitromed Inc CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITION AND METHOD OF USE
ITMI20021861A1 (it) 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) * 2002-11-14 2004-05-15 Dinamite Dipharma S P A Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
SI1978947T1 (sl) * 2006-02-03 2014-12-31 Nicox Science Ireland Riverside One Nitrooksiderivati za uporabo pri zdravljenju mišičnih distrofij
CN100427475C (zh) * 2006-11-30 2008-10-22 华南理工大学 萘普生-2-芳基吗啉乙酯及其制备方法与应用
BRPI0813438A2 (pt) * 2007-06-28 2014-12-23 Nicox Sa Processo para preparar um composto, uso de um composto, e, composto.
WO2009149053A2 (en) * 2008-06-02 2009-12-10 Dr. Reddy's Laboratories Ltd. Naproxcinod process and solid dispersion
ITRM20080325A1 (it) 2008-06-20 2009-12-21 Nicox Sa Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en) 2010-03-31 2011-11-16 Lonza Ag Process for the production of esters of nitric acid
TWI417276B (zh) 2011-03-01 2013-12-01 Everlight Chem Ind Corp ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
WO2014111957A1 (en) 2013-01-21 2014-07-24 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents
CA3167343A1 (en) 2020-02-10 2021-08-19 Brigitte DUQUESROIX-CHAKROUN Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57145841A (en) * 1981-03-05 1982-09-09 Nissan Chem Ind Ltd L-menthyl naphthylpropionate and its preparation
IT1243367B (it) 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
CA2190087C (en) * 1994-05-10 2005-08-02 Piero Del Soldato Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) * 1995-08-25 1997-03-05 蔡雄 可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) * 1995-10-09 1997-04-17 Russinsky Limited Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr) 1996-12-12 1999-12-17 Hoechst Marion Roussel Inc Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

Also Published As

Publication number Publication date
HUP0202435A3 (en) 2004-03-01
DE60020753T2 (de) 2006-03-16
IT1313596B1 (it) 2002-09-09
EP1200386B1 (en) 2003-10-01
DK1384707T3 (da) 2005-08-15
ES2208390T3 (es) 2004-06-16
ATE251109T1 (de) 2003-10-15
CN1198786C (zh) 2005-04-27
DK1200386T3 (da) 2003-12-22
PT1200386E (pt) 2004-02-27
AU778694B2 (en) 2004-12-16
CA2380116C (en) 2011-07-05
DE60020753D1 (de) 2005-07-14
HUP0202435A2 (hu) 2002-11-28
IL147639A0 (en) 2002-08-14
EP1200386A1 (en) 2002-05-02
MXPA02001256A (es) 2005-06-06
PL200165B1 (pl) 2008-12-31
NO327669B1 (no) 2009-09-07
RU2248348C2 (ru) 2005-03-20
CA2380116A1 (en) 2001-02-15
TR200200290T2 (tr) 2002-05-21
DE60005682D1 (de) 2003-11-06
CN1367773A (zh) 2002-09-04
KR100687820B1 (ko) 2007-02-28
US7238829B2 (en) 2007-07-03
ITMI991753A0 (it) 1999-08-04
NO20020515D0 (no) 2002-02-01
WO2001010814A1 (en) 2001-02-15
PT1384707E (pt) 2005-08-31
JP2003506425A (ja) 2003-02-18
ZA200200478B (en) 2003-10-29
KR20020013974A (ko) 2002-02-21
EP1384707B1 (en) 2005-06-08
HU227109B1 (en) 2010-07-28
DE60005682T2 (de) 2004-09-16
ATE297372T1 (de) 2005-06-15
US6700011B1 (en) 2004-03-02
AU6438500A (en) 2001-03-05
NO20020515L (no) 2002-02-01
ITMI991753A1 (it) 2001-02-04
BR0012915A (pt) 2002-06-04
JP4667691B2 (ja) 2011-04-13
US20050119339A1 (en) 2005-06-02
ES2243859T3 (es) 2005-12-01
ZA200304525B (en) 2004-04-28
BRPI0012915B1 (pt) 2015-09-01
EP1384707A1 (en) 2004-01-28
JP2011042690A (ja) 2011-03-03

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