PL135822B1 - Method of obtaining novel triple-substituted imidazole derivatives - Google Patents

Method of obtaining novel triple-substituted imidazole derivatives Download PDF

Info

Publication number
PL135822B1
PL135822B1 PL1981232352A PL23235281A PL135822B1 PL 135822 B1 PL135822 B1 PL 135822B1 PL 1981232352 A PL1981232352 A PL 1981232352A PL 23235281 A PL23235281 A PL 23235281A PL 135822 B1 PL135822 B1 PL 135822B1
Authority
PL
Poland
Prior art keywords
acid
group
formula
phenyl
radical
Prior art date
Application number
PL1981232352A
Other languages
English (en)
Polish (pl)
Other versions
PL232352A1 (2
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PL232352A1 publication Critical patent/PL232352A1/xx
Publication of PL135822B1 publication Critical patent/PL135822B1/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46Oxygen atoms
    • C07D213/50Ketonic radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/26Radicals substituted by carbon atoms having three bonds to hetero atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
PL1981232352A 1980-07-25 1981-07-25 Method of obtaining novel triple-substituted imidazole derivatives PL135822B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH571580 1980-07-25

Publications (2)

Publication Number Publication Date
PL232352A1 PL232352A1 (2) 1982-12-20
PL135822B1 true PL135822B1 (en) 1985-12-31

Family

ID=4298165

Family Applications (8)

Application Number Title Priority Date Filing Date
PL23700381A PL237003A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700281A PL237002A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700181A PL237001A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700481A PL237004A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700581A PL237005A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700081A PL237000A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23699781A PL236997A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL1981232352A PL135822B1 (en) 1980-07-25 1981-07-25 Method of obtaining novel triple-substituted imidazole derivatives

Family Applications Before (7)

Application Number Title Priority Date Filing Date
PL23700381A PL237003A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700281A PL237002A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700181A PL237001A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700481A PL237004A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700581A PL237005A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23700081A PL237000A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole
PL23699781A PL236997A1 (en) 1980-07-25 1981-07-25 Process for preparing novel trisubstituted derivatives of imidazole

Country Status (23)

Country Link
US (1) US4447431A (2)
EP (1) EP0045081B1 (2)
JP (1) JPS5756466A (2)
KR (13) KR850000883B1 (2)
AR (1) AR230269A1 (2)
AT (1) ATE17349T1 (2)
AU (2) AU7340481A (2)
CA (1) CA1175431A (2)
DD (2) DD201677A5 (2)
DE (1) DE3173434D1 (2)
DK (1) DK331881A (2)
ES (8) ES504257A0 (2)
FI (1) FI812326L (2)
GB (1) GB2080805B (2)
GR (1) GR75287B (2)
IE (1) IE52071B1 (2)
IL (1) IL63410A (2)
NO (1) NO812542L (2)
NZ (1) NZ197828A (2)
PL (8) PL237003A1 (2)
PT (1) PT73424B (2)
SU (8) SU1235454A3 (2)
ZA (1) ZA815078B (2)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2123831B (en) * 1981-07-20 1986-01-15 Ciba Geigy Ag Trisubstituted oxazo compounds
EP0084756A1 (de) * 1982-01-22 1983-08-03 Ciba-Geigy Ag Trisubstituierte Oxazaverbindungen
FR2633291B1 (fr) * 1988-06-27 1990-09-07 Oreal Derives d'hydroxy-4 isoxazoles, leur procede de preparation et compositions cosmetiques et pharmaceutiques les contenant
US5252322A (en) * 1989-09-22 1993-10-12 The Gillette Company Skin tanning compositions containing imidazoles
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
MX9300141A (es) * 1992-01-13 1994-07-29 Smithkline Beecham Corp Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US5593992A (en) * 1993-07-16 1997-01-14 Smithkline Beecham Corporation Compounds
US5670527A (en) * 1993-07-16 1997-09-23 Smithkline Beecham Corporation Pyridyl imidazole compounds and compositions
US5593991A (en) * 1993-07-16 1997-01-14 Adams; Jerry L. Imidazole compounds, use and process of making
JPH09505055A (ja) * 1993-11-08 1997-05-20 スミスクライン・ビーチャム・コーポレイション サイトカイン媒介疾患治療用オキサゾール
US5723477A (en) * 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
IL118544A (en) 1995-06-07 2001-08-08 Smithkline Beecham Corp History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
US5739143A (en) * 1995-06-07 1998-04-14 Smithkline Beecham Corporation Imidazole compounds and compositions
US6369068B1 (en) 1995-06-07 2002-04-09 Smithkline Beecham Corporation Amino substituted pyrimidine containing compounds
ZA9610687B (en) * 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
ZA97175B (en) * 1996-01-11 1997-11-04 Smithkline Beecham Corp Novel substituted imidazole compounds.
AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
PL187516B1 (pl) * 1996-01-11 2004-07-30 Smithkline Beecham Corp Nowe podstawione pochodne imidazolu, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związki
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
JP2000507558A (ja) * 1996-03-25 2000-06-20 スミスクライン・ビーチャム・コーポレイション Cns損傷についての新規な治療
WO1998007425A1 (en) 1996-08-21 1998-02-26 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
RU2222534C2 (ru) * 1997-04-24 2004-01-27 Орто-Макнейл Фармасьютикал, Инк. Замещенные имидазолы, способ их получения, фармацевтическая композиция на их основе, способы лечения цитокин-опосредованных заболеваний
CA2294057A1 (en) 1997-06-13 1998-12-17 Smithkline Beecham Corporation Novel pyrazole and pyrazoline substituted compounds
AU8154998A (en) 1997-06-19 1999-01-04 Smithkline Beecham Corporation Novel aryloxy substituted pyrimidine imidazole compounds
US6489325B1 (en) 1998-07-01 2002-12-03 Smithkline Beecham Corporation Substituted imidazole compounds
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
TW517055B (en) 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
WO1999001452A1 (en) 1997-07-02 1999-01-14 Smithkline Beecham Corporation Novel cycloalkyl substituted imidazoles
AR016294A1 (es) * 1997-07-02 2001-07-04 Smithkline Beecham Corp Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion
US7301021B2 (en) * 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
WO1999017776A1 (en) 1997-10-08 1999-04-15 Smithkline Beecham Corporation Novel cycloalkenyl substituted compounds
WO1999032121A1 (en) 1997-12-19 1999-07-01 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
CN1548436A (zh) * 1998-05-22 2004-11-24 ʷ��˿�������ȳ�ķ���޹�˾ 新的2-烷基取代咪唑化合物
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
JP2003525201A (ja) * 1998-08-20 2003-08-26 スミスクライン・ビーチャム・コーポレイション 新規な置換トリアゾール化合物
WO2000025791A1 (en) * 1998-11-04 2000-05-11 Smithkline Beecham Corporation Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
WO2000029399A1 (en) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
TR200201364T2 (tr) 1999-11-22 2002-10-21 Smithkline Beecham P. L. C. Yeni bileşikler.
EP1233951B1 (en) 1999-11-23 2005-06-01 SmithKline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
US6759410B1 (en) * 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
ATE305787T1 (de) 1999-11-23 2005-10-15 Smithkline Beecham Corp 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
AU1781601A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
GB0005357D0 (en) 2000-03-06 2000-04-26 Smithkline Beecham Plc Compounds
ES2218391T3 (es) * 2000-03-06 2004-11-16 Smithkline Beecham Plc Derivados de imidazol como inhibidores de raf-cinasa.
ATE521353T1 (de) * 2000-10-23 2011-09-15 Glaxosmithkline Llc Neues trisubstitutiertes 8h-pyridoä2,3- düpyrimidin-7-onderivat zur behandlung von durch csbp/p38kinase vermittelten krankheiten
GB0112348D0 (en) * 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
US20040192689A1 (en) * 2001-09-05 2004-09-30 Dean David Kenneth Heterocycle-carboxamide derivatives as raf kinase inhibitors
BR0215156A (pt) * 2001-12-18 2004-10-19 Hoffmann La Roche Cis-imidazolinas como inibidores de mdm 2
TW200505446A (en) * 2003-01-17 2005-02-16 Fuj Isawa Pharmaceutical Co Ltd Inhibitor of cox
WO2004099130A2 (en) * 2003-05-08 2004-11-18 Astellas Pharma Inc. 1,2-diarylimidazoles useful as inhibitors of cox
EP1865959A2 (en) * 2005-03-25 2007-12-19 Glaxo Group Limited Process for preparing pyridoý2,3-d¨pyrimidin-7-one and 3,4-dihydropyrimidoý4,5-d¨pyrimidin-2(1h)-one derivatives
UY29440A1 (es) 2005-03-25 2006-10-02 Glaxo Group Ltd Nuevos compuestos
WO2013049272A2 (en) 2011-09-29 2013-04-04 Theraceutix, Llc Composition and method for treatment of symptoms associated with various skin conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558645A (en) * 1968-07-08 1971-01-26 Sandoz Ag 2-(4-(4',5-diphenyl - 2 - imidazolyl)-phenoxy) lower aliphatic monocarboxylic acids
CH561202A5 (2) * 1971-05-10 1975-04-30 Ciba Geigy Ag
GB1469532A (en) * 1973-06-28 1977-04-06 Dumex Ltd As Imimdazolyl-alkanoic acid derivatives
US4372964A (en) * 1980-10-30 1983-02-08 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-1H-imidazole-2-methanols

Also Published As

Publication number Publication date
ES8306120A1 (es) 1983-05-16
US4447431A (en) 1984-05-08
ZA815078B (en) 1982-07-28
PL237001A1 (en) 1983-02-28
IE52071B1 (en) 1987-06-10
ES514582A0 (es) 1983-05-16
IL63410A0 (en) 1981-10-30
ES8306124A1 (es) 1983-05-16
KR850002756A (ko) 1985-05-15
SU1205763A3 (ru) 1986-01-15
PL237004A1 (en) 1983-02-28
FI812326A7 (fi) 1982-01-26
ES514580A0 (es) 1983-05-16
KR850002750A (ko) 1985-05-15
IE811680L (en) 1982-01-25
DD202554A5 (de) 1983-09-21
KR850000889B1 (ko) 1985-06-26
ES514579A0 (es) 1983-05-16
ATE17349T1 (de) 1986-01-15
KR850002752A (ko) 1985-05-15
KR850000891B1 (ko) 1985-06-26
KR850002747A (ko) 1985-05-15
KR850002744A (ko) 1985-05-15
SU1145928A3 (ru) 1985-03-15
PL237000A1 (en) 1983-02-28
KR850000890B1 (ko) 1985-06-26
SU1169534A3 (ru) 1985-07-23
IL63410A (en) 1986-04-29
PL232352A1 (2) 1982-12-20
KR850000886B1 (ko) 1985-06-26
ES8306123A1 (es) 1983-05-16
PL237005A1 (en) 1983-02-28
ES514585A0 (es) 1983-07-01
KR850000887B1 (ko) 1985-06-26
ES8306121A1 (es) 1983-05-16
KR850000883B1 (ko) 1985-06-26
ES514584A0 (es) 1983-05-16
FI812326L (fi) 1982-01-26
AR230269A1 (es) 1984-03-01
EP0045081A2 (de) 1982-02-03
CA1175431A (en) 1984-10-02
EP0045081A3 (en) 1982-04-07
SU1235454A3 (ru) 1986-05-30
KR850000892B1 (ko) 1985-06-26
ES8306119A1 (es) 1983-05-16
KR850002753A (ko) 1985-05-15
SU1227112A3 (ru) 1986-04-23
DE3173434D1 (en) 1986-02-20
ES514583A0 (es) 1983-05-16
PT73424B (en) 1983-06-20
KR850002755A (ko) 1985-05-15
GB2080805B (en) 1984-03-07
ES8301472A1 (es) 1982-12-01
ES8307245A1 (es) 1983-07-01
DK331881A (da) 1982-01-26
EP0045081B1 (de) 1986-01-08
KR850002748A (ko) 1985-05-15
PT73424A (en) 1981-08-01
SU1152520A3 (en) 1985-04-23
KR850002745A (ko) 1985-05-15
NO812542L (no) 1982-01-26
KR850002746A (ko) 1985-05-15
SU1138023A3 (ru) 1985-01-30
KR850000885B1 (ko) 1985-06-26
KR850001064B1 (ko) 1985-07-25
AU7340481A (en) 1982-01-28
ES8306122A1 (es) 1983-05-16
KR850002754A (ko) 1985-05-15
SU1205764A3 (ru) 1986-01-15
ES514581A0 (es) 1983-05-16
PL237002A1 (en) 1983-02-28
KR850000873B1 (ko) 1985-06-22
ES504257A0 (es) 1982-12-01
GB2080805A (en) 1982-02-10
KR850000911B1 (ko) 1985-06-27
GR75287B (2) 1984-07-13
KR850000884B1 (ko) 1985-06-26
NZ197828A (en) 1985-11-08
KR850002749A (ko) 1985-05-15
PL237003A1 (en) 1983-02-28
KR830006230A (ko) 1983-09-20
KR850000888B1 (ko) 1985-06-26
PL236997A1 (en) 1983-01-03
AU5655586A (en) 1986-09-11
DD201677A5 (de) 1983-08-03
JPS5756466A (en) 1982-04-05

Similar Documents

Publication Publication Date Title
PL135822B1 (en) Method of obtaining novel triple-substituted imidazole derivatives
EP0040696B1 (en) Aminothiadiazoles as gastric secretion inhibitors
US5446160A (en) Process for preparing imidazopyridine derivatives
JPH0656809A (ja) チアゾールの分枝状アルキルアミノ誘導体、製造方法および医薬組成物
IE862605L (en) Preparation of disubstituted pyridine -2,3- dicarboxylates
AU2006264051B2 (en) Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
EP0130729A2 (en) Alkylthio- and alkylsulfinyl-benzimidazole derivatives
IL290169B1 (en) Process and intermediates for the preparation of pyroxasulfone
US6395902B1 (en) Oxathiazolidinyl pyridines
HU190425B (en) Process for producing n-substituted-2-pyridyl-indole derivatives and pharmaceutical compositions containing them
AU2012349288A1 (en) Pyridone derivative and medicine containing same
CA2028538A1 (en) 4-substituted isoquinolone derivatives, their production and use
GB2125404A (en) Thiazole derivatives
AU2020318159A1 (en) Method for producing morphinan derivative
WO2009123483A1 (en) Process for preparation of telmisartan
US5565479A (en) Condensed thiazole derivative, production process thereof and pharmaceutical composition thereof
US5734059A (en) Production intermediate and process for producing pyridine derivative
El‐Deen Use of 3–(2′‐formyl‐1′‐chlorovinyl) coumarin in the syntheses of pyrazol, salicylaldazine and pyrimidine derivatives
HU200459B (en) New process for producing 7-bromo-beta-carboline compounds
US6555694B1 (en) Method for production of pyrrolidinone derivatives
Kawasaki et al. New access to 1, 3-dialkyl-2, 3-dihydro-2-imino-1 H-imidazoles and their application to the first total synthesis of naamine B, a marine 2, 3-dihydro-2-imino-1, 3-dimethyl-1 H-imidazole alkaloid
EP0811612B1 (en) Process for preparing dithiocarbonimide derivatives
NO148556B (no) Analogifremgangsmaate for fremstilling av farmakologisk aktive triazinoner.
EP0102157B1 (en) Amino pyrimidinones and their preparation
US5077407A (en) Substituted 2-[monoannelated (3,4-,4,5-, and 5,6-) pyridylalkylenesulfinyl]benzimidazoles