NZ525799A - Dipeptide mimetics formed from glutamine and a thiazolidine or pyrrolidine group useful as dipeptidyl peptidase IV effectors - Google Patents
Dipeptide mimetics formed from glutamine and a thiazolidine or pyrrolidine group useful as dipeptidyl peptidase IV effectorsInfo
- Publication number
- NZ525799A NZ525799A NZ525799A NZ52579999A NZ525799A NZ 525799 A NZ525799 A NZ 525799A NZ 525799 A NZ525799 A NZ 525799A NZ 52579999 A NZ52579999 A NZ 52579999A NZ 525799 A NZ525799 A NZ 525799A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pharmaceutical composition
- salts
- exemplified
- composition according
- dipeptide
- Prior art date
Links
- 108010016626 Dipeptides Proteins 0.000 title claims abstract description 26
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 title claims abstract description 7
- 125000000719 pyrrolidinyl group Chemical group 0.000 title claims abstract description 6
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 title claims abstract description 5
- 239000012636 effector Substances 0.000 title abstract description 36
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 title abstract description 8
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 title abstract description 8
- 150000003839 salts Chemical class 0.000 claims abstract description 33
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- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 claims description 3
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| DE19823831A DE19823831A1 (de) | 1998-05-28 | 1998-05-28 | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
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| NZ508260A NZ508260A (en) | 1998-05-28 | 1999-05-28 | Dipeptide mimetics formed from an amino acid and a thiazolidine or pyrrolidine group useful as dipeptidyl peptidase IV effectors |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20020006899A1 (en) * | 1998-10-06 | 2002-01-17 | Pospisilik Andrew J. | Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals |
| BR9813233A (pt) | 1997-09-29 | 2000-08-22 | Point Therapeutics Inc | Estimulação de células hematopoéticas in vitro |
| DE19823831A1 (de) * | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
| DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
| DE19834591A1 (de) * | 1998-07-31 | 2000-02-03 | Probiodrug Ges Fuer Arzneim | Verfahren zur Steigerung des Blutglukosespiegels in Säugern |
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| US6110949A (en) * | 1999-06-24 | 2000-08-29 | Novartis Ag | N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV |
| US6172081B1 (en) * | 1999-06-24 | 2001-01-09 | Novartis Ag | Tetrahydroisoquinoline 3-carboxamide derivatives |
| US6107317A (en) * | 1999-06-24 | 2000-08-22 | Novartis Ag | N-(substituted glycyl)-thiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV |
| US7064145B2 (en) * | 2000-02-25 | 2006-06-20 | Novo Nordisk A/S | Inhibition of beta cell degeneration |
| JP2003523396A (ja) | 2000-02-25 | 2003-08-05 | ノボ ノルディスク アクティーゼルスカブ | ベータ細胞変性の抑制 |
| ES2582376T3 (es) * | 2000-03-31 | 2016-09-12 | Royalty Pharma Collection Trust | Método para la mejora de la señalización de islotes en diabetes mellitus y para su prevención |
| EP1480961B1 (en) * | 2002-02-28 | 2006-12-27 | Prosidion Ltd. | Glutaminyl based dpiv inhibitors |
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1998
- 1998-05-28 DE DE19823831A patent/DE19823831A1/de not_active Withdrawn
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1999
- 1999-05-28 UA UA2000116790A patent/UA54599C2/uk unknown
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- 1999-05-28 DE DE59904100T patent/DE59904100D1/de not_active Expired - Lifetime
- 1999-05-28 HU HU0102001A patent/HUP0102001A3/hu unknown
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- 1999-05-28 KR KR1020007013350A patent/KR100628668B1/ko not_active Expired - Fee Related
- 1999-05-28 DE DE59910084T patent/DE59910084D1/de not_active Expired - Fee Related
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- 1999-05-28 ES ES04005976T patent/ES2271723T3/es not_active Expired - Lifetime
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- 1999-05-28 NZ NZ525799A patent/NZ525799A/en unknown
- 1999-05-28 JP JP2000550837A patent/JP2002516318A/ja active Pending
- 1999-05-28 CN CNA2007101369808A patent/CN101095675A/zh active Pending
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- 1999-05-28 CN CNA2004100833079A patent/CN1637018A/zh active Pending
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- 1999-05-28 EP EP02005352A patent/EP1215207B1/de not_active Expired - Lifetime
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- 1999-05-28 RU RU2003121766/04A patent/RU2309161C2/ru not_active IP Right Cessation
- 1999-05-28 KR KR1020047008261A patent/KR100630258B1/ko not_active Expired - Fee Related
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- 1999-05-28 WO PCT/EP1999/003712 patent/WO1999061431A1/de not_active Ceased
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- 1999-05-28 CN CNA2004100833064A patent/CN1636593A/zh active Pending
- 1999-05-28 PT PT02005353T patent/PT1214936E/pt unknown
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- 1999-05-28 DE DE59913840T patent/DE59913840D1/de not_active Expired - Fee Related
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2000
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2002
- 2002-12-06 HK HK02108901.9A patent/HK1047887B/zh not_active IP Right Cessation
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2003
- 2003-02-10 US US10/361,956 patent/US20030134802A1/en not_active Abandoned
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2004
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2005
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2006
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