NZ503662A - Crystalline polymorph of (-)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]-methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one and its use as a fungicide - Google Patents
Crystalline polymorph of (-)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]-methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one and its use as a fungicideInfo
- Publication number
- NZ503662A NZ503662A NZ503662A NZ50366298A NZ503662A NZ 503662 A NZ503662 A NZ 503662A NZ 503662 A NZ503662 A NZ 503662A NZ 50366298 A NZ50366298 A NZ 50366298A NZ 503662 A NZ503662 A NZ 503662A
- Authority
- NZ
- New Zealand
- Prior art keywords
- triazol
- phenyl
- hydroxylpropyl
- difluorophenyl
- ylmethyl
- Prior art date
Links
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title abstract 2
- 230000000855 fungicidal effect Effects 0.000 title 1
- 239000000417 fungicide Substances 0.000 title 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94618397A | 1997-10-07 | 1997-10-07 | |
| PCT/US1998/020476 WO1999018097A1 (en) | 1997-10-07 | 1998-10-05 | Crystalline antifungal polymorph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ503662A true NZ503662A (en) | 2002-10-25 |
Family
ID=25484068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ503662A NZ503662A (en) | 1997-10-07 | 1998-10-05 | Crystalline polymorph of (-)-4-[4-[4-[4-[[(2R-cis)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)furan-3-yl]-methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1-ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one and its use as a fungicide |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1021439B1 (enExample) |
| JP (4) | JP2001519346A (enExample) |
| KR (1) | KR100626109B1 (enExample) |
| CN (1) | CN1125067C (enExample) |
| AR (1) | AR015947A1 (enExample) |
| AT (1) | ATE263163T1 (enExample) |
| AU (1) | AU759982B2 (enExample) |
| BR (1) | BR9812866A (enExample) |
| CA (1) | CA2305803C (enExample) |
| CO (1) | CO4970829A1 (enExample) |
| CZ (1) | CZ299835B6 (enExample) |
| DE (1) | DE69822859T2 (enExample) |
| DK (1) | DK1021439T3 (enExample) |
| ES (1) | ES2217594T3 (enExample) |
| HU (1) | HU225233B1 (enExample) |
| ID (1) | ID29290A (enExample) |
| IL (1) | IL135331A (enExample) |
| IN (1) | IN1998CH02232A (enExample) |
| MX (1) | MX225999B (enExample) |
| MY (1) | MY130126A (enExample) |
| NO (1) | NO318827B1 (enExample) |
| NZ (1) | NZ503662A (enExample) |
| PE (1) | PE120499A1 (enExample) |
| PH (1) | PH11998002606B1 (enExample) |
| PL (1) | PL189317B1 (enExample) |
| PT (1) | PT1021439E (enExample) |
| SK (1) | SK285190B6 (enExample) |
| TW (1) | TW589310B (enExample) |
| WO (1) | WO1999018097A1 (enExample) |
| ZA (1) | ZA989063B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2130540A1 (en) | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) * | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| EP2451805A1 (en) | 2009-07-09 | 2012-05-16 | Sandoz AG | A crystalline form of posaconazole |
| US9199919B2 (en) | 2010-05-19 | 2015-12-01 | Sandoz Ag | Process for the preparation of chiral hydrazides |
| RU2580318C2 (ru) | 2010-05-19 | 2016-04-10 | Сандоз Аг | Получение промежуточных продуктов для синтеза позаконазола |
| US9206146B2 (en) | 2010-05-19 | 2015-12-08 | Sandoz Ag | Purification of posaconazole and of posaconazole intermediates |
| EP2571871B1 (en) * | 2010-05-19 | 2017-06-21 | Sandoz AG | Process for the preparation of chiral triazolones |
| CN108329303A (zh) | 2011-06-16 | 2018-07-27 | 桑多斯股份公司 | 制备手性化合物的方法 |
| US9102664B2 (en) | 2011-09-19 | 2015-08-11 | Msn Laboratories Private Limited | Process for the preparation of triazole antifungal drug, its intermediates and polymorphs thereof |
| MX370849B (es) * | 2013-07-25 | 2020-01-08 | Sandoz Ag | Proceso mejorado para preparar la forma cristalina iv del posaconazol. |
| ITMI20132117A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132114A1 (it) | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132118A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| ITMI20132115A1 (it) * | 2013-12-18 | 2015-06-19 | Djada Pharmaceutical Sa | Una forma cristallina di posaconazolo |
| KR102331856B1 (ko) | 2014-10-21 | 2021-11-29 | 다케다 야쿠힌 고교 가부시키가이샤 | 결정 형태의 5-클로로-n4-[2-(디메틸포스포릴)페닐]-n2-｛2-메톡시-4-[4-(4-메틸피페라진-1-일)피페리딘-1-일]피리미딘-2,4-디아민 |
| CN104387374A (zh) * | 2014-10-21 | 2015-03-04 | 江苏恒盛药业有限公司 | 泊沙康唑晶型i的制备工艺 |
| CN104370894A (zh) * | 2014-10-21 | 2015-02-25 | 江苏恒盛药业有限公司 | 无定型泊沙康唑的制备工艺 |
| WO2017025292A1 (en) | 2015-08-08 | 2017-02-16 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Gastro-resistant formulation containing posaconazole |
| EA039213B1 (ru) | 2015-12-24 | 2021-12-17 | Такеда Фармасьютикал Компани Лимитед | Сокристалл, способ его получения и лекарственное средство, содержащее сокристалл |
| EP3925601B1 (en) | 2016-02-26 | 2024-07-17 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Gastro-resistant formulation containing posaconazole and a polymeric precipitation inhibitor |
| CN105949278B (zh) * | 2016-03-30 | 2019-12-06 | 南京曼杰生物科技有限公司 | 一种取代的四氢呋喃水溶性衍生物及其应用 |
| WO2017032908A1 (en) | 2016-07-08 | 2017-03-02 | Synthon B.V. | Pharmaceutical composition comprising amorphous posaconazole |
| TR201620462A2 (tr) | 2016-12-31 | 2018-07-23 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ |
| TR201722493A2 (tr) | 2017-12-28 | 2019-07-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Posakonazol i̇çeren kati farmasöti̇k kompozi̇syon |
| WO2022034232A1 (en) | 2020-08-13 | 2022-02-17 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Gastro-resistant high-strength formulation containing posaconazole |
| AU2022324717A1 (en) | 2021-11-25 | 2024-06-13 | Alfred E. Tiefenbacher (Gmbh Und Co. Kg) | Granules containing posaconazole |
| EP4091604B1 (en) | 2021-11-25 | 2024-04-03 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Granules containing posaconazole |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL103558A0 (en) * | 1991-10-30 | 1993-03-15 | Schering Corp | Tri-substituted tetrahydrofuran antifungals |
| PL181193B1 (pl) * | 1993-12-21 | 2001-06-29 | Schering Corp | Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków |
| NZ278882A (en) * | 1994-01-24 | 1997-06-24 | Janssen Pharmaceutica Nv | Piperazine-containing azole antifungal compounds |
| US5625064A (en) * | 1995-04-19 | 1997-04-29 | Schering Corporation | Process for the preparation of triazolones |
| SK27097A3 (en) * | 1995-06-02 | 1997-09-10 | Schering Corp | Tetrahydrofuran antifungals |
-
1998
- 1998-10-05 JP JP2000514908A patent/JP2001519346A/ja not_active Withdrawn
- 1998-10-05 WO PCT/US1998/020476 patent/WO1999018097A1/en not_active Ceased
- 1998-10-05 BR BR9812866-3A patent/BR9812866A/pt not_active Application Discontinuation
- 1998-10-05 CN CN98811886A patent/CN1125067C/zh not_active Expired - Lifetime
- 1998-10-05 ZA ZA989063A patent/ZA989063B/xx unknown
- 1998-10-05 PL PL98339659A patent/PL189317B1/pl unknown
- 1998-10-05 PT PT98951994T patent/PT1021439E/pt unknown
- 1998-10-05 CO CO98057733A patent/CO4970829A1/es unknown
- 1998-10-05 ID IDW20000632A patent/ID29290A/id unknown
- 1998-10-05 NZ NZ503662A patent/NZ503662A/xx not_active IP Right Cessation
- 1998-10-05 CA CA002305803A patent/CA2305803C/en not_active Expired - Lifetime
- 1998-10-05 EP EP98951994A patent/EP1021439B1/en not_active Expired - Lifetime
- 1998-10-05 ES ES98951994T patent/ES2217594T3/es not_active Expired - Lifetime
- 1998-10-05 KR KR20007003709A patent/KR100626109B1/ko not_active Expired - Lifetime
- 1998-10-05 CZ CZ20001264A patent/CZ299835B6/cs not_active IP Right Cessation
- 1998-10-05 IL IL13533198A patent/IL135331A/xx not_active IP Right Cessation
- 1998-10-05 AT AT98951994T patent/ATE263163T1/de active
- 1998-10-05 DE DE69822859T patent/DE69822859T2/de not_active Expired - Lifetime
- 1998-10-05 SK SK512-2000A patent/SK285190B6/sk not_active IP Right Cessation
- 1998-10-05 AU AU97803/98A patent/AU759982B2/en not_active Expired
- 1998-10-05 DK DK98951994T patent/DK1021439T3/da active
- 1998-10-05 AR ARP980104957A patent/AR015947A1/es not_active Application Discontinuation
- 1998-10-05 HU HU0004899A patent/HU225233B1/hu unknown
- 1998-10-05 PE PE1998000942A patent/PE120499A1/es not_active IP Right Cessation
- 1998-10-06 TW TW087116562A patent/TW589310B/zh not_active IP Right Cessation
- 1998-10-06 MY MYPI98004576A patent/MY130126A/en unknown
- 1998-10-06 IN IN2232CH1998 patent/IN1998CH02232A/en unknown
- 1998-10-06 PH PH11998002606A patent/PH11998002606B1/en unknown
-
2000
- 2000-04-06 NO NO20001779A patent/NO318827B1/no not_active IP Right Cessation
- 2000-04-06 MX MXPA00003404 patent/MX225999B/es active IP Right Grant
-
2008
- 2008-01-04 JP JP2008000110A patent/JP2008106075A/ja not_active Withdrawn
-
2012
- 2012-05-18 JP JP2012114724A patent/JP2012153729A/ja active Pending
- 2012-05-18 JP JP2012114725A patent/JP2012153730A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired |