LU88778I2 - Anastrozole optionellement sous forme d'un sel d'addition d'acide pharmaceutiquement acceptable (Arimidex (R)) - Google Patents
Anastrozole optionellement sous forme d'un sel d'addition d'acide pharmaceutiquement acceptable (Arimidex (R))Info
- Publication number
- LU88778I2 LU88778I2 LU88778C LU88778C LU88778I2 LU 88778 I2 LU88778 I2 LU 88778I2 LU 88778 C LU88778 C LU 88778C LU 88778 C LU88778 C LU 88778C LU 88778 I2 LU88778 I2 LU 88778I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- radical
- cyano
- hydroxy
- alkyl
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878714013A GB8714013D0 (en) | 1987-06-16 | 1987-06-16 | (substituted-aralkyl)heterocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
LU88778I2 true LU88778I2 (fr) | 1996-11-05 |
Family
ID=10618970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU88778C LU88778I2 (fr) | 1987-06-16 | 1988-06-14 | Anastrozole optionellement sous forme d'un sel d'addition d'acide pharmaceutiquement acceptable (Arimidex (R)) |
Country Status (22)
Country | Link |
---|---|
US (2) | US4935437A (fr) |
EP (1) | EP0296749B1 (fr) |
JP (1) | JP2609290B2 (fr) |
AT (1) | ATE113277T1 (fr) |
AU (1) | AU605872B2 (fr) |
CA (1) | CA1337420C (fr) |
DE (1) | DE3851914T2 (fr) |
DK (1) | DK174573B1 (fr) |
ES (1) | ES2063036T3 (fr) |
FI (1) | FI97804C (fr) |
GB (1) | GB8714013D0 (fr) |
HK (1) | HK1000206A1 (fr) |
HU (1) | HU211142A9 (fr) |
IE (1) | IE65570B1 (fr) |
IL (1) | IL86499A (fr) |
LU (1) | LU88778I2 (fr) |
MX (1) | MX9202876A (fr) |
NL (1) | NL970012I2 (fr) |
NO (2) | NO170080C (fr) |
NZ (1) | NZ225037A (fr) |
PT (1) | PT87720B (fr) |
ZA (1) | ZA883691B (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8810067D0 (en) * | 1988-04-28 | 1988-06-02 | Ucb Sa | Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides |
NZ236440A (en) * | 1989-12-15 | 1993-07-27 | Merck & Co Inc | Reversal of sexual phenotype in poultry using an inhibitor of steroid biotransformation and/or aromatase inhibitor, poultry produced by this process |
EP0445073A1 (fr) * | 1990-02-27 | 1991-09-04 | Ciba-Geigy Ag | Benzofurannes |
EP0457716A1 (fr) * | 1990-04-20 | 1991-11-21 | Ciba-Geigy Ag | Dérivés de naphtaline |
TW224461B (fr) * | 1990-09-18 | 1994-06-01 | Ciba Geigy Ag | |
US5162337A (en) * | 1990-10-05 | 1992-11-10 | Merck & Co., Inc. | Animal growth promotion |
CH683151A5 (de) * | 1991-04-24 | 1994-01-31 | Ciba Geigy Ag | Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus. |
KR100219760B1 (ko) * | 1996-03-13 | 1999-09-01 | 김성환 | 보온 단열재 |
GB0012293D0 (en) * | 2000-05-23 | 2000-07-12 | Astrazeneca Ab | Pharmaceutical combination |
GB0129457D0 (en) | 2001-12-10 | 2002-01-30 | Astrazeneca Ab | Method of treatment |
WO2005105762A1 (fr) * | 2004-05-05 | 2005-11-10 | Natco Pharma Limited | Procede ameliore pour la preparation d'une anastrozole a purete elevee |
GB0412492D0 (en) | 2004-06-04 | 2004-07-07 | Sterix Ltd | Compound |
GB0414120D0 (en) * | 2004-06-24 | 2004-07-28 | Generics Uk Ltd | Novel processes and intermediates |
US20060035950A1 (en) * | 2004-08-09 | 2006-02-16 | Mohammed Alnabari | Novel processes for preparing substantially pure anastrozole |
WO2006077428A1 (fr) | 2005-01-21 | 2006-07-27 | Astex Therapeutics Limited | Composes pharmaceutiques |
US20060189670A1 (en) * | 2005-02-22 | 2006-08-24 | Glenmark Pharmaceuticals Limited | Process for the preparation of anastrozole and intermediates thereof |
EP1705168A1 (fr) * | 2005-03-21 | 2006-09-27 | Helm AG | Procédé amelioré de bromuration d'alkylbenzènes dans la chaine laterale |
EP1751121A2 (fr) * | 2005-04-06 | 2007-02-14 | Sicor Inc. | Procede de preparation de l'anastrozole |
CN101208312A (zh) * | 2005-06-27 | 2008-06-25 | 西科尔公司 | 用于合成阿那曲唑及纯化一种阿那曲唑中间体的方法 |
US20070032660A1 (en) * | 2005-06-27 | 2007-02-08 | Alessandro Pontiroli | Purification process for Anastrozole intermediate |
EP2397472A1 (fr) | 2005-09-30 | 2011-12-21 | Cadila Healthcare Limited | Procédé de preparation d' un intermédiaire du bromure de benzyle |
US20080207915A1 (en) * | 2005-10-05 | 2008-08-28 | Radhakrishnan Tarur Venkatasub | Process for the Preparation of 2,2'-[5-(1H-1,2,4-Triazole-1-Ylmethyl) -1,3-Phenylene] Di (2-Methylpropionitrile) |
WO2007039919A1 (fr) * | 2005-10-06 | 2007-04-12 | Natco Pharma Limited | Formes cristallines d'anastrozole |
US20070100148A1 (en) * | 2005-10-31 | 2007-05-03 | Veerender Murki | Process for preparing anastrozole |
WO2007105231A1 (fr) * | 2006-03-10 | 2007-09-20 | Shilpa Medicare Ltd. | Procédé amélioré permettant de préparer un anastrozole a haut degré de pureté |
AR061016A1 (es) * | 2006-05-19 | 2008-07-30 | Synthon Bv | Proceso para la purificacion de anastrozol |
EP2029557A1 (fr) * | 2006-06-05 | 2009-03-04 | Cadila Healthcare Ltd. | Procédé de préparation d'anastrozole pur |
WO2008034644A2 (fr) * | 2006-09-22 | 2008-03-27 | Synthon B.V. | Procédé de fabrication d'anastrozole |
US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
EP2073807A1 (fr) | 2006-10-12 | 2009-07-01 | Astex Therapeutics Limited | Combinaisons pharmaceutiques |
KR101502322B1 (ko) * | 2006-10-17 | 2015-03-13 | 시플라 리미티드 | 순수한 아나스트로졸의 제조방법 |
US20080177081A1 (en) * | 2007-01-19 | 2008-07-24 | Formosa Laboratories, Inc. | Process for Preparation of Anastrozole |
CN101307027B (zh) * | 2007-05-17 | 2011-09-07 | 杜焕达 | 一种阿那曲唑的新的制备方法 |
WO2009018811A1 (fr) * | 2007-08-06 | 2009-02-12 | Schebo Biotech Ag | Nouveaux médicaments, procédé pour leur production et leur utilisation thérapeutique médicale |
MX2010004195A (es) | 2007-10-16 | 2010-06-02 | Repros Therapeutics Inc | Trans-clomifeno para el sindrome metabolico. |
WO2009128919A1 (fr) * | 2008-04-15 | 2009-10-22 | Concert Pharmaceuticals, Inc. | Analogues d'anastrozole portant du deutérium en tant qu'inhibiteurs d'aromatase pour le traitement du cancer du sein |
US20100111901A1 (en) * | 2008-11-03 | 2010-05-06 | Auspex Pharmaceuticals, Inc. | Triazole inhibitors of aromatase |
DE102010046464A1 (de) | 2009-03-19 | 2011-04-21 | Amw Gmbh | Transdermales System mit Aromatasehemmer |
EP2343278A1 (fr) | 2010-01-07 | 2011-07-13 | Hexal AG | Procédé de préparation de dérivés de phényle trisubstitué comprenant un groupe (1H-1,2,4-triazol-1-yl)alkyle |
DE102010026883A1 (de) | 2010-03-11 | 2011-12-15 | Amw Gmbh | Transdermales System mit Aromatasehemmer |
WO2013130832A1 (fr) | 2012-02-29 | 2013-09-06 | Repros Therapeutics Inc. | Polythérapie pour le traitement d'une carence en androgène |
CN103172580B (zh) * | 2013-03-29 | 2015-04-22 | 凯莱英医药集团(天津)股份有限公司 | 一种阿那曲唑的制备方法 |
ITRM20130285A1 (it) | 2013-05-14 | 2014-11-15 | Corden Pharma Latina S P A Con Uni Co Socio | Metodo per la preparazione di anastrozolo di grado farmaceutico |
CN103342663B (zh) * | 2013-07-15 | 2015-07-29 | 凯莱英医药集团(天津)股份有限公司 | 一种阿那曲唑关键中间体的制备方法 |
CN104387332B (zh) * | 2014-11-27 | 2016-04-13 | 江苏正大清江制药有限公司 | 一种合成芳香化酶抑制剂的方法 |
WO2017081171A1 (fr) | 2015-11-10 | 2017-05-18 | Paracrine Therapeutics Ab | Traitement d'un cancer du sein négatif pour er à l'aide d'un inhibiteur du pdgf-cc et d'un anti-œstrogène |
CN106083748B (zh) * | 2016-06-21 | 2019-08-16 | 扬子江药业集团江苏海慈生物药业有限公司 | 一种阿那曲唑的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2431407C2 (de) * | 1974-06-29 | 1982-12-02 | Bayer Ag, 5090 Leverkusen | 1,2,4-Triazol-1-yl-alkanone und -alkanole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide |
JPS55313A (en) * | 1978-06-13 | 1980-01-05 | Kissei Pharmaceut Co Ltd | Imidazole derivative |
CA1134828A (fr) * | 1978-12-28 | 1982-11-02 | Tadao Tanouchi | Derives de la pyridine |
ZA84652B (en) * | 1983-02-02 | 1985-09-25 | Lilly Co Eli | Aromatase inhibiting pyrimidine derivatives |
US4755526A (en) * | 1984-06-18 | 1988-07-05 | Eli Lilly And Company | Method of inhibiting aromatase |
US4801594A (en) * | 1984-06-18 | 1989-01-31 | Eli Lilly And Company | Aromatase inhibitors |
US4766140A (en) * | 1984-06-18 | 1988-08-23 | Eli Lilly And Company | Method of inhibiting aromatase |
GB2162513B (en) * | 1984-06-25 | 1988-01-20 | Toyama Chemical Co Ltd | Dihydropyridine derivatives |
US4699652A (en) * | 1985-07-22 | 1987-10-13 | Hoffmann-La Roche Inc. | Fungicidal pyridine derivatives for use in agriculture |
EP0228995A1 (fr) * | 1985-12-20 | 1987-07-15 | Ciba-Geigy Ag | Microbicides |
US4749713A (en) * | 1986-03-07 | 1988-06-07 | Ciba-Geigy Corporation | Alpha-heterocycle substituted tolunitriles |
EP0275955B1 (fr) * | 1987-01-21 | 1990-07-04 | Ciba-Geigy Ag | Composition microbicide |
-
1987
- 1987-06-16 GB GB878714013A patent/GB8714013D0/en active Pending
-
1988
- 1988-05-19 IE IE150588A patent/IE65570B1/en active Protection Beyond IP Right Term
- 1988-05-24 ZA ZA883691A patent/ZA883691B/xx unknown
- 1988-05-25 IL IL86499A patent/IL86499A/xx not_active IP Right Cessation
- 1988-05-31 AU AU16911/88A patent/AU605872B2/en not_active Expired
- 1988-06-10 US US07/204,743 patent/US4935437A/en not_active Ceased
- 1988-06-14 DE DE3851914T patent/DE3851914T2/de not_active Expired - Lifetime
- 1988-06-14 EP EP88305429A patent/EP0296749B1/fr not_active Expired - Lifetime
- 1988-06-14 PT PT87720A patent/PT87720B/pt not_active IP Right Cessation
- 1988-06-14 ES ES88305429T patent/ES2063036T3/es not_active Expired - Lifetime
- 1988-06-14 AT AT88305429T patent/ATE113277T1/de active
- 1988-06-14 LU LU88778C patent/LU88778I2/fr unknown
- 1988-06-15 NO NO882628A patent/NO170080C/no not_active IP Right Cessation
- 1988-06-15 CA CA000569512A patent/CA1337420C/fr not_active Expired - Lifetime
- 1988-06-15 NZ NZ225037A patent/NZ225037A/xx unknown
- 1988-06-16 JP JP63147068A patent/JP2609290B2/ja not_active Expired - Lifetime
- 1988-06-16 DK DK198803304A patent/DK174573B1/da not_active IP Right Cessation
- 1988-06-16 FI FI882882A patent/FI97804C/fi active Protection Beyond IP Right Term
-
1992
- 1992-06-15 MX MX9202876A patent/MX9202876A/es unknown
-
1995
- 1995-05-31 HU HU95P/P00144P patent/HU211142A9/hu unknown
-
1996
- 1996-04-03 US US08/627,311 patent/USRE36617E/en not_active Expired - Lifetime
-
1997
- 1997-03-04 NL NL970012C patent/NL970012I2/nl unknown
- 1997-05-16 NO NO1997006C patent/NO1997006I1/no unknown
- 1997-09-05 HK HK97101733A patent/HK1000206A1/xx not_active IP Right Cessation
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